CN104837814B - 新型化合物及其用途 - Google Patents

新型化合物及其用途 Download PDF

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CN104837814B
CN104837814B CN201380050982.9A CN201380050982A CN104837814B CN 104837814 B CN104837814 B CN 104837814B CN 201380050982 A CN201380050982 A CN 201380050982A CN 104837814 B CN104837814 B CN 104837814B
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cancer
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cell
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CN104837814A (zh
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S·奥格洛德金斯基
P·史密斯
S·麦基翁
L·帕特森
R·J·埃林顿
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Ankoserick Enterprise Co ltd
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Biostars
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
    • C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
    • C07C225/34—Amino anthraquinones
    • C07C225/36—Amino anthraquinones the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Urology & Nephrology (AREA)
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  • Emergency Medicine (AREA)
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  • Dermatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
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CN201380050982.9A 2012-08-08 2013-08-07 新型化合物及其用途 Active CN104837814B (zh)

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Application Number Priority Date Filing Date Title
GBGB1214169.3A GB201214169D0 (en) 2012-08-08 2012-08-08 New compounds and uses thereof
GB1214169.3 2012-08-08
PCT/GB2013/052106 WO2014023956A1 (en) 2012-08-08 2013-08-07 New compounds and uses thereof

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US (2) US10385009B2 (enExample)
EP (1) EP2882708B1 (enExample)
JP (1) JP6450678B2 (enExample)
CN (1) CN104837814B (enExample)
AU (1) AU2013301340B2 (enExample)
CA (1) CA2881324C (enExample)
DK (1) DK2882708T3 (enExample)
ES (1) ES2702573T3 (enExample)
GB (1) GB201214169D0 (enExample)
PL (1) PL2882708T3 (enExample)
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Publication number Priority date Publication date Assignee Title
CN104897818A (zh) * 2015-06-19 2015-09-09 重庆医药高等专科学校 一种同时测定比卡鲁胺中6种有关物质的uplc方法
KR101988757B1 (ko) * 2017-12-19 2019-06-12 가톨릭대학교 산학협력단 1,2-디하이드록시-3-메틸안트라퀴논을 유효성분으로 하는 간암 예방 또는 치료용 조성물
WO2019230756A1 (ja) * 2018-05-30 2019-12-05 国立大学法人大阪大学 ヒト血管の形成、構造または機能に影響を及ぼす物質のスクリーニング方法、およびヒト血管の製造方法
CN113368056A (zh) * 2021-04-29 2021-09-10 重庆医科大学 一种负载巴诺蒽醌的无载体纳米递送系统及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US5132327A (en) * 1989-10-13 1992-07-21 National Research Development Corporation Anti-cancer compounds
WO1998049172A1 (en) * 1997-04-28 1998-11-05 University Of Vermont Regioisomeric benzothiopyranopyridines having antitumor activity
CN102397561A (zh) * 2011-09-26 2012-04-04 沈阳药科大学 米托蒽醌作为淋巴示踪剂的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE445996B (sv) 1977-08-15 1986-08-04 American Cyanamid Co Nya atrakinonderivat
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
SE459005B (sv) 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
KR20040068613A (ko) * 1994-03-25 2004-07-31 이소테크니카 인코포레이티드 중수소화된 화합물 이를 포함하는 고혈압 치료용 조성물
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
GB9813062D0 (en) * 1998-06-18 1998-08-19 Univ Wales Medicine An anthraquinone and its derivatives
US6376531B1 (en) * 1998-11-13 2002-04-23 Rupert Charles Bell Method of treatment using deuterium compounds
PT1104760E (pt) * 1999-12-03 2003-06-30 Pfizer Prod Inc Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios
US7074835B2 (en) * 2002-03-15 2006-07-11 Btg International Limited Formulations of anthraquinone derivatives
WO2006031719A2 (en) * 2004-09-14 2006-03-23 Novacea, Inc. 1,4-bis-n-oxide-5,8-dihydroxyanthracenedione compounds and the use thereof
AU2006220886A1 (en) * 2005-03-04 2006-09-14 Novacea, Inc. Treatment of hyperproliferative diseases with anthraquinones
US8420861B2 (en) * 2007-10-16 2013-04-16 D. Richard Ishmael Anti-tumor compounds derived from 1,4,5,8-tetrachloroanthraquinone
GB201005939D0 (en) * 2010-04-09 2010-05-26 Biostatus Ltd Method of analysing a cell or other biological material containing nucleic acid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US5132327A (en) * 1989-10-13 1992-07-21 National Research Development Corporation Anti-cancer compounds
WO1998049172A1 (en) * 1997-04-28 1998-11-05 University Of Vermont Regioisomeric benzothiopyranopyridines having antitumor activity
CN102397561A (zh) * 2011-09-26 2012-04-04 沈阳药科大学 米托蒽醌作为淋巴示踪剂的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Hydrogen-Deuterium Exchange Studies Utilizing a Thermospray Mass Spectrometer Interface;Marshall M.Siegel;《Anal. Chem.》;19881031;第60卷(第19期);2090-2095页 *

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EP2882708B1 (en) 2018-10-03
US11401234B2 (en) 2022-08-02
JP2015529660A (ja) 2015-10-08
CN104837814A (zh) 2015-08-12
EP2882708A1 (en) 2015-06-17
AU2013301340A1 (en) 2015-02-19
GB201214169D0 (en) 2012-09-19
US20150307441A1 (en) 2015-10-29
US20200270200A1 (en) 2020-08-27
US10385009B2 (en) 2019-08-20
JP6450678B2 (ja) 2019-01-09
CA2881324A1 (en) 2014-02-13
DK2882708T3 (en) 2019-01-21
ES2702573T3 (es) 2019-03-04
PL2882708T3 (pl) 2019-04-30
AU2013301340B2 (en) 2017-10-26
WO2014023956A1 (en) 2014-02-13
CA2881324C (en) 2021-08-17

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