CN104854130A - Erythroferrone和erfe多肽以及调控铁代谢的方法 - Google Patents

Erythroferrone和erfe多肽以及调控铁代谢的方法 Download PDF

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Publication number
CN104854130A
CN104854130A CN201380065041.2A CN201380065041A CN104854130A CN 104854130 A CN104854130 A CN 104854130A CN 201380065041 A CN201380065041 A CN 201380065041A CN 104854130 A CN104854130 A CN 104854130A
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seq
erfe
polypeptide
hepcidin
iron
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Chinese (zh)
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T·甘茨
E·内梅特
L·考茨
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • C07K2317/00—Immunoglobulins specific features
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    • G01N2333/52—Assays involving cytokines
    • G01N2333/525—Tumor necrosis factor [TNF]
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
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  • Urology & Nephrology (AREA)
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CN201380065041.2A 2012-11-01 2013-10-31 Erythroferrone和erfe多肽以及调控铁代谢的方法 Pending CN104854130A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261721322P 2012-11-01 2012-11-01
US61/721,322 2012-11-01
PCT/US2013/067771 WO2014071015A1 (en) 2012-11-01 2013-10-31 Erythroferrone and erfe polypeptides and methods of regulating iron metabolism

Publications (1)

Publication Number Publication Date
CN104854130A true CN104854130A (zh) 2015-08-19

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CN201380065041.2A Pending CN104854130A (zh) 2012-11-01 2013-10-31 Erythroferrone和erfe多肽以及调控铁代谢的方法

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US (2) US20160122409A1 (https=)
EP (1) EP2914619B1 (https=)
JP (1) JP6501362B2 (https=)
KR (1) KR102186218B1 (https=)
CN (1) CN104854130A (https=)
AU (1) AU2013337808B2 (https=)
BR (1) BR112015009954A2 (https=)
CA (1) CA2890040A1 (https=)
ES (1) ES2731609T3 (https=)
RU (1) RU2684216C2 (https=)
WO (1) WO2014071015A1 (https=)

Cited By (4)

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CN109983029A (zh) * 2016-08-05 2019-07-05 西拉鲁思治疗公司 Erfe特异性抗体组合物和使用方法
CN110267979A (zh) * 2016-10-03 2019-09-20 西拉鲁思治疗公司 Erfe融合多肽组合物及使用方法
CN110636857A (zh) * 2017-03-13 2019-12-31 因全惜客生命科学有限公司 人红富铁激素的抗体及其用途
CN111032041A (zh) * 2017-05-16 2020-04-17 健艾仕生物医药有限公司 治疗类风湿关节炎的组合物和方法

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NZ748511A (en) * 2016-04-27 2023-05-26 Vladimir Badmaev Method maintaining iron homeostasis with shogaols
US11255865B2 (en) 2017-06-06 2022-02-22 The Regents Of The University Of California Immunoassay for human erythroferrone
TW201945026A (zh) * 2018-01-29 2019-12-01 美商希拉諾斯醫療公司 結合erfe之抗體及使用方法
WO2019212364A1 (en) * 2018-05-01 2019-11-07 Christopher Joseph Pemberton Test for heart failure
CA3045370A1 (en) * 2018-06-08 2019-12-08 Pfizer Inc. Methods of treating metabolic disease
JP2022522265A (ja) * 2019-01-16 2022-04-15 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル エリスロフェロンの変異体及びその使用
US20220372135A1 (en) 2019-09-27 2022-11-24 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
US12508262B2 (en) 2020-04-30 2025-12-30 Keros Therapeutics, Inc. Methods of using ALK2 inhibitors
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
JP2026506602A (ja) 2023-02-13 2026-02-25 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 鉄過剰関連疾患の処置方法

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109983029A (zh) * 2016-08-05 2019-07-05 西拉鲁思治疗公司 Erfe特异性抗体组合物和使用方法
CN110267979A (zh) * 2016-10-03 2019-09-20 西拉鲁思治疗公司 Erfe融合多肽组合物及使用方法
CN110636857A (zh) * 2017-03-13 2019-12-31 因全惜客生命科学有限公司 人红富铁激素的抗体及其用途
CN110636857B (zh) * 2017-03-13 2024-04-30 因全惜客生命科学有限公司 人红富铁激素的抗体及其用途
CN111032041A (zh) * 2017-05-16 2020-04-17 健艾仕生物医药有限公司 治疗类风湿关节炎的组合物和方法
CN117085015A (zh) * 2017-05-16 2023-11-21 健艾仕生物医药有限公司 治疗类风湿关节炎的组合物和方法

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JP6501362B2 (ja) 2019-04-17
US20160122409A1 (en) 2016-05-05
KR20150077471A (ko) 2015-07-07
JP2015536337A (ja) 2015-12-21
BR112015009954A2 (pt) 2017-08-22
KR102186218B1 (ko) 2020-12-03
RU2684216C2 (ru) 2019-04-04
CA2890040A1 (en) 2014-05-08
AU2013337808A1 (en) 2015-05-14
EP2914619A1 (en) 2015-09-09
EP2914619A4 (en) 2016-05-11
EP2914619B1 (en) 2019-05-29
ES2731609T3 (es) 2019-11-18
US20180355008A1 (en) 2018-12-13
RU2015120601A (ru) 2016-12-20
AU2013337808B2 (en) 2017-12-21
WO2014071015A1 (en) 2014-05-08

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