CN104837489A - 三环吲哚衍生物的结晶方法 - Google Patents

三环吲哚衍生物的结晶方法 Download PDF

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Publication number
CN104837489A
CN104837489A CN201380062872.4A CN201380062872A CN104837489A CN 104837489 A CN104837489 A CN 104837489A CN 201380062872 A CN201380062872 A CN 201380062872A CN 104837489 A CN104837489 A CN 104837489A
Authority
CN
China
Prior art keywords
composition
formula
compound
group
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380062872.4A
Other languages
English (en)
Chinese (zh)
Inventor
S.尼尔森
S.B.A.P.巴拉吉
U.P.莫卡帕蒂
A.M.卡达维帕兰普穆罕默德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1300647.3A external-priority patent/GB201300647D0/en
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Priority to CN202010090283.9A priority Critical patent/CN111362863A/zh
Publication of CN104837489A publication Critical patent/CN104837489A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
CN201380062872.4A 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法 Pending CN104837489A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010090283.9A CN111362863A (zh) 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN3689/DEL/2012 2012-11-30
IN3689DE2012 2012-11-30
GB1300647.3 2013-01-15
GBGB1300647.3A GB201300647D0 (en) 2013-01-15 2013-01-15 Crystallization
PCT/EP2013/074986 WO2014083113A1 (en) 2012-11-30 2013-11-28 Crystallization process of tricyclic indole derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202010090283.9A Division CN111362863A (zh) 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法

Publications (1)

Publication Number Publication Date
CN104837489A true CN104837489A (zh) 2015-08-12

Family

ID=54266915

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380062872.4A Pending CN104837489A (zh) 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法
CN202010090283.9A Pending CN111362863A (zh) 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202010090283.9A Pending CN111362863A (zh) 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法

Country Status (12)

Country Link
US (1) US10709798B2 (enExample)
EP (1) EP2943195A1 (enExample)
JP (1) JP6280560B2 (enExample)
KR (1) KR20150088802A (enExample)
CN (2) CN104837489A (enExample)
AU (1) AU2013351152A1 (enExample)
BR (1) BR112015012138A2 (enExample)
CA (1) CA2892485A1 (enExample)
IN (1) IN2015DN03978A (enExample)
MX (1) MX2015006871A (enExample)
RU (1) RU2015118217A (enExample)
WO (1) WO2014083113A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2015118217A (ru) 2012-11-30 2017-01-11 ДжиИ ХЕЛТКЕР ЛИМИТЕД Способ кристаллизации трициклических индольных производных
US20160144477A1 (en) * 2014-11-21 2016-05-26 Diane Scott Coated compressive subpad for chemical mechanical polishing

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102448933A (zh) * 2009-03-27 2012-05-09 通用电气健康护理有限公司 作为pbr配体的吲哚衍生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177440B1 (en) * 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
CA2310250A1 (en) 1997-11-14 1999-05-27 August Masaru Watanabe Treatment for alzheimer's disease
DZ2769A1 (fr) 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
JP2005527466A (ja) 2001-08-09 2005-09-15 イーライ・リリー・アンド・カンパニー ｓＰＬＡ２インヒビターとしてのシクロヘプトＢインドール誘導体
WO2003014082A1 (en) 2001-08-09 2003-02-20 Eli Lilly And Company Cyclopenta ` b ! indole derivatives as spla2 inhibitors
SG183837A1 (en) * 2010-03-26 2012-10-30 Ge Healthcare Ltd Tricyclic indole derivatives as pbr ligands
GB201016038D0 (en) 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) * 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
GB201021263D0 (en) 2010-12-15 2011-01-26 Ge Healthcare Ltd Solid phase extraction method
US9220795B2 (en) * 2011-09-22 2015-12-29 Ge Healthcare Limited Indole derivatives
RU2015118217A (ru) 2012-11-30 2017-01-11 ДжиИ ХЕЛТКЕР ЛИМИТЕД Способ кристаллизации трициклических индольных производных

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102448933A (zh) * 2009-03-27 2012-05-09 通用电气健康护理有限公司 作为pbr配体的吲哚衍生物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HARRY WADSWORTH ET AL: "[18F]GE-180:A novel flurine-18 labelled PET tracer for imaging Translocator protein 18 kDa(TSPO)", 《BIOORGANIC& MEDICINAL CHEMISTRY LETTERS》 *

Also Published As

Publication number Publication date
BR112015012138A2 (pt) 2017-07-11
WO2014083113A1 (en) 2014-06-05
KR20150088802A (ko) 2015-08-03
EP2943195A1 (en) 2015-11-18
RU2015118217A (ru) 2017-01-11
CN111362863A (zh) 2020-07-03
AU2013351152A1 (en) 2015-05-21
CA2892485A1 (en) 2014-06-05
US20150335766A1 (en) 2015-11-26
MX2015006871A (es) 2015-09-16
US10709798B2 (en) 2020-07-14
IN2015DN03978A (enExample) 2015-10-02
JP2016507477A (ja) 2016-03-10
JP6280560B2 (ja) 2018-02-14

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Application publication date: 20150812

RJ01 Rejection of invention patent application after publication