CN104826075B - A kind of Chinese medicine for treating intractable headache - Google Patents
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Abstract
The present invention relates to the Chinese medicine for the treatment of intractable headache, can effectively solve the problems, such as the medication of intractable headache, its technical scheme solved is made up of the material medicine of following parts by weight meter：20 40 parts of the tuber of pinellia processed, 20 40 parts of Ligusticum wallichii, 10 20 parts of the rhizome of Chinese monkshood processed, 10 30 parts of baked ginger, process 5 15 parts of 10 20 parts of scorpio, 10 30 parts of honeycomb, 20 40 parts of schizonepeta, 10 30 parts of notopterygium root, 10 30 parts of the root of herbaceous peony, 10 30 parts of the flower bud of lily magnolia, 10 30 parts of watermelon clothing, 10 30 parts of Fructus Corni, 10 30 parts of hairyvein agrimony and radix glycyrrhizae, traditional Chinese medicine composite of the present invention is enriched, simple production process, drug safety, it is reliable and stable, clinical efficacy protrudes, it is the active drug for treating intractable headache, is that the one of the field of Chinese medicines innovates greatly.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine for treating intractable headache.
Background technology
Intractable headache is the common disease of Neurology, belongs to nerve, vascular headache, and women is more than male, had
Obvious Career orientation, crowd's incidence of disease is in 3 ﹪ or so.Its symptom feature be recurrent exerbation, when pain when stop, course of disease time compared with
Long, it has a strong impact on normal work and the life of people during breaking out, great pain is brought to patient.Intractable headache at present
Western medicine more using based on analgesia, calm, hypnotic or 5 hydroxy color amine antagonists, these medicines can only temporary relief of symptoms,
Long-term use of side effect is obvious.
Traditional Chinese medicine thinks that it is that human righteousness is weak that this is sick, wind, phlegm, the stasis of blood, the result of multi-pathogenesis.Chinese medicine
Intractable headache shows the superiority of uniqueness in clinical practice, turns into the focus of the current area research.It is substantial amounts of clinical
And experimental study fully confirms, carry out Coryza Treated by Syndrome Differentiation intractable headache using traditional Chinese medical theory and improving curative effect, reduce Western medicine not
Good reaction, reduce recurrence rate etc. and play a significant role.
Existing " a kind of Chinese medicine preparation for treating intractable headache ", number of patent application：201310077505.3.It is clinical at present
Medication can not fully meet being actually needed for many patients, and New drug discovery is imperative, and treatment intractable headache Chinese medicine is opened
The problem of hair and application are still current urgent need to resolve.
The content of the invention
For the above situation, to solve the defect of prior art, the purpose of the present invention is just to provide one kind and treats intractable
The Chinese medicine of headache, can effectively solve the problems, such as the medication of intractable headache.
Intractable headache belongs to traditional Chinese medicine " intermittent headache " category.《Medical center carpenter's line marker is had a headache》：" shallow and nearly person, name say headache；It is deep
And farther, name say intermittent headache.Headache soldier however extremely, be easy to dismiss；Intermittent headache is made only seldom, rear sense of touch recurrence." its machine of falling ill
It is made as being known as convulsive seizure due to phlegm-fire, feels exopathogen again to phlegm stagnating in meridian, qi and blood is not smooth, raw in hemostasis, phlegm and blood stasis, upper to violate clear sun, therefore warp of having a headache
It is refractory long.The rules for the treatment of are with eleminating phlegm and freeing channels, opening the orifice and activating blood circulation.Accordingly, the technical scheme that the present invention solves is to be by following parts by weight meter
Material medicine be made：Tuber of pinellia 20-40 parts processed, Ligusticum wallichii 20-40 parts, rhizome of Chinese monkshood 10-20 parts processed, baked ginger 10-30 parts, process scorpio 10-
20 parts, honeycomb 10-30 parts, schizonepeta 20-40 parts, notopterygium root 10-30 parts, root of herbaceous peony 10-30 parts, flower bud of lily magnolia 10-30 parts, watermelon clothing 10-30
Part, Fructus Corni 10-30 parts, hairyvein agrimony 10-30 parts and radix glycyrrhizae 5-15 parts, by Ligusticum wallichii, process scorpio, hairyvein agrimony, the flower bud of lily magnolia and be blended in one
Rise, add Ligusticum wallichii, process the ethanol that scorpio, hairyvein agrimony, the mass concentration of 8 times of weight of the flower bud of lily magnolia are 75%, heating and refluxing extraction 2 hours,
Filtering, obtains the first filtrate, the first decompression filtrate recycling ethanol, obtains decoction, and is concentrated into the 1/2-1/3 of original volume, and A liquid is made；
The dregs of a decoction after ethanol is extracted again and the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeycomb, schizonepeta, notopterygium root, the root of herbaceous peony, watermelon clothing, Fructus Corni and
Radix glycyrrhizae mixes, and adds the water of 6 times of weight of material medicine, decocts twice, 1.5 hours every time, collecting decoction, filtering, obtains the
Two filtrates, the second filtrate decompression are concentrated into the 1/2-1/3 of original volume, and B liquid is made, and then mix A liquid and B liquid, are concentrated into 50
Relative density is 1.10-1.30 clear cream at DEG C（Medicinal extract）, the 20-60% of clear cream weight auxiliary material is added, it is normal according to pharmaceutical preparation
Chinese medicine preparation clinically is made in regulation Preparation Method；Described auxiliary material is sucrose, starch, dextrin, talcum powder, magnesium stearate, sulphur
Sour calcium, Steviosin one or more kinds of composition therein, described Chinese medicine preparation are capsule, pill, granule, piece
Agent or one kind of oral liquid.
Traditional Chinese medicine composite of the present invention is enriched, simple production process, and drug safety is reliable and stable, and clinical efficacy protrudes,
It is the active drug for treating intractable headache, is that the one of the field of Chinese medicines innovates greatly.
Embodiment
The embodiment of the present invention is described in further detail with reference to embodiments.
Embodiment 1
In the specific implementation, Chinese medicine composition of the present invention can be made up of the material medicine of following parts by weight meter：The tuber of pinellia processed
30 parts, 30 parts of Ligusticum wallichii, 15 parts of the rhizome of Chinese monkshood processed, 20 parts of baked ginger, process 15 parts of scorpio, 20 parts of honeycomb, 30 parts of schizonepeta, 20 parts of notopterygium root, the root of herbaceous peony
7.5 parts of 20 parts, 20 parts of the flower bud of lily magnolia, 20 parts of watermelon clothing, 20 parts of Fructus Corni, 20 parts of hairyvein agrimony and radix glycyrrhizae, by Ligusticum wallichii, process scorpio, red crowned crane
Grass, the flower bud of lily magnolia mix, and add Ligusticum wallichii, process the ethanol that scorpio, hairyvein agrimony, the mass concentration of 8 times of weight of the flower bud of lily magnolia are 75%, add
Circumfluence distillation 2 hours, filtering, obtains the first filtrate, the first decompression filtrate recycling ethanol, obtains decoction, and be concentrated into original volume
1/2-1/3, A liquid is made；The dregs of a decoction after ethanol is extracted again and the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeycomb, schizonepeta, notopterygium root, the root of herbaceous peony,
Watermelon clothing, Fructus Corni and radix glycyrrhizae mix, and add the water of 6 times of weight of material medicine, decoct twice, 1.5 hours every time, merge
Decocting liquid, filtering, obtains the second filtrate, the second filtrate decompression is concentrated into the 1/2-1/3 of original volume, and B liquid is made, then by A liquid and B liquid
Mixing, it is concentrated into the clear cream that relative density at 50 DEG C is 1.10-1.30（Medicinal extract）, the 20-60% of addition clear cream weight auxiliary material,
Chinese medicine preparation clinically is made according to pharmaceutical preparation customary preparation methods；Described auxiliary material is sucrose, starch, dextrin, talcum
Powder, magnesium stearate, calcium sulfate, Steviosin one or more kinds of composition therein, described Chinese medicine preparation be capsule,
Pill, granule, one kind of tablet or oral liquid.
Embodiment 2
The preparation method of granule specifically follows the steps below：
（1）Each material medicine is weighed respectively by following weight：Tuber of pinellia 200g processed, Ligusticum wallichii 400g, rhizome of Chinese monkshood 100g processed, baked ginger
300g, process scorpio 100g, honeycomb 300g, schizonepeta 200g, notopterygium root 300g, root of herbaceous peony 100g, flower bud of lily magnolia 300g, watermelon clothing 100g, mountain Zhu
Cornel 300g, hairyvein agrimony 100g and radix glycyrrhizae 150g；
（2）The Ligusticum wallichii weighed up, process scorpio, hairyvein agrimony, the flower bud of lily magnolia and mix, add Ligusticum wallichii, process scorpio, hairyvein agrimony,
The mass concentration of 8 times of weight of the flower bud of lily magnolia is 75% ethanol, heating and refluxing extraction 2 hours, filtering, obtains the first filtrate, the first filtrate subtracts
Receipts ethanol is pushed back, obtains decoction, and is concentrated into the 1/2-1/3 of original volume, A liquid is made；
（3）The dregs of a decoction after ethanol is extracted and the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeycomb, schizonepeta, notopterygium root, the root of herbaceous peony, watermelon clothing,
Fructus Corni and radix glycyrrhizae mix, and add the water of 6 times of weight of material medicine, decoct twice, 1.5 hours every time, collecting decoction, mistake
Filter, obtains the second filtrate, the second filtrate decompression is concentrated into the 1/2-1/3 of original volume, and B liquid is made；
（4）A liquid and B liquid are mixed, the clear cream that relative density at 50 DEG C is 1.10 is concentrated into, adds sucrose and dextrin, mix
It is even, particle is made, dries, produces.
Embodiment 3
The preparation method of tablet specifically follows the steps below：
（1）Each material medicine is weighed respectively by following weight：Tuber of pinellia 300g processed, Ligusticum wallichii 300g, rhizome of Chinese monkshood 150g processed, baked ginger
200g, process scorpio 150g, honeycomb 200g, schizonepeta 300g, notopterygium root 200g, root of herbaceous peony 200g, flower bud of lily magnolia 200g, watermelon clothing 200g, mountain Zhu
Cornel 200g, hairyvein agrimony 200g and radix glycyrrhizae 75g；
（2）The Ligusticum wallichii weighed up, process scorpio, hairyvein agrimony, the flower bud of lily magnolia and mix, add Ligusticum wallichii, process scorpio, hairyvein agrimony,
The mass concentration of 8 times of weight of the flower bud of lily magnolia is 75% ethanol, heating and refluxing extraction 2 hours, filtering, obtains the first filtrate, the first filtrate subtracts
Receipts ethanol is pushed back, obtains decoction, and is concentrated into the 1/2-1/3 of original volume, A liquid is made；
（3）The dregs of a decoction after ethanol is extracted and the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeycomb, schizonepeta, notopterygium root, the root of herbaceous peony, watermelon clothing,
Fructus Corni and radix glycyrrhizae mix, and add the water of 6 times of weight of material medicine, decoct twice, 1.5 hours every time, collecting decoction, mistake
Filter, obtains the second filtrate, the second filtrate decompression is concentrated into the 1/2-1/3 of original volume, and B liquid is made；
（4）A liquid and B liquid are mixed, are concentrated at 50 DEG C, relative density is 1.30 clear cream, adds starch and mixes, does
It is dry, crush, add talcum powder and magnesium stearate, mixing is tabletted, every weight 0.5g.
Embodiment 4
The preparation method of capsule specifically follows the steps below：
（1）Each material medicine is weighed respectively by following weight：Tuber of pinellia 400g processed, Ligusticum wallichii 200g, rhizome of Chinese monkshood 200g processed, baked ginger
100g, process scorpio 200g, honeycomb 100g, schizonepeta 400g, notopterygium root 100g, root of herbaceous peony 300g, flower bud of lily magnolia 100g, watermelon clothing 300g, mountain Zhu
Cornel 100g, hairyvein agrimony 300g and radix glycyrrhizae 50g；
（2）The Ligusticum wallichii weighed up, process scorpio, hairyvein agrimony, the flower bud of lily magnolia and mix, add Ligusticum wallichii, process scorpio, hairyvein agrimony,
The mass concentration of 8 times of weight of the flower bud of lily magnolia is 75% ethanol, heating and refluxing extraction 2 hours, filtering, obtains the first filtrate, the first filtrate subtracts
Receipts ethanol is pushed back, obtains decoction, and is concentrated into the 1/2-1/3 of original volume, A liquid is made；
（3）The dregs of a decoction after ethanol is extracted and the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeycomb, schizonepeta, notopterygium root, the root of herbaceous peony, watermelon clothing,
Fructus Corni and radix glycyrrhizae mix, and add the water of 6 times of weight of material medicine, decoct twice, 1.5 hours every time, collecting decoction, mistake
Filter, obtains the second filtrate, the second filtrate decompression is concentrated into the 1/2-1/3 of original volume, and B liquid is made；
（4）A liquid and B liquid are mixed, are concentrated into the clear cream that relative density at 50 DEG C is 1.20, starch is added and mixes, dry,
Crush, add calcium sulfate and talcum powder, mix, particle is made, load capsule, every weight 0.5g.
Embodiment 5
The preparation method of pill specifically follows the steps below：
（1）Each material medicine is weighed respectively by following weight：Tuber of pinellia 250g processed, Ligusticum wallichii 350g, rhizome of Chinese monkshood 150g processed, baked ginger
250g, process scorpio 150g, honeycomb 150g, schizonepeta 250g, notopterygium root 150g, root of herbaceous peony 250g, flower bud of lily magnolia 150g, watermelon clothing 250g, mountain Zhu
Cornel 150g, hairyvein agrimony 250g and radix glycyrrhizae 120g；
（2）The Ligusticum wallichii weighed up, process scorpio, hairyvein agrimony, the flower bud of lily magnolia and mix, add Ligusticum wallichii, process scorpio, hairyvein agrimony,
The mass concentration of 8 times of weight of the flower bud of lily magnolia is 75% ethanol, heating and refluxing extraction 2 hours, filtering, obtains the first filtrate, the first filtrate subtracts
Receipts ethanol is pushed back, obtains decoction, and is concentrated into the 1/2-1/3 of original volume, A liquid is made；
（3）The dregs of a decoction after ethanol is extracted and the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeycomb, schizonepeta, notopterygium root, the root of herbaceous peony, watermelon clothing,
Fructus Corni and radix glycyrrhizae mix, and add the water of 6 times of weight of material medicine, decoct twice, 1.5 hours every time, collecting decoction, mistake
Filter, obtains the second filtrate, the second filtrate decompression is concentrated into the 1/2-1/3 of original volume, and B liquid is made；
（4）A liquid and B liquid are mixed, are concentrated into the clear cream that relative density at 50 DEG C is 1.20, starch is added and mixes, dry,
Crush, add sucrose and talcum powder, mix, pill is made, the weight 0.5g per ball.
Chinese medicine composition of the present invention has rapid-action, curative for effect, safe and reliable in clinical practice, has wide face
Bed application prospect, and satisfied effect is achieved through clinical test, relevant testing data is as follows：
Case scenario
In March, 2012 in July, 2013 is selected in 112 intractable headache patients of treat-and-release, age 20-45 year,
It is average 32.5 years old；The course of disease is -4 years 6 months, average 28 months.Patient is randomly divided into two groups：Treatment group 56, control group 56
Example.Control group and treatment group patient are in age and the course of disease and the order of severity etc. no significant difference (P>0.05).
Standard
1.1 tcm diagnosis standard
Tcm diagnosis standard is examined with reference to the intractable headache that nineteen ninety encephalopathic academic board of the whole nation association of traditional Chinese medicine formulates
Disconnected standard：Headache recurrent exerbation>6 months, headache position is more to toss about hair in head side volume temporo, forehead, mountain peak top, or left or right
Make, or in full headache.The property of headache is mostly to jump pain, shouting pain, distending pain, dusk pain, secret anguish, or headache such as to split.Headache is sent out every time
Make sustainable several minutes, a few hours, a couple of days, the person that also has continued for several weeks.
1.2 case inclusive criterias
1. meet intractable headache diagnostic criteria；2. age person between 20-45 year at the age；3. informed consent.
1.3 case exclusion standards（Including inadaptable card and reject standard）
1. the age is below 20 one full year of life or 45 one full year of life above persons；2. the gestational period, women breast-feeding their children；3. be associated with it is cardiovascular,
The severe primary disease patient such as lung, liver, kidney and hemopoietic system；4. cranial injury and diseases of the five sense organs.
2. test method
2.1 group technology：This research uses（RCT methods）At random, check experiment is observed, and experiment is included to above-mentioned
Case uses random pair group technology, and treatment group and control group are found on random table, and ensures two groups of cases in state of an illness journey
Degree and sex, age, the course of disease etc. no difference of science of statistics（P>0.05）.
2.2 therapeutic scheme
Control group（Western medicine group）:Take flunarizine hydrochloride（Xian-Janssen Pharmaceutical Ltd. produces, lot number：
20120201）Treatment, 10mg is taken before sleeping every night.The course for the treatment of is 2 weeks, and other drugs are disabled during observation.
Treatment group（Chinese medicine group）:Chinese medicine prepared by oral the inventive method, 10g/ times, 3 times/day, 2 weeks/course for the treatment of.One
Two groups of curative effects are counted after the course for the treatment of.
3. curative effect judge index
Issued according to the Ministry of Public Health《New Chinese medicine guideline of clinical investigations》Work out.
Cure：Without recurrence in 1 year after treatment；
It is effective：Symptom disappears substantially after treatment, though or have headache symptom it is lighter, do not influence normal work and life；
Effectively：Attack times significantly reduce after treatment, and symptom relatively gently can still endure；
It is invalid：Symptom is unchanged after treatment.
4. statistical method total data is examined through SPSS11.0 software processings, measurement data using t, money is counted
Material uses χ2Examine, ranked data are examined with Ridit.
5. result
5.1 two groups of patient clinical curative effects compare, and are shown in Table 1.
1 two groups of patient's curative effects of table compare
| Group | Cure | It is effective | Effectively | It is invalid | Total effective rate | Cure rate |
| Treatment group（56） | 42 | 11 | 3 | 0 | 100% | 75% |
| Control group（56） | 4 | 45 | 7 | 0 | 100% | 7% |
As seen from the above table, treatment group totally 56：42 are cured, effective 11, effective 3, invalid 0, effective percentage is
100%, cure rate 75%；Control group totally 56：4 are cured, effective 45, effective 7, invalid 0, total effective rate is
100%, cure rate 7%.Two groups of curative effects compare to be analyzed through Ridit, P ＞ 0.05, no significant difference；Two groups of cure rates
Compare and analyzed through Ridit, P ＜ 0.01, difference is statistically significant.
5.2 follow-up situations recur 14, recurrence rate to 112 intractable headache follow-up of patients 1 year after the treatment of Chinese medicine group
For 25%, 52 are recurred after the treatment of Western medicine group, recurrence rate 93%, control group and treatment group compare recurrence rate significant difference (P
<0.01).Illustrate that treatment group is evident in efficacy and be better than control group.
6. conclusion
The prescription of present invention treatment intractable headache is formed with the taste drug matching of the tuber of pinellia, rhizome of Chinese monkshood etc. 14, in being directed to
The incompatibility of medicine eighteen incompatibilities.The anti-rhizome of Chinese monkshood of the tuber of pinellia is recorded in earliest《Sheng Nong's herbal classic》,《Chinese pharmacology》Teaching material according to《Legendary god of farming's book on Chinese herbal medicine
Through》Discussion, and cohosh is belonged to together according to the rhizome of Chinese monkshood and monkshood, set in tuber of pinellia entry " the anti-rhizome of Chinese monkshood, anti-monkshood ", but
Modern theory studies the evidence that science can be not yet provided for the clinical saying of the anti-rhizome of Chinese monkshood of the tuber of pinellia.
The tuber of pinellia initially uses with the rhizome of Chinese monkshood and sees holy doctor Zhang Zhongjing《Sheng Nong's herbal classic》Red ball, monkshood polished rice soup and Xiao Qinglong Tang
Plus-minus side, clinical practice proves that the tuber of pinellia compatibility rhizome of Chinese monkshood is distinguished and controls difficult miscellaneous disease, truly has unexpected good therapeutic effect.The present invention
Application of set prescription holy doctor Zhang Zhongjing exists《Sheng Nong's herbal classic》Prescription uses the ratio of the tuber of pinellia and rhizome of Chinese monkshood compatibility（The tuber of pinellia: the rhizome of Chinese monkshood=2: 1）
Treat intractable headache, clinical efficacy is notable, drug safety, reliable and stable, be treat intractable headache active drug, medication
Safety, reliable and stable, clinical efficacy protrudes, and is that the one of the field of Chinese medicines innovates greatly, has actual clinical value.
Claims (6)
1. a kind of Chinese medicine for treating intractable headache, it is characterised in that be made up of the material medicine of following parts by weight meter：System
Tuber of pinellia 20-40 parts, Ligusticum wallichii 20-40 parts, rhizome of Chinese monkshood 10-20 parts processed, baked ginger 10-30 parts, process scorpio 10-20 parts, honeycomb 10-30 parts,
Schizonepeta 20-40 parts, notopterygium root 10-30 parts, root of herbaceous peony 10-30 parts, flower bud of lily magnolia 10-30 parts, watermelon clothing 10-30 parts, Fructus Corni 10-30 parts,
Hairyvein agrimony 10-30 parts and radix glycyrrhizae 5-15 parts, by Ligusticum wallichii, process scorpio, hairyvein agrimony, the flower bud of lily magnolia and mix, add Ligusticum wallichii, process it is complete
The ethanol that scorpion, hairyvein agrimony, the mass concentration of 8 times of weight of the flower bud of lily magnolia are 75%, heating and refluxing extraction 2 hours, filtering, obtains the first filtrate,
First decompression filtrate recycling ethanol, decoction is obtained, and be concentrated into the 1/2-1/3 of original volume, A liquid is made；After ethanol is extracted again
The dregs of a decoction mix with the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeycomb, schizonepeta, notopterygium root, the root of herbaceous peony, watermelon clothing, Fructus Corni and radix glycyrrhizae, add
The water of 6 times of weight of material medicine, decoct twice, 1.5 hours every time, collecting decoction, filtering, obtain the second filtrate, the second filtrate subtracts
Pressure is concentrated into the 1/2-1/3 of original volume, and B liquid is made, and then mixes A liquid and B liquid, being concentrated into relative density at 50 DEG C is
1.10-1.30 clear cream, the 20-60% of clear cream weight auxiliary material is added, is made clinically according to pharmaceutical preparation customary preparation methods
Chinese medicine preparation；Described auxiliary material is sucrose, starch, dextrin, talcum powder, magnesium stearate, calcium sulfate, Steviosin one kind therein
Or two or more compositions, described Chinese medicine preparation are one kind of capsule, pill, granule, tablet or oral liquid.
2. the Chinese medicine for the treatment of intractable headache according to claim 1, it is characterised in that by the original of following parts by weight meter
Material medicine is made：30 parts of the tuber of pinellia processed, 30 parts of Ligusticum wallichii, 15 parts of the rhizome of Chinese monkshood processed, 20 parts of baked ginger, process 15 parts of scorpio, 20 parts of honeycomb, schizonepeta 30
7.5 parts of part, 20 parts of notopterygium root, 20 parts of the root of herbaceous peony, 20 parts of the flower bud of lily magnolia, 20 parts of watermelon clothing, 20 parts of Fructus Corni, 20 parts of hairyvein agrimony and radix glycyrrhizae, will
Ligusticum wallichii, process scorpio, hairyvein agrimony, the flower bud of lily magnolia and mix, add Ligusticum wallichii, to process scorpio, hairyvein agrimony, the quality of 8 times of weight of the flower bud of lily magnolia dense
The ethanol for 75% is spent, heating and refluxing extraction 2 hours, filtering, the first filtrate is obtained, the first decompression filtrate recycling ethanol, obtains decoction,
And the 1/2-1/3 of original volume is concentrated into, A liquid is made；The dregs of a decoction and the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeybee after ethanol is extracted again
Room, schizonepeta, notopterygium root, the root of herbaceous peony, watermelon clothing, Fructus Corni and radix glycyrrhizae mix, and add the water of 6 times of weight of material medicine, decoct two
It is secondary, 1.5 hours every time, collecting decoction, filtering, the second filtrate is obtained, the second filtrate decompression is concentrated into the 1/2-1/3 of original volume, system
Into B liquid, then A liquid and B liquid are mixed, the clear cream that relative density at 50 DEG C is 1.10-1.30 is concentrated into, adds clear cream weight
20-60% auxiliary material, Chinese medicine preparation clinically is made according to pharmaceutical preparation customary preparation methods；Described auxiliary material is sucrose, formed sediment
Powder, dextrin, talcum powder, magnesium stearate, calcium sulfate, Steviosin one or more kinds of composition therein, described Chinese medicine
Preparation is one kind of capsule, pill, granule, tablet or oral liquid.
3. the Chinese medicine for the treatment of intractable headache according to claim 1, it is characterised in that the preparation side of described granule
Method specifically follows the steps below：
（1）Each material medicine is weighed respectively by following weight：Tuber of pinellia 200g processed, Ligusticum wallichii 400g, rhizome of Chinese monkshood 100g processed, baked ginger 300g,
Process scorpio 100g, honeycomb 300g, schizonepeta 200g, notopterygium root 300g, root of herbaceous peony 100g, flower bud of lily magnolia 300g, watermelon clothing 100g, Fructus Corni
300g, hairyvein agrimony 100g and radix glycyrrhizae 150g；
（2）The Ligusticum wallichii weighed up, process scorpio, hairyvein agrimony, the flower bud of lily magnolia and mix, add Ligusticum wallichii, process scorpio, hairyvein agrimony, the flower bud of lily magnolia 8
The mass concentration of times weight is 75% ethanol, heating and refluxing extraction 2 hours, and filtering obtains the first filtrate, and the first filtrate decompression is returned
Ethanol is received, obtains decoction, and is concentrated into the 1/2-1/3 of original volume, A liquid is made；
（3）The dregs of a decoction and the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeycomb, schizonepeta, notopterygium root, the root of herbaceous peony, watermelon clothing, mountain Zhu after ethanol is extracted
Cornel and radix glycyrrhizae mix, and add the water of 6 times of weight of material medicine, decoct twice, 1.5 hours every time, collecting decoction, filtering,
The second filtrate is obtained, the second filtrate decompression is concentrated into the 1/2-1/3 of original volume, B liquid is made；
（4）A liquid and B liquid are mixed, the clear cream that relative density at 50 DEG C is 1.10 is concentrated into, adds sucrose and dextrin, mix, system
Into particle, dry, produce.
4. the Chinese medicine for the treatment of intractable headache according to claim 1, it is characterised in that the preparation method of described tablet
Specifically follow the steps below：
（1）Each material medicine is weighed respectively by following weight：Tuber of pinellia 300g processed, Ligusticum wallichii 300g, rhizome of Chinese monkshood 150g processed, baked ginger 200g,
Process scorpio 150g, honeycomb 200g, schizonepeta 300g, notopterygium root 200g, root of herbaceous peony 200g, flower bud of lily magnolia 200g, watermelon clothing 200g, Fructus Corni
200g, hairyvein agrimony 200g and radix glycyrrhizae 75g；
（2）The Ligusticum wallichii weighed up, process scorpio, hairyvein agrimony, the flower bud of lily magnolia and mix, add Ligusticum wallichii, process scorpio, hairyvein agrimony, the flower bud of lily magnolia 8
The mass concentration of times weight is 75% ethanol, heating and refluxing extraction 2 hours, and filtering obtains the first filtrate, and the first filtrate decompression is returned
Ethanol is received, obtains decoction, and is concentrated into the 1/2-1/3 of original volume, A liquid is made；
（3）The dregs of a decoction and the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeycomb, schizonepeta, notopterygium root, the root of herbaceous peony, watermelon clothing, mountain Zhu after ethanol is extracted
Cornel and radix glycyrrhizae mix, and add the water of 6 times of weight of material medicine, decoct twice, 1.5 hours every time, collecting decoction, filtering,
The second filtrate is obtained, the second filtrate decompression is concentrated into the 1/2-1/3 of original volume, B liquid is made；
（4）A liquid and B liquid are mixed, are concentrated at 50 DEG C, relative density is 1.30 clear cream, adds starch and mixes, dries, powder
It is broken, talcum powder and magnesium stearate are added, mixing is tabletted, every weight 0.5g.
5. the Chinese medicine for the treatment of intractable headache according to claim 1, it is characterised in that the preparation side of described capsule
Method specifically follows the steps below：
（1）Each material medicine is weighed respectively by following weight：Tuber of pinellia 400g processed, Ligusticum wallichii 200g, rhizome of Chinese monkshood 200g processed, baked ginger 100g,
Process scorpio 200g, honeycomb 100g, schizonepeta 400g, notopterygium root 100g, root of herbaceous peony 300g, flower bud of lily magnolia 100g, watermelon clothing 300g, Fructus Corni
100g, hairyvein agrimony 300g and radix glycyrrhizae 50g；
（2）The Ligusticum wallichii weighed up, process scorpio, hairyvein agrimony, the flower bud of lily magnolia and mix, add Ligusticum wallichii, process scorpio, hairyvein agrimony, the flower bud of lily magnolia 8
The mass concentration of times weight is 75% ethanol, heating and refluxing extraction 2 hours, and filtering obtains the first filtrate, and the first filtrate decompression is returned
Ethanol is received, obtains decoction, and is concentrated into the 1/2-1/3 of original volume, A liquid is made；
（3）The dregs of a decoction and the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeycomb, schizonepeta, notopterygium root, the root of herbaceous peony, watermelon clothing, mountain Zhu after ethanol is extracted
Cornel and radix glycyrrhizae mix, and add the water of 6 times of weight of material medicine, decoct twice, 1.5 hours every time, collecting decoction, filtering,
The second filtrate is obtained, the second filtrate decompression is concentrated into the 1/2-1/3 of original volume, B liquid is made；
（4）A liquid and B liquid are mixed, are concentrated into the clear cream that relative density at 50 DEG C is 1.20, starch is added and mixes, dry, powder
It is broken, calcium sulfate and talcum powder are added, is mixed, particle is made, loads capsule, every weight 0.5g.
6. the Chinese medicine for the treatment of intractable headache according to claim 1, it is characterised in that the preparation method of described pill
Specifically follow the steps below：
（1）Each material medicine is weighed respectively by following weight：Tuber of pinellia 250g processed, Ligusticum wallichii 350g, rhizome of Chinese monkshood 150g processed, baked ginger 250g,
Process scorpio 150g, honeycomb 150g, schizonepeta 250g, notopterygium root 150g, root of herbaceous peony 250g, flower bud of lily magnolia 150g, watermelon clothing 250g, Fructus Corni
150g, hairyvein agrimony 250g and radix glycyrrhizae 120g；
（2）The Ligusticum wallichii weighed up, process scorpio, hairyvein agrimony, the flower bud of lily magnolia and mix, add Ligusticum wallichii, process scorpio, hairyvein agrimony, the flower bud of lily magnolia 8
The mass concentration of times weight is 75% ethanol, heating and refluxing extraction 2 hours, and filtering obtains the first filtrate, and the first filtrate decompression is returned
Ethanol is received, obtains decoction, and is concentrated into the 1/2-1/3 of original volume, A liquid is made；
（3）The dregs of a decoction and the tuber of pinellia processed, the rhizome of Chinese monkshood processed, baked ginger, honeycomb, schizonepeta, notopterygium root, the root of herbaceous peony, watermelon clothing, mountain Zhu after ethanol is extracted
Cornel and radix glycyrrhizae mix, and add the water of 6 times of weight of material medicine, decoct twice, 1.5 hours every time, collecting decoction, filtering,
The second filtrate is obtained, the second filtrate decompression is concentrated into the 1/2-1/3 of original volume, B liquid is made；
（4）A liquid and B liquid are mixed, are concentrated into the clear cream that relative density at 50 DEG C is 1.20, starch is added and mixes, dry, powder
It is broken, sucrose and talcum powder are added, mixes, pill is made, the weight 0.5g per ball.
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| 九仙丹治血管神经性头痛;肖永兴;《新中医》;19941115(第11期);第15页"验方介绍"部分 * |
| 芎芷辛麻蝎合芍药甘草汤治顽固性头痛;戴鲁平 等;《中国中医药信息杂志》;20000315;第7卷(第3期);第48页左栏"治疗方法"部分 * |
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