CN104825885A - Buccal tablets for treating stomatitis and preparation method thereof - Google Patents
Buccal tablets for treating stomatitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses buccal tablets for treating stomatitis, which are prepared from the following main raw materials in parts by weight: 10-20 parts of honeysuckle, 3-5 parts of propolis, 5-10 parts of lophatherum gracile, 4-8 parts of natural indigo, 5-15 parts of radix sophorae flavescentis, 6-10 parts of radix glycyrrhizae, 15-25 parts of vitamin B2, 3-7 parts of fructus forsythiae and 6-10 parts of folium isatidis. The buccal tablets have the efficacies of eliminating ozostomia, treating stomatitis and speeding the healing of an ulcer surface. Compared with the prior art, the buccal tablets have more remarkable curative effects and a short treatment cycle and can be used for a long time.
Description
Technical field
The invention discloses a kind of buccal tablet, especially a kind of buccal tablet and method for making for the treatment of stomatitis.The invention belongs to traditional Chinese medicine field.
Background technology
Stomatitis is the inflammation of oral mucosa, can involve the places such as cheek mucosa, tongue, gums, palate.More common for period children's, especially infant, can fall ill merely when also can be secondary to the systemic diseases such as diarrhoea, malnutrition, actute infection, eipathia asthenia.What cause stomatitis mainly contains antibacterial, virus and fungus.The cause of disease: bacterial infection stomatitis often with streptococcus and staphylococcus for Main Pathogenic Bacteria.These antibacterials, under the low situation of the Abwehrkraft des Koepers such as actute infection, long-term diarrhea, if oral cavity is unclean, then cause antibacterial amount reproduction, thus cause Acute oral mucosa injury.
Clinical manifestation 1. stomatocace: each position, oral cavity all can occur, is common in lip, the place such as tongue and cheek mucosa, can spread to lip and bottleneck throat.From the beginning of mucosa hyperemia, edema, can have herpes, rear erosion of differing in size or ulcer, wound surface covers the canescence or yellow pseudomembrane that thicker fibrinous exudate formed, clear border, be easy to wipe, leave over the rotten to the corn face of hemorrhage after wiping, occur pseudomembrane again soon.Local pain, lymphadenectasis.Refusing to eat, agitation, heating 39 DEG C ~ 40 DEG C.General Symptoms the lighter about one week temperature recovery is normal, and ulcer is fully recovered gradually; Dehydration and acidosis can be there is in severe one.2. herpetic stomatitis: during onset, heating reaches 38 DEG C ~ 40 DEG C, after 1 ~ 2 day, there is exanthema vesiculosum that is single or cluster in each position oral mucosa such as gums, lip are interior, tongue, cheek mucosa, diameter 2 ~ 3mm, there is blush around, form ulcer after rapid ulceration, have yellow-white cellulosic secretions to cover, multiple ulcer can be fused into irregular large ulcer, sometimes involves palate and pharyngeal.Also often skin ulcer herpes occurs in bicker and all skin of lip, pain is play, refusing to eat, sialorrhea, agitation quite, the frequent enlargement of submandibular lymph nodes.Body temperature recovered normal afterwards at 3 ~ 5 days, the course of disease 1 ~ 2 week.Sustainable 2 ~ 3 weeks of regional glandular enlargement.Primary disease should be differentiated with herpangina, and the latter is caused by Coxsackie virus, is multiplely born in summer and autumn, and skin ulcer rash mainly occurs in pharyngeal and soft palate, sometimes sees tongue but does not involve gums and cheek mucosa, submandibular lymph nodes enlargement.3. drug sensitivity stomatitis: after having taken certain medicine, makes oral mucosa generation acute inflammation show.General 24 hours morbidities after the tablet has been ingested.Its early symptom is that oral mucosa is congested, edema or occur erythema and vesicle etc.Because medicine constantly absorbs, early symptom is increased the weight of gradually and forms mucosa to fester.This mucosa face of festering is different from the performance of general aphtha, and on it festers face, cover courageous and upright secretions, ulceration swelling, usually cause zest to have an intense pain, child is refusing to eat because of pain.4. candidiasis angular cheilitis: feature is often for bilateral is suffered from, skin and the mucosa in bicker district are chapped, and contiguous skin and mucosa hyperemia, often there are erosion and exudate in the place of chapping, or has thin crust, pain or hemorrhage when dehiscing.This kind is with the wet white rotten to the corn mycotic angular cheilitis for feature, should distinguish with hypovitaminosis B2 or antibacterial angular cheilitis, the former is concurrent glossitis, cheilitis, scrotitis or vulvitis simultaneously, the many single-shots of the latter in side bicker, positive bacterial culture (based on streptococcus); And candidiasis angular cheilitis is multiple is born in child, health decaying patient and inpatient with haematological diseases.The angular cheilitis of older patients is many to be shortened relevant with preferred vertical dimension of occlusion, and bicker district skin subsides in channel form, causes saliva to be overflowed in ditch by bicker, therefore often in dampness, is conducive to fungus growth breeding.
In the method for existing Chinese medicine stomatitis, Authorization Notice No. CN 103505656 B(application number 201310465529.6) patent discloses a kind of Chinese medicine preparation for the treatment of stomatitis, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are: Herba Arthraxonis Hispidi 58-83 part, Caulis et Radix Periplocae Forrestii 53-78 part, Radix embeliae laetae 52-78 part, Machilus grifsii Hance 48-73 part, Herba Fragariae nilerrensis 44-71 part, Herba Lophatheri 43-68 part, Herba Hyperici Patuli 40-63 part, Fructus nephelii topengii 38-59 part, Flos Jasmini Nudiflori 38-58 part, Herba Osbeckiae 35-54 part, Herba Lepisori Thunbergiani 33-53 part, Herba Polygalae Japonicae 33-46 part, Aster oreophilus Franch 28-43 part Radix Tinosporae 25-41 part Herba Sarcandrae 18-38 part Rhizoma Bistortae 10-28 part.Authorization Notice No. CN 102600365 B(application number 201210091494.X) patent discloses a kind of medicament for the treatment of stomatitis, it is characterized in that, it is made up by weight of following bulk drugs: Herba Asari 10-20 part, Calyx seu Fructus physalis 20-30 part, Fructus Gardeniae 10-30 part, Margarita powder 20-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Fructus Evodiae 5-15 part, Indigo Naturalis 5-10 part, Radix Scutellariae 10-20 part and Lasiosphaera Seu Calvatia 10-20 part.
Along with the development of Chinese Chinese medicine, on treatment stomatitis, it is little that people appreciate the side effect for the treatment of by Chinese herbs stomatitis gradually, bear painful little advantage, and Chinese traditional treatment great attention to whole idea, pay attention to comprehensive control, pay attention to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, therapeutic effect demonstrates the advantage for the treatment of by Chinese herbs stomatitis more.Chinese medicine has treatment stomatitis, adjusts and mend endocrine, improves intestinal circulation, supplements trace element needed for health, the special efficacy of hard masses softening and resolving, and persistent, treating both the principal and secondary aspects of a disease, has no side effect and efficacy consolidation, not easily to recur.
Summary of the invention
For the present situation of existing stomatitis, an object of the present invention is the buccal tablet providing treatment stomatitis, has feature easy to operate, evident in efficacy, with low cost.Another object is just to provide the preparation method of above-mentioned buccal tablet.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The buccal tablet for the treatment of stomatitis, takes off the primary raw material stating weight proportion and is prepared from: Flos Lonicerae 10-20 part, propolis 3-5 part, Herba Lophatheri 5-10 part, Indigo Naturalis 4-8 part, Radix Sophorae Flavescentis 5-15 part, Radix Glycyrrhizae 6-10 part, vitamin B2 15-25 part, Fructus Forsythiae 3-7 part, Folium Isatidis 6-10 part.
The buccal tablet for the treatment of stomatitis, preferred version is, takes off the primary raw material stating weight proportion and is prepared from: Flos Lonicerae 13-18 part, propolis 3.5-4.5 part, Herba Lophatheri 6-9 part, Indigo Naturalis 5-7 part, Radix Sophorae Flavescentis 8-13 part, Radix Glycyrrhizae 7-9 part, vitamin B2 18-23 part, Fructus Forsythiae 4-6 part, Folium Isatidis 7-9 part.
The buccal tablet for the treatment of stomatitis, preferred version is, takes off the primary raw material stating weight proportion and is prepared from: Flos Lonicerae 15 parts, propolis 4 parts, Herba Lophatheri 7.5 parts, Indigo Naturalis 6 parts, Radix Sophorae Flavescentis 10 parts, 8 parts, Radix Glycyrrhizae, vitamin B2 20 parts, Fructus Forsythiae 5 parts, Folium Isatidis 8 parts.
The preparation method of above-mentioned buccal tablet, is characterized in that, step is as follows:
(1) Flos Lonicerae, Herba Lophatheri, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Fructus Forsythiae and Folium Isatidis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 20-30 hour, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly to stir-fry 5-10 minute with large ferrum spoon, take out, grind to form smalls and cross 80-120 mesh sieve;
(2) Indigo Naturalis be placed on clean tile, little fire dries 2-6 minute slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;
(3) propolis is placed in clean container, adds the warm water of 30-40 DEG C, be stirred well to after propolis melts completely and add vitamin B2, stir latter standing 4-6 hour stand-by;
(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in iron plate upper baking 10-20 minute, is processed into circle or other shapes according to the processing technique of tablet.
Above-mentioned preparation method, under step (1) is placed in shady and cool tree shade, sealing and standing 23-28 hour (preferred, under being placed in shady and cool tree shade, sealing and standing 25 hours).
Above-mentioned preparation method, the large ferrum spoon of step (1) stir-fries 6-9 minute (preferred, repeatedly to stir-fry 7 minutes with large ferrum spoon) repeatedly.
Above-mentioned preparation method, Indigo Naturalis is placed on clean tile by step (2), and little fire dries 3-5 minute (preferred, Indigo Naturalis be placed on clean tile, little fire dries 4 minutes slowly) slowly.
Above-mentioned preparation method, propolis is placed in clean container by step (3), adds the warm water (preferred, to be placed in clean container by propolis, to add the warm water of 35 DEG C) of 33-38 DEG C.
Above-mentioned preparation method, the consumption of step (3) warm water is the 4-6 of propolis weight doubly (preferred, the consumption of warm water is 5 times of propolis weight).
Above-mentioned preparation method, step (3) adds vitamin B2, stir latter standing 4.5-5.5 hour stand-by (preferred, add vitamin B2, stir rear leave standstill 5 hours stand-by).
Using method: for making the present invention reach optimum therapeuticing effect, first gargle with clear water, then, by buccal tablet, be placed on containing spending or being directly placed on ulcer surface in mouth, one for several times, each a slice.
The pharmacological effect of each crude drug is respectively:
Flos Lonicerae: modern study proves, Flos Lonicerae contains chlorogenic acid, the pharmacological components such as luteolin glycosides, to Hemolytic streptococcus, the various pathogens such as staphylococcus aureus and upper respiratory tract infection Causative virus etc. have stronger restraint, in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, respiratory tract infection can be used for the treatment of with other medicines compatibility, bacillary dysentery, acute urinary, hypertension etc. more than 40 plant disease, Flos Lonicerae is cold in nature, sweet in the mouth, enter lung, the heart, stomach warp, there is heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treats effect of wind, cure mainly disease under distension, epidemic febrile disease is generated heat, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.
Propolis: enriching and the bioactive substance of uniqueness contained by propolis, make it have the several functions such as antibacterial, antiinflammatory, antipruritic, antioxidation, enhancing immunity, blood sugar lowering, blood fat reducing, antitumor, medical treatment, health-care effect is widely had to human body, now become the focus of various countries' scientific research, and become emerging health product and extremely praise highly.Antibacterial action.The sterilizing of propolis energy, sterilization, sterilization, antibacterial, mildew-resistant, anticorrosion, solve the defect that antibiotic only works to single microorganism, and be free from side effects.Good therapeutic effect is had in daily life to dermatosis.Antivirus action.Propolis is natural antiviral substance, has very strong suppression and killing action to multiple virus.Antioxidation.Propolis is called as antioxidant and free radical scavenger, effectively can remove the refuses such as excess activated oxygen because the bad life habits such as fat, overworked, environmental pollution, smoking and extraneous factor produce and free radical.Enhancing immunity effect.The immune system of human body is easily infracting by virus, and propolis can strengthen body immunity, strengthens the ability of human body opposing virus infraction.Antitumaous effect.Both at home and abroad large quantifier elimination shows, propolis has good effect pressing down cancer anticancer aspect.Promote cell regeneration effect.Propolis can accelerate the healing of tissue regeneration and wound.Effects of beautification and nourishing face.Propolis can decompose pigment, calm down wrinkle, delaying senility etc., is women's cosmetic good merchantable brand.Analgesic activity.Propolis also has good effect in analgesia.Prophylaxis of tumours.Containing abundant cancer-resisting substance in propolis, research proves, cancer patient after taking propolis, can cancerous cell be reduced and chemotherapy can be alleviated, side effect that radiotherapy causes.Resisting hypertension.Suffering from hypertensive patient takes containing very many Flavonoid substances and the propolis with very strong anti-oxidation ability continuously, not only can reduce over the harm of lipid oxide to blood vessel, prevent sclerosis of blood vessels, and effectively can also reduce the content of triglyceride, reduce platelet aggregation, improve microcirculation, too high blood pressure can be reduced, prevent the generation of unexpected thing.Thus, middle-aged and elderly people, particularly hypertension, heart disease, arteriosclerosis patient, usually take propolis, quite has benifit to good health and a long life.
Herba Lophatheri: have refrigerant, antipyretic, diuresis and the effect of hastening parturition; Cure mainly: in the heart disease heat, cough with dyspnea, haematemesis, pyretic toxicity wind, only quench one's thirst, press borax poison, expectorant, control fanatical unhappiness, apoplectic aphasia in silence, pain wind syndrome of head, spasmolytic are throbbed with fear, pestilence fan is vexed, kill small worm, heat extraction delays spleen, there is clearing heat and relieving fidgetness, effect ten of inducing diuresis for treating stranguria syndrome cures mainly calentura excessive thirst, aphtha of the mouth and tongue, gingival swelling and pain, children's's night crying due to fright in infant, cough due to lung-heat, gastric heat is vomitted the sound of vomiting, hot urination stranguria with turbid discharge.
Indigo Naturalis: have another name called Concha Meretricis Seu Cyclinae powder, indigo-blue flower, for the leaf of Acanthaceae Acanthaceous indigo platymiscium Acanthaceous indigo, Polygonaceae arsesmart polygonum tinctorium ait., pulse family anil Folium et Caulis Indigoferae Tinctoriae, Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort. or stem and leaf are through processing obtained dried powder or agglomerate.The property of medicine: this product is navy blue powder, body is light, and easily fly upward, micro-have careless stink smell, salty in the mouth, cold in nature.Composition: its main component has indirubin, indigo.Find according to modern pharmacological research, this medical instrument has effect of antitumor, anti-inflammatory and antalgic, antiulcer, antibacterial, clearing away heat and cooling blood, removing toxic substances, and for the malicious macule of temperature, laryngopharynx swelling and pain, spits blood, epistaxis, the symptoms such as spitting of blood.
Radix Sophorae Flavescentis: GUIXIN, liver, stomach, large intestine, urinary bladder channel.It is bitter, cold.There is heat clearing and damp drying, parasite killing, the merit of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.
Radix Glycyrrhizae: western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and antiallergic action, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, have good effects to chronic adrenocortical hypofunction; Glycyrrhiza preparation can promote stomach mucus to be formed and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, be usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect, and function of relieving cough and calming asthma enoxolone has obvious central antitussive effect, and heavy dose of enoxolone can make mouse breathing suppress.In addition glycyrrhizin, glycyrrhetate still have anti-inflammatory and antiallergic, anti-liver injury, anti-promoting, antibacterial, anti AIDS virus (glycyrrhizin) effect.
Vitamin B2: vitamin B2 (chemical formula: C17H20N4O6, formula weight 376.37) is riboflavin again, is slightly soluble in water, in neutrality or acid solution, heating is stable.For the ingredient (yellow enzyme plays and passs hydrogen effect in biological oxidation) of yellow enzymes prothetic group in body, when lacking, just affecting the biological oxidation of body, making metabolism generation obstacle.Its pathological changes shows as the inflammation at mouth, eye and external genitalia position more, and as angular cheilitis, cheilitis, glossitis, eye conjunctivitis and scrotitis etc., therefore this product can be used for the control of above-mentioned disease.Act on 1, promote the regeneration of growth and cell; 2, the normal growth of skin, fingernail, hair is impelled; 3, help prevention and eliminate in oral cavity, the inflammation of lip, tongue and skin reacts, and is referred to as oral cavity reproductive syndrome; 4, promote vision, alleviate the fatigue of eyes; 5, the absorption of human body to ferrum is affected; 6, combine with other materials, thus affect biological oxidation and energy metabolism.
Fructus Forsythiae: enter the heart, liver, gallbladder, stomach, three burnt, large intestine the six channels.Function cures mainly: heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.
Folium Isatidis: bitter in the mouth, cold in nature.Gui Jing returns liver, the heart, stomach, spleen channel.Effect heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Cure mainly for the high hot excessive thirst of calentura; Coma; Macule; Spit blood; Epistaxis; Jaundice; Dysentery; Erysipelas; Sore throat; Aphtha; Mumps.
Compared with prior art, technical advantage of the present invention is embodied in:
1, the present invention's medical material used does not have toxicity, and the health mechanism for sufferer can not cause damage, and audient crowd is wide, and applicable child and old people take.
2, bright the used medical material relative inexpensiveness of this law, compared with prior art the bright obtained buccal tablet cost of this law more
Add cheap.
3, therapeutic effect of the present invention is compared to prior art, and therapeutic effect is more obvious, and treatment cycle is short, does not have obvious sequela, can life-time service.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1the buccal tablet for the treatment of stomatitis, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Flos Lonicerae 10 parts, propolis 3 parts, Herba Lophatheri 5 parts, Indigo Naturalis 4 parts, Radix Sophorae Flavescentis 5 parts, 6 parts, Radix Glycyrrhizae, vitamin B2 15 parts, Fructus Forsythiae 3 parts, Folium Isatidis 6 parts.
The buccal tablet preparation process for the treatment of stomatitis is as follows:
(1) Flos Lonicerae, Herba Lophatheri, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Fructus Forsythiae and Folium Isatidis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 20 hours, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly stir-fry 5 minutes with large ferrum spoon, take out, grind to form smalls and cross 80 mesh sieves;
(2) Indigo Naturalis be placed on clean tile, little fire dries 2 minutes slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;
(3) be placed in clean container by propolis, add the warm water of 30 DEG C, the consumption of warm water is 4 times of propolis weight, is stirred well to after propolis melts completely and adds vitamin B2, stir rear leave standstill 4 hours stand-by;
(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in the upper baking of iron plate 10 minutes, is processed into circle or other shapes according to the processing technique of tablet.
typical case one: Zhao XX, man, 27 years old, school postgraduate, often have a meal irregular, like having fast food, like pungent food, suffer from stomatitis, stomatitis is not cured for a long time, there is the symptom of halitosis due to stomatitis in sufferer, oral inflammation aggravates, and with implication, implication distributes rotten stench, to the halitosis caused by stomatitis that hospital seeks medical advice, under the suggestion of doctor of traditional Chinese medicine, employ buccal tablet obtained in the present embodiment 1.
Use the buccal tablet obtained by this enforcement 1, one day for several times, an a slice, and use 2 days, implication obviously alleviates, and mood is good greatly, and after continuing to take 5, implication recovers normal, and stomatitis is fully recovered, and sufferer self-induction therapeutic effect is good.
embodiment 2the buccal tablet for the treatment of stomatitis, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part): Flos Lonicerae 20 parts, propolis 5 parts, Herba Lophatheri 10 parts, Indigo Naturalis 8 parts, Radix Sophorae Flavescentis 15 parts, 10 parts, Radix Glycyrrhizae, vitamin B2 25 parts, Fructus Forsythiae 7 parts, Folium Isatidis 10 parts.
The buccal tablet preparation process for the treatment of stomatitis is as follows:
(1) Flos Lonicerae, Herba Lophatheri, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Fructus Forsythiae and Folium Isatidis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 30 hours, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly stir-fry 10 minutes with large ferrum spoon, take out, grind to form smalls and cross 120 mesh sieves;
(2) Indigo Naturalis be placed on clean tile, little fire dries 6 minutes slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;
(3) be placed in clean container by propolis, add the warm water of 40 DEG C, the consumption of warm water is 6 times of propolis weight, is stirred well to after propolis melts completely and adds vitamin B2, stir rear leave standstill 6 hours stand-by;
(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in the upper baking of iron plate 20 minutes, is processed into circle or other shapes according to the processing technique of tablet.
model case two:zheng XX, female, 45 years old, suffer from stomatitis, stomatitis, patient does not too pay close attention to stomatitis disease, does not seek medical advice in time, along with stomatitis is serious all the more, there is the symptom of halitosis in sufferer, with dense implication when speaking, with rotten-egg odour, sufferer and other people normal talk are had a strong impact on, sufferer then arrives hospital and seeks medical advice, treatment stomatitis while and alleviate halitosis, under the suggestion of doctor, use the buccal tablet obtained by this enforcement 2.
Use buccal tablet obtained by the present embodiment 1, use 2 days, sufferer implication is obviously thin out, and rotten-egg odour alleviates, ulcer surface has not ached, and continues use after 3 days, and sufferer implication recovers normal, and rotten-egg odour disappears, ulcer surface is fully recovered, and takes a slice buccal tablet, one day breath freshening after recovery from illness through normal morning.
embodiment 3the buccal tablet for the treatment of stomatitis, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part): Flos Lonicerae 13 parts, propolis 3.5 parts, Herba Lophatheri 6 parts, Indigo Naturalis 5 parts, Radix Sophorae Flavescentis 8 parts, 7 parts, Radix Glycyrrhizae, vitamin B2 18 parts, Fructus Forsythiae 4 parts, Folium Isatidis 7 parts.
The buccal tablet preparation process for the treatment of stomatitis is as follows:
(1) Flos Lonicerae, Herba Lophatheri, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Fructus Forsythiae and Folium Isatidis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 23 hours, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly stir-fry 6 minutes with large ferrum spoon, take out, grind to form smalls and cross 90 mesh sieves;
(2) Indigo Naturalis be placed on clean tile, little fire dries 3 minutes slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;
(3) be placed in clean container by propolis, add the warm water of 33 DEG C, the consumption of warm water is 4.5 times of propolis weight, is stirred well to after propolis melts completely and adds vitamin B2, stir rear leave standstill 4.5 hours stand-by;
(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in the upper baking of iron plate 13 minutes, is processed into circle or other shapes according to the processing technique of tablet.
typical case three: ancient sacrificial utensil XX, man, 35 years old, the business department manager of certain company, like pungent food, suffer from stomatitis, stomatitis is not cured for a long time, and sufferer too seriously causes the symptom occurring halitosis due to stomatitis, oral inflammation aggravates, and with implication, implication distributes rotten stench.Seek medical advice to hospital and be diagnosed as stomatitis, under the suggestion of doctor of traditional Chinese medicine, employ buccal tablet obtained in the present embodiment 3.
Use the buccal tablet obtained by this enforcement 3, use 1 day, implication obviously alleviates, and continues use 3 days, and implication recovers normal, and stomatitis makes moderate progress, and sufferer self-induction therapeutic effect is good.
embodiment 4the buccal tablet for the treatment of stomatitis, takes off the primary raw material stating weight proportion and is prepared from (getting 25g for every part): Flos Lonicerae 18 parts, propolis 4.5 parts, Herba Lophatheri 9 parts, Indigo Naturalis 7 parts, Radix Sophorae Flavescentis 13 parts, 9 parts, Radix Glycyrrhizae, vitamin B2 23 parts, Fructus Forsythiae 6 parts, Folium Isatidis 9 parts.
The buccal tablet preparation process for the treatment of stomatitis is as follows:
(1) Flos Lonicerae, Herba Lophatheri, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Fructus Forsythiae and Folium Isatidis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 28 hours, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly stir-fry 9 minutes with large ferrum spoon, take out, grind to form smalls and cross 110 mesh sieves;
(2) Indigo Naturalis be placed on clean tile, little fire dries 5 minutes slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;
(3) be placed in clean container by propolis, add the warm water of 38 DEG C, the consumption of warm water is 5.5 times of propolis weight, is stirred well to after propolis melts completely and adds vitamin B2, stir rear leave standstill 5.5 hours stand-by;
(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in the upper baking of iron plate 18 minutes, is processed into circle or other shapes according to the processing technique of tablet.
model case four:section XX, female, 36 years old, suffer from stomatitis, patient does not too pay close attention to stomatitis disease, does not seek medical advice in time, along with stomatitis is serious all the more, there is the symptom of halitosis in sufferer, with dense implication when speaking, with rotten-egg odour, had a strong impact on sufferer and other people normal talk, sufferer then arrives hospital and seeks medical advice, while treatment stomatitis, the buccal tablet obtained by this enforcement 4 is used, in order to the symptom of the halitosis disease for the treatment of caused by stomatitis under the suggestion of doctor.
Use buccal tablet obtained by the present embodiment 4, use 2 days, sufferer implication is obviously thin out, and rotten-egg odour alleviates, and continues use 3 days, and sufferer implication recovers normal, and rotten-egg odour disappears, and halitosis symptom is cured.
embodiment 5the buccal tablet for the treatment of stomatitis, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Flos Lonicerae 15 parts, propolis 4 parts, Herba Lophatheri 7.5 parts, Indigo Naturalis 6 parts, Radix Sophorae Flavescentis 10 parts, 8 parts, Radix Glycyrrhizae, vitamin B2 20 parts, Fructus Forsythiae 5 parts, Folium Isatidis 8 parts.
The buccal tablet preparation process for the treatment of stomatitis is as follows:
(1) Flos Lonicerae, Herba Lophatheri, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Fructus Forsythiae and Folium Isatidis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 25 hours, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly stir-fry 7 minutes with large ferrum spoon, take out, grind to form smalls and cross 100 mesh sieves;
(2) Indigo Naturalis be placed on clean tile, little fire dries 4 minutes slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;
(3) be placed in clean container by propolis, add the warm water of 35 DEG C, the consumption of warm water is 5 times of propolis weight, is stirred well to after propolis melts completely and adds vitamin B2, stir rear leave standstill 5 hours stand-by;
(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in the upper baking of iron plate 15 minutes, is processed into circle or other shapes according to the processing technique of tablet.
test example 1:the clinical practice of the buccal tablet of embodiment 5 gained treatment stomatitis: in January ,-2015 in July, 2013,400 routine patients are screened in 5 hospitals, max age 45 years old, minimal ages 10 years old, all suffer from because of stomatitis, sufferer is divided into two groups at random, experimental group 200 people, matched group 200 people, experimental group uses the buccal tablet obtained by this enforcement 5, and matched group uses other medicines, observe 5 days time limits, test and the symptom of patient was comprehensively checked in first 1 day, regularly check inquiry patient body situation and impression during experiment, and make a record.Effective: malaise symptoms alleviates or partial disappearance.Cure: malaise symptoms disappears, and without recurrence.Invalid: malaise symptoms is unchanged or recur.Result is as shown in the table:
As can be seen from Table 1, therapeutic effect: healing 180 example (90%) taking embodiment 5 product, effective 16 examples (8%), invalid 4 examples (2%), total effective rate 98%.Can find out that the successful taking embodiment 5 product is better than taking other products.
Prove through clinical trial, use buccal tablet of the present invention compared with the medicine of other treatment stomatitis, treatment means is more comprehensive thoroughly to have no side effect between the operating period, while treatment stomatitis, can alleviate the symptom such as pain, halitosis brought by stomatitis.Prove through clinical trial, Chinese drugs agentia effective percentage of the present invention is 98%.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat the buccal tablet of stomatitis, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Flos Lonicerae 10-20 part, propolis 3-5 part, Herba Lophatheri 5-10 part, Indigo Naturalis 4-8 part, Radix Sophorae Flavescentis 5-15 part, Radix Glycyrrhizae 6-10 part, vitamin B2 15-25 part, Fructus Forsythiae 3-7 part, Folium Isatidis 6-10 part.
2. the buccal tablet for the treatment of stomatitis according to claim 1, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Flos Lonicerae 13-18 part, propolis 3.5-4.5 part, Herba Lophatheri 6-9 part, Indigo Naturalis 5-7 part, Radix Sophorae Flavescentis 8-13 part, Radix Glycyrrhizae 7-9 part, vitamin B2 18-23 part, Fructus Forsythiae 4-6 part, Folium Isatidis 7-9 part.
3. the buccal tablet for the treatment of stomatitis according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Flos Lonicerae 15 parts, propolis 4 parts, Herba Lophatheri 7.5 parts, Indigo Naturalis 6 parts, Radix Sophorae Flavescentis 10 parts, 8 parts, Radix Glycyrrhizae, vitamin B2 20 parts, Fructus Forsythiae 5 parts, Folium Isatidis 8 parts.
4. the preparation method of the buccal tablet of the treatment stomatitis according to any one of claim 1-3, it is characterized in that, step is as follows:
(1) Flos Lonicerae, Herba Lophatheri, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Fructus Forsythiae and Folium Isatidis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 20-30 hour, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly to stir-fry 5-10 minute with large ferrum spoon, take out, grind to form smalls and cross 80-120 mesh sieve;
(2) Indigo Naturalis be placed on clean tile, little fire dries 2-6 minute slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;
(3) propolis is placed in clean container, adds the warm water of 30-40 DEG C, be stirred well to after propolis melts completely and add vitamin B2, stir latter standing 4-6 hour stand-by;
(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in iron plate upper baking 10-20 minute, is processed into circle or other shapes according to the processing technique of tablet.
5. preparation method according to claim 4, is characterized in that: under step (1) is placed in shady and cool tree shade, sealing and standing 23-28 hour (preferred, under being placed in shady and cool tree shade, sealing and standing 25 hours).
6. preparation method according to claim 4, is characterized in that: the large ferrum spoon of step (1) stir-fries 6-9 minute (preferred, repeatedly to stir-fry 7 minutes with large ferrum spoon) repeatedly.
7. preparation method according to claim 4, is characterized in that: Indigo Naturalis is placed on clean tile by step (2), and little fire dries 3-5 minute (preferred, Indigo Naturalis be placed on clean tile, little fire dries 4 minutes slowly) slowly.
8. preparation method according to claim 4, is characterized in that: propolis is placed in clean container by step (3), adds the warm water (preferred, to be placed in clean container by propolis, to add the warm water of 35 DEG C) of 33-38 DEG C.
9. preparation method according to claim 4, is characterized in that: the consumption of step (3) warm water is the 4-6 of propolis weight doubly (preferred, the consumption of warm water is 5 times of propolis weight).
10. preparation method according to claim 4, is characterized in that: step (3) adds vitamin B2, stir latter standing 4.5-5.5 hour stand-by (preferred, add vitamin B2, stir rear leave standstill 5 hours stand-by).
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| CN107397898A (en) * | 2017-07-12 | 2017-11-28 | 田建波 | A kind of Chinese medicine composition for treating stomatopathy and preparation method thereof |
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Application publication date: 20150812 |