KR102186218B1 - 에리트로페론 및 erfe 폴리펩티드 및 철 대사의 조절 방법 - Google Patents
에리트로페론 및 erfe 폴리펩티드 및 철 대사의 조절 방법 Download PDFInfo
- Publication number
- KR102186218B1 KR102186218B1 KR1020157013416A KR20157013416A KR102186218B1 KR 102186218 B1 KR102186218 B1 KR 102186218B1 KR 1020157013416 A KR1020157013416 A KR 1020157013416A KR 20157013416 A KR20157013416 A KR 20157013416A KR 102186218 B1 KR102186218 B1 KR 102186218B1
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- South Korea
- Prior art keywords
- seq
- erfe
- iron
- hepcidin
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- Prior art date
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- Expired - Fee Related
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261721322P | 2012-11-01 | 2012-11-01 | |
| US61/721,322 | 2012-11-01 | ||
| PCT/US2013/067771 WO2014071015A1 (en) | 2012-11-01 | 2013-10-31 | Erythroferrone and erfe polypeptides and methods of regulating iron metabolism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150077471A KR20150077471A (ko) | 2015-07-07 |
| KR102186218B1 true KR102186218B1 (ko) | 2020-12-03 |
Family
ID=50628048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157013416A Expired - Fee Related KR102186218B1 (ko) | 2012-11-01 | 2013-10-31 | 에리트로페론 및 erfe 폴리펩티드 및 철 대사의 조절 방법 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20160122409A1 (https=) |
| EP (1) | EP2914619B1 (https=) |
| JP (1) | JP6501362B2 (https=) |
| KR (1) | KR102186218B1 (https=) |
| CN (1) | CN104854130A (https=) |
| AU (1) | AU2013337808B2 (https=) |
| BR (1) | BR112015009954A2 (https=) |
| CA (1) | CA2890040A1 (https=) |
| ES (1) | ES2731609T3 (https=) |
| RU (1) | RU2684216C2 (https=) |
| WO (1) | WO2014071015A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109414468B (zh) * | 2016-04-27 | 2021-09-10 | 弗拉基米尔·巴德玛耶夫 | 利用姜烯酚维持体内铁质平衡的方法 |
| WO2018027184A1 (en) * | 2016-08-05 | 2018-02-08 | Silarus Therapeutics, Inc. | Erfe specific antibodies compositions and methods of use |
| US20200040054A1 (en) * | 2016-10-03 | 2020-02-06 | Silarus Therapeutics, Inc. | Erfe fusion polypeptides compositions and methods of use |
| CN110636857B (zh) * | 2017-03-13 | 2024-04-30 | 因全惜客生命科学有限公司 | 人红富铁激素的抗体及其用途 |
| CA3063100A1 (en) * | 2017-05-16 | 2018-11-22 | Generos Biopharma Ltd. | Compositions and methods for treating rheumatoid arthritis |
| EP3634477A4 (en) * | 2017-06-06 | 2021-03-03 | The Regents of the University of California | IMMUNOLOGICAL DOSAGE FOR HUMAN ERYTHROFERRONE |
| WO2019148186A1 (en) * | 2018-01-29 | 2019-08-01 | Silarus Therapeutics, Inc. | Antibodies binding erfe and methods of use |
| WO2019212364A1 (en) * | 2018-05-01 | 2019-11-07 | Christopher Joseph Pemberton | Test for heart failure |
| CA3045370A1 (en) * | 2018-06-08 | 2019-12-08 | Pfizer Inc. | Methods of treating metabolic disease |
| JP2022522265A (ja) * | 2019-01-16 | 2022-04-15 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | エリスロフェロンの変異体及びその使用 |
| CN114761013A (zh) | 2019-09-27 | 2022-07-15 | 迪斯克医药公司 | 治疗骨髓纤维化和相关病症的方法 |
| US12508262B2 (en) | 2020-04-30 | 2025-12-30 | Keros Therapeutics, Inc. | Methods of using ALK2 inhibitors |
| WO2021231798A1 (en) | 2020-05-13 | 2021-11-18 | Disc Medicine, Inc. | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
| JP2026506602A (ja) | 2023-02-13 | 2026-02-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 鉄過剰関連疾患の処置方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006046073A2 (en) | 2004-10-28 | 2006-05-04 | Ares Trading S.A. | C1q related protein |
| JP2008530222A (ja) | 2005-02-16 | 2008-08-07 | ザ ジェネラル ホスピタル コーポレイション | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
| WO2010040998A1 (en) | 2008-10-06 | 2010-04-15 | Cambridge Enterprise Llimited | Modulation of the activity and differentiation of cells expressing the osteoclast-associated receptor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2506668C (en) * | 2002-11-19 | 2014-08-19 | Drg International, Inc. | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor |
| TW201307390A (zh) * | 2007-02-02 | 2013-02-16 | Amgen Inc | 海帕西啶(hepcidin)、海帕西啶拮抗劑及使用方法 |
| CN102245626A (zh) * | 2008-12-05 | 2011-11-16 | 加利福尼亚大学董事会 | 微型铁调素肽及其使用方法 |
| WO2013112663A1 (en) * | 2012-01-26 | 2013-08-01 | The Johns Hopkins University | Myonectin (ctrp15), compositions comprising same, and methods of use |
-
2013
- 2013-10-31 AU AU2013337808A patent/AU2013337808B2/en not_active Ceased
- 2013-10-31 RU RU2015120601A patent/RU2684216C2/ru active
- 2013-10-31 KR KR1020157013416A patent/KR102186218B1/ko not_active Expired - Fee Related
- 2013-10-31 JP JP2015540784A patent/JP6501362B2/ja not_active Expired - Fee Related
- 2013-10-31 CN CN201380065041.2A patent/CN104854130A/zh active Pending
- 2013-10-31 WO PCT/US2013/067771 patent/WO2014071015A1/en not_active Ceased
- 2013-10-31 BR BR112015009954A patent/BR112015009954A2/pt not_active Application Discontinuation
- 2013-10-31 CA CA2890040A patent/CA2890040A1/en not_active Abandoned
- 2013-10-31 ES ES13851277T patent/ES2731609T3/es active Active
- 2013-10-31 EP EP13851277.7A patent/EP2914619B1/en not_active Not-in-force
-
2015
- 2015-04-28 US US14/698,608 patent/US20160122409A1/en not_active Abandoned
-
2018
- 2018-06-01 US US15/996,152 patent/US20180355008A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006046073A2 (en) | 2004-10-28 | 2006-05-04 | Ares Trading S.A. | C1q related protein |
| JP2008530222A (ja) | 2005-02-16 | 2008-08-07 | ザ ジェネラル ホスピタル コーポレイション | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
| WO2010040998A1 (en) | 2008-10-06 | 2010-04-15 | Cambridge Enterprise Llimited | Modulation of the activity and differentiation of cells expressing the osteoclast-associated receptor |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2684216C2 (ru) | 2019-04-04 |
| ES2731609T3 (es) | 2019-11-18 |
| JP6501362B2 (ja) | 2019-04-17 |
| AU2013337808A1 (en) | 2015-05-14 |
| CN104854130A (zh) | 2015-08-19 |
| BR112015009954A2 (pt) | 2017-08-22 |
| KR20150077471A (ko) | 2015-07-07 |
| WO2014071015A1 (en) | 2014-05-08 |
| US20180355008A1 (en) | 2018-12-13 |
| EP2914619A1 (en) | 2015-09-09 |
| AU2013337808B2 (en) | 2017-12-21 |
| JP2015536337A (ja) | 2015-12-21 |
| EP2914619B1 (en) | 2019-05-29 |
| CA2890040A1 (en) | 2014-05-08 |
| RU2015120601A (ru) | 2016-12-20 |
| EP2914619A4 (en) | 2016-05-11 |
| US20160122409A1 (en) | 2016-05-05 |
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