CN104815256B - A kind of pharmaceutical composition for treating pulmonary abscess and its application - Google Patents
A kind of pharmaceutical composition for treating pulmonary abscess and its application Download PDFInfo
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- CN104815256B CN104815256B CN201510209095.2A CN201510209095A CN104815256B CN 104815256 B CN104815256 B CN 104815256B CN 201510209095 A CN201510209095 A CN 201510209095A CN 104815256 B CN104815256 B CN 104815256B
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Abstract
The invention discloses a kind of pharmaceutical composition for treating pulmonary abscess and its application, said preparation is prepared by acceptable auxiliary material on active constituent and pharmacy, and the active constituent is prepared by the traditional Chinese medicinal material raw materials of following parts by weight through ethanol solution refluxing extraction:18 30 parts of duckweed, 20 33 parts of luffa root, 20 33 parts of radix ampelopsis, 10 50 parts of water chestnut, 9 16 parts of the tuber of stemona, eliminate completely 9 16 parts, 9 16 parts of dandelion, 36 parts of Schisandra chinensis, 59 parts of mulberry leaf, 11 20 parts of field pennycress.The pharmaceutical composition of the present invention agrees with the pulmonary abscess interpretation of the cause, onset and process of an illness afterwards by oral administration, and the substantially reduced patient symptom of energy improves the total effective rate that pulmonary abscess is treated.
Description
Technical field
The invention belongs to technical field of Chinese medicine, in particular to a kind of pharmaceutical composition for treating pulmonary abscess and its
Answer pharmaceutical applications.
Background technology
Pulmonary abscess is the lung tissue purulent lesion caused by Different types of etiopathogenises.Early stage is purulent inflammation, then bad
It is dead to form abscess.The prime of life is mostly occurred in, man is more than female.Transtracheal infection, Hematogenous infection and multiple purulence are had according to pathogenic factor
Swollen and lung cancer etc. blocks caused infection.The factor that pulmonary abscess occurs is bacterium infection, bronchial obstruction, in addition systemic resistance power
It reduces.Primary abscess is because sucking pathogenic bacteria or pneumonia cause, and secondary abscess is in the base for having lesion (as blocked)
On plinth, by being sent out outside lung, bronchiectasis and (or) immunosuppressive condition cause.
The scope of pulmonary abscess category traditional Chinese medical science lung carbuncle.The cause of disease includes:1st, the heresy of being invaded by exogenous pathogen,invasion of exogenous pathogen affection of exogenous wind-heat, invasion lung are defended or are felt
The heresy having a cold, is not with the passing of time cured, strongly fragrant and change heat, and heat symptoms caused by an exopathgen heap soil or fertilizer over and around the roots is held back in lung, and the lung network stasis of blood is stagnant, the hot stasis of blood mutually knot into pulmonary abscess.2nd, phlegm heat
Accumulate lung due to eating and drinking without temperance, the pungent product of addiction delicious food;Or be addicted to drink excessively, it grows damp and hot into phlegm;Or lung gold is known as stagnation of phlegm-heat;
Or because of excessive fatigue, lung is defended not admittedly, and exopathogen is interior in an opponent's defence to invade, inside and outside to close heresy, and causes accumulation phlegm-heat in the interior, steams and burns in lung, formation pulmonary abscess.
At present, treatment pulmonary abscess uses antibiotic mostly, but antibiotic usage is excessive, can increase the several of infection drug-fast bacteria
Rate, and since pulmonary abscess needs long-term treatment, antibiotic is used for a long time, great side effect can be brought to human body.The traditional Chinese medical science has
Long history, has accumulated rich experience over the past thousands of years, have to many diseases original opinion and it is definite the effect of.
Invention content
In view of the deficiencies in the prior art, the present invention is improved civil Empirical formula, provides a kind of medicine for treating pulmonary abscess
Compositions and its application.
In order to achieve the object of the present invention, the present inventor by a large number of experiments study and persistent exploration, be finally obtained as
Lower technical solution:
A kind of pharmaceutical composition for treating pulmonary abscess is prepared by acceptable auxiliary material on active constituent and pharmacy,
The wherein described active constituent is prepared by the traditional Chinese medicinal material raw materials of following parts by weight through ethanol solution refluxing extraction:Duckweed 18-
30 parts, 20-33 parts of luffa root, 20-33 parts of radix ampelopsis, 10-50 parts of water chestnut, 9-16 parts of the tuber of stemona, eliminate 9-16 parts, dandelion 9-16 completely
Part, 3-6 parts of Schisandra chinensis, 5-9 parts of mulberry leaf, 11-20 parts of field pennycress.
Preferably, the pharmaceutical composition of pulmonary abscess is treated as described above, wherein the active constituent is by following parts by weight
Traditional Chinese medicinal material raw materials be prepared through ethanol solution refluxing extraction:22-25 parts of duckweed, 24-28 parts of luffa root, 24-28 parts of radix ampelopsis,
26-35 parts of water chestnut, 11-13 parts of the tuber of stemona eliminate 11-13 parts completely, 11-13 parts of dandelion, 4-5 parts of Schisandra chinensis, 6-8 parts of mulberry leaf, lose
14-16 parts of sauce grass.
It is further preferred that the pharmaceutical composition of pulmonary abscess is treated as described above, wherein the active constituent is by as follows
The traditional Chinese medicinal material raw materials of parts by weight are prepared through ethanol solution refluxing extraction:23 parts of duckweed, 26 parts of luffa root, 26 parts of radix ampelopsis, water chestnut
30 parts of shepherd's purse, 12 parts of the tuber of stemona, eliminate completely 12 parts, 12 parts of dandelion, 4 parts of Schisandra chinensis, 7 parts of mulberry leaf, 15 parts of field pennycress.
It should be noted that pharmaceutical composition of the present invention traditional Chinese medicinal material raw materials used in the preparation have following source:
Duckweed selects the drying herb of plant and of its applications duckweed Spirodela polyrrhiza (L.) Schleid..Luffa root selects calabash
The dry root of Lu Ke plants sponge gourd Luffa cylindrica (L.) Roem..Radix ampelopsis selects vitaceae radix ampelopsis
The dried root of Ampelopsis japonica (Thunb.) Makino.Water chestnut selects Cyperaceae water chestnut platymiscium water chestnut
The drying bulb of Eleocharis dulcis (Burm.f.) Trin.ex Henschel.The tuber of stemona selects Stemonaceae plant upright hundred
The dried root of portion Stemona sessilifolia (Miq.) Miq..It eliminates completely and selects composite family Senecio plant honeysuckle a thousand li
Light Seneeio dianthus Franch. dry herb.Dandelion selects feverfew dandelion Taraxacum
The drying herb of mongolicum Hand.-Mazz..Schisandra chinensis selects Magnoliacea plant schisandra chinensis Schisandra
The dry mature fruit of sphenanthera Rehd.etWils..Mulberry leaf select the drying of moraceae plants mulberry Morus alba L.
Leaf.Field pennycress selects the drying root-like stock of field pennycress section plant patrima villosa (bitter vegetarian) P.villosa (Thunb.) Juss..
The pharmaceutical composition for the treatment of pulmonary abscess of the present invention is solid orally ingestible, including tablet, capsule, particle
Agent.According to the common process of formulation art, those skilled in the art be easy to by above-mentioned Chinese medical extract form activity into
Divide and be prepared into common solid orally ingestible with available auxiliary material in pharmacy, such as granule, tablet, capsule.
Compared with prior art, pharmaceutical composition of the invention agrees with the pulmonary abscess interpretation of the cause, onset and process of an illness afterwards by oral administration, can substantially reduced trouble
Person's symptom improves the total effective rate of pulmonary abscess treatment.
Specific embodiment
It is the specific preparation example of pharmaceutical composition of the present invention and clinical practice test example and toxicity test example below, to this hair
Bright technical solution and technique effect is further explained and describes.
Embodiment 1:The preparation of Chinese medical extract
It weighs duckweed 230g, luffa root 260g, radix ampelopsis 260g, water chestnut 300g, tuber of stemona 120g, eliminate 120g, dandelion completely
120g, Schisandra chinensis 40g, mulberry leaf 70g and field pennycress 150g, mixing are ground into coarse powder, and it is molten to add in the ethyl alcohol that volumetric concentration is 95%
Liquid 18L, heating and refluxing extraction, altogether repetition are extracted twice, for the first time extraction 2h, second of extraction 1.5h, merging extracting solution, four layers
Ethyl alcohol is recovered under reduced pressure to no alcohol taste in filtered through gauze, and then (condition is that inlet air temperature is 100 DEG C, leaving air temp 80 for spray drying
DEG C, temperature of charge be 80 DEG C, atomizing pressure be 0.2 megapascal, spray velocity 5ml/s), dried object crushing sieve with 100 mesh sieve, obtain
Chinese medical extract.
Embodiment 2:The preparation of tablet
Prescription
Preparation process:The Chinese medical extract prepared by 1 formulation and technology of embodiment is taken to sieve with 100 mesh sieve, microcrystalline cellulose and low
Substitution hydroxypropyl cellulose crosses 80 mesh sieve, weighs the Chinese medical extract, low-substituted hydroxypropyl cellulose, microcrystalline cellulose of recipe quantity
It is uniformly mixed, adds in 8% Gonak and pelletize in right amount, 60 DEG C of dryings, 16 mesh sieve whole grain, are added in dry particl
The magnesium stearate mixing of recipe quantity suppresses 1000, every Chinese medical extract containing 200mg.
Embodiment 3:The preparation of capsule
Prescription:
Preparation process:By the Chinese medical extract (take by 1 formulation and technology of embodiment prepare), pregelatinized starch, sweet in prescription
Dew alcohol and superfine silica gel powder sieve with 100 mesh sieve respectively, and mixing adds 95% ethanol solution of 6%PVP to pelletize in right amount, 60 DEG C of drying, 18 mesh
Sieve whole grain, capsule charge.
Embodiment 4:Chinese medicinal tablet treats the experimental study of pulmonary abscess patient
Pulmonary abscess patient 56, symptom and sign are shown as:1) patient's onset is more anxious, fever with aversion to cold, body temperature raising, cough
Pectoralgia, cough spit stench phlegm, and dry mouth and throat is short of breath, red tongue body, bitter yellow greasy, slippery and rapid pulse;2) lung abscess position breath sound subtracts
It is low, audible and moist rales;Blood routine examination finds that Leukocyte Counts and neutrophil leucocyte are significantly raised;Chest x-ray rabat is examined
Look into visible lung's purulence ulcer.Wherein, male 35, women 21;Age is 26 years old minimum, 59 years old maximum, average (46.2 ± 7.5)
Year;Course of disease longest 26d, the most short 5d of the course of disease, average (8.3 ± 2.6) d.All patients are randomly divided into two groups, Chinese medicine group and Western medicine
Each 28 of group, two groups of ages, gender, symptom, sign, the equal no difference of science of statistics of the course of disease are comparable.Chinese medicine group oral traditional Chinese medicine
Tablet (is made) by the formulation and technology of embodiment 2, and 5 tablets once, 3 times/d, and 7d is 1 course for the treatment of.Western medicine group vein gives enough moulds
Extract for treating, 7d are 1 course for the treatment of.Two groups treat 3 courses for the treatment of after count curative effect, the results are shown in Table 1.
Table 1:Two groups of Clinical efficacy comparisons [example (%)]
Criterion of therapeutical effect is cured:Symptom and sign disappear, and x-ray checks that lesion absorbs, other laboratory examinations restore normal.It is aobvious
Effect:Symptom and sign disappear substantially, and x-ray checks that lesion largely absorbs, other laboratory examinations are normal.Effectively:Symptom
And sign is substantially reduced, x-ray checks that focal part absorbs, other laboratory examination parts are restored.In vain:Symptom and sign have no
Improve.
Embodiment 5:The acute toxicity test of Chinese medical extract
ICR mouse 40 are taken, weight (is taken by 1 formulation and technology of embodiment intragastric administration on mice Chinese medical extract at 25~30 grams
Prepare), experiment has been carried out to the median lethal dose (LD50) of administration and has been measured, but do not measure LD50, therefore carried out maximum tolerance
Amount experiment.As a result:With maximum dosage-feeding 50g/kg gavages, it is equivalent to mouse in clinical intend daily dosage 100 times, seven days of adult
None is dead, puts to death each internal organs of mouse anatomic observation and does not find toxic reaction, administration group is with blank control group mouse without any difference
It is different.
Claims (4)
1. a kind of purposes of Chinese medicine composition in the drug for preparing treatment pulmonary abscess, the drug is by active constituent and pharmacy
Acceptable auxiliary material is prepared, which is characterized in that the active constituent is by the traditional Chinese medicinal material raw materials of following parts by weight through ethyl alcohol
Solution refluxing extraction is prepared:18-30 parts of duckweed, 20-33 parts of luffa root, 20-33 parts of radix ampelopsis, 10-50 parts of water chestnut, tuber of stemona 9-
16 parts, eliminate completely 9-16 parts, 9-16 parts of dandelion, 3-6 parts of Schisandra chinensis, 5-9 parts of mulberry leaf, 11-20 parts of field pennycress.
2. purposes according to claim 1, which is characterized in that the active constituent by following parts by weight traditional Chinese medicinal material raw materials
It is prepared through ethanol solution refluxing extraction:22-25 parts of duckweed, 24-28 parts of luffa root, 24-28 parts of radix ampelopsis, 26-35 parts of water chestnut,
11-13 parts of the tuber of stemona, eliminate completely 11-13 parts, 11-13 parts of dandelion, 4-5 parts of Schisandra chinensis, 6-8 parts of mulberry leaf, 14-16 parts of field pennycress.
3. purposes according to claim 2, which is characterized in that the active constituent by following parts by weight traditional Chinese medicinal material raw materials
It is prepared through ethanol solution refluxing extraction:23 parts of duckweed, 26 parts of luffa root, 26 parts of radix ampelopsis, 30 parts of water chestnut, 12 parts of the tuber of stemona, one
Clear off 12 parts, 12 parts of dandelion, 4 parts of Schisandra chinensis, 7 parts of mulberry leaf, 15 parts of field pennycress.
4. according to any one of the claim 1-3 purposes, which is characterized in that the pharmaceutical composition includes tablet, capsule
Agent, granule.
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CN201510209095.2A CN104815256B (en) | 2015-04-28 | 2015-04-28 | A kind of pharmaceutical composition for treating pulmonary abscess and its application |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103784620A (en) * | 2014-02-26 | 2014-05-14 | 青岛市中心医院 | Traditional Chinese medicine for treating pulmonary abscess and preparation method thereof |
CN104069408A (en) * | 2014-05-30 | 2014-10-01 | 洛阳新火种节能技术推广有限公司 | Formula for treating lung abscess |
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2015
- 2015-04-28 CN CN201510209095.2A patent/CN104815256B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103784620A (en) * | 2014-02-26 | 2014-05-14 | 青岛市中心医院 | Traditional Chinese medicine for treating pulmonary abscess and preparation method thereof |
CN104069408A (en) * | 2014-05-30 | 2014-10-01 | 洛阳新火种节能技术推广有限公司 | Formula for treating lung abscess |
Non-Patent Citations (1)
Title |
---|
40例急性肺脓肿临床观察;赵庆君 等;《上海中医药杂志》;19880915(第09期);8 * |
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Inventor after: Wang Jingluan Inventor after: Sun Nina Inventor after: Han Weizhong Inventor after: Li Guo Inventor before: Wang Jingluan Inventor before: Han Weizhong Inventor before: Tong Li Inventor before: Li Guo |
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