CN104815111A - Traditional Chinese medicine composition for treating lumbar disc herniation, cervical spondylosi and osteoproliferation - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating lumbar disc herniation, cervical spondylosi and osteoproliferation. The traditional Chinese medicine composition is prepared from the following raw medicinal materials, by weight, 110-120 parts of cibotium rhizome, 70-80 parts of himalayan teasel root, 70-80 parts of rhizoma drynariae, 70-80 parts of achyranthes root, 70-80 parts of cudweed herb, 35-40 parts of the seed of cowherb, 90-110 parts of Chinese angelica, 70-80 parts of pseudo-ginseng, 45-55 parts of frankincense, 45-55 parts of myrrh, 70-80 parts of speranskia herb, 70-80 parts of corydalis tuber, 45-55 parts of ligusticum wallichii, 35-40 parts of dragons blood and 45-55 parts of Herba Siegesbeckiae. The traditional Chinese medicine composition has effects of tonifying the liver and kidney, warming and activating meridian, strengthening muscles and bones, eliminating swelling, easing pain and promoting blood circulation to remove blood stasis, and has a good effect of treating diseases such as lumbar disc herniation, cervical spondylosi and osteoproliferation, etc.

Description

A kind of Chinese medicine composition for the treatment of prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny, belong to technical field of traditional Chinese medicine preparation.

Background technology

Prolapse of lumbar intervertebral disc, cervical spondylosis and osteoproliferation disease are one of modal multiple diseases of orthopedics department, though this disease does not directly threaten the life of people, but after most of patients is ill, handicapped, hurt like hell, even needing of having is lain up, and treatment cycle is long, greatly inconvenience and painful is brought, the serious work affecting patient and healthy to patient.

Theory of Chinese medical science is thought: the morbidity of prolapse of lumbar intervertebral disc, cervical spondylosis and osteoproliferation disease and wound, strain, obstruction of collaterals by blood stasis, be affected by the cold damp, caused by liver and kidney deficiency etc. are relevant.

Wound and strain: momentaryly bear super-strength external force, comprise and turn round, frustrate, hit, fall, or bear the strain of super-strength external force for a long time, as worked with taking incorrect posture constant tension under particular state, all can cause the acute of joint or chronic injury, more to occur in the weight-bearing joints such as neck, waist section, spinal column and hip, knee joint, ankle.When these External Force Actings are in above-mentioned position, the most concentrated stressed local joint generation pathological changes can be caused, serious cause that muscle damages bone injury, blood flow does not follow Chang Dao and overflow and form blood stasis outward in arteries and veins and stagnate, cause joint skeleton structural damage, lose nourishing, hinder to some extent outward, inside damage to some extent, as " roman class is wanted " sequence: institute's cloud " and limbs damage in outward, then QI and blood is hindered in interior, and battalion defends does not pass through to some extent.”

Affection of exogenous wind-cold damp: the ground of humidity that be affected by the cold, catch a cold, occupy for a long time, to paddle in spite of the rain, exopathogen is taken advantage of a loophole and is invaded flesh table meridians, visitor in joint, muscles and bones, cause the whole or a certain local meridian qi and blood of body to run numbness resistance obstructed, muscles and bones is lost foster, gradually becomes rheumatism involving the bone.As " Plain Questions 2 numbness opinion " " wet three gas of wind and cold are mixed extremely, and and are numbness ".

The kidney usually involved in chronic disease, The liver and the kidney have a common source, eventually to caused by liver and kidney deficiency: the traditional Chinese medical science is thought " kidney controlling essence storage, the raw marrow of main bone ", if kidney essense abundance, body is strong, skeleton profile and internal structure normal." liver storing blood, main muscle Shugu profit joint ", then muscle arteries and veins is powerful for liver blood abundance, quietly protects all bones, bone marrow of supplementing nutrition; Dynamic then retrain all bones, exempt to cause excessive impairment caused by overstrain.If deficiency of kidney-essence, deficiency of liver-blood, then development of bone marrow is abnormal, and muscles is not hard, and flourish foster weary source, bone marrow of can not supplementing nutrition, of a specified duration must see the joint pains such as Thoracolumbar disk.

The current treatment for prolapse of lumbar intervertebral disc, cervical spondylosis and osteoproliferation disease is main mainly with temporary relieve pain, easily occurs side effect, and easily recur in life-time service process.

Summary of the invention

For the deficiency that above-mentioned prior art exists, the object of this invention is to provide a kind of Chinese medicine composition for the treatment of prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny, there is bone and muscle strengthening, subduing swelling and relieving pain, effect of blood circulation promoting and blood stasis dispelling, has good therapeutic effect to prolapse of lumbar intervertebral disc, cervical spondylosis and osteoproliferation disease etc.

For achieving the above object, the present invention adopts following technical proposals:

Treating a Chinese medicine composition for prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny, is be made up of the crude drug of following weight portion:

Rhizoma Cibotii 110-120 part, Radix Dipsaci 70-80 part, Rhizoma Drynariae 70-80 part, Radix Achyranthis Bidentatae 70-80 part, Rhizoma Homalomenae 70-80 part, Semen Vaccariae 35-40 part, Radix Angelicae Sinensis 90-110 part, Radix Notoginseng 70-80 part, Olibanum 45-55 part, Myrrha 45-55 part, Herba speranskiae tuberculatae 70-80 part, Rhizoma Corydalis 70-80 part, Rhizoma Chuanxiong 45-55 part, Sanguis Draxonis 35-40 Fen, Herba Siegesbeckiae 45-55 part.

Preferably, the Chinese medicine composition of this treatment prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny is made up of the crude drug of following weight portion:

Rhizoma Cibotii 112.5 parts, Radix Dipsaci 75 parts, Rhizoma Drynariae 75 parts, Radix Achyranthis Bidentatae 75 parts, Rhizoma Homalomenae 75 parts, Semen Vaccariae 37.5 parts, Radix Angelicae Sinensis 100 parts, Radix Notoginseng 75 parts, Olibanum 50 parts, Myrrha 50 parts, Herba speranskiae tuberculatae 75 parts, Rhizoma Corydalis 75 parts, Rhizoma Chuanxiong 50 parts, Sanguis Draxonis 37.5 Fen, Herba Siegesbeckiae 50 parts.

Chinese medicine composition of the present invention can further and one or more pharmaceutically acceptable adjuvants make oral formulations and external preparation, can be tablet, pill, capsule or unguentum.

Described adjuvant is selected from calcium phosphate, magnesium stearate, Pulvis Talci, dextrin, starch, gelatinous fibre element, methylcellulose, sanlose, polyvinylpyrrolidone, one or more in Oleum Sesami and Plumbum preparatium.

Preferably, Chinese medicine composition of the present invention can make externally used paste with adjuvant Oleum Sesami and Plumbum preparatium, and its preparation method is:

(1) take each taste crude drug in prescription ratio, by Sanguis Draxonis and Radix Notoginseng two taste medicine, pulverize, sieve for subsequent use; By Olibanum, Myrrha and Rhizoma Corydalis three taste medicine, pulverize, sieve, mix with Sanguis Draxonis, Radix Notoginseng medicated powder, for subsequent use;

(2) by Rhizoma Cibotii, Radix Dipsaci, Rhizoma Drynariae, Radix Achyranthis Bidentatae, Rhizoma Homalomenae, Semen Vaccariae, Radix Angelicae Sinensis, Herba speranskiae tuberculatae, Rhizoma Chuanxiong, Herba Siegesbeckiae ten taste medicine, give as one thinks fit cataclasm, add the Oleum Sesami of 2200-2300 part, soak 24h, be heated to oil boiling extract, it is degree that spice explodes to the inner coke yellow of surperficial dark brown, and remove medicinal residues, the medicine oil after removing slag is for subsequent use;

(3) the medicine oil of step (2) is heated to 320-330 DEG C, refines oil, time initial, oil smoke is blue or green cigarette, turn black gradually and then become white dense smoke, reducing heating-up temperature when there is white cigarette, and observe oil bloom, until oil bloom when pot central authorities are coalescent, representing oil refining close to completing, reducing heating-up temperature further, do and drip into pearl inspection, in heat-obtaining oil a little instillation cold water, if oil droplet becomes round bead shape at the water surface, blow not loose or loose after coalescent again time, show old tender matters, stop oil refining;

(4) in the medicine oil refined, add the red lead powder of 675-825 part, stir, make it fully change and be oxidized, at 300-320 DEG C, continue agitating heating 20-30 minute, receive cream, obtained oil pill paste, for subsequent use;

(5) oil pill paste prepared by step (4) is placed in cold water, soaks 72 hours, within every 24 hours, change water once, releasing fire-toxin, the water in the most oil pill paste of drop, In Shade, for subsequent use;

(6) by the oil pill paste heat fused after step (5) releasing fire-toxin, control the temperature of oil pill paste lower than 70 DEG C, add Sanguis Draxonis prepared by step (1), Radix Notoginseng, Olibanum, Myrrha and Rhizoma Corydalis fine powder, stir evenly, coating, get product plaster.

In step (6), coating weight is 0.25-0.30g/cm ².

This externally applied ointment adjuvant used is Oleum Sesami and Plumbum preparatium, the kind that Oleum Sesami records for " Chinese Pharmacopoeia " 2010 version (), every regulation that its quality is relevant under should meeting " Chinese Pharmacopoeia " version (one) the 393rd page of Oleum Sesami item in 2010.The kind that Plumbum preparatium records for " Beijing's medical material standard ", quality standard relevant under its quality should meet " Beijing's medical material standard " the 117th page of Plumbum preparatium item.

The preparation technology of externally applied ointment of the present invention, according to the physicochemical property of prescription drug principle active component and main component, in conjunction with the conventional custom of being used as medicine of each medicine, be divided into 5 taste Chinese medicines directly to pulverize prescription 15 herbal medicine adding oil pill paste and neutralize other 10 herbal medicines after fried extraction, add Plumbum preparatium again and refine into oil pill paste, extract the active substance of each medicine of prescription respectively.

1, the independent pulverizing of Sanguis Draxonis, Radix Notoginseng: because Sanguis Draxonis, Radix Notoginseng are comparatively rare Chinese medicine is the loss reduced in preparation technology, therefore after it being pulverized separately, then with other 3 herbal medicine fine powder facing-ups, the preparing process finally mixed with the oil pill paste refined again.

2, the co-grinding of 3 herbal medicines: Olibanum, Myrrha are resinae medicine, the effective ingredient heating destructible of Rhizoma Corydalis, for fully retaining the effective ingredient of three herbal medicines, reduce the loss in technique preparation, therefore by 3 herbal medicine co-grindings, and with incremental method and Sanguis Draxonis, Radix Notoginseng fine powder facing-up, directly add in the oil pill paste refined.

3, the fried extraction of other 10 herbal medicines: according to black plaster tradition frying technological process, Rhizoma Cibotii in prescription, Radix Dipsaci, Rhizoma Drynariae, Radix Achyranthis Bidentatae, Rhizoma Homalomenae, Semen Vaccariae, Radix Angelicae Sinensis, Herba speranskiae tuberculatae, Rhizoma Chuanxiong, Herba Siegesbeckiae 10 taste are given as one thinks fit the stock of drugs of pulverizing, with Oleum Sesami by fried for pharmaceutical decocting piece extraction, remove slag, refine oil again Plumbum preparatium to be added and extract in ointment, refine into the traditional handicraft of oil pill paste.

The Chinese medicine composition for the treatment of prolapse of lumbar intervertebral disc of the present invention, cervical spondylosis and hyperosteogeny, its prescription is according to being: Rhizoma Cibotii is bitter sweet warm in nature, energy complementary energy row, function invigorating the liver and kidney, strong psoas muscle, hard muscles and bones, again except wind-cold damp pathogen, therefore is usually used in soreness of waist and knee joint, muscles and bones is unable waits disease, and to deficiency of the liver and kindey, the person that has wind-cold damp pathogen concurrently, particularly suitable.Existing eliminating evil power has again a merit of tonification." beautiful Chinese catalpa medicine solution ": " let out wet cold removing, play flaccidity pain relieving, let out kidney liver dampness, consciousness restoring, bone and muscle strengthening, control lumbago knee joint pain, " can treat main disease, eliminating primary symptom, is be monarch drug.Sweet and the tepor of Radix Dipsaci, can liver and kidney tonifying, and hardship is rushed down pungent loose, and can pass through blood vessels, activating collaterals to relieve pain, has benefit and can declare, the capable and feature of not rushing down, and therefore, can be used for aching pain in waist and back; Podomere flaccidity syndrome and arthralgia syndrome; Fall and flutter wound, damage muscle folding bone." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians are determined in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, tissue regeneration promoting blood, removing blood stasis with potent drugs blood." Rhizoma Drynariae hardship, temperature, enters Liver and kidney warp.The kidney invigorating pain relieving, continuous muscle of invigorating blood circulation is cured the wound." Kaibao Bencao " carries it: " removing blood stasis stops blooding, and benefit is traumaticd fracture.Radix Achyranthis Bidentatae enters Liver and kidney two warp, can invigorating the liver and kidney, bone and muscle strengthening, again can promoting blood circulation, sharp joint, for controlling the conventional key medicine of waist knee joint pain.To the soreness of waist and knee joint that deficiency of the liver and kindey causes, normal and Radix Dipsaci, Rhizoma Cibotii is equivalent to be used." herbal classic ": " gonalgia can not be bent, by vim and vigour for main cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs ".Rhizoma Homalomenae is mainly used in rheumatic arthralgia clinically, joint aches, and the disease such as contracture of the limbs paralysis, really according to dispelling wind and removing obstruction in the collateral, and the effect of strong muscles and bones." decoction pieces is newly joined ": " enter blood system, wind-damp dispelling arthralgia pain, bone and muscle strengthening, control podomere ache." Semen Vaccariae sweetness and bitterness is put down, and can walk blood system, the special tonneau of merit, and its feature is row and not live, walks and does not keep, kind sharp blood vessels, therefore energy reducing swelling and alleviating pain.Book on Chinese herbal medicine is looked for the truth ": Semen Vaccariae, property is walked and does not keep.Then knowing abnormal smells from the patient catharsis, how does Xun Er extremely, have again blood and gram to stop? hemostasis analgesic therapy sayed again by what book, can incised wound be controlled, like with the meaning of promoting the circulation of blood again symbolic animal of the birth year be contrary to, Ju knows that blood stasis is not all right, obtain this then row, blood goes out incessantly, obtains this and then stops, non-therefore only also, obtain its abnormal smells from the patient and think sensible, then blood is in the long stream of the open sore part, and blood is from loose each warp, so that its blood is from only, its pain is namely fixed, must with till only." the sweet benefit of Radix Angelicae Sinensis is pungent loose, it is logical that hardship lets out temperature, can enrich blood, can invigorate blood circulation again, for traumatic injury, and can promoting blood circulation and stopping pain.Radix Notoginseng has dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.Cure mainly breast ventral spine pain, tumbling down swells and ache.Compendium of Material Medica cloud: " pseudo-ginseng hemostatic, loose blood, analgesic therapy." Olibanum and Myrrha all with eliminating stasis to stop pain for wanting.Both gas of cause are fragrant, and perfume (or spice) can be walked to alter and benefaction, thus energy promoting the circulation of blood dissipating blood stasis, promoting the circulation of QI dredging collateral, blood diarrhea due to disorder of QI then pain stops certainly; Two medicines also use every benefit to increase the effect of promoting blood circulation and stopping pain.Compendium of Material Medica: " Olibanum is invigorated blood circulation, and Myrrha falls apart blood, all can alleviating pain and detumescence, granulation promoting, therefore two medicines are often held concurrently mutually and use." the pungent temperature of Herba speranskiae tuberculatae, enter liver, kidney channel.Pungent loose temperature, function expelling wind and dampness; Channels sootheing and network vessel quickening, promoting blood circulation and stopping pain.Main air pain of dampness syndrome; Muscles and bones contracture; The disturbance of lower legs due to pathogenic cold and dampness; Lumbar strain; " detailed outline ": control all rheumatalgia contractures of muscles and bones, the disturbance of lower legs due to pathogenic cold and dampness.Rhizoma Corydalis acrid, bitter, warm.Invigorate blood circulation, circulation of qi promoting, pain relieving.Be mainly used in all pain cards of stagnation of QI and blood.The pungent loose temperature of this product is led to, " stagnation of QI in energy promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body." its analgesic effect is excellent, no matter which kind of pain card, all can compatibility application." Japan hanako materia medica " record: " Rhizoma Corydalis, except wind, controls gas, and warm waist knee joint ， Po Disorder addiction, flutters damage blood stasis, and sudden and violent lumbago." the pungent Wen Xiang of Rhizoma Chuanxiong alters, walk and do not keep, outer thorough fur, bypass extremity, has the effect such as blood-activating and qi-promoting, wind-expelling pain-stopping for the gas medicine in blood.Cure mainly anemofrigid-damp arthralgia, costa sternales twinge, treating swelling and pain by traumatic injury, arthralgia due to cold spasm, etc. disease.Above 12 taste medicines: Radix Dipsaci, Rhizoma Drynariae, Radix Achyranthis Bidentatae, the strong muscles and bones of Rhizoma Homalomenae energy principal drug assistance; Rear eight taste medicines can strengthen the active cold expelling of monarch drug, the effect of blood-activating analgetic.Be ministerial drug altogether.The pain relieving of Sanguis Draxonis promoting blood circulation to remove blood stasis, is most commonly used to traumatic injury, the swelling and pain due to blood stasis of tendon breaking fracture, for orthopedics department commonly uses key medicine." detailed outline ": " the loose all pains of stagnant blood.” Herba Siegesbeckiae is bitter, cold.Return liver, kidney channel.Function wind-damp dispelling, the meridian dredging, heat-clearing and toxic substances removing.Therefore being usually used in rheumatic arthralgia, numb limbs and tense tendons, flaccidity of the lower limbs is unable waits disease." Bencao Tujing ": " treating the liver the kidney-wind syndrome gas, quadriplegia, arthralgia, weakness of the waist and knees person." Sanguis Draxonis, Herba Siegesbeckiae can slow down the property of the warm-dryness syndrome of monarch drug, and monarch drug can be assisted again to treat disease of holding concurrently.Be adjuvant drug.Radix Achyranthis Bidentatae, Semen Vaccariae, property are apt to away alter, and thoroughly can reach meridians, through sick institute, the double use making medicine.All medicines share, and medicine card conforms to, and effect is complementary, plays liver and kidney tonifying altogether, effect of promoting the flow of QI in the collateral by warming the meridian.Liver and kidney must be mended, and meridians temperature is led to, QI and blood logical and, all cards are from removing.

The Chinese medicine composition for the treatment of prolapse of lumbar intervertebral disc of the present invention, cervical spondylosis and hyperosteogeny, in its prescription, the pharmacodynamic analysis of each taste medicine is as follows:

1, Rhizoma Cibotii: be the dry rhizome of Dicksoniaceae Rhizoma Cibotii.Every regulation that its quality is relevant under meeting " Chinese Pharmacopoeia " version (one) the 209th page of Rhizoma Cibotii item in 2010.Rhizoma Cibotii rhizome starch-containing about 30%. Rhizoma Osmundae rhizome is starch-containing is 48.5%, and containing tannin class. containing pterosin (pterosin) R, onychin (onitin), onychin-2'-O-glycoside, onychin-2'-O-allose glycoside, Europe Herba pteridii latiusculi Yi Lu glycoside, pterosin Z.Rhizoma Cibotii is containing 11 kinds of trace element, and wherein the content of magnesium, calcium, potassium, aluminum is higher.

2, Radix Dipsaci: be the dry root of Dipsacaceae plant Radix Dipsaci.Every regulation that its quality is relevant under meeting " Chinese Pharmacopoeia " version (one) the 309th page of Radix Dipsaci item in 2010.Radix Dipsaci root is containing iridoid glucoside: sweroside (swero-side), Semen Strychni glycoside (loganin), cantleyoside (cantleyoside); Triterpenoid saponin: akeboside D, volatile oil; Its composition has 41 kinds, that has identified has 29 kinds, what wherein content was higher has carvotanacetone, other: hederagenin (hederagenin), cupreol, daucosterol (darcos-terol), sucrose (sucrose) and the more Trace Element Titanium of content.

3, Rhizoma Drynariae: be the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi.Every regulation that its quality is relevant under meeting " Chinese Pharmacopoeia " version (one) the 239th page of Mongolian oak Herba pteridii latiusculi item in 2010.Drynaria fortunei(Kunze) J.Smith rhizome is starch-containing 16.4%, glucose 5.37%, also containing naringin.Drynaria fortunei(Kunze) J.Smith rhizome is containing naringin (naringin), 21-hopenen, fernene [fern-9 (11) ene], 7-fernene (fern-7-ene, ) 3-wild goose tooth alkene (filic-3-ene), cupreol (β-sitosterol), stigmasterol (sting-masterol), oil recovery sterol (campesterol) and tetracyclic triterpenoid: ring jackfruit sterol-acetas (cycloardenyl acetate), ring Rhizoma Polypodiodis Nipponicae steryl acetate (cy-clomargenyl acetate), cyclolaudenol acetas, 9, 10-ring Pilus Caprae seu Ovis steroid-25-enol-3 β-acetas.Precipice Rhizoma Zingiberis Recens Herba pteridii latiusculi rhizome is containing 21-hopenen, 13 (18) neohopenes, 9 (11)-fernenes, cupreol, stigmasterol, campesterol and tetracyclic triterpenoid: ring jackfruit steryl acetate, ring Rhizoma Polypodiodis Nipponicae sterol enolacetate, cyclolaudenol acetas, 9,10-ring Pilus Caprae seu Ovis steroid-25-enol-3 β-acetas.

4, Radix Achyranthis Bidentatae: be the dry root of amaranthaceous plant Radix Achyranthis Bidentatae.Every regulation that its quality is relevant under meeting " Chinese Pharmacopoeia " version (one) the 67th page of Radix Achyranthis Bidentatae item in 2010.Root is containing triterpenoid saponin: oleanolic acid α-L-rhamnopyranosyl-β-D-galactopyranosyl glucoside, again containing multiple polysaccharide, also containing ecdysterone, inokosterone, rubrosterone and arginine, glycine, serine, aspartic acid, glutamic acid, threonine, proline, tyrosine, tryptophan, valine (valine), phenylalanine, leucine and alkaloids and Coumarins compound.

5, Rhizoma Homalomenae: be the dry tuber of aroid Rhizoma Homalomenae.Every regulation that its quality is relevant under meeting " Chinese Pharmacopoeia " version (one) the 31st page of Rhizoma Homalomenae item in 2010.Rhizoma Homalomenae contains the volatile oil of about 0.69%, certified composition has australene (α-pinene), nopinene (β-pinene) limonene (limonene), linalool (l inalool), alpha-terpineol (α-terpineol), nerol (nerol), geraniol (geraniol), eugenol (eugenol), geranial (geranial), β-terpineol (β-terpineol), isoborneol (isoborneol), terpinene-4-alcohol (terpinen-4-ol), literary composition Herba Pogostemonis alcohol (patchouli alcohol).

6, Semen Vaccariae: be the dry mature seed of pinkwort Vaccaria segetalis Vaccaria segetalis (Neck.) Garcke.Its quality meets the pertinent regulations under " Chinese Pharmacopoeia " version in 2010 the 49th page of Semen Vaccariae item.Main containing triterpenoid saponin, what be called vacsedoside (vac-segoside) has A, B, C, D4 kind, all for by the derivative polysaccharid glucoside of gypsogenin (gypsogenin).The hydrolysis of four kinds of Saponins all same vaccaroside (vaccraoside), be namely gypsogenin-3-β-D-Glucose aldehydic acid glycoside (gypsogenin-3-β-D-giucuronoside.Again containing flavonoid glycoside: Semen Vaccariae flavonoid glycoside (vaccarin), isosaponaretin (isosaponarin).Also containing phytin. (phytin), phospholipid (phospholipid), stigmasterol (stigmasterol) etc.Also containing xanthone composition in herb: Semen Vaccariae xanthone (vaccaxan-thone), Vaccaria segetalis xanthone (sapxanthone), 1,8-dihydroxy-3,5-dimethoxy 9-xanthone (1,8-dihydroxy-3,5-dimethoxy-9H-xanthen-9-One).

7, Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Every regulation that its quality is relevant under meeting " Chinese Pharmacopoeia " version (one) the 124th page of Radix Angelicae Sinensis item in 2010.Containing the organic acid such as volatile oil, ferulic acid, sucrose, vitamin, aminoacid and the composition such as inorganic elements and choline, wherein volatile oil and ferulic acid (ferulic acid) main active that is Radix Angelicae Sinensis, the volatile ingredient in (1) Radix Angelicae Sinensis is made up of neutral oil, phenol oil and acid-soluble oil three part.

Neutral oil accounts for volatilization and spatters 88% of total amount, has butylidene phthalide (butylidens phthalide), australene (α-pinene), nopinene, to P-cymene (p-cymene)

Phenol oil: phenol oil accounts for 10% of volatile oil total amount, has phenol (phenol), o-cresol (o-cresol), p-cresol (p-cresol)

Acid-soluble oil: acid-soluble oil accounts for 2% of volatile oil total amount, has phthalic anhydride (phthalic anhydride), Azelaic Acid (azelaic acid)

(2) organic acid: mainly containing ferulic acid (ferulic acid), succinic acid (succinic acid), nicotinic acid (nicotinic acid), vanillic acid (vanillic acid), positive tetracosanoic acid (n-tetraco-sanoic acid), Palmic acid (palmitic acid).

(3) saccharide: containing sucrose, fructose, glucose isolate the arabinogalactan (arabigalactan) with anticomplementary activity.

(4) aminoacid: Radix Angelicae Sinensis is containing 17 seed amino acids, and comprise needed by human but can not 7 seed amino acids of self synthesis, as aspartic acid, valine, methionine, histidine etc., total amino acid content be 6.5%.

(5) inorganic elements: Radix Angelicae Sinensis contains 20 kinds of constants and small-scale inorganic element, wherein 16 kinds is that human body is necessary, as calcium, zinc, phosphorus, selenium etc.Other is still containing a small amount of xanthotoxin, isopimpinellin, vitamin B12, vitamin A, adenine etc.

8, Radix Notoginseng: be the dry root bark of Araliaceae acanthopanax gracilistylus.Every regulation that its quality is relevant under meeting " Chinese Pharmacopoeia " version (one) the 61st page of Cortex Acanthopancis item in 2010.Seed is containing black periplocin, Cortex Acanthopancis enzyme, Cortex Acanthopancis acid, Cortex Acanthopancis alkali, fatty oil, protein, phlegmatic temperament.Gained volatile oil name slender acanthopanax haze wax after enzymolysis, the methyl ester containing isothiocyanic acid, isopropyl ester, allyl ester, butyl ester, secondary butyl ester, butylene-3-ester, amylene-4-ester, phenyl ester, benzyl ester, phenethyl ester and 3-methyl mercapto propyl ester.Fatty oil is the glyceride of multiple fatty acid, and its fatty acid is erucic acid, twenty carbene-11-acid, oleic acid, linoleic acid, linolenic acid, Palmic acid, arachidic acid, stearic acid, behenic acid.

9, Olibanum: the resin oozed out for olive subject plant Boswellia carterii and congener Boswellia bhaw-dajiana Birdw. bark.Its quality meets the pertinent regulations under " Chinese Pharmacopoeia " version (one) the 207th page of Olibanum item in 2010.Through qualification, this kind resin oozed out for olive subject plant Boswellia carterii bark used.Resinous 60%-70%, gummy 27%-35%, volatile oil 3%-8%.The main component of resin is free α, β-Olibanum ester acid, in conjunction with the acid of Olibanum ester, olibanoresene, table Thin Layer scanning, shows lupeol and tirucallol; Natural gum is calcium salt and magnesium salt, the bassorin of Arabic heteropolysaccharide acid, in addition still containing bitter principle; Volatile oil is containing pinene, racemization limonene, α-phellandrene, β-phellandrene, α-Camphora olefine aldehydr, cumaldehyde, phellandral, o-methyl-benzene ethyl ketone, Eucarvone etc.

10, Myrrha: be olive subject plant Herba Violae tree or the dry resin of Ha Didingshu.Its quality meets the pertinent regulations under " Chinese Pharmacopoeia " version (one) the 173rd page of Myrrha item in 2010.Through qualification, this kind dry resin for olive subject plant Herba Violae tree used.Resinous 25%-35%, volatile oil 2.5%-9%, gummy 57%-65%, the major part of resin can be dissolved in ether, and insoluble part is containing α and β heerabomyrrholic acid, and soluble part contains α, β and γ myrrholic acid, commiphorinic acid, α and β heerabomyrrhol, still containing heeraboresene, commiferin.Volatile oil is resinophore in atmosphere, containing eugenol, and m-cresol, cumaldehyde, pinene, limonene, cinnamic aldehyde, heerabolene etc., and containing multiple furan sesquiterpene compounds.

Natural gum hydrolysis obtains arabinose, galactose and xylose.

11, Herba speranskiae tuberculatae: be the dry herb of ranunculaceae plant Herba clematidis intricatae.Every regulation relevant under its quality meets " Guangxi medical material standard " the 196th page of Herba speranskiae tuberculatae item.If Herba speranskiae tuberculatae is mainly containing eastern alpine rush or palm-bark rain cape element, caffeic acid, inositol, triacontanol, the Multiple components such as cupreol, ethyl stearte, n-hexacosane alcohol, caffeic acetate.There is loose wind damp eliminating, effect of removing toxic substances pain relieving.

12, Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis.Every regulation that its quality is relevant under meeting " Chinese Pharmacopoeia " 2010 version () the 130th Ye Herba Siegesbeckiae item.Containing multiple isoquinoline alkaloid, have corydalis A,B,C,D, penta element, oneself element, heptan plain, Xin Su, the ninth of the ten Heavenly Stems element, certain herbaceous plants with big flowers is plain, son is plain, Chou prime, the third of the twelve Earthly Branches element, coptisine, dehydrogenation Corydaline, Rhizoma Corydalis amine alkali, dehydrogenation Rhizoma Corydalis amine alkali and ancient human relations amine alkali etc.

13, Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong.Every regulation that its quality is relevant under meeting " Chinese Pharmacopoeia " version (one) the 38th page of Rhizoma Chuanxiong item in 2010.Rhizome has 40 kinds containing the fuel-displaced middle composition of volatile oil about 1%. qualification, account for 93.64% of volatile oil, wherein main constituent is ligustilide, 3-fourth Fu lactone and sabinene. lactone compound contained in rhizome, except above-mentioned two kinds of mentioning, still containing Ding Xi Fu lactone, cnidium lactone, neocindilide, 4-hydroxyl-3-Ding Fu lactone, chuanxingol, Diligustilide, and 3-butyl-3, 6, 7. trihydroxy-4, 5, 6, 7-tetrahydrochysene Phthalide etc. nitrogen-containing compound has tetramethylpyazine vanillic acid, ferulic acid (ferul ic acid), sedanoic acid (sadanic acid), chrysophanic acid (chrysophic acid), Palmic acid, vanillin and linoleic acid. in addition, Rhizome of Ligusticum Sinense Oliv. Cv. Chuanxiong is still containing neutral oil, its composition is 15, 16, 17, octadecanoid acid ethyl ester, different 17, isooctadecane acetoacetic ester and different methyl margarate. separately containing 5, 5 '-Lian furan feeds formyl ether, spathulenol, Sitosterolum, sucrose and a kind of fatty glyceride.

14, Sanguis Draxonis: the resin oozed out for babassu Sanguis Draxonis fruit is through being processed into.Its quality meets the pertinent regulations under " Chinese Pharmacopoeia " version (one) the 133rd page of item in 2010.Containing dracorubin, dracorhodin, demethyl dracorubin, demethyl dracorhodin, (2S)-5-methoxyl group-6-methyl flavane-7-alcohol, (2S)-5-methoxyl group flavane-7-alcohol, 2 in red resin, 4-dihydroxy-5-methyl-6-methoxyl group looks into diketone, 2,4-dihydroxy-6-methoxy chalcones; Another containing resin acid, different resin acid, rosin acid, dehydrogenation rosin acid, fragrant loose glue fat acid, oleanolic acid, Dianthus chinensis aldehyde and Folium Vaccinii vitis-idaeae aldehyde etc.

15, Herba Siegesbeckiae: be the dry aerial parts of composite family Zhi Wu pig label, Xian Geng pig label or Mao Geng pig label.Every regulation that its quality is relevant under meeting " Chinese Pharmacopoeia " 2010 version () the 345th Ye Herba Siegesbeckiae item.Through qualification, this kind is used plants the dry aerial parts of thing pig label for Compositae.Containing the fragrant alkene lactone of 9 β-isobutyl acyl-oxygen sill in Herba Siegesbeckiae stem, the fragrant alkene lactone of 9 beta-hydroxy-8 β-isobutene. acyl-oxygen sill, 8 β-isobutyryl Oxy-1 4-Tibet base-costunolide, the fragrant alkene lactone of 14-hydroxyl-8 β-isobutyl acyl-oxygen sill, 9 β, the fragrant alkene lactone of 14-dihydroxy-8 β-isobutyl acyl-oxygen sill, 8 β, 9 beta-dihydroxy-1 β, 10 α-epoxy-11 β, 13-dihydro costunolide, 14-hydroxyl-8 β-isobutyryl Oxy-1 β, 10 α-epoxy costunolide, 15-hydroxyl-9 α-acetoxyl group-8 β isobutyryl Oxy-1 4-oxo buys blue slope grass lactone, 15 hydroxyl-8 β-isobutyryl Oxy-1 4-oxo buys blue slope grass lactone, 19-acetoxyl group-12-oxo-10, 11-dihydro geranyl nerol, 19-acetoxyl group-15-hydrogen peroxide-12-oxo-13, 14E-dehydrogenation-10, 11, 14, 15,-tetrahydrochysene geranyl nerol, 19-acetoxyl group-15-hydroxyl-12-oxo-13, 14E-dehydrogenation-10, 11, 14, 15-tetrahydrochysene geranyl nerol, 2 β, 15, 16-trihydroxy-mapping-8 (14)-pimanthrene, 15, 16-dihydroxy-2-oxo-mapping-8 (14)-pimanthrene, 15, 16, 18-trihydroxy-2-oxo-mapping-8 (14)-pimanthrene, 1 α-acetoxyl group-2 α, 3 α-epoxy isoalantolactone.

Beneficial effect of the present invention:

Chinese medicine composition of the present invention has liver and kidney tonifying, promoting the flow of QI in the collateral by warming the meridian, bone and muscle strengthening, subduing swelling and relieving pain, effect of blood circulation promoting and blood stasis dispelling, has good therapeutic effect to prolapse of lumbar intervertebral disc, cervical spondylosis and osteoproliferation disease etc.Clinical proof: adopt Chinese medicine preparation of the present invention, the bed cure rate for prolapse of lumbar intervertebral disc is 37.5%, and total effective rate is 91.7%; Cervical spondylosis clinical cure rate 29.4%, total effective rate is 94.1%, other degenerative osteoarthritis clinical cure rates 26.7%, and total effective rate is 93.3%.Obvious adverse reaction is had no, use safety in clinical practice.

Detailed description of the invention

Below by instantiation, the present invention will be further elaborated, should be noted that following explanation is only to explain the present invention, not limiting its content.

Embodiment 1: the preparation of the externally applied ointment for the treatment of prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny

Prescription: Rhizoma Cibotii 1125 grams, Radix Dipsaci 750 grams, Rhizoma Drynariae 750 grams, Radix Achyranthis Bidentatae 750 grams, Rhizoma Homalomenae 750 grams, Semen Vaccariae 375 grams, Radix Angelicae Sinensis 1000 grams, Radix Notoginseng 750 grams, Olibanum 500 grams, Myrrha 500 grams, Herba speranskiae tuberculatae 750 grams, Rhizoma Corydalis 750 grams, Rhizoma Chuanxiong 500 grams, Sanguis Draxonis 375 Ke, Herba Siegesbeckiae 500 grams;

Adjuvant: 22.5 kilograms, Oleum Sesami, Plumbum preparatium 7.5 kilograms.

Preparation method:

In prescription ratio, take above ten five tastes, Sanguis Draxonis, Radix Notoginseng are pulverized as fine powder respectively, for subsequent use, and Olibanum, Myrrha, Rhizoma Corydalis are pulverized, and cross 100 mesh sieves, with Sanguis Draxonis, Radix Notoginseng fine powder facing-up, sieve, and mixing is for subsequent use.All the other Rhizoma Cibotii, Radix Dipsaci, Rhizoma Drynariae, Radix Achyranthis Bidentatae, Rhizoma Homalomenae, Semen Vaccariae, Radix Angelicae Sinensis, Herba speranskiae tuberculatae, Rhizoma Chuanxiong, Herba Siegesbeckiae ten taste, give as one thinks fit cataclasm, fried withered with putting in pot with Oleum Sesami 22.5Kg, removes slag, filter, and the refining of medicine oil is to dripping into pearl; Separately get Plumbum preparatium 7.5Kg, under fully stirring, (by same direction) is slowly sprinkled in oil cauldron, adds rear continuation agitating heating and refines 20 minutes, receives cream, is put by cream in appropriate cold water, soak 72 hours releasing fire-toxin.Within every 24 hours, change water once, after releasing fire-toxin terminates, the water in the clean oil pill paste of drop, after slow fire fusing, add the fine powder for subsequent use of 5 herbal medicines such as above-mentioned Sanguis Draxonis, Radix Notoginseng, stirring evenly, evenly sharing on cloth by often opening 25g, stripping and slicing, packaging, to obtain final product.Concrete technology step is as follows.

(1) pulverizing of medicine is directly added:

1, the porphyrize of Sanguis Draxonis, Radix Notoginseng: the Sanguis Draxonis, the Radix Notoginseng that take expense in prescription ratio, Sanguis Draxonis porphyrize, Radix Notoginseng is pulverized, and crosses 100 mesh sieves, for subsequent use.

2, the pulverizing of Olibanum etc. three herbal medicine: in prescription ratio, takes the Olibanum of expense, Myrrha, Rhizoma Corydalis 3 taste, pulverizes, and crosses 100 mesh sieves, for subsequent use.

3, the facing-up of fine drug powder: by Sanguis Draxonis, Radix Notoginseng fine powder and Rhizoma Corydalis, Olibanum, Myrrha fine powder incremental method facing-up, sieve, mixing, for subsequent use.

(2) the fried extraction of prescription other drug and the preparation of oil pill paste:

1, the fried extraction of prescription other drug: take Rhizoma Cibotii, Radix Dipsaci, Rhizoma Drynariae, Radix Achyranthis Bidentatae, Rhizoma Homalomenae, Semen Vaccariae, Radix Angelicae Sinensis, Herba speranskiae tuberculatae, Rhizoma Chuanxiong, Herba Siegesbeckiae ten taste pharmaceutical decocting piece in prescription ratio, give as one thinks fit cataclasm, be placed in fill Oleum Sesami 22.5Kg pot in, soak 24 hours, then heating extraction, during beginning, firepower is slightly large, to oil boiling, firepower is suitably reduced, to prevent outside oil spill from taking the dish out of the pot.Often stir stirring during heating, spice is heated evenly, until it is degree that spice explodes to the inner coke yellow of surperficial dark brown, now temperature reaches 220 DEG C, explodes well and fishes for medicinal residues with iron wire sieve, and the medicine oil after removing slag is for subsequent use.

2, refine oil: get above-mentioned medicine oil and continue to temper, medicine oil is heated to pasta boiling (counting roughly oil liquid temperature is 320-330 DEG C), continue heating and treat that blue or green cigarette thickens or Bai Yanshi, firepower should be reduced to moderate heat, oil temperature is reduced, and constantly stir with strainer simultaneously and raise oil, make the timely loss of flue gas, with preventing oil spill or burning., when starting to refine oil, oil smoke is blue or green cigarette, turns black gradually and then becomes white dense smoke, when seeing white dense smoke, representing oil refining close to completing, now should continue to make firepower become little fire, and observe oil bloom, until oil bloom when pot central authorities are coalescent, represent oil refining close to completing, now make firepower reduce, do and drip into pearl inspection, in heat-obtaining oil a little instillation cold water, as oil droplet becomes round bead shape at the water surface, blow not loose or loose after coalescent again time, show old tender matters, oil refining should be stopped.

3, Xia Dan: the medicine refined oil is connected pot and leaves burning things which may cause a fire disaster, under fully stirring, by even for red lead powder 7.5Kg spreading in ointment, makes its abundant chemical combination oxidation, after adding, continues agitating heating and stop heating after about 20 minutes, receive cream, for subsequent use.Lower red hourly velocity should be moderate.(generate fatty acid lead salt) after alseodaphne hainanensis is fully changed, red color disappears, and ointment becomes pitchy, and take a morsel in instillation cold water, if cream is tack-free, viscosity is suitable, represents that alseodaphne hainanensis is fused good.

4, releasing fire-toxin: put by above-mentioned oil pill paste in appropriate cold water, soaks 72 hours, within every 24 hours, changes water once, and after releasing fire-toxin terminates, the water in the most oil pill paste of drop, puts shady and cool place, for subsequent use.

(3) molding of plaster:

1, the mixing of oil pill paste and fine powder:, slow fire heating makes fusing (controlling ointment temperature lower than 70 DEG C), adds above-mentioned Sanguis Draxonis for subsequent use, Olibanum, Myrrha, Radix Notoginseng fine powder, fully stirs evenly, for subsequent use.

2, the coating of finished product plaster: by above-mentioned finished product oil pill paste for subsequent use, evenly shares in 95cm by often opening 25g ²on cloth, quality inspection, packaging, to obtain final product.

Usage and dosage: external, thermoplastic, is affixed on affected part, or follows the doctor's advice.

Embodiment 2: the preparation of the externally applied ointment for the treatment of prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny

Prescription: Rhizoma Cibotii 1100 grams, Radix Dipsaci 800 grams, Rhizoma Drynariae 700 grams, Radix Achyranthis Bidentatae 800 grams, Rhizoma Homalomenae 700 grams, Semen Vaccariae 400 grams, Radix Angelicae Sinensis 900 grams, Radix Notoginseng 800 grams, Olibanum 450 grams, Myrrha 550 grams, Herba speranskiae tuberculatae 700 grams, Rhizoma Corydalis 800 grams, Rhizoma Chuanxiong 450 grams, Sanguis Draxonis 400 Ke, Herba Siegesbeckiae 450 grams.

Adjuvant: 22.5 kilograms, Oleum Sesami, Plumbum preparatium 6.75 kilograms.

Preparation method and usage and dosage are with embodiment 1.

Embodiment 3: the preparation of the externally applied ointment for the treatment of prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny

Prescription: Rhizoma Cibotii 1200 grams, Radix Dipsaci 700 grams, Rhizoma Drynariae 800 grams, Radix Achyranthis Bidentatae 700 grams, Rhizoma Homalomenae 800 grams, Semen Vaccariae 350 grams, Radix Angelicae Sinensis 1100 grams, Radix Notoginseng 700 grams, Olibanum 550 grams, Myrrha 450 grams, Herba speranskiae tuberculatae 800 grams, Rhizoma Corydalis 700 grams, Rhizoma Chuanxiong 550 grams, Sanguis Draxonis 350 Ke, Herba Siegesbeckiae 550 grams.

Adjuvant: 22.5 kilograms, Oleum Sesami, Plumbum preparatium 8.25 kilograms.

Preparation method and usage and dosage are with embodiment 1.

Embodiment 4: the preparation of the pharmaceutical preparation for the treatment of prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny

Prescription: Rhizoma Cibotii 1125 grams, Radix Dipsaci 750 grams, Rhizoma Drynariae 750 grams, Radix Achyranthis Bidentatae 750 grams, Rhizoma Homalomenae 750 grams, Semen Vaccariae 375 grams, Radix Angelicae Sinensis 1000 grams, Radix Notoginseng 750 grams, Olibanum 500 grams, Myrrha 500 grams, Herba speranskiae tuberculatae 750 grams, Rhizoma Corydalis 750 grams, Rhizoma Chuanxiong 500 grams, Sanguis Draxonis 375 Ke, Herba Siegesbeckiae 500 grams;

Adjuvant: starch 25.5 kilograms, magnesium stearate 8.25 kilograms.

Be prepared into capsule in conventional manner, specification is 0.25g/ grain.

Clinical data:

One, physical data

(1) case source: treatment group case is selected from prolapse of lumbar intervertebral disc, cervical spondylosis and other degenerative osteoarthritiies patient totally 168 examples of going to a doctor in March, 2007 in June, 2012, wherein prolapse of lumbar intervertebral disc 72 example, cervical spondylosis 51 example and other degenerative osteoarthritiies 45 example, separately establish pain-relieving plaster for arthritis matched group 96 example, wherein prolapse of lumbar intervertebral disc 33 example, cervical spondylosis 32 example and other degenerative osteoarthritiies patient 31 example.

(2) ordinary circumstance: carried out statistical analysis to 168 examples for the treatment of group and the situation such as sex, age, the course of disease of the routine patient of matched group 96, table 1 ~ 3 are seen in every statistical result.

The comparison of table 1 liang group sex

Note: * two groups compare P>0.05.

The comparison at table 2 liang group age

Note: * two groups compare P>0.05

The comparison of table 3 liang group state of an illness distribution situation

Note: * two groups compare P>0.05.

Two, diagnostic criteria

(1) clinical criteria of prolapse of lumbar intervertebral disc

Prolapse of lumbar intervertebral disc refers to the Anular disruption of lumbar disc, vertebral pulp in it is outstanding to intraspinal tube with the posterior longitudinal ligament covered on it together with remaining fiber, spinal nerve root near compressing, produce the series of symptoms such as lumbago and skelalgia, this disease belongs to the sick category such as lumbago, arthromyodynia of the traditional Chinese medical science.

1, Western medicine diagnose standard

(1) pain is apt to occur in lower waist, and radiates to lower limb.

(2) local tenderness point is had.

(3) straight-leg raising test and the reinforcement test positive.

(4) positive with buttocks test.

(5) change of dermal sensation, muscular strength and tendon reflex.

(6) change of spinal column attitude.

(7) x-ray l spine ap & lat sheet prompting skoliosis or lumbar vertebra physiological lordosis disappear.

(8) CT or MRI prompting has annuler bulge.

(9) myelography prompting has intervertebral disk hernia.

Wherein first three items is basic basis.

2, differential diagnosis in tcm: deficiency of the liver and kindey, cold-evil hinders network

Primary symptom: waist, based on acid, has radiated pain, pain relieved by pressing happiness is rubbed, knee joint skelasthenia, numb limbs and tense tendons, and meet labor more very, sleeping side alleviates, normal recurrent exerbation.

Secondary disease: partially yang deficiency person, cramp and pain in the lower abdomen, complexion white, light red tongue, deep-thready pulse, partially deficiency of YIN person, vexed insomnia, dryness of the mouth and throat, flushed face, feverish sensation in the palms and soles, red tongue, stringy,thready and rapid pulse.

(2) clinical criteria of cervical spondylosis

Cervical spondylosis system cervical vertebra and accessory structure degenerative change thereof, a series of clinical symptoms stimulating or oppress cervical nerves, vertebral artery, cervical spinal, sympathetic nerve etc. to occur, are referred to as cervical vertebra syndrome, are called for short cervical spondylosis.Neck type, spondylotic radiculopathy, myeloid form, vertebral artery type, adrenergic type and mixed type etc. can be divided into according to diseased region and clinical manifestation.With neck type and spondylotic radiculopathy more common, primary disease belongs to impediment syndrome, myopathy, headache, the category such as dizzy.

1, Western medicine diagnose standard

(1) be more common in middle-aged and elderly people, have if between twenty and fifty damage history, strain history, Cervical Malformation or other inducements etc. also can fall ill.

(2) most is Retarder theory morbidity.If have neck trauma history or strain history, also can acute attack.The course of disease is longer, time light time heavy, can recurrent exerbation,

(3) typing and clinical manifestation

The difference such as neck type: Zhu Sutou, neck, shoulder pain sensation, and with corresponding pressure pain point.

Spondylotic radiculopathy: have typical root symptom (numb, pain), its scope is consistent with the region that cervical nerves is arranged, pressure measurement by compression of neck or the upper limb distraction test positive.

Myeloid form: have compression of spinal cord to show.Central type symptom is first from upper limb, and peripheral symptom is first from lower limb, and limbs soft power of withering is weak, moving difficulty, or has zonesthesia, paraesthesia, and physiological reflex is hyperfunction, and pathologic reflex occurs, as Hoffmann's sign or Babinski-sign positive etc.

Vertebral artery type: outbreak of once dampinging off, and have neck type dizzy, revolve the neck test positive.

Adrenergic type: dizzy, dim eyesight, tinnitus, numbness of hand, tachycardia, a series of sympathetic symptoms such as precordialgia.

Mixed type: have above-mentioned two above sings and symptomses of type concurrently.

(4) X-ray film display: cervical curvature changes, unstable or hyperosteogeny is formed, uncovertebral joint hyperosteogeny, ligament calcification.Myeloid form then sagittal canal diameter is narrow.

(5) lab testing: normal.

(6) other check: have ready conditions and can do myelography, CT, MRI check, contribute to primary disease diagnosis.Vertebral artery figure and the diagnosis of electroencephalogram to vertebral artery type have reference value.

Clinical manifestation and x-ray finding all meet cervical vertebra patient, can make a definite diagnosis.

2, differential diagnosis in tcm

Wind-cold channel blocking network is demonstrate,proved

Cervical region is affected by the cold and falls ill, neck pain, movable unfavorable, acroanesthesia string pain, and spasm of the limbs, or amyotrophy, refer to acroanesthesia, and limbs acid is cold, meets cold increasing the weight of, get Wen Zeshu, dark tongue quality, white and thin fur, deep and stringy pulse or late heavy.

Syndrome of qi stagnation and blood stasis

Fall ill because of cervical trauma or strain, neck pain, night is more so, dynamic then aggravate, and its pain mostly is twinge, and pain spot is fixing not to be moved, and often accompany acroanesthesia, red tongue, or purple secretly has ecchymosis, stringy and thready pulse or puckery.

Insufficiency of vital energy and blood card neck distending pain increases the weight of, and limbs wither weak, and numb unable, insensitive, Mental fatigue shape is tired, and gas is sayed micro-less, dizziness and blurred vision, blurring of vision, Hiccough and deaf, or step is too unstable, the dyskinesia, pale tongue, thready and weak pulse.

(3) other degenerative osteoarthritis clinical criterias

Basic demand according to Ministry of Public Health bureau of drug administration " guideline of clinical investigations of new Chinese medicine treatment hyperosteogeny " is worked out.

1. Western medicine diagnose standard: osteoarthrosis swelling pain; Movable or tired postemphasis; X-ray film shows: osteoarthrosis degenerative change.

2. tcm diagnosis standard: bone joint pain; Have history of repeated attack, premorbid has inducement more.

3. Standards of Chinese Medical Syndrome Differentiation: wind-cold damp pathogen is demonstrate,proved, and arthralgia swelling, aversion to cold, enters cold rnning weight, obtains Wen Ze and subtracts.

(4), symptom, sign score and severity Scaling standard

1 symptom, sign score standard

(1) pain

Normal: limbs, without pain disappearance person after pain and treatment, are 0 point.

Slight: time static, injury sense is swollen or mild pain, and adding severe one time movable, is 1 point.

Moderate: sad place distending pain time static, obvious aggravation person time movable is 2 points.

Severe: the obvious pain in injury time static, is reluctant activity suffering limb person, is 3 points.

(2) swelling

Normal: without swelling, identical with strong side limb circumference, be 0 point.

Slight: injury skin texture is smooth-going, flexible, than person within all path length 1cm of strong side same area, be 1 point.

Moderate: injury skin is nervous, elasticity reduces, and than all path length 1 ~ 2cm persons of strong side same area, is 2 points.

Severe: injury skin anxiety is shinny, follows the string, person above than strong side same area week path length 2cm is 3 points.

(3) tenderness

Normal: local, without tenderness person, is 0 point.

Slight: local tenderness need the person of exerting oneself, and is 1 point.

Moderate: tenderness obvious person in local is 2 points.

Severe: tenderness violent or tenderness person in local is 3 points.

(4) muscle spasm

Normal: of flaccid muscles without spasm, be 0 point.

Slight: muscle is spasm slightly, elasticity can, be 1 point.

Moderate: muscle spasm, poor flexibility is 2 points.

Severe: muscle spasm is as tabular, and elasticity loss is 3 points.

(5) movable function obstacle

Normal: freely, affected part, without pain, is 0 point to joint motion.

Slight: during joint motion, affected part pain is slight, does not affect joint motion, or range of activity minimizing (difference) is less than 10 ° of persons, is 1 point.

Moderate: during joint motion, affected part pain increases the weight of, and affects joint motion, and range of motion reduces (difference) 10 ° ~ 20 ° persons, is 2 points.

Severe: during joint motion, affected part pain is obviously aggravated, and affects joint motion, range of motion reduces (difference) and is greater than 20 ° of persons, is 3 points.

(6) dizzy

Normal: to be 0 point without vertigo symptoms.

Slight: dizziness and blurred vision, time when doing only, be 1 point.

Moderate: look thing and rotate, can not walk, be 2 points.

Severe: dizzy for falling forward, can not walk, be 3 points.

(7) numb limbs and tense tendons

Normal: limbs are normal, are 0 point.

Slight: slightly numb, time when doing only, be 1 point.

Moderate: numbness can be born, and often shows effect is 2 points.

Severe: numbness unbearably, constantly, is 3 points.

(8) have a headache

Normal: no headache symptom is 0 point.

Slight: slight headache, time when doing only, be 1 point.

Moderate: headache can be born, and often showing effect, is 2 points.

Severe: unbearably, continuing more than, is 3 points in headache.

2 severity Scaling standards

Slight: symptom, sign total mark <6 divide.

Moderate: 6≤symptom, sign total mark <12 divide.

Severe: symptom, sign total mark >=12 point

Three, case inclusive criteria

Allly meet above-mentioned diagnostic criteria, be by the patient of more than two or two courses for the treatment of of drug treatment completed treatment and include case in.

Four, case exclusion standard

1, severe cardiac, liver, kidney and disease of hematopoietic system is suffered from, the disease such as tuberculosis, tumor patient;

2, the swelling of local skin tensioned property blister, or suffering limb height, severe pain and suspicious osteofascial compartment syndrome person;

3, anemia of pregnant woman or women breast-feeding their children and hyperirritability body constitution or to this drug allergy person.

4, curative compliance is poor, does not complete by doctor's advice and observes Drug therapy course for the treatment of, cannot judge curative effect, or not congruent the affecting the treatment property of data and safety judgement person, or is participating in other drug experimenter.

Five, methods of clinical observation

(1) medicine, administrated method and the course for the treatment of

1, medicine: externally applied ointment prepared by embodiment 1, is prepared by the court Drug Manufacturing Room; Pain-relieving plaster for arthritis (Henan Lingrui Pharmacy Stock Co., Ltd).

2, administrated method: the externally applied ointment that treatment group uses embodiment 1 to prepare, matched group uses pain-relieving plaster for arthritis, and thermoplastic, is affixed on affected part, often pastes 10 ~ 12 days, or follows the doctor's advice.

3, the course for the treatment of: 2 subsides are a course for the treatment of, use 2 ~ 4 courses for the treatment of continuously.

(2) observation item and observation index

1, safety observations

After observing medication, local organization is with or without untoward reaction such as edema, vesicle, erythra, allergy.

2, health giving quality observation index

(1) change of the clinical symptoms such as patients with lumbar disc herniation dysfunction, pain before and after medication and sign is observed.

(2) change of the clinical symptoms such as Patients with Cervical Spondylopathy dysfunction, pain before and after medication and sign is observed.

(3) change of the clinical symptoms such as hyperosteogeny patient dysfunction, pain before and after medication and sign is observed.

(4) the X sheet of medication Patients Before And After or the situation of change of CT or waist B ultrasonic is observed.

(3) curative effect determinate standard

1. the criterion of therapeutical effect of prolapse of lumbar intervertebral disc:

(1), curative effect of disease criterion: " the new Chinese medicine guideline of clinical investigations " the 3rd volume " guideline of clinical investigations of new Chinese medicine treatment prolapse of lumbar intervertebral disc " promulgated for 1997 by Ministry of Health of the People's Republic of China judges.

1. clinical recovery: lumbago and skelalgia disappears substantially, Negative straight-leg raising test, recover normally to work symptom, somatic feature score improvement rate is more than 95%.

2. effective: flank pain partial disappearance, without obvious pressure pain point, Negative straight-leg raising test, basic recovery normally works, and symptom, somatic feature score improvement rate are at 65%-95%.

3. effective: to have slight lumbago and skelalgia, straight-leg raising test is positive, and part is resumed work, and symptom, somatic feature score improvement rate are 30% ~ 65%.

4. invalid: lumbago and skelalgia is without improvement, and straight-leg raising test is positive, and not competent work, symptom, somatic feature score improvement rate are below 30%.

(2), symptom, sign evaluation criteria: efficacy evaluation is carried out in the change according to sings and symptoms integration.

2. the criterion of therapeutical effect of cervical spondylosis

(1), curative effect of disease criterion: with reference to " Chinese medical disease Standardization of diagnosis and curative effect " and Ministry of Health of the People's Republic of China's " new Chinese medicine guideline of clinical investigations ", and in conjunction with synthetic determinations such as symptom, somatic feature score, TCD and x-ray inspections.

1. clinical cure: symptom, sign disappear completely, functional rehabilitation is normal, and the normal or x-ray of TCD is taken the photograph sheet and obviously improved, and symptom, somatic feature score improvement rate are more than 95%.

2. effective: symptom, sign disappear substantially, TCD has and obviously to change or x-ray is taken the photograph sheet and made moderate progress, and symptom, somatic feature score improvement rate are at 65%-95%.

3. effective: the improvement of symptom, sign, TCD and the x-ray inspection person of being improved, symptom, somatic feature score improvement rate are 30% ~ 65%.

4. invalid: without improvement, TCD and x-ray, symptom, sign check that symptom, somatic feature score improvement rate are below 30% without changing.

(2), symptom, sign evaluation criteria: efficacy evaluation is carried out in the change according to sings and symptoms integration.

3. the criterion of therapeutical effect of bone matrix hyperplasia

(1), curative effect of disease criterion: with reference to " the traditional Chinese medical science osteopathia Standardization of diagnosis and curative effect " criterion of therapeutical effect with hyperosteogeny in " new Chinese medicine guideline of clinical investigations ", and in conjunction with synthetic determinations such as symptom, somatic feature score, x-ray inspections.

1. clinical cure: symptom, sign disappear completely, functional rehabilitation is normal, and x-ray is taken the photograph sheet and obviously improved, and degeneration bone becomes disappearance, and symptom, somatic feature score improvement rate are more than 95%.

2. effective: symptom, sign disappear substantially, and x-ray is taken the photograph sheet and made moderate progress, degeneration bone becomes basic and disappears, and symptom, somatic feature score improvement rate are at 65%-95%.

3. effective: symptom, sign take a turn for the better, x-ray inspection is improved, the change of degeneration bone take a favorable turn, and symptom, somatic feature score improvement rate are at 30%-65%.

4. invalid: without improvement, x-ray, symptom, sign check that, without changing, the change of degeneration bone has no obvious change, and symptom, somatic feature score improvement rate are below 30%.

(2), symptom, sign evaluation criteria: efficacy evaluation is carried out in the change according to sings and symptoms integration.

Six, clinical curative effect analysis

(1) efficacy analysis of prolapse of lumbar intervertebral disc clinical observation

1, the analysis of comprehensive therapeutic effect: clinical treatment prolapse of lumbar intervertebral disc patient is totally 105 examples, wherein treatment group 72 example, matched group 33 example, undertaken evaluating and statistical disposition by comprehensive therapeutic effect evaluation criteria, result treatment group clinical cure 27 example, account for 37.5%, effective 26 examples, account for 36.1%, total effective rate is 91.7%, matched group clinical cure 7 example, accounts for 21.2%, effective 8 examples, account for 24.2%, total effective rate is 81.8%, and treatment group is obviously better than matched group (P<0.05), refers to table 4.

The curative effect situation of table 4 prescription plaster treatment prolapse of lumbar intervertebral disc

Note: * compares P<0.05 with matched group.

2, symptom, somatic feature score situation of change: clinical symptoms and somatic feature score before and after 72 routine intervertebral disk hernia patient treatments of clinical treatment are summed up, result shows, after adopting this preparation for treating, the clinical symptoms of patient can obviously be improved, clinical symptoms integration after treatment obviously reduces, in table 5.

Front and back symptom integration curative effect situation (X ± S) treated by table 5

(2) clinical curative effect analysis of cervical spondylosis

1. comprehensive therapeutic effect analysis: clinical treatment cervical spondylosis is totally 83 examples, wherein treatment group 51 example, matched group 32 example, undertaken evaluating and statistical disposition by comprehensive therapeutic effect evaluation criteria, result cervical spondylosis clinical cure 15 example, accounts for 29.4%, effective 25 examples, account for 49.0%, total effective rate is 94.1%, matched group clinical cure 6 example, accounts for 18.8%, effective 10 examples, account for 31.3%, total effective rate is 81.3%, and treatment group is obviously better than matched group (P<0.05), refers to table 6.

The comprehensive therapeutic effect of table 6 clinical treatment cervical spondylosis

* compare with matched group (P<0.05)

(3) the Comprehensive Clinical efficacy analysis of other degenerative osteoarthritiies: other degenerative osteoarthritiies of clinical treatment are totally 76 examples, wherein treatment group 45 example, matched group 31 example, undertaken evaluating and statistical disposition by comprehensive therapeutic effect evaluation criteria, other degenerative osteoarthritis clinical cure 12 examples of result, account for 26.7%, effective 23 examples, account for 51.1%, total effective rate is 93.3%, matched group clinical cure 5 example, account for 16.1%, effective 11 examples, account for 35.5%, total effective rate is 83.9%, treatment group is obviously better than matched group (P<0.05), refer to table 7.

The comprehensive therapeutic effect of other degenerative osteoarthritiies of table 7 clinical treatment compares

* compare with matched group (P<0.05)

(4) efficacy analysis of cervical spondylosis and other degenerative osteoarthritis clinical symptoms, sign: in 96 routine cervical spondylosiss of the externally applied ointment treatment prepared in clinical employing embodiment 1, other degenerative osteoarthritiies patient, except there is above-mentioned comprehensive therapeutic effect, the clinical symptoms such as the pain after most of patients medication, dizzy, headache, local numb limbs and tense tendons all have clear improvement, disease integration after treatment obviously declines, in table 8.

Table 8 symptom integral improves situation

(5) analysis of severity extent and curative effect, in the externally applied ointment treatment prolapse of lumbar intervertebral disc, cervical spondylosis and other degenerative osteoarthritiies 168 example that adopt embodiment 1 to prepare, patients with mild 43 example, moderate patient 46 example, severe 49 example, clinical cure rate is respectively 45.8%, 38.20%, and 22.4%, show that this preparation is better to patients with mild curative effect, clinical cure rate and obvious effective rate can be significantly improved, in table 9.

The analysis of table 9 severity extent and curative effect

Note: * compares P<0.05 with severe group, * * P<0.01.

(6) analysis of the course for the treatment of and curative effect: the prolapse of lumbar intervertebral disc that the externally applied ointment adopting embodiment 1 to prepare is treated, cervical spondylosis and the routine patient of other degenerative osteoarthritiies 168, carry out the analysis of the course for the treatment of and curative effect, result shows, with the increase of the course for the treatment of, its cure rate significantly improves, in 168 routine patients, treat 62 people of two courses for the treatment of, 65 people of three courses for the treatment of, 41 people of four courses for the treatment of, its clinical cure rate is respectively 35.5%, 43.1% and 51.2%, this shows the patient of cure rate apparently higher than treatment two course for the treatment of of treatment four course for the treatment of, P < 0.05, and have no Ineffective Cases, in table 10.

The analysis of the table 10 externally applied ointment of the present invention course for the treatment of and therapeutic effect relationship

Note: * P<0.05 compared with two courses for the treatment of

(7) safety testing result: in 168 routine patients for the treatment of, treating the longest was 4 courses for the treatment of, minimum 2 courses for the treatment of, be showed no obvious adverse reaction and toxic and side effects, few patients uses rear local to occur the micro-reaction such as to itch of skin, do not affect treatment, can recover after drug withdrawal, have no irritated and other untoward reaction generation.

Seven, model case

1, patient Chen, female, 66 years old, retired worker, people from Changyi City, because lumbago accompanies bottom right acroesthesia uncomfortable more than 10 years.To our hospital on 05 02nd, 2012, patient is tired, for a long time station, walking for a long time, bend over activity time and overcast and rainy lumbago exacerbation of symptoms, rest slightly alleviates.Have a medical check-up: lumbar curvature straightens, tenderness between L4/5L5/S1 sour jujube, bilateral erector spinae anxiety companion tenderness, left buttocks tenderness, without lower limb radiating pain.Two patellar tendon, Achilles tendon reflex are normal, two lower limb straight-leg raising test (-), strengthen experiment (-), " 4 " word test (-).Left lower extremity dermal sensation weakens, and two big toe dorsiflexion power, plantar flexion power are normal.Ankle shake contraction, kneecap shake contraction are negative.Lumbar vertebra CT:L4/5 annuler bulge, L5/S1 intervertebral disk hernia.Be diagnosed as: prolapse of lumbar intervertebral disc, lumbar vertebra arthritis.Give plaster external application prepared by the embodiment of the present invention 2.After 15 days patient again further consultation time state waist and bottom right acroesthesia symptom comparatively before obviously alleviate, have a medical check-up comparatively and take a turn for the better, do not occur anaphylaxis, advise and continue Dressed plaster treatment.Patient altogether Dressed plaster 2 pastes, and the time is January, and when following up a case by regular visits to after January, patient states waist and bottom right acroesthesia symptom is alleviated substantially, and efficacy determination is clinical effective.

2, patient Hao so-and-so, man, 63 years old, retired worker, people from Changle, Shandong, to our hospital on November 3rd, 2011, patient had lumbago medical history 2 years, exacerbation of symptoms closely over the past half year, massages at local clinic row.Cupping for treatment, effect is work not, and symptom day by day increases the weight of, the stiff discomfort of lumbosacral region sense, waist and two buttocks sense pain.Exacerbation of symptoms after sitting.Physical examination: lumbar vertebra is anteflexion 60 °, after stretch 20 ° limited, L3-5 spinous process side tenderness, without radiating pain, on the left of straight-leg raising test 70 °, 60 °, right side.Lumbar X sheet shows: lumbar vertebra many places hyperosteogeny changes, and changes into work with its trailing edge hypertrophy of L3-5.Be diagnosed as: arthritis due to lumbar vertebra hyperplasia.Give plaster external application prepared by the embodiment of the present invention 3.State during patient's further consultation after 15 days that lumbosacral region is stiff, waist and two lower limb pain symptom comparatively before obviously alleviate, have mild pain sense during seat, advise and continue Dressed plaster treatment, patient altogether Dressed plaster 4 pastes 60 days, treatment terminates that rear patient states that lumbosacral region is stiff, waist and two lower limb pain symptom disappear substantially, during seat, lumbosacral region has slight discomfort, physical examination: lumbar vertebra is anteflexion 85 °, after stretch 30 ° limited, L4-5 spinous process side tenderness, without radiating pain, on the left of straight-leg raising test 70 °, 70 °, right side.Efficacy determination is clinical effective.

3, grandson patient so-and-so, female, 52 years old, people from Changyi City, there is lumbago companion right lower extremity pain after lifting weight before 2 years in patient, tired, stand for a long time, bend over activity time and overcast and rainy lumbago exacerbation of symptoms, have a rest and slightly alleviate.Reconstructed image is added without lumbago during cough sneeze, after lifting weight before 20 days, lumbago companion right lower extremity pain symptom increases the weight of, slightly alleviate after rest, without overcast and rainy discomfort, to our hospital on 05 30th, 2012, have a medical check-up: lumbar curvature straightens, tenderness between L4/5, L5/S1 sour jujube, on the right side of L5/S1, about 2cm place on the lower side can touch tuberosity companion tenderness, bilateral erector spinae anxiety companion tenderness, two buttocks tenderness, without lower limb radiating pain.Right patellar tendon, Achilles tendon reflex weakens, right lower extremity straight-leg raising test 60 ° (+), strengthens experiment (+), " 4: " word test (-).Two skin of lower extremity feels that normal ， You Hallux toe dorsiflexion power weakens, and plantar flexion power is normal.Lumbar vertebra CT shows: L4/5, L5/S1 intervertebral disk hernia, L4/5 spinal canal stenosis, L5/S1 degeneration of intervertebral disc, lumbar retrogression.Be diagnosed as: prolapse of lumbar intervertebral disc, lumbar vertebra arthritis, give plaster external application prepared by the embodiment of the present invention 2, after 15 days, patient's readme flank pain symptom obviously alleviates, and haves a medical check-up without exception, advises and continues Dressed plaster treatment.Patient altogether Dressed plaster 2 pastes, and the time is January, and when following up a case by regular visits to after January, patient states flank pain symptom and disappears completely, and activity freely.Efficacy determination is clinical cure.

4, patient flourish so-and-so, female, 53 years old, people from Weifang City, without obvious inducement, patient occurred that neck-shoulder pain was uncomfortable before 2 years, tired and meet that neck-shoulder pain exacerbation of symptoms companion two upper limb numbness when weather turns cold is uncomfortable, headache, dizzy, without Nausea and vomiting, alleviate after rest, limited without shoulder mobility, without " stepping on Cotton Gossypii " sense of walking.To our hospital on 02 27th, 2012, have a medical check-up: cervical curvature straightens, tenderness between C3/4, C4/5, C5/6 supraspinatus, neck both sides muscular tone companion tenderness, interscapular region can touch streak thing companion tenderness, head test (+), two skin of upper extremity sensation is normal, Huffman disease (-).Cervical vertebra CT:C5/6, C6/7 intervertebral disk hernia (central type).Be diagnosed as: cervical spondylosis (radiculopathy), give plaster external application prepared by the embodiment of the present invention 3, after 15 days, patient's readme neck-shoulder pain symptom obviously alleviates, Non Apparent Abnormality of having a medical check-up, and advises and continues Dressed plaster treatment.Patient altogether Dressed plaster 4 pastes totally, and the time is February, and when following up a case by regular visits to after February, patient states neck-shoulder pain symptom and substantially alleviates, and efficacy determination is clinical effective.

5, patient Lee so-and-so, female, 41 years old, people from Fangzi District, Weifang City, patient was uncomfortable without obvious inducement neck-shoulder pain before first quarter moon, and engenders left upper extremity pain, and after tired, pain symptom increases the weight of.No headache, dizziness, limited without shoulder mobility, without " stepping on Cotton Gossypii " sense of walking.To our hospital on 03 16th, 2012, have a medical check-up: cervical curvature straightens, tenderness on C3/4C4/5C5/6C6/7 sour jujube, neck both sides muscular tone companion tenderness, interscapular region tenderness, head test (-), both arms clump nerve stretching test (+), right Huffman disease (+), tentative diagnosis is: cervical spondylosis (mixed type), give plaster external application prepared by the embodiment of the present invention 2, after 10 days patient's readme neck and shoulder part and left upper extremity pain symptom comparatively before obviously alleviate, to have a medical check-up right Huffman disease (±), abnormal without other, patient is advised to continue Dressed plaster treatment.Patient altogether Dressed plaster 2 pastes, and the time is January, and when following up a case by regular visits to after January, patient's readme neck and shoulder part and left upper extremity pain symptom are alleviated substantially.Efficacy determination is clinical effective.

Claims (8)

1. treating a Chinese medicine composition for prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny, it is characterized in that, is be made up of the crude drug of following weight portion:

Rhizoma Cibotii 110-120 part, Radix Dipsaci 70-80 part, Rhizoma Drynariae 70-80 part, Radix Achyranthis Bidentatae 70-80 part, Rhizoma Homalomenae 70-80 part, Semen Vaccariae 35-40 part, Radix Angelicae Sinensis 90-110 part, Radix Notoginseng 70-80 part, Olibanum 45-55 part, Myrrha 45-55 part, Herba speranskiae tuberculatae 70-80 part, Rhizoma Corydalis 70-80 part, Rhizoma Chuanxiong 45-55 part, Sanguis Draxonis 35-40 Fen, Herba Siegesbeckiae 45-55 part.

2. a kind of Chinese medicine composition for the treatment of prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny as claimed in claim 1, it is characterized in that, be made up of the crude drug of following weight portion:

Rhizoma Cibotii 112.5 parts, Radix Dipsaci 75 parts, Rhizoma Drynariae 75 parts, Radix Achyranthis Bidentatae 75 parts, Rhizoma Homalomenae 75 parts, Semen Vaccariae 37.5 parts, Radix Angelicae Sinensis 100 parts, Radix Notoginseng 75 parts, Olibanum 50 parts, Myrrha 50 parts, Herba speranskiae tuberculatae 75 parts, Rhizoma Corydalis 75 parts, Rhizoma Chuanxiong 50 parts, Sanguis Draxonis 37.5 Fen, Herba Siegesbeckiae 50 parts.

3. treat a Chinese medicine preparation for prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny, it is characterized in that, this Chinese medicine preparation is made up of Chinese medicine composition according to claim 1 and one or more pharmaceutically acceptable adjuvants.

4. a kind of Chinese medicine preparation for the treatment of prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny as claimed in claim 3, it is characterized in that, the dosage form of described Chinese medicine preparation is tablet, pill, capsule or unguentum.

5. a kind of Chinese medicine preparation for the treatment of prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny as claimed in claim 3, it is characterized in that, described adjuvant is selected from calcium phosphate, magnesium stearate, Pulvis Talci, dextrin, starch, gelatinous fibre element, methylcellulose, sanlose, polyvinylpyrrolidone, one or more in Oleum Sesami and Plumbum preparatium.

6. a kind of Chinese medicine preparation for the treatment of prolapse of lumbar intervertebral disc, cervical spondylosis and hyperosteogeny as claimed in claim 3, is characterized in that, this Chinese medicine preparation is made up of Chinese medicine composition according to claim 1 and adjuvant Oleum Sesami and Plumbum preparatium.

7. the preparation method of the Chinese medicine preparation for the treatment of prolapse of lumbar intervertebral disc according to claim 6, cervical spondylosis and hyperosteogeny, is characterized in that, step is:

(1) take each taste crude drug in prescription ratio, by Sanguis Draxonis and Radix Notoginseng two taste medicine, pulverize, sieve for subsequent use; By Olibanum, Myrrha and Rhizoma Corydalis three taste medicine, pulverize, sieve, mix with Sanguis Draxonis, Radix Notoginseng medicated powder, for subsequent use;

(2) by Rhizoma Cibotii, Radix Dipsaci, Rhizoma Drynariae, Radix Achyranthis Bidentatae, Rhizoma Homalomenae, Semen Vaccariae, Radix Angelicae Sinensis, Herba speranskiae tuberculatae, Rhizoma Chuanxiong, Herba Siegesbeckiae ten taste medicine, give as one thinks fit cataclasm, add the Oleum Sesami of 2500-2600 part, soak 24h, be heated to oil boiling extract, it is degree that spice explodes to the inner coke yellow of surperficial dark brown, and remove medicinal residues, the medicine oil after removing slag is for subsequent use;

(3) the medicine oil of step (2) is heated to 320-330 DEG C, refines oil, refine to water Cheng Zhu;

(4) in the medicine oil refined, add the red lead powder of 675-825 part, stir, make it fully change and be oxidized, continue agitating heating 20-30 minute, receive cream, obtained oil pill paste, for subsequent use;

(5) oil pill paste prepared by step (4) is placed in cold water, soaks 72 hours, within every 24 hours, change water once, releasing fire-toxin, the water in the most oil pill paste of drop, In Shade, for subsequent use;

(6) by the oil pill paste heat fused after step (5) releasing fire-toxin, control the temperature of oil pill paste lower than 70 DEG C, add the mixing fine powders of Sanguis Draxonis prepared by step (1), Radix Notoginseng and Olibanum, Myrrha, Rhizoma Corydalis, stir evenly, coating, get product plaster.

8. preparation method as claimed in claim 7, it is characterized in that, in step (6), coating weight is 0.25-0.30g/cm ².