CN104855390B - A kind of bactericidal composition containing cyproconazole Yu propamidine - Google Patents
A kind of bactericidal composition containing cyproconazole Yu propamidine Download PDFInfo
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- CN104855390B CN104855390B CN201510210267.8A CN201510210267A CN104855390B CN 104855390 B CN104855390 B CN 104855390B CN 201510210267 A CN201510210267 A CN 201510210267A CN 104855390 B CN104855390 B CN 104855390B
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- propamidine
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Abstract
The invention discloses a kind of bactericidal composition containing cyproconazole Yu propamidine, with cyproconazole and propamidine as effective ingredient, the weight ratio of cyproconazole and propamidine is between 20:1～1:50, in described bactericidal composition, the percetage by weight of effective ingredient is 10～80%, and the dosage form of described bactericidal composition is the one in cream or wettable powder or suspending agent or microemulsion or aqueous emulsion or water-dispersible granules；Bactericidal composition containing cyproconazole Yu propamidine of the present invention, have fungicidal spectrum wide, efficiently, the feature such as low toxicity, low-residual, potentiation be notable, and reduce the features such as use cost, it is particularly advantageous in the production of pollution-free food, said composition preventive effect is significantly higher than the preventive effect of alone cyproconazole and propamidine, and can reduce the application dosage of each bioactive substance.
Description
Technical field
The invention belongs to technical field of pesticide, relate to pesticide combination technology, contain particularly to one
There is the bactericidal composition of cyproconazole and propamidine.
Background technology
Cyproconazole is a kind of triazole bactericidal agent, chemical name: 2-(4-chlorphenyl)-3-cyclopropyl
-1-(1H-1,2,4-triazol-1-yls) butyl-2-alcohol, molecular formula: C15H18ClN3O, relative molecular weight:
291.78, structural formula is as follows:
Triadimenol is triazole bactericidal agent, is sterol demethylation inhibitors, has prevention and controls
Treatment effect；To the Erysiphales on cereal crop, coffee, Radix Betae, fruit tree and Fructus Vitis viniferae, rust
Zoopagales, to belong to the mould genus of spore, beak genus, Septoria, Venturia bacterium the most effective.Kill with other
Microbial inoculum is used with, can prevent and treat frumentum eye spot disease, leaf spot and net blotch very well；Preventing and treating wheat rust
Lasting period is 4～6 weeks, and preventing and treating powdery mildew is 3～4 weeks；
Propamidine is a kind of acid amidine compounds, chemical name: 1,3-bis-(4-amidino groups benzene oxygen
Base) propane, molecular formula: C17H20N4O2, relative molecular weight is 312.37, its structural formula:
Propamidine belongs to acid amidine compounds, and this compounds is pharmaceutically early having application and grinding
Study carefully.It pharmaceutically has protozoacide, antiviral, antifungal and antibacterium isoreactivity.By
In its cause hypotension, liver damage one-level to toxic and side effects such as the toxicity of kidney, limit its
Pharmaceutically medical；NZYM company of the U.S. finds that pentamidine is to grass in the once accidental time
The bacteriostatic activity of certain kind of berries ash arrhizus bacteria, and from 1999, Xibei Univ. of Agricultural & Forest Science & Technology was without public affairs
Evil pesticide research service centre cooperates with NZYM company of the U.S., starts to be devoted to such chemical combination
The disinfectant use in agriculture research of thing.
Through scientific research for many years, it was demonstrated that propamidine is as efficient, wide spectrum, environmental protection, nothing
The feasibility of the antibacterial of public hazards.Propamidine sterilization mechanism is unique, it is possible to change original pathogenic bacteria bacterium
The cellularity of silk and hypha form, the breeding of suppression pathogenic bacteria, make cell respectively organize disintegrate, lead
Pathogenic bacterium are disintegrated dead；Propamidine melon fruits and vegetables, tea, Nicotiana tabacum L., Chinese herbal medicine, flowers,
Use on the industrial crops such as afforestation gray mold, downy mildew, powdery mildew, anthrax, withered
Disease, bacterial wilt, mosaic disease, pathologic Hemerocallis citrina Baroni, little leaf, root rot, the cankers etc. of withering are equal
There is good prevention effect；To Fructus Lycopersici esculenti, Fructus Cucumidis sativi, Fructus Fragariae Ananssae, the gray mold of Fructus Vitis viniferae, leaf mold
There are the killing effect of uniqueness, simultaneously to virosis, leaf spot, powdery mildew, root rot, anthrax
Sick grade has good therapeutic effect；Simultaneously can be mixed with medicine, mixed rear excellent, tool
Having interior absorption, all plants easily can absorb as absorbing moisture, kills in plant
Bacterium, instant effect, within three days, can sterilize；It addition, root of the crop, stem, leaf are had significantly by propamidine
Facilitation, noresidue, pollution-free.
Prior art there are and be used alone cyproconazole or propamidine and other antimicrobial combination
Compounding form, but yet there are no the relevant report that cyproconazole and propamidine are compounding, there is no phase yet
The technology enlightenment answered determine both compounding after effect how.
Summary of the invention
It is an object of the invention to provide a kind of bactericidal composition containing cyproconazole Yu propamidine,
Said composition have fungicidal spectrum wide, efficiently, low toxicity, low-residual, potentiation is notable, use
The features such as low cost, are particularly advantageous in the production of pollution-free food.
Bactericidal composition containing cyproconazole Yu propamidine of the present invention, with cyproconazole and third
Alkane amidine is that active ingredient is compounding to be formed, and cyproconazole is 20:1～1 with the weight ratio of propamidine:
50。
The present invention is characteristic research based on cyproconazole, using cyproconazole with propamidine as effectively becoming
Part compounding, inventor gives optimum proportioning: the weight ratio of described cyproconazole and propamidine
For 5:1～1:10.In this ratio range, its co-toxicity coefficient is higher, has significantly increasing
Effect effect can significantly reduce the compositions cost after compounding simultaneously, is suitable to promote.
Bactericidal composition containing cyproconazole Yu propamidine of the present invention, with cyproconazole and third
Alkane amidine is that active ingredient is compounding to be formed, and wherein the percetage by weight of effective ingredient is 10～80%,
Inconspicuous less than this content then bactericidal effect, substantially there is no practical function, and contain higher than this
Weight range then can cause the waste of effective ingredient.
Cyproconazole is different from the propamidine mechanism of action, and cyproconazole is as sterol demethylation
Inhibitor, it is possible to making somatic cells film function be destroyed, this is equivalent to destroy thalline
Protective layer, and now propamidine can enter antibacterial by the above-mentioned effect of cyproconazole, at thalline
Inside work, change pathogen hyphal cell structure and hypha form, suppress the breeding of pathogenic bacteria,
Make cell respectively organize disintegrate, cause pathogenic bacteria to be disintegrated dead；It is visible that both can play the most mutually
Benefit effect, it may be said that be inside and outside minor, cyproconazole mainly produces impact suppression antibacterial to cell membrane,
Propamidine is from internal sabotage cellularity.Thus play obvious potentiation.And why control
Make above-mentioned consumption, it is simply that in order to balance synergism between the two, if one-sided improve or
Reduce the consumption of a certain component, then can be substantially reduced both synergism, than being used alone
Any one effect in Liang Zhe is the best many.
The dosage form of bactericidal composition of the present invention be cream or wettable powder or suspending agent or
One in microemulsion or aqueous emulsion or water-dispersible granules.
Auxiliary element in bactericidal composition of the present invention include acceptable organic solvent,
Emulsifying agent, surfactant, inert filler etc.；The most acceptable organic solvent includes, molten
Agent oil, fat hydrocarbon organic solvent, arene organic solvent, plant oil solvent, alcohols
Organic solvent, lipid organic solvent or organic solvent of ketone etc.；Adoptable surfactant has
Anionic surfactant and nonionic surfactant.Other auxiliary element also includes
Xanthan gum, the thickening agent such as carboxymethyl starch sodium, the antifreezing agent such as ethylene glycol, glycerol, carbamide；
The fillers such as Kaolin, bentonite, attapulgite, precipitated calcium carbonate, sulfur, and other agriculture
The acceptable stabilizer of medicine preparation, safener, coloring agent etc., above-mentioned various auxiliary elements
Directly to use conventional selection of the prior art, do not repeat them here.
Above-mentioned composition be applicable to cereal crops, coffee, Fructus Vitis viniferae, fruit tree, Semen arachidis hypogaeae, vegetable,
The powdery mildews of industrial crops such as tea, Nicotiana tabacum L., Chinese herbal medicine, flowers, afforestation, scab,
Virosis, brown rot, white rot, leaf spot, root rot, anthrax and by alternaric bacteria,
Botrytis cinerea, the microbial disease of sclerotiniose etc. have good therapeutic effect, to Fructus Lycopersici esculenti, Huang
Melon, Fructus Fragariae Ananssae, the gray mold of Fructus Vitis viniferae, powdery mildew, leaf mold have unique killing effect, additionally
Wheat rust is also had longer prevention effect.
The cyproconazole that the present invention provides as can be seen here and the bactericidal composition of propamidine, have sterilization
Spectrum is wide, efficiently, low toxicity, low-residual, potentiation significantly and reduce the features such as use cost,
It is particularly advantageous in the production of pollution-free food.Said composition preventive effect is significantly higher than alone cyproconazole and third
The preventive effect of alkane amidine, and the application dosage of each bioactive substance can be reduced.
Detailed description of the invention
The technical scheme related to invention below in conjunction with embodiment is further described, in order to have
Help the understanding of the present invention, but not as the restriction to technical scheme, in addition to specifically mentioned,
Component ratio is all weight percentage.
Being compounded by a certain percentage with propamidine by cyproconazole, its ratio is 20/1,15/1,
10/1,5/1,1/1,1/5,1/10,1/15,1/20,1/25,1/30,1/35,1/40,1/45,
1/50 compares with 20% cyproconazole aqueous suspension agent and 2% propamidine water preparation, carries out Fructus Vitis viniferae white lead
Disease, graw mold of tomato, grey mould fruit rot of strawberry, the Toxicity Determination of fruit tree leaves pinta.Result shows
Show: each medicament is 175.25～218.53 to the co-toxicity coefficient of uncinula necator.Show to have aobvious
The synergistic effect write, wherein the most prominent with 5/1 to 1/10 effect.
Using dosage: 12～18 grams of active ingredient/mus, spray medicine 5～7 days effects are obvious, anti-
Control wheat rust, Fructus Vitis viniferae Fructus Lycopersici esculenti powdery mildew, Fructus Lycopersici esculenti, grey mould fruit rot of strawberry, kafir lily leaf spot,
The preventive effects more than 90% such as fruit tree leaves pinta.
Embodiment one
12% cyproconazole propamidine cream
Raw material forms: the 10% former medicine of cyproconazole, the 2% former medicine of propamidine, 10%N-methylpyrrole
Alkanone, 10% dehydrated alcohol, 5% calcium dodecyl benzene sulfonate, 6% triphenoethyl benzene phenol polyoxy
Vinyl Ether, 4% phenethyl phenolformaldehyde resin polyoxyethylene ether, remaining is mended with solvent naphtha 200#
Foot.Cream mode is prepared routinely.
Field test 1:
Experimental pharmacy is that 12% cyproconazole propamidine cream is prepared by embodiment one, right
It is 20% cyproconazole aqueous suspension agent (laboratory self-control) according to medicament, 2% propamidine water preparation (market
Buy, Zhenghai, Ningbo City Lv Yuan capital goods in the agricultural sector company limited)；Controlling object is that Fructus Vitis viniferae is white
Powder is sick:
During medication, temperature on average is at 20-25 DEG C, and weather is based on fine to cloudy, and cyproconazole and propamidine compound rear synergistic effect
Substantially.
Embodiment two
51% cyproconazole propamidine wettable powder
Raw material consists of the 50% former medicine of cyproconazole, the 1% former medicine of propamidine, the 12% di-2-ethylhexylphosphine oxide bitter edible plant
Sodium sulfonate, 5% sodium lauryl sulphate, 8% calcium lignosulfonate, remaining is supplied with ammonium sulfate.
Can wet-milling mode prepare routinely.
Field test 1:
Experimental pharmacy is that 51% cyproconazole propamidine can be prepared by embodiment two by wet-milling, right
It is 20% cyproconazole aqueous suspension agent (laboratory self-control) according to medicament, 2% propamidine water preparation (market
Buy, Zhenghai, Ningbo City Lv Yuan capital goods in the agricultural sector company limited)；Controlling object, Fructus Lycopersici esculenti ash
Mildew；
During medication, temperature on average is at 20-25 DEG C, and weather is based on fine to cloudy, and cyproconazole and the compounding rear consumption of propamidine reduce,
Effect is obvious.
Embodiment three
51% cyproconazole propamidine wettable powder
Raw material consists of the 1% former medicine of cyproconazole, the 50% former medicine of propamidine, the 13% di-2-ethylhexylphosphine oxide bitter edible plant
Sodium sulfonate, 3% sodium lauryl sulphate, remaining is supplied with Kaolin.Routinely can wet-milling side
Formula is prepared.
Field test 1:
Experimental pharmacy is that 51% cyproconazole propamidine can be prepared by embodiment three by wet-milling, right
It is 20% cyproconazole aqueous suspension agent (laboratory self-control) according to medicament, 2% propamidine water preparation (market
Buy, Zhenghai, Ningbo City Lv Yuan capital goods in the agricultural sector company limited)；Controlling object tomato gray mould
Sick；
During medication, temperature on average is at 20-25 DEG C, and weather is based on fine to cloudy, and cyproconazole and the compounding rear consumption of propamidine reduce,
Effect is obvious.
Embodiment four
21% cyproconazole propamidine suspending agent；
Raw material consists of the 20% former medicine of cyproconazole, the 1% former medicine of propamidine, and 1.2% pulls open powder, and 1%
Di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate, 1.3% calcium dodecyl benzene sulfonate, 3% triphenoethyl benzene phenol polyoxy
Vinyl Ether, 1.5% white carbon, 0.20% xanthan gum, 5% ethylene glycol, remaining is supplied with water, presses
The Conventional suspending agents mode of production is prepared.
Field test 1:
Experimental pharmacy is that 21% cyproconazole propamidine suspending agent is prepared by embodiment four, right
It is 20% cyproconazole aqueous suspension agent (laboratory self-control) according to medicament, 2% propamidine water preparation (market
Buy, Zhenghai, Ningbo City Lv Yuan capital goods in the agricultural sector company limited)；Controlling object is Fructus Fragariae Ananssae ash
Mildew；
During medication, temperature on average is at 20-25 DEG C, and weather is based on fine to cloudy, and cyproconazole and propamidine compound rear synergistic effect
Substantially.
Embodiment five
30% cyproconazole propamidine suspending agent；
Raw material consists of the 25% former medicine of cyproconazole, the 5% former medicine of propamidine, 1.5% polyoxyethylene alkane
Base ether, 1% dispersant pulls open powder, 3% calcium dodecyl benzene sulfonate, 2% white carbon, and 0.15%
Xanthan gum, 5% ethylene glycol, remaining supplies with water, routinely the preparation of the suspending agent mode of production.
Field test 1:
Experimental pharmacy is that 30% cyproconazole propamidine suspending agent is prepared by embodiment five, right
It is 20% cyproconazole aqueous suspension agent (laboratory self-control) according to medicament, 2% propamidine water preparation (market
Buy, Zhenghai, Ningbo City Lv Yuan capital goods in the agricultural sector company limited)；Controlling object is fruit tree leaves
Pinta；
During medication, temperature on average is at 20-25 DEG C, and weather is based on fine to cloudy, and cyproconazole and the compounding rear consumption of propamidine reduce,
Effect is obvious.
Embodiment six
8% cyproconazole propamidine microemulsion
Raw material consists of the 4% former medicine of cyproconazole, the 4% former medicine of propamidine, 5% dimethylbenzene, 6% ring
Ketone, 15% toluene, 5% phenethyl phenolformaldehyde resin polyoxyethylene ether, 3% dodecyl
Benzenesulfonic acid calcium, 7% alkylphenol polyoxyethylene, 5% ethylene glycol, remaining is supplied with water, by often
Rule microemulsion mode is prepared.
Field test 1:
Experimental pharmacy is that 8% cyproconazole propamidine microemulsion is prepared by embodiment six, right
It is 20% cyproconazole aqueous suspension agent (laboratory self-control) according to medicament, 2% propamidine water preparation (market
Buy, Zhenghai, Ningbo City Lv Yuan capital goods in the agricultural sector company limited)；Controlling object is that Fructus Vitis viniferae is white
Powder is sick；
During medication, temperature on average is at 20-25 DEG C, and weather is based on fine to cloudy, and cyproconazole and the compounding rear consumption of propamidine reduce,
Effect is obvious.
Field control effectiveness test 2:
Experimental pharmacy is that 8% cyproconazole propamidine microemulsion is prepared by embodiment six, right
It is 20% cyproconazole aqueous suspension agent (laboratory self-control) according to medicament, 2% propamidine water preparation (market
Buy, Zhenghai, Ningbo City Lv Yuan capital goods in the agricultural sector company limited)；Controlling object is tomato leaf
Pinta:
During medication, temperature on average is at 21-25 DEG C, and weather is based on fine, and cyproconazole and the compounding rear consumption of propamidine reduce, effect
Substantially.
Embodiment seven
17% cyproconazole propamidine aqueous emulsion
Raw material forms: the 15% former medicine of cyproconazole, the 2% former medicine of propamidine, 10% acetone, 5%N-
Methyl pyrrolidone, 15% dimethylbenzene, 5% calcium dodecyl benzene sulfonate, 3% triphenoethyl benzene
Phenol polyethenoxy ether, 4% phenethyl phenolformaldehyde resin polyoxyethylene ether, 5% base phenol polyoxy second
Alkene ether, 5% ethylene glycol, remaining is supplied with water.Water and milk mode is joined routinely.
Field test 1:
Experimental pharmacy is that 17% cyproconazole propamidine aqueous emulsion is prepared by embodiment seven, right
It is 20% cyproconazole aqueous suspension agent (laboratory self-control) according to medicament, 2% propamidine water preparation (market
Buy, Zhenghai, Ningbo City Lv Yuan capital goods in the agricultural sector company limited)；Controlling object is Fructus Lycopersici esculenti ash
Mildew；
During medication, temperature on average is at 20-25 DEG C, and weather is based on fine to cloudy, and cyproconazole and propamidine compound rear synergistic effect
Substantially.
Embodiment eight
77% cyproconazole propamidine water dispersion granule
Raw material forms: the 70% former medicine of cyproconazole, the 7% former medicine of propamidine；4% di-2-ethylhexylphosphine oxide LOMAR PWA EINECS 246-676-2
Sodium, 5%WG-3,5% fatty alcohol sulphuric acid sodium salt, 2% carboxymethyl starch sodium, remaining uses carboxymethyl
Starch Sodium is supplied, and extruder grain mode is prepared routinely.
Field test 1:
Experimental pharmacy is that 77% cyproconazole propamidine granule is prepared by embodiment eight, right
It is 20% cyproconazole aqueous suspension agent (laboratory self-control) according to medicament, 2% propamidine water preparation (market
Buy, Zhenghai, Ningbo City Lv Yuan capital goods in the agricultural sector company limited)；Controlling object is Fructus Fragariae Ananssae ash
Mildew；
During medication, temperature on average is at 20-25 DEG C, and weather is based on fine to cloudy, and cyproconazole and propamidine compound rear synergistic effect
Substantially.
Embodiment nine
77% cyproconazole propamidine water dispersion granule
Raw material forms: the 7% former medicine of cyproconazole, the 70% former medicine of propamidine；4% di-2-ethylhexylphosphine oxide LOMAR PWA EINECS 246-676-2
Sodium, 4.5%WG-3,5% fatty alcohol sulphuric acid sodium salt, 2.5% carboxymethyl starch sodium, remaining uses carboxylic
Methyl starch sodium is supplied, and extruder grain mode is prepared routinely.
Field test 1:
Experimental pharmacy is that 77% cyproconazole propamidine granule is prepared by embodiment eight, right
It is 20% cyproconazole aqueous suspension agent (laboratory self-control) according to medicament, 2% propamidine water preparation (market
Buy, Zhenghai, Ningbo City Lv Yuan capital goods in the agricultural sector company limited)；Controlling object is fruit tree leaves
Pinta；
During medication, temperature on average is at 20-25 DEG C, and weather is based on fine to cloudy, and cyproconazole and propamidine compound rear synergistic effect
Substantially.
From above example and field test it can be seen that cyproconazole is compounded with propamidine
After, the consumption of its every mu effective ingredient reduces, and the most anti-efficiency improves, and anti-efficiency is all 91%
Above；And cyproconazole and propamidine weight ratio are when 5/1 to 1/10, and its anti-efficiency is 95%
Above；Can be drawn by embodiment one and example nine, when cyproconazole with propamidine weight ratio is
When 5/1 and 1/10, its preventive effect is up to 98%.
Claims (3)
1. the bactericidal composition containing cyproconazole with propamidine, it is characterised in that: with ring
Azoles alcohol and propamidine are effective ingredient, and cyproconazole is 20:1～1 with the weight ratio of propamidine:
50, in described bactericidal composition, the weight fraction of effective ingredient is 10～80%.
Bactericidal composition containing cyproconazole Yu propamidine the most according to claim 1,
It is characterized in that: cyproconazole is 5:1～1:10 with the weight ratio of propamidine.
Bactericidal composition containing cyproconazole Yu propamidine the most according to claim 1,
It is characterized in that: the dosage form of described bactericidal composition be cream or wettable powder or suspending agent or
One in microemulsion or aqueous emulsion or water-dispersible granules.
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| CN108902160A (en) * | 2018-08-09 | 2018-11-30 | 江西省农业科学院植物保护研究所 | A kind of bactericidal composition and fungicide for preventing and treating Asparagus Stem Blight |
| CN111903685B (en) * | 2020-07-28 | 2022-02-18 | 西北农林科技大学 | Bactericidal composition, bactericide and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1613847A (en) * | 2004-09-13 | 2005-05-11 | 西北农林科技大学无公害农药研究服务中心 | Bactericidal compound of aromatic diamidine and use thereof |
| CN101692807A (en) * | 2009-10-20 | 2010-04-14 | 陕西上格之路生物科学有限公司 | Dispersible oil suspension agent containing cyproconazole |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1613847A (en) * | 2004-09-13 | 2005-05-11 | 西北农林科技大学无公害农药研究服务中心 | Bactericidal compound of aromatic diamidine and use thereof |
| CN101692807A (en) * | 2009-10-20 | 2010-04-14 | 陕西上格之路生物科学有限公司 | Dispersible oil suspension agent containing cyproconazole |
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