CN104871026B - 靶物质的体外磁共振检测 - Google Patents

靶物质的体外磁共振检测 Download PDF

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CN104871026B
CN104871026B CN201380065739.4A CN201380065739A CN104871026B CN 104871026 B CN104871026 B CN 104871026B CN 201380065739 A CN201380065739 A CN 201380065739A CN 104871026 B CN104871026 B CN 104871026B
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target substance
bound
magnetic nanoparticles
target
binding
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CN104871026A (zh
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R.文卡特桑
A.巴拉苏拉马尼安
C.R.阿特雷亚
R.赫格德
R.U.穆克赫杰
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General Electric Co
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General Electric Co
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/448—Relaxometry, i.e. quantification of relaxation times or spin density
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/32—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Bacillus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

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  • Immunology (AREA)
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  • Molecular Biology (AREA)
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  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
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  • Food Science & Technology (AREA)
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  • Condensed Matter Physics & Semiconductors (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201380065739.4A 2012-12-17 2013-12-13 靶物质的体外磁共振检测 Expired - Fee Related CN104871026B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN3886/DEL/2012 2012-12-17
IN3886DE2012 2012-12-17
GB201301992A GB201301992D0 (en) 2013-02-05 2013-02-05 In-vitro magnetic resonance detection of a target substance
GB1301992.2 2013-02-05
PCT/EP2013/076569 WO2014095645A1 (en) 2012-12-17 2013-12-13 In-vitro magnetic resonance detection of a target substance

Publications (2)

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CN104871026A CN104871026A (zh) 2015-08-26
CN104871026B true CN104871026B (zh) 2020-01-10

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US (1) US10156567B2 (cg-RX-API-DMAC7.html)
EP (1) EP2932289A1 (cg-RX-API-DMAC7.html)
JP (1) JP6371303B2 (cg-RX-API-DMAC7.html)
CN (1) CN104871026B (cg-RX-API-DMAC7.html)
WO (1) WO2014095645A1 (cg-RX-API-DMAC7.html)

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JP6244289B2 (ja) * 2014-10-29 2017-12-06 学校法人 神野学園 クドア・セプテンプンクタータの検出方法
JP6915949B2 (ja) 2016-07-21 2021-08-11 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． Ｉｖｄオートメーションシステムのための磁気シールド
CN107478834A (zh) * 2017-09-05 2017-12-15 杨蕾 一种检测沙门氏菌磁共振成像试剂盒的制备方法
EP3575813B1 (en) * 2018-05-30 2022-06-29 Siemens Healthcare GmbH Quantitative mapping of a magnetic resonance imaging parameter by data-driven signal-model learning
CN109658468B (zh) * 2018-12-12 2022-12-13 深圳先进技术研究院 磁共振参数成像方法、装置、设备及存储介质
EP4047356A4 (en) * 2019-10-17 2023-11-22 Riken DETECTION METHOD AND SYSTEM FOR DETECTION OF MASTITIS IN A DOMESTIC ANIMAL
IL295143B1 (en) * 2020-02-13 2025-10-01 Hoffmann La Roche A method for determining the loading state of AAV particles using nuclear magnetic resonance relaxometry
CN112611868A (zh) * 2020-12-18 2021-04-06 厦门大学 一种用于磁共振分析方法检测新型冠状病毒的探针及其制备方法
WO2023076447A1 (en) * 2021-10-28 2023-05-04 Massachusetts Institute Of Technology Micro magnetic resonance relaxometry (μmrr) for rapid and non-invasive detection of senescence in mesenchymal stem cells
WO2024263744A1 (en) * 2023-06-20 2024-12-26 Regents Of The University Of Michigan Methods for magnetic resonance molecular imaging of nanoconstructs and uses thereof

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WO2010109346A1 (en) * 2009-03-25 2010-09-30 Koninklijke Philips Electronics N.V. Quantification of intracellular and extracellular spio agents with r2 and r2* mapping
WO2011120712A1 (de) * 2010-04-01 2011-10-06 Hochschule Für Angewandte Wissenschaften Fachhochschule Würzburg-Schweinfurt Verfahren zur bestimmung der anwesenheit eines analyten mittels magnetischer kleinstpartikel sowie vorrichtung hierfür
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US20160195526A1 (en) 2016-07-07
US10156567B2 (en) 2018-12-18
JP6371303B2 (ja) 2018-08-08
WO2014095645A1 (en) 2014-06-26
CN104871026A (zh) 2015-08-26
EP2932289A1 (en) 2015-10-21
JP2016503159A (ja) 2016-02-01

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