CN104854071B - 由6,10,14-三甲基十五碳-5,9,13-三烯-2-酮或6,10,14-三甲基十五碳-5,9-二烯-2-酮制备的(6r,10r)-6,10,14-三甲基十五烷-2-酮 - Google Patents

由6,10,14-三甲基十五碳-5,9,13-三烯-2-酮或6,10,14-三甲基十五碳-5,9-二烯-2-酮制备的(6r,10r)-6,10,14-三甲基十五烷-2-酮 Download PDF

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CN104854071B
CN104854071B CN201380065784.XA CN201380065784A CN104854071B CN 104854071 B CN104854071 B CN 104854071B CN 201380065784 A CN201380065784 A CN 201380065784A CN 104854071 B CN104854071 B CN 104854071B
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ketone
formula
group
isomer
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CN104854071A (zh
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沃纳·邦拉蒂
托马斯·内切尔
乔纳森·艾伦·米德洛克
雷奈·托拜厄斯·史德姆勒
约翰内斯·提斯楚米
格拉尔杜斯·卡雷尔·玛丽亚·韦尔兹尔
安德里亚斯·翰德里克斯·玛丽亚·弗里斯·德
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/42—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/303—Compounds having groups having acetal carbon atoms bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
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    • C07C43/313—Compounds having groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C07C45/82—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Seasonings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
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CN201380065784.XA 2012-12-18 2013-12-18 由6,10,14-三甲基十五碳-5,9,13-三烯-2-酮或6,10,14-三甲基十五碳-5,9-二烯-2-酮制备的(6r,10r)-6,10,14-三甲基十五烷-2-酮 Active CN104854071B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12197812 2012-12-18
EP12197812.6 2012-12-18
PCT/EP2013/077233 WO2014096098A1 (en) 2012-12-18 2013-12-18 (6r,10r)-6,10,14-trimetylpentadecan-2-one prepared from 6,10,14-trimetylpentadeca-5,9,13-trien-2-one or 6,10,14-trimetylpentadeca-5,9-dien-2-one

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CN104854071A CN104854071A (zh) 2015-08-19
CN104854071B true CN104854071B (zh) 2018-05-11

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US (1) US9611200B2 (cg-RX-API-DMAC10.html)
EP (1) EP2935185B1 (cg-RX-API-DMAC10.html)
JP (1) JP6582324B2 (cg-RX-API-DMAC10.html)
CN (1) CN104854071B (cg-RX-API-DMAC10.html)
BR (1) BR112015014423B1 (cg-RX-API-DMAC10.html)
EA (1) EA033302B9 (cg-RX-API-DMAC10.html)
MY (1) MY173272A (cg-RX-API-DMAC10.html)
WO (1) WO2014096098A1 (cg-RX-API-DMAC10.html)

Families Citing this family (5)

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ES2739229T3 (es) * 2012-12-18 2020-01-29 Dsm Ip Assets Bv Uso de mezclas de isómeros E/Z para obtener productos cuantitativamente específicos combinando hidrogenación asimétrica e isomerización
US9452961B2 (en) * 2012-12-18 2016-09-27 Dsm Ip Assets B.V. (6R,10R)-6,10,14-trimetylpentadecan-2-one prepared from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one
EA029733B1 (ru) * 2012-12-18 2018-05-31 ДСМ АйПи АССЕТС Б.В. Применение смесей e/z-изомеров для количественного получения определенных продуктов посредством комбинированной асимметрической гидрогенизации
WO2017098050A1 (en) * 2015-12-11 2017-06-15 Dsm Ip Assets B.V. Process for the manufacture of 6,10,14-trimethylpentadecan-2-one, isophytol and alpha-tocopherol
IL291512B2 (en) * 2019-09-25 2026-05-01 Bayer Ag A process involving the use of novel iridium catalysts for the enantioselective hydrogenation of 4-substituted 2,1-dihydroquinolines

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US4028385A (en) * 1974-09-02 1977-06-07 Kuraray Co., Ltd. Process for preparing stereospecific farnesylacetic acid and ester thereof
CN1092758A (zh) * 1992-11-25 1994-09-28 芝加哥罗约拉大学 叔炔醇制备方法
CN1393435A (zh) * 1996-07-05 2003-01-29 可乐丽股份有限公司 制备6－甲基－3－庚烯－2－酮的方法和制备植酮或异植醇的方法
CN101087774A (zh) * 2004-12-22 2007-12-12 帝斯曼知识产权资产管理有限公司 用手性铱络合物对烯烃的非对称氢化

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JPS6036479A (ja) * 1983-08-08 1985-02-25 Kotobuki Seiyaku Kk １，３−ジオキサン誘導体、本化合物を有効成分とする抗潰瘍剤及びその製造方法
US5028385A (en) 1989-04-10 1991-07-02 Baldi Alfonso L Treatment of metals for coating or activation
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EP0970953B1 (en) 1998-07-10 2004-09-29 DSM IP Assets B.V. Manufacture of d,1-alpha-tocopherol
DE19840747A1 (de) 1998-09-07 2000-03-09 Basf Ag Kontinuierliches Verfahren zur Herstellung von ungesättigten Ketonen
JP4464131B2 (ja) 2001-09-28 2010-05-19 ディーエスエム アイピー アセッツ ビー．ブイ． エチニル化法
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CN1968943B (zh) 2004-06-11 2011-08-10 帝斯曼知识产权资产管理有限公司 生产色满衍生物尤其是α-生育酚及其链烷酸酯的方法
EP2522647B1 (en) 2011-05-10 2014-04-30 DSM IP Assets B.V. Process of separating chiral isomers of chroman compounds and their derivatives and precursors
EP2535323A1 (en) * 2011-06-14 2012-12-19 DSM IP Assets B.V. Hydrogenation of ketones having at least a carbon-carbon double bond in the gamma-,delta-position
ES2739229T3 (es) * 2012-12-18 2020-01-29 Dsm Ip Assets Bv Uso de mezclas de isómeros E/Z para obtener productos cuantitativamente específicos combinando hidrogenación asimétrica e isomerización
MY170264A (en) * 2012-12-18 2019-07-15 Dsm Ip Assets Bv Nitrogen monoxide as cis/trans isomerization catalysts for unsaturated compounds
US9452961B2 (en) * 2012-12-18 2016-09-27 Dsm Ip Assets B.V. (6R,10R)-6,10,14-trimetylpentadecan-2-one prepared from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one
MY170265A (en) * 2012-12-18 2019-07-15 Dsm Ip Assets Bv Polythiols as cis/trans isomerization catalysts for unsaturated compounds
EA029733B1 (ru) * 2012-12-18 2018-05-31 ДСМ АйПи АССЕТС Б.В. Применение смесей e/z-изомеров для количественного получения определенных продуктов посредством комбинированной асимметрической гидрогенизации
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028385A (en) * 1974-09-02 1977-06-07 Kuraray Co., Ltd. Process for preparing stereospecific farnesylacetic acid and ester thereof
CN1092758A (zh) * 1992-11-25 1994-09-28 芝加哥罗约拉大学 叔炔醇制备方法
CN1393435A (zh) * 1996-07-05 2003-01-29 可乐丽股份有限公司 制备6－甲基－3－庚烯－2－酮的方法和制备植酮或异植醇的方法
CN101087774A (zh) * 2004-12-22 2007-12-12 帝斯曼知识产权资产管理有限公司 用手性铱络合物对烯烃的非对称氢化

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BR112015014423A2 (pt) 2017-07-11
WO2014096098A1 (en) 2014-06-26
EA033302B1 (ru) 2019-09-30
EA033302B9 (ru) 2020-01-22
EA201500665A1 (ru) 2015-12-30
JP6582324B2 (ja) 2019-10-02
US20150329456A1 (en) 2015-11-19
US9611200B2 (en) 2017-04-04
BR112015014423B1 (pt) 2020-12-01
EP2935185B1 (en) 2019-02-20
JP2016506393A (ja) 2016-03-03
EP2935185A1 (en) 2015-10-28
CN104854071A (zh) 2015-08-19
MY173272A (en) 2020-01-09

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