CN1048018C - 膦酸二酯衍生物 - Google Patents

膦酸二酯衍生物 Download PDF

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Publication number
CN1048018C
CN1048018C CN94190513A CN94190513A CN1048018C CN 1048018 C CN1048018 C CN 1048018C CN 94190513 A CN94190513 A CN 94190513A CN 94190513 A CN94190513 A CN 94190513A CN 1048018 C CN1048018 C CN 1048018C
Authority
CN
China
Prior art keywords
group
lower alkyl
compound
phenyl
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94190513A
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English (en)
Chinese (zh)
Other versions
CN1112365A (zh
Inventor
黑木保久
宫田一义
中村静夫
近藤光由
岩本武史
奈波智惠子
津田可彦
井上泰秀
金矢淳
佐藤圭吾
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Factory Inc
Publication of CN1112365A publication Critical patent/CN1112365A/zh
Application granted granted Critical
Publication of CN1048018C publication Critical patent/CN1048018C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65128—Six-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Game Rules And Presentations Of Slot Machines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN94190513A 1993-06-17 1994-05-31 膦酸二酯衍生物 Expired - Fee Related CN1048018C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP146528/93 1993-06-17
JP146528/1993 1993-06-17
JP14652893 1993-06-17

Publications (2)

Publication Number Publication Date
CN1112365A CN1112365A (zh) 1995-11-22
CN1048018C true CN1048018C (zh) 2000-01-05

Family

ID=15409687

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94190513A Expired - Fee Related CN1048018C (zh) 1993-06-17 1994-05-31 膦酸二酯衍生物

Country Status (10)

Country Link
US (1) US5624918A (enExample)
EP (1) EP0655456B1 (enExample)
KR (1) KR100297623B1 (enExample)
CN (1) CN1048018C (enExample)
AT (1) ATE196145T1 (enExample)
AU (1) AU664337B2 (enExample)
CA (1) CA2142597C (enExample)
DE (1) DE69425804T2 (enExample)
TW (1) TW278078B (enExample)
WO (1) WO1995000524A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3533542B2 (ja) * 1994-03-08 2004-05-31 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
AU679344B2 (en) * 1994-03-08 1997-06-26 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivative
US6292113B1 (en) 1997-03-25 2001-09-18 Primax Electronics Ltd. Finger operated module for generating encoding signals
US6157369A (en) * 1997-10-14 2000-12-05 Logitech, Inc. Optical-mechanical roller with ratchet
DE19756388A1 (de) * 1997-12-18 1999-06-24 Hoechst Marion Roussel De Gmbh Substituierte 2-Aryl-4-amino-chinazoline
US6184226B1 (en) * 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US6326949B1 (en) 1999-03-11 2001-12-04 Logitech Europe S.A. Wheel support guide for vertical wheel support movement
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
ES2360933T3 (es) * 2000-04-27 2011-06-10 Astellas Pharma Inc. Derivados de heteroarilo condensados.
EP1408980A4 (en) * 2001-06-21 2004-10-20 Ariad Pharma Inc NEW QUINAZOLINES AND THEIR USE
WO2004056352A1 (en) * 2002-12-19 2004-07-08 Scios, Inc. TREATMENT OF OBESITY AND ASSOCIATED CONDITIONS WITH TGF-β INHIBITORS
CN1784391B (zh) * 2003-03-03 2010-06-09 沃泰克斯药物股份有限公司 可用作离子通道调控剂的喹唑啉
US7713983B2 (en) 2003-03-03 2010-05-11 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
CL2004000409A1 (es) * 2003-03-03 2005-01-07 Vertex Pharma Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu
US8283354B2 (en) 2004-09-02 2012-10-09 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
US7928107B2 (en) 2004-09-02 2011-04-19 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
DK2473487T3 (en) * 2009-09-03 2017-02-06 Bristol Myers Squibb Co QUINAZOLINES AS CALCIUM CHANNEL INHIBITORS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS543589A (en) * 1977-06-09 1979-01-11 Omron Tateisi Electronics Co Coating defect detecting apparatus of sheet form objects
JPH04243888A (ja) * 1991-01-24 1992-08-31 Otsuka Pharmaceut Factory Inc イミダゾ［１，２−ａ］ピリジン誘導体、その製造方法及びその中間体としてのα−ハロケトン誘導体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU523040B2 (en) * 1978-05-15 1982-07-08 Kanebo Limited Calcium -antagonistic composition
US4434162A (en) * 1981-02-17 1984-02-28 Kanebo, Ltd. Phosphonic acid ester, pharmaceutical compositions containing the same and method of using the same
JPH0651625B2 (ja) * 1986-12-29 1994-07-06 株式会社大塚製薬工場 高脂質血症治療剤
US4822780A (en) * 1987-07-08 1989-04-18 Otsuka Pharmaceutical Factory, Inc. Carboxamide compounds
AU606808B2 (en) * 1988-06-29 1991-02-14 Otsuka Pharmaceutical Factory, Inc. Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same
CA2002864C (en) * 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JP2584336B2 (ja) * 1989-05-30 1997-02-26 株式会社大塚製薬工場 カルボン酸アミド誘導体
JP2696150B2 (ja) * 1991-02-05 1998-01-14 株式会社大塚製薬工場 キノリン誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS543589A (en) * 1977-06-09 1979-01-11 Omron Tateisi Electronics Co Coating defect detecting apparatus of sheet form objects
JPH04243888A (ja) * 1991-01-24 1992-08-31 Otsuka Pharmaceut Factory Inc イミダゾ［１，２−ａ］ピリジン誘導体、その製造方法及びその中間体としてのα−ハロケトン誘導体

Also Published As

Publication number Publication date
US5624918A (en) 1997-04-29
WO1995000524A1 (fr) 1995-01-05
AU6855894A (en) 1995-01-17
KR100297623B1 (ko) 2001-11-14
KR950702997A (ko) 1995-08-23
AU664337B2 (en) 1995-11-09
DE69425804T2 (de) 2001-02-08
DE69425804D1 (en) 2000-10-12
EP0655456A4 (en) 1996-03-27
TW278078B (enExample) 1996-06-11
ATE196145T1 (de) 2000-09-15
CN1112365A (zh) 1995-11-22
CA2142597A1 (en) 1995-01-05
EP0655456A1 (en) 1995-05-31
CA2142597C (en) 2004-01-13
EP0655456B1 (en) 2000-09-06

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GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee