CN104873792A - Lower extremity varicose ulcer treatment pharmaceutical composition - Google Patents
Lower extremity varicose ulcer treatment pharmaceutical composition Download PDFInfo
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- CN104873792A CN104873792A CN201510295471.4A CN201510295471A CN104873792A CN 104873792 A CN104873792 A CN 104873792A CN 201510295471 A CN201510295471 A CN 201510295471A CN 104873792 A CN104873792 A CN 104873792A
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Abstract
The invention belongs to the technical field of medicines and particularly relates to a lower extremity varicose ulcer treatment pharmaceutical composition including ingredients of golden cypress, angelica root, Saposhnikovia divaricata, lignum millettiae, radix lithospermi, rhizoma alismatis, dendrobe, cortex dictam, parasitic loranthus, radix angelicae tuhuo, Pinellia ternata, cowherb seed and the like. The curative effect for the lower extremity varicose ulcer is precision, the amazing effects of clearing heat and promoting diuresis, promoting blood circulation to remove meridian obstruction, dispersing swelling and expelling pus, dispelling rotten tissue and promoting tissue growth are achieved, and the pharmaceutical composition serves as an effective medicine for lower extremity varicose ulcer treatment.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of varicose ulcer of lower extremity.
Background technology
Varicose ulcer of lower extremity, the traditional Chinese medical science is called " ecthyma ", also known as leg opening poison, ecthyma.Uncommon finger occurs in the chronic ulcer of shank bottom, and how by standing for a long time or excessively bearing a heavy burden, and cause shank flaccidity of muscles and vessels, blue veins appears, and the stasis of blood stops venation, heat-transformation for a long time, or skin of leg breakage contamination, and damp invasion of lower energizer forms, and the open sore part is prolonged not to heal.Be equivalent to the Chronic leg ulcer of doctor trained in Western medicine.Primary disease is secondary to the disease such as varicose veins of the lower extremity and erysipelas more.Its clinical characters to be mainly in shank outside in before lower 1/3 intersection, affected part chronic skin ecchymosis before ulcer occurs, coarse, though the open sore part is prolonged more not or closed up after festering, often easily to recur because of local damage.This disease is commonly called as always rotten lower limb, is disease common clinically, and often the course of disease is longer, recovery is slower.
The traditional Chinese medical science thinks that the etiology and pathogenesis of varicose ulcer of lower extremity is mainly summarised as the aspects such as damp invasion of lower energizer, insufficiency of the spleen leading to overabundance of dampness, blood stasis due to qi deficiency, utilize modern scientific research method, science and the reliability of Chinese medicine varicose ulcer of lower extremity are significantly improved, and effective percentage is high, obviously can shorten the time of ulcer healing, alleviate the misery of patient, and toxic and side effects is little, the Chinese medicine preparation of therefore profound under instruction of Chinese Medicine theory exploration treatment varicose ulcer of lower extremity to be applied to clinical expansion necessary.
Summary of the invention
The invention provides a kind of pharmaceutical composition for the treatment of varicose ulcer of lower extremity, its determined curative effect, safety is high, can be used as the ideal medicament compositions for the treatment of varicose ulcer of lower extremity.Pharmaceutical composition prescription of the present invention is rigorous, and compatibility science is evident in efficacy, easy to prepare, and patient compliance is good, without any side effects, clinic promotion and application.
For achieving the above object, technical scheme provided by the invention is the pharmaceutical composition of described treatment varicose ulcer of lower extremity, by the composition and ratio of crude drug is: Cortex Phellodendri 20-30g, Radix Angelicae Dahuricae 15-18g, Radix Saposhnikoviae 12-18g, Caulis Spatholobi 10-15g, Radix Arnebiae (Radix Lithospermi) 8-12g, Rhizoma Alismatis 18-22g, Herba Dendrobii 8-12g, Cortex Dictamni 15-20g, Herba Taxilli 10-15g, Radix Angelicae Pubescentis 8-12g, Rhizoma Pinelliae 3-8g, Semen Vaccariae 6-10g.
Most preferred technique scheme of the present invention is that pharmaceutical composition of the present invention is obtained by the material medicine of following weight proportion: Cortex Phellodendri 25g, Radix Angelicae Dahuricae 16g, Radix Saposhnikoviae 15g, Caulis Spatholobi 12g, Radix Arnebiae (Radix Lithospermi) 10g, Rhizoma Alismatis 20g, Herba Dendrobii 10g, Cortex Dictamni 18g, Herba Taxilli 13g, Radix Angelicae Pubescentis 10g, Rhizoma Pinelliae 5g, Semen Vaccariae 8g.
Present invention also offers the preparation method of described pharmaceutical composition, specifically comprise: take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, decoct 2 times after soaking 2h, add the water of medicine gross weight 3 times at every turn, decoct 2 hours, merge decoction liquor, filter; When filtrate concentrates 80 DEG C, relative density is the extractum of 1.21, cold drying, the traditional Chinese medicine fine powder of pulverizing, eventually passes normal process steps and adds pharmaceutically acceptable excipients and make clinical acceptable dosage form.
Pharmaceutical composition of the present invention can be prepared into external preparation.Preferably be prepared into lotion, liniment or ointment.
When above-mentioned external preparation is ointment, its prescription is:
The preparation method of described ointment, have the following steps: first the glycerol of recipe quantity, carbamide and ethyl hydroxybenzoate are dissolved in hot water, the traditional Chinese medicine fine powder adding recipe quantity again adds water to enough after being stirred to and dissolving completely, regulate pH value to 7.0 with appropriate triethanolamine.
The present invention, relative to prior art, has following clear superiority:
Pharmaceutical composition prescription of the present invention mainly develops according to the pathogenic characteristic of varicose ulcer of lower extremity patient, Cortex Phellodendri, Rhizoma Alismatis, Cortex Dictamni in side, and clearing away heat-damp and promoting diuresis detoxifies, and is monarch drug; The Radix Angelicae Dahuricae, Radix Saposhnikoviae, Herba Taxilli, Radix Angelicae Pubescentis, wind-damp dispelling, bone and muscle strengthening, numbness relieving and pain relieving, detumescence and apocenosis are ministerial drug; Help with Caulis Spatholobi, Radix Arnebiae (Radix Lithospermi), Semen Vaccariae, promoting blood circulation to remove obstruction in the collateral of enriching blood, putrefaction removing life; Herba Dendrobii, the Rhizoma Pinelliae, heat clearing away dispels dampness, dispersing swelling and dissipating binds for making medicine.This pharmaceutically dosage form is advanced, and preparation is simple, is suitable for large technological process to be produced, and determined curative effect, easy to use, have no side effect, patient compliance is good.In prescription, all medicines share the effect with clearing away heat-damp and promoting diuresis, promoting blood circulation to remove obstruction in the collateral, detumescence and apocenosis, putrefaction removing life, have extremely strong specific aim curative effect to varicose ulcer of lower extremity especially damp heat downward flowing type varicose ulcer of lower extremity.Through clinical practice checking, its determined curative effect, mild in medicine property and, do not occur toxic and side effects and untoward reaction, safety coefficient is high.
Further, in pharmaceutical composition of the present invention, the function of each crude drug cures mainly:
Cortex Phellodendri, bitter, cold.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
The Radix Angelicae Dahuricae, pungent, temperature.Return stomach, large intestine, lung meridian.Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Radix Saposhnikoviae, acrid, sweet, warm.Return bladder, liver, spleen channel.Inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Caulis Spatholobi, bitter, sweet, temperature.Return liver, kidney channel.Enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Radix Arnebiae (Radix Lithospermi) is sweet, salty, cold.GUIXIN, Liver Channel.Removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Rhizoma Alismatis, sweet, cold.Return kidney, urinary bladder channel.Diuresis, clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.
Herba Dendrobii, sweet, be slightly cold.Return stomach, kidney channel.Reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.
Cortex Dictamni is bitter, cold.Return spleen, stomach, urinary bladder channel.Heat clearing and damp drying, removing toxic substances of dispeling the wind.For damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia, jaundice dark coloured urine.
Herba Taxilli, bitter, sweet, flat.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension.
Radix Angelicae Pubescentis, pungent, bitter, tepor.Return kidney, urinary bladder channel.Expelling wind and removing dampness, numbness relieving and pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.
The Rhizoma Pinelliae, pungent, temperature; Poisonous.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus.
Semen Vaccariae is bitter, flat.Return liver, stomach warp.Promoting blood circulation to restore menstrual flow, stimulating milk secretion is subsided a swelling.For agalactia, amenorrhea, dysmenorrhea, acute mastitis swells and ache.
The present invention also asks the purposes protecting aforementioned pharmaceutical compositions in the medicine of preparation treatment varicose ulcer of lower extremity.In clinical observation process, treatment group and matched group is divided into treat at random 91 routine varicose ulcer of lower extremity patients, after treatment group uses Drug therapy 1-4 of the present invention course for the treatment of, clinical effectiveness shows, after treatment group varicose ulcer of lower extremity disease patient treatment, symptom can significantly improve.And body weight, heart rate, blood pressure are showed no obvious change before and after treatment group treatment.Treatment group does not find obvious adverse events in whole therapeutic process.Result shows that the clinical application safety of we is high, can study further as the active drug for the treatment of varicose ulcer of lower extremity and apply.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 ointment
The each raw material of the present invention is taken: Cortex Phellodendri 25g, Radix Angelicae Dahuricae 16g, Radix Saposhnikoviae 15g, Caulis Spatholobi 12g, Radix Arnebiae (Radix Lithospermi) 10g, Rhizoma Alismatis 20g, Herba Dendrobii 10g, Cortex Dictamni 18g, Herba Taxilli 13g, Radix Angelicae Pubescentis 10g, Rhizoma Pinelliae 5g, Semen Vaccariae 8g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, decoct 2 times after soaking 2h, add the water of medicine gross weight 3 times at every turn, decoct 2 hours, merge decoction liquor, filter; When filtrate concentrates 80 DEG C, relative density is the extractum of 1.21, cold drying, and the traditional Chinese medicine fine powder of pulverizing is for subsequent use.
Glycerol 80g, carbamide 100g and ethyl hydroxybenzoate 3g are dissolved in hot water, then add traditional Chinese medicine fine powder 120g be stirred to dissolve completely after add water to 1000g, regulate pH value to 7.0 namely to obtain ointment with appropriate triethanolamine.
When using medicine composite for curing varicose ulcer of lower extremity of the present invention, use prepared ointment, apply affected part gently at every turn, every day 3-4 time.
Embodiment 2 lotion
The each raw material of the present invention is taken: Cortex Phellodendri 25g, Radix Angelicae Dahuricae 16g, Radix Saposhnikoviae 15g, Caulis Spatholobi 12g, Radix Arnebiae (Radix Lithospermi) 10g, Rhizoma Alismatis 20g, Herba Dendrobii 10g, Cortex Dictamni 18g, Herba Taxilli 13g, Radix Angelicae Pubescentis 10g, Rhizoma Pinelliae 5g, Semen Vaccariae 8g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, decoct 2 times after soaking 2h, add the water of medicine gross weight 3 times at every turn, decoct 2 hours, merge decoction liquor, filter; When filtrate concentrates 80 DEG C, relative density is the extractum of 1.21, and cold drying, the traditional Chinese medicine fine powder of pulverizing, adds ethanol and mix well, then adds to enough with distilled water.
Embodiment 3 liniment
The each raw material of the present invention is taken: Cortex Phellodendri 25g, Radix Angelicae Dahuricae 16g, Radix Saposhnikoviae 15g, Caulis Spatholobi 12g, Radix Arnebiae (Radix Lithospermi) 10g, Rhizoma Alismatis 20g, Herba Dendrobii 10g, Cortex Dictamni 18g, Herba Taxilli 13g, Radix Angelicae Pubescentis 10g, Rhizoma Pinelliae 5g, Semen Vaccariae 8g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, decoct 2 times after soaking 2h, add the water of medicine gross weight 3 times at every turn, decoct 2 hours, merge decoction liquor, filter; When filtrate concentrates 80 DEG C, relative density is the extractum of 1.21, cold drying, the traditional Chinese medicine fine powder of pulverizing, joins during ethanol and propylene glycol stir, then adds to distilled water enough.
Embodiment 4 ointment
The each raw material of the present invention is taken: Cortex Phellodendri 20g, Radix Angelicae Dahuricae 15g, Radix Saposhnikoviae 12g, Caulis Spatholobi 10g, Radix Arnebiae (Radix Lithospermi) 8g, Rhizoma Alismatis 18g, Herba Dendrobii 8g, Cortex Dictamni 15g, Herba Taxilli 10g, Radix Angelicae Pubescentis 8g, Rhizoma Pinelliae 3g, Semen Vaccariae 6g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, decoct 2 times after soaking 2h, add the water of medicine gross weight 3 times at every turn, decoct 2 hours, merge decoction liquor, filter; When filtrate concentrates 80 DEG C, relative density is the extractum of 1.21, cold drying, and the traditional Chinese medicine fine powder of pulverizing is for subsequent use.
Glycerol 60g, carbamide 80g and ethyl hydroxybenzoate 1g are dissolved in hot water, then add traditional Chinese medicine fine powder 120g be stirred to dissolve completely after add water to 1000g, regulate pH value to 7.0 namely to obtain ointment with appropriate triethanolamine.
Embodiment 5 ointment
The each raw material of the present invention is taken: Cortex Phellodendri 30g, Radix Angelicae Dahuricae 18g, Radix Saposhnikoviae 18g, Caulis Spatholobi 15g, Radix Arnebiae (Radix Lithospermi) 12g, Rhizoma Alismatis 22g, Herba Dendrobii 12g, Cortex Dictamni 20g, Herba Taxilli 15g, Radix Angelicae Pubescentis 12g, Rhizoma Pinelliae 8g, Semen Vaccariae 10g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, decoct 2 times after soaking 2h, add the water of medicine gross weight 3 times at every turn, decoct 2 hours, merge decoction liquor, filter; When filtrate concentrates 80 DEG C, relative density is the extractum of 1.21, cold drying, and the traditional Chinese medicine fine powder of pulverizing is for subsequent use.
Glycerol 80g, carbamide 80g and ethyl hydroxybenzoate 3g are dissolved in hot water, then add traditional Chinese medicine fine powder 100g be stirred to dissolve completely after add water to 1000g, regulate pH value to 7.0 namely to obtain ointment with appropriate triethanolamine.
The clinical observation of embodiment 6 medicine composite for curing varicose ulcer of lower extremity of the present invention
1, case-data: select hospital outpatient varicose ulcer of lower extremity patient 91 example, point treatment group and matched group.Treatment group 46 example, man 30 example, female 16 example; Age is between 31-80 year; The course of disease was at 5 months-12 years, and wound surface maximum area 6.2cm × 5.9cm is one-sided extremity ulcer 42 place, bilateral 8 place, totally 50 places; Matched group 45 example, man 31 example, female 14 example; Age, the course of disease was at 4 months-12.5 years, and wound surface maximum area 6.1cm × 6.0cm is one-sided extremity ulcer 40 place, bilateral 10 place, totally 50 places between 30-82 year.The data of two groups of patients comprises sex, age, the state of an illness, severity extent aspect etc. and compares, and P > 0.05, there was no significant difference, has comparability.
2, tcm diagnosis foundation and disease type is formulated according to " disease of tcm curative effect is for standard " " ecthyma ":
1) comparatively common with shank in shank (inner side).
2) local is from the beginning of pain after often first itching, and color is red, rotten to the corn, transfers ulcer to rapidly.Ulcer differs in size, in greyish white or kermesinus, and surface or with yellow pus tongue, pus is dirty smelly unpleasant.Sick ulcer edge is thickening raised for a long time, surrounding color of the leather darkness, unrestrained swollen or with eczema, easy recurrent exerbation after closing up.
3) patient that lower limb suffer from flaccidity of muscles and vessels (varicosis) is more common in.
Syndrome-classification belongs to damp invasion of lower energizer: skin ulcer complexion is dark, or upper attached pus tongue, and pus is contaminated, dirty smelly unpleasant, and surrounding is unrestrained swollen scorching hot.With eczema, do during sufferings, very have fever with aversion to cold.Yellowish fur, rapid pulse.
3, Therapeutic Method:
Treatment group: use the ointment prepared by embodiment 1, apply affected part gently, every day 3-4 time, 1 week be 1 course for the treatment of at every turn.
Matched group: after adopting Polyvinyl Pyrrolidone-Iodine liquid disinfectant, normal saline gauze covers ulcer place, and 2 times on the 1st 1 week is 1 course for the treatment of.
Two groups all get 1-4 the course for the treatment of after add up clinical efficacy result.Lifting affected limb when treatments period all requires that patient puts down sleeping, wears stretch socks when walking lowerly.
4, the standard of curative effect evaluation:
1) cure: bordering epithelia tissue is creeped to center by edge rapidly, and ulcer heals completely;
2) effective: ulcer is dry, without obvious sepage or a small amount of sepage, granulation tissue is fresh, and bordering epithelia tissue is creeped soon, and ulcer obviously reduces (being greater than 50%);
3) invalid: ulcer is oozed out more, granulation tissue is stale, and bordering epithelia tissue is creeped slowly, and ulcer reduces not obvious.
5, therapeutic effect:
In clinical observation process, 91 routine patients all complete clinical observation, without exiting and the case that comes off.After two groups 4 courses for the treatment of, clinical effectiveness compares, treatment group clinical recovery rate 76%, effective percentage 100%, and clinical effectiveness is remarkable; Matched group clinical recovery rate 60%, effective percentage 92%.Two groups of therapeutic outcomes compare, and treatment group is significantly better than matched group (P < 0.05), especially cure rate aspect treatment group clinical effectiveness more remarkable (P < 0.01).Concrete outcome is:
After 1 course for the treatment of: the recovery from illness for the treatment of group ulcer is 7 places, effective 35 places, and total effective rate is 84%;
Effective 23 places of matched group ulcer, total effective rate 46%;
After 2 courses for the treatment of: the recovery from illness for the treatment of group ulcer is 19 places, effective 29 places, and total effective rate is 96%;
The recovery from illness of matched group ulcer is 11 places, effective 25 places, and total effective rate is 72%;
After 3 courses for the treatment of: the recovery from illness for the treatment of group ulcer is 28 places, effective 22 places, total effective rate 100%;
The recovery from illness of matched group ulcer is 20 places, effective 24 places, total effective rate 88%;
After 4 courses for the treatment of: the recovery from illness for the treatment of group ulcer is 38 places, effective 12 places, total effective rate 100%;
The recovery from illness of matched group ulcer is 30 places, and effective is 16 places, total effective rate 92%.
The above results shows, after the medicine composite for curing of varicose ulcer of lower extremity disease patient the application of the invention, symptom can significantly improve, and shows that pharmaceutical composition of the present invention can shorten the time of ulcer healing effectively, alleviates the misery of patient.In addition, rear body weight, heart rate, blood pressure are showed no obvious change to treatment group before the treatment.Treatment group does not find obvious adverse events in whole therapeutic process.Thus medicine composite for curing varicose ulcer of lower extremity determined curative effect of the present invention is described, safety is high, can be used as the medicine of varicose ulcer of lower extremity first-selection.
Claims (9)
1. treat the pharmaceutical composition of varicose ulcer of lower extremity for one kind, it is characterized in that, the composition and ratio of its primary raw material medicine is: Cortex Phellodendri 20-30g, Radix Angelicae Dahuricae 15-18g, Radix Saposhnikoviae 12-18g, Caulis Spatholobi 10-15g, Radix Arnebiae (Radix Lithospermi) 8-12g, Rhizoma Alismatis 18-22g, Herba Dendrobii 8-12g, Cortex Dictamni 15-20g, Herba Taxilli 10-15g, Radix Angelicae Pubescentis 8-12g, Rhizoma Pinelliae 3-8g, Semen Vaccariae 6-10g.
2. a kind of pharmaceutical composition for the treatment of varicose ulcer of lower extremity as claimed in claim 1, it is characterized in that, the composition and ratio of its primary raw material medicine is: Cortex Phellodendri 25g, Radix Angelicae Dahuricae 16g, Radix Saposhnikoviae 15g, Caulis Spatholobi 12g, Radix Arnebiae (Radix Lithospermi) 10g, Rhizoma Alismatis 20g, Herba Dendrobii 10g, Cortex Dictamni 18g, Herba Taxilli 13g, Radix Angelicae Pubescentis 10g, Rhizoma Pinelliae 5g, Semen Vaccariae 8g.
3. a kind of pharmaceutical composition for the treatment of varicose ulcer of lower extremity as described in claim 1,2, it is characterized in that, the preparation method of described pharmaceutical composition comprises following steps: take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, decoct 2 times after soaking 2h, add the water of medicine gross weight 3 times at every turn, decoct 2 hours, merge decoction liquor, filter; When filtrate concentrates 80 DEG C, relative density is the extractum of 1.21, and cold drying, is ground into traditional Chinese medicine fine powder, eventually passes normal process steps and adds pharmaceutically acceptable excipients and make clinical acceptable dosage form.
4. a kind of pharmaceutical composition for the treatment of varicose ulcer of lower extremity as claimed in claim 3, it is characterized in that, described pharmaceutical composition can be made into external preparation.
5. a kind of pharmaceutical composition for the treatment of varicose ulcer of lower extremity as claimed in claim 4, it is characterized in that, described external preparation is preferably lotion, liniment or ointment.
6. a kind of pharmaceutical composition for the treatment of varicose ulcer of lower extremity as claimed in claim 5, it is characterized in that, described ointment prescription is:
7. a kind of pharmaceutical composition for the treatment of varicose ulcer of lower extremity as claimed in claim 6, it is characterized in that, the preparation method of described ointment comprises following steps: be first dissolved in hot water by the glycerol of recipe quantity, carbamide and ethyl hydroxybenzoate, the traditional Chinese medicine fine powder adding recipe quantity again adds water to enough after being stirred to and dissolving completely, regulate pH value to 7.0 with appropriate triethanolamine.
8. the purposes of medicine as claimed in claim 1 or 2 in the medicine of preparation treatment varicose ulcer of lower extremity.
9. the purposes of medicine as claimed in claim 1 or 2 in the medicine of preparation treatment damp heat downward flowing type varicose ulcer of lower extremity.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213810A (en) * | 2015-11-14 | 2016-01-06 | 张丽 | One treats cirsoid Chinese Traditional Medicines |
| CN114470056A (en) * | 2022-03-04 | 2022-05-13 | 山东中医药大学附属医院 | A Chinese medicinal preparation for treating lower limb venous ulcer, and its preparation method and application method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110158A (en) * | 1994-04-15 | 1995-10-18 | 彭勃 | Zizhi medical cream |
| CN103301234A (en) * | 2013-07-10 | 2013-09-18 | 于天德 | Traditional Chinese medicine composition for treating wound healing and preparation method thereof |
| CN104189318A (en) * | 2014-08-09 | 2014-12-10 | 陈丹 | Necrotic tissue eliminating and granulation promoting cream and production method thereof |
-
2015
- 2015-06-02 CN CN201510295471.4A patent/CN104873792A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110158A (en) * | 1994-04-15 | 1995-10-18 | 彭勃 | Zizhi medical cream |
| CN103301234A (en) * | 2013-07-10 | 2013-09-18 | 于天德 | Traditional Chinese medicine composition for treating wound healing and preparation method thereof |
| CN104189318A (en) * | 2014-08-09 | 2014-12-10 | 陈丹 | Necrotic tissue eliminating and granulation promoting cream and production method thereof |
Non-Patent Citations (5)
| Title |
|---|
| 中国药材公司: "《中国民间单验方》", 31 October 1994, 科学出版社 * |
| 刘桂菊: "中药米红药膏治疗压疮36例报告", 《现代康复》 * |
| 武忠业等: "王品三治疮疡方药介绍", 《中医药学刊》 * |
| 王敏等: "《中国彝族民间医药验方研究》", 30 November 2007, 云南民族出版社 * |
| 胡啸明等: "臁疮中医外治法的研究进展", 《四川中医》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213810A (en) * | 2015-11-14 | 2016-01-06 | 张丽 | One treats cirsoid Chinese Traditional Medicines |
| CN114470056A (en) * | 2022-03-04 | 2022-05-13 | 山东中医药大学附属医院 | A Chinese medicinal preparation for treating lower limb venous ulcer, and its preparation method and application method |
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