CN104812744B - 7,8‑二羟黄酮和7,8‑取代的黄酮衍生物、组合物及其相关方法 - Google Patents

7,8‑二羟黄酮和7,8‑取代的黄酮衍生物、组合物及其相关方法 Download PDF

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CN104812744B
CN104812744B CN201380062367.XA CN201380062367A CN104812744B CN 104812744 B CN104812744 B CN 104812744B CN 201380062367 A CN201380062367 A CN 201380062367A CN 104812744 B CN104812744 B CN 104812744B
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CN104812744A (zh
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叶克强
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Emory University
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61P25/16—Anti-Parkinson drugs
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
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    • C07—ORGANIC CHEMISTRY
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
    • C—CHEMISTRY; METALLURGY
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/38—2,3-Dihydro derivatives, e.g. isoflavanones
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380062367.XA 2012-11-05 2013-11-01 7,8‑二羟黄酮和7,8‑取代的黄酮衍生物、组合物及其相关方法 Active CN104812744B (zh)

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US201261722339P 2012-11-05 2012-11-05
US61/722,339 2012-11-05
US201361845399P 2013-07-12 2013-07-12
US61/845,399 2013-07-12
PCT/US2013/067972 WO2014071134A1 (en) 2012-11-05 2013-11-01 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto

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CN109574975B (zh) * 2019-01-14 2023-07-14 上海博芮健制药有限公司 7,8-二羟基黄酮衍生物的晶型及其制备方法和应用
WO2020154434A1 (en) * 2019-01-24 2020-07-30 Pharmatrophix, Inc. Compositions and methods for treating and preventing cognitive dysfunction
CN111825649A (zh) * 2019-04-15 2020-10-27 上海博芮健制药有限公司 7,8-二羟基黄酮衍生物的纯化方法
CN114075162A (zh) * 2020-08-20 2022-02-22 上海博芮健制药有限公司 7,8-二羟基黄酮衍生物的晶型b及其制备方法、应用
CN112168976B (zh) * 2020-10-15 2022-11-04 天津科技大学 一种黄酮衍生物前药及合成和作为抗肿瘤药物的应用
WO2023288069A1 (en) * 2021-07-15 2023-01-19 Emory University Methods of using substituted flavones for treating bone disorders
WO2023072228A1 (en) * 2021-10-29 2023-05-04 Tsinghua University Methods and products for treating or diagnosing schizophrenia
KR20240144096A (ko) 2021-11-02 2024-10-02 플레어 테라퓨틱스 인크. Pparg 역 효능제 및 그의 용도
TWI887826B (zh) * 2022-11-02 2025-06-21 美商佩特拉製藥公司 用於治療疾病之磷酸肌醇3-激酶(pi3k)異位色烯酮抑制劑

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AU2018201060B2 (en) 2019-05-16
JP2019089817A (ja) 2019-06-13
JP2021050230A (ja) 2021-04-01
ES2823237T3 (es) 2021-05-06
WO2014071134A1 (en) 2014-05-08
AU2019213454B2 (en) 2020-07-09
US20150274692A1 (en) 2015-10-01
CN107868071B (zh) 2021-07-20
AU2013337742B2 (en) 2017-11-23
US9682948B2 (en) 2017-06-20
EP2914585B1 (en) 2018-03-07
EP3369730B1 (en) 2020-08-05
CN104812744A (zh) 2015-07-29
JP2015535290A (ja) 2015-12-10
CN107868071A (zh) 2018-04-03
EP2914585A1 (en) 2015-09-09
JP6479670B2 (ja) 2019-03-06
CA2890075C (en) 2021-01-05
AU2013337742A1 (en) 2015-05-21
CA2890075A1 (en) 2014-05-08
EP3369730A1 (en) 2018-09-05
US10526303B2 (en) 2020-01-07
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