KR100297623B1 - 포스폰산디에스테르유도체 - Google Patents

포스폰산디에스테르유도체 Download PDF

Info

Publication number
KR100297623B1
KR100297623B1 KR1019950700619A KR19950700619A KR100297623B1 KR 100297623 B1 KR100297623 B1 KR 100297623B1 KR 1019950700619 A KR1019950700619 A KR 1019950700619A KR 19950700619 A KR19950700619 A KR 19950700619A KR 100297623 B1 KR100297623 B1 KR 100297623B1
Authority
KR
South Korea
Prior art keywords
group
alkyl group
hydrogen atom
phenyl
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019950700619A
Other languages
English (en)
Korean (ko)
Other versions
KR950702997A (ko
Inventor
구로기야스히사
미야따가즈요시
나까무라시즈오
곤또미쓰요시
이와모또다께시
나바지에꼬
쓰다요시히꼬
이노우에야스히데
가나야준
사또게이고
Original Assignee
오츠까 요시미쯔
가부시키가이샤 오츠까 세이야꾸 고죠
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오츠까 요시미쯔, 가부시키가이샤 오츠까 세이야꾸 고죠 filed Critical 오츠까 요시미쯔
Publication of KR950702997A publication Critical patent/KR950702997A/ko
Application granted granted Critical
Publication of KR100297623B1 publication Critical patent/KR100297623B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65128—Six-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Game Rules And Presentations Of Slot Machines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1019950700619A 1993-06-17 1994-05-31 포스폰산디에스테르유도체 Expired - Fee Related KR100297623B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14652893 1993-06-17
JP93-146528 1993-06-17
PCT/JP1994/000883 WO1995000524A1 (fr) 1993-06-17 1994-05-31 Derive de diester phosphonique

Publications (2)

Publication Number Publication Date
KR950702997A KR950702997A (ko) 1995-08-23
KR100297623B1 true KR100297623B1 (ko) 2001-11-14

Family

ID=15409687

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950700619A Expired - Fee Related KR100297623B1 (ko) 1993-06-17 1994-05-31 포스폰산디에스테르유도체

Country Status (10)

Country Link
US (1) US5624918A (enExample)
EP (1) EP0655456B1 (enExample)
KR (1) KR100297623B1 (enExample)
CN (1) CN1048018C (enExample)
AT (1) ATE196145T1 (enExample)
AU (1) AU664337B2 (enExample)
CA (1) CA2142597C (enExample)
DE (1) DE69425804T2 (enExample)
TW (1) TW278078B (enExample)
WO (1) WO1995000524A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3533542B2 (ja) * 1994-03-08 2004-05-31 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
WO1995024410A1 (en) * 1994-03-08 1995-09-14 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivative
US6292113B1 (en) 1997-03-25 2001-09-18 Primax Electronics Ltd. Finger operated module for generating encoding signals
US6157369A (en) 1997-10-14 2000-12-05 Logitech, Inc. Optical-mechanical roller with ratchet
DE19756388A1 (de) 1997-12-18 1999-06-24 Hoechst Marion Roussel De Gmbh Substituierte 2-Aryl-4-amino-chinazoline
US6184226B1 (en) * 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US6326949B1 (en) 1999-03-11 2001-12-04 Logitech Europe S.A. Wheel support guide for vertical wheel support movement
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
CN100345830C (zh) * 2000-04-27 2007-10-31 安斯泰来制药有限公司 稠合杂芳基衍生物
EP1408980A4 (en) 2001-06-21 2004-10-20 Ariad Pharma Inc NEW QUINAZOLINES AND THEIR USE
US20040192583A1 (en) * 2002-12-19 2004-09-30 Satyanarayana Medicherla Treatment of obesity and associated conditions with TGF-beta inhibitors
US7713983B2 (en) 2003-03-03 2010-05-11 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
CL2004000409A1 (es) 2003-03-03 2005-01-07 Vertex Pharma Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu
ZA200507979B (en) * 2003-03-03 2007-03-28 Vertex Pharma Inc Quinazolines useful as modulators of ion channels
US8283354B2 (en) 2004-09-02 2012-10-09 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
US7928107B2 (en) 2004-09-02 2011-04-19 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
EP3575288B1 (en) * 2009-09-03 2021-10-27 Bristol-Myers Squibb Company Quinazolines as potassium ion channel inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0371564A2 (en) * 1988-11-29 1990-06-06 Janssen Pharmaceutica N.V. (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives
JPH0543589A (ja) * 1991-02-05 1993-02-23 Otsuka Pharmaceut Factory Inc キノリン誘導体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS543589A (en) * 1977-06-09 1979-01-11 Omron Tateisi Electronics Co Coating defect detecting apparatus of sheet form objects
AU523040B2 (en) * 1978-05-15 1982-07-08 Kanebo Limited Calcium -antagonistic composition
US4434162A (en) * 1981-02-17 1984-02-28 Kanebo, Ltd. Phosphonic acid ester, pharmaceutical compositions containing the same and method of using the same
JPH0651625B2 (ja) * 1986-12-29 1994-07-06 株式会社大塚製薬工場 高脂質血症治療剤
US4822780A (en) * 1987-07-08 1989-04-18 Otsuka Pharmaceutical Factory, Inc. Carboxamide compounds
AU606808B2 (en) * 1988-06-29 1991-02-14 Otsuka Pharmaceutical Factory, Inc. Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same
JP2584336B2 (ja) * 1989-05-30 1997-02-26 株式会社大塚製薬工場 カルボン酸アミド誘導体
JP2549950B2 (ja) * 1991-01-24 1996-10-30 株式会社大塚製薬工場 イミダゾ［１，２−ａ］ピリジン誘導体、その製造方法及びその中間体としてのα−ハロケトン誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0371564A2 (en) * 1988-11-29 1990-06-06 Janssen Pharmaceutica N.V. (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives
JPH0543589A (ja) * 1991-02-05 1993-02-23 Otsuka Pharmaceut Factory Inc キノリン誘導体

Also Published As

Publication number Publication date
DE69425804D1 (en) 2000-10-12
DE69425804T2 (de) 2001-02-08
CN1112365A (zh) 1995-11-22
CA2142597C (en) 2004-01-13
CA2142597A1 (en) 1995-01-05
CN1048018C (zh) 2000-01-05
KR950702997A (ko) 1995-08-23
EP0655456A1 (en) 1995-05-31
WO1995000524A1 (fr) 1995-01-05
TW278078B (enExample) 1996-06-11
AU664337B2 (en) 1995-11-09
ATE196145T1 (de) 2000-09-15
US5624918A (en) 1997-04-29
EP0655456B1 (en) 2000-09-06
EP0655456A4 (en) 1996-03-27
AU6855894A (en) 1995-01-17

Similar Documents

Publication Publication Date Title
KR100297623B1 (ko) 포스폰산디에스테르유도체
KR0185225B1 (ko) 포스폰산 디에스테르 유도체
EP0749974B1 (en) Phosphonic diester derivative
KR100296163B1 (ko) 포스폰산디에스테르유도체
US5538978A (en) 9-purinyl phosphonic acid derivatives
JPWO1993023409A1 (ja) ホスホン酸ジエステル誘導体
JPWO1994018212A1 (ja) ホスホン酸ジエステル誘導体
EP0882730B1 (en) Phosphonic acid diester derivatives
US5494912A (en) 9-purinyl phosphonic acid derivitives for treating gout
KR100305959B1 (ko) 포스폰산디에스테르유도체
JP2926274B2 (ja) ホスホン酸ジエステル誘導体
JP3533542B2 (ja) ホスホン酸ジエステル誘導体
JPWO1995000524A1 (ja) ホスホン酸ジエステル誘導体
JPS61140593A (ja) 新規ベンジルホスフイン酸エステル誘導体、その製造法およびそれを有効成分とする医薬組成物

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 20070511

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20080525

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20080525