CN104800812A - Suppository for treating infant common cold due to wind-cold and preparation method thereof - Google Patents
Suppository for treating infant common cold due to wind-cold and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a suppository for treating infant common cold due to wind-cold. The suppository is prepared by taking the raw materials by weight part: 25 to 35 parts of radix bupleuri, 12 to 25 parts of rheum officinale, 12 to 25 parts of skullcap, 12 to 25 parts of radix paeoniae alba, 12 to 25 parts of pinellia ternate, 25 to 35 parts of ginger, 12 to 25 parts of immature bitter orange, 3 to 8 parts of herba lagotis, 3 to 8 parts of flos farfarae, 3 to 8 parts of fructus perillae, 10 to 20 parts of acetaminophen and 80 to 90 parts of matrix. The invention also discloses a preparation method of the suppository. The suppository provided by the invention is prepared by combining Chinese and western medicine components and is capable of achieving the purpose of treating both symptoms and root causes; under the condition of considering the specificity of infant medicine-taking, the suppository has the advantages of convenience in taking and prolonged acting time of the medicines; the liver first-pass effect is avoided and the whole-body treating function is achieved.
Description
Technical field
The present invention relates to a kind of suppository for the treatment of chill cold in children and preparation method thereof, belong to technical field of traditional Chinese medicine preparation.
Background technology
Exogenous high fever is common disease in children, and the traditional Chinese medical science is thought, high heat rises because exterior evil inward invasion, hangs out in few sun, and forms YANG MING excess syndrome when few sun must not be separated, and then occurs the symptoms such as high heat.Infantile hyperpyrexia caused by exogenous pathogenic factor belongs to department of pediatrics emergency case category, and its sickness rate is higher, accounts for more than 60% of gop number, very large to the health threat of children's.Current treatment infantile hyperpyrexia caused by exogenous pathogenic factor is based on Western medicine, as sulfa drugs and antibiotics, in view of infant upper respiratory tract infection more than 90% is caused by virus, antibiotic unsatisfactory curative effect, and easily develop immunity to drugs, there is no Utopian chemotherapy medicine at present.Therefore, develop a kind of novel pharmaceutical preparation tool being used for the treatment of infantile hyperpyrexia caused by exogenous pathogenic factor to be of great significance.
Summary of the invention
For the deficiency that above-mentioned prior art exists, the object of this invention is to provide a kind of suppository for the treatment of chill cold in children, Chinese medicine and western medicine component combines, and reaches the object for the treatment of both the principal and secondary aspects of a disease; Consider the particularity of pediatric pharmaceuticals simultaneously, be developed to the suppository of rectally to there is medication convenient, and can prolong drug action time etc. advantage; And can liver first-pass effect be avoided, play whole body therapeutic effect.
Another object of the present invention is to provide this preparation method being used for the treatment of chill cold in children suppository.
For achieving the above object, the present invention adopts following technical proposals:
Treating a suppository for chill cold in children, is be made up of the raw material of following weight portion:
Radix Bupleuri 25-35 part, Radix Et Rhizoma Rhei 12-25 part, Radix Scutellariae 12-25 part, Radix Paeoniae Alba 12-25 part, Rhizoma Pinelliae 12-25 part, Rhizoma Zingiberis Recens 25-35 part, Fructus Aurantii Immaturus 12-25 part, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 3-8 part, Flos Farfarae 3-8 part, Fructus Perillae 3-8 part, acetaminophen 10-20 part, substrate 80-90 part.
Preferably, the suppository of this treatment chill cold in children is made up of the raw material of following weight portion:
Radix Bupleuri 28-32 part, Radix Et Rhizoma Rhei 15-20 part, Radix Scutellariae 15-20 part, Radix Paeoniae Alba 15-20 part, Rhizoma Pinelliae 15-20 part, Rhizoma Zingiberis Recens 28-32 part, Fructus Aurantii Immaturus 15-20 part, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 4-6 part, Flos Farfarae 4-6 part, Fructus Perillae 4-6 part, acetaminophen 13-17 part, substrate 80-90 part.
Preferred further, the suppository of this treatment chill cold in children is made up of the raw material of following weight portion:
Radix Bupleuri 30 parts, Radix Et Rhizoma Rhei 18 parts, Radix Scutellariae 18 parts, the Radix Paeoniae Alba 18 parts, the Rhizoma Pinelliae 18 parts, 30 parts, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 18 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 5 parts, Flos Farfarae 5 parts, Fructus Perillae 5 parts, acetaminophen 15 parts, substrate 85 parts.
Described substrate is selected from semi-synthetic fatty acid glyceride, cocoa butter, Myrj 45 or hydrogenated vegetable oil;
Preferably, described substrate is semi-synthetic fatty acid glyceride.
The preparation method of the suppository of this treatment chill cold in children, step is as follows:
(1) by Radix Bupleuri, Radix Et Rhizoma Rhei, Radix Scutellariae, the Radix Paeoniae Alba, the Rhizoma Pinelliae, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.), Flos Farfarae, Fructus Perillae mixing, twice is decocted with water, merging filtrate, it is 1.2 (50 DEG C of surveys) that filtrate is concentrated into relative density, dry, pulverize, sieve, obtain Chinese medical concrete powder;
(2) acetaminophen is pulverized, sieved for subsequent use;
(3) by substrate heat fused, respectively the acetaminophen powder of the Chinese medical concrete powder of step (1) and step (2) is joined in the substrate after fusing, stirring and evenly mixing, pour in mould, be cooled to 35-40 DEG C, scrape mould, in 5-10 DEG C of cooling 10-20min, the demoulding, to obtain final product.
In step (1), the concrete operations of soak by water are: the water adding 8 times of quality carries out first time decoction, and decocting time is 2h, filters, and the water adding 6 times of quality in medicinal residues again carries out second time and decocts, and decocting time is 1.5h.
In step (1), baking temperature is 80 DEG C, adopts drying under reduced pressure.
In step (1) and step (2), after pulverizing, all cross 100 mesh sieves.
In medicament composing prescription, the pharmacological action of each medicine is as follows:
Radix Bupleuri: pungent, bitter, is slightly cold.Return liver, gallbladder, lung meridian.There is evacuation bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, effect of elevate a turnable ladder yang-energy.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium.
Radix Et Rhizoma Rhei: bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.There is heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, effect of dampness removing jaundice eliminating.To stagnate constipation for excess-heat, heat in blood tells nosebleed, conjunctival congestion pharyngeal swelling, carbuncle furuncle, abdominalgia with intestinal abscess, blood stasis amenorrhea, postpartum stagnation, traumatic injury, hygropyretic dysentery, jaundice dark coloured urine, stranguria, edema; Externally treating burns and scalds.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.
Radix Scutellariae: bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.There is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.For hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed.
The Radix Paeoniae Alba: bitter, sour, is slightly cold.Return liver, spleen channel.Nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.For blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.
The Rhizoma Pinelliae: pungent, warm; Poisonous.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For damp-phlegm cold-phlegm, cough with asthma abundant expectoration, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus.
Rhizoma Zingiberis Recens: pungent, tepor.Return lung, spleen, stomach warp.Induce sweat cold expelling, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, solving toxin of fish and crab.For anemofrigid cold, gastrofrigid vomiting, cold-phlegm is coughed, and fish Eriocheir sinensis is poisoning.
Fructus Aurantii Immaturus: bitter, pungent, sour, is slightly cold.Return spleen, stomach warp.Dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock of expectorant, the thoracic obstruction, blocked-up chest, visceroptosis.
Lagotis clarkei Hook. F (Lagotis brevituba Maxim.): bitter, sweet, cold.Return lung, the heart, Liver Channel.Heat clearing away, removing toxic substances, dampness removing, suppressing the hyperactive liver, promoting the circulation of blood, regulating menstruation.For excessive thirst of generating heat, cough due to lung-heat, has a headache dizzy, jaundice due to damp-heat.
Flos Farfarae: pungent, micro-hardship, temperature.Return lung meridian.Nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.Cough for new chronic cough, dyspnea and cough with excessive sputum, chronic cough hemoptysis.
Fructus Perillae: pungent, temperature.Return lung meridian.Lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, loosening bowel to relieve constipation.QI rising in reverse order is stopped up, cough and asthma, dryness of the intestine constipation for expectorant.
The pungent table that cools completely of Radix Bupleuri in prescription, expelling pathogenic factors from muscles for clearing heat, Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, this two medicine is principal agent; The Radix Paeoniae Alba, the Rhizoma Pinelliae declare expelling pathogenic factors from the exterior clearly, removing toxic substances heat radiation, Rhizoma Zingiberis Recens tepor, and induce sweat cold expelling, energy throat of holding concurrently, preventing phlegm from forming and stopping coughing, Fructus Aurantii Immaturus energy dispelling the stagnated QI removing food stagnancy, and loose painful abdominal mass of reducing phlegm is accessory drugs altogether; Radix Et Rhizoma Rhei bitter in the mouth is cold in nature, the row that can detoxify is stagnant, and Lagotis clarkei Hook. F (Lagotis brevituba Maxim.), Flos Farfarae, Fructus Perillae play effect of heat-clearing and toxic substances removing, relieving cough and asthma altogether, are adjuvant drug; Full side, based on pungent cool bitter cold, can declare heat clearing away, expelling pathogenic factors from muscles table, have again the merit of clearing away interior-heat.Therefore the wind heat exterior syndrome to the multiple exogenous high fever of children's, heat in both the exterior and interior etc., all have stronger fever allaying and detoxification function.
Beneficial effect of the present invention:
(1) the invention provides a kind of compound preparation being used for the treatment of the treating both the principal and secondary aspects of a disease of infantile common cold, wherein see high heat based on disease, carry out prescription by Chinese medicinal components assistant with acetaminophen; Wherein acetaminophen can prompt drop be warm soon, in order to take stopgap measures, Chinese medicinal components carries out compatibility use, synergism according to the relation of monarch, jointly plays evacuation and brings down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, heat clearing and damp drying, effect of eliminating fire and detoxication, in order to effect a permanent cure, reach treating both the principal and secondary aspects of a disease and the effect of prolongation blood drug level.
(2) the present invention considers the particularity of pediatric pharmaceuticals, this is developed to the suppository of rectally, has medication convenient, can avoid liver first-pass effect, play whole body therapeutic effect, and can prolong drug action time.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, should be noted that following explanation is only to explain the present invention, not limiting its content.
Embodiment 1: the preparation of the suppository for the treatment of chill cold in children
Formula: Radix Bupleuri 30 parts, Radix Et Rhizoma Rhei 18 parts, Radix Scutellariae 18 parts, the Radix Paeoniae Alba 18 parts, the Rhizoma Pinelliae 18 parts, 30 parts, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 18 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 5 parts, Flos Farfarae 5 parts, Fructus Perillae 5 parts, acetaminophen 15 parts, semi-synthetic fatty acid glyceride 85 parts.
Preparation method:
(1) take Radix Bupleuri, Radix Et Rhizoma Rhei, Radix Scutellariae, the Radix Paeoniae Alba, the Rhizoma Pinelliae, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.), Flos Farfarae, Fructus Perillae by formula ratio, decoct with water twice, filter and (add 8 times of water gagings for the first time, decoct 2 hours; Second time adds 6 times of water gagings, decocts 1.5 hours), merging filtrate, is concentrated into the extractum that relative density is 1.2 (50 DEG C), 80 DEG C of drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, (every 1g extract powder is about 3g containing medical material) for subsequent use;
(2) acetaminophen is ground into fine powder, crosses 100 mesh sieves, for subsequent use;
(3) by semi-synthetic fatty acid glyceride heat fused in 70 DEG C of water-baths, respectively acetaminophen and traditional Chinese medicinal extract powder are joined in the semi-synthetic fatty acid glyceride substrate of fusing, heat while stirring, after mixing, in about 40 DEG C (before namely solidifying) impouring moulds, slightly cold, scrape mould, put into 5 ~ 10 DEG C of refrigerator and cooled but 10 minutes, the demoulding, the suppository of chill cold in children must be used for the treatment of, make 1000 (1.5g/ grains).
Embodiment 2: the preparation of the suppository for the treatment of chill cold in children
Formula: Radix Bupleuri 25 parts, Radix Et Rhizoma Rhei 25 parts, Radix Scutellariae 12 parts, the Radix Paeoniae Alba 25 parts, the Rhizoma Pinelliae 12 parts, 35 parts, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 12 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 8 parts, Flos Farfarae 3 parts, Fructus Perillae 8 parts, acetaminophen 10 parts, semi-synthetic fatty acid glyceride 90 parts.
Preparation method is with embodiment 1.
Embodiment 3: the preparation of the suppository for the treatment of chill cold in children
Formula: Radix Bupleuri 35 parts, Radix Et Rhizoma Rhei 12 parts, Radix Scutellariae 25 parts, the Radix Paeoniae Alba 12 parts, the Rhizoma Pinelliae 25 parts, 25 parts, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 25 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 3 parts, Flos Farfarae 8 parts, Fructus Perillae 3 parts, acetaminophen 20 parts, semi-synthetic fatty acid glyceride 80 parts.
Preparation method is with embodiment 1.
Embodiment 4: the preparation of the suppository for the treatment of chill cold in children
Formula: Radix Bupleuri 25 parts, Radix Et Rhizoma Rhei 25 parts, Radix Scutellariae 12 parts, the Radix Paeoniae Alba 25 parts, the Rhizoma Pinelliae 12 parts, 35 parts, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 12 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 8 parts, Flos Farfarae 3 parts, Fructus Perillae 8 parts, acetaminophen 10 parts, semi-synthetic fatty acid glyceride 90 parts.
Preparation method is with embodiment 1.
Embodiment 5: the preparation of the suppository for the treatment of chill cold in children
Formula: Radix Bupleuri 28 parts, Radix Et Rhizoma Rhei 20 parts, Radix Scutellariae 15 parts, the Radix Paeoniae Alba 20 parts, the Rhizoma Pinelliae 15 parts, 32 parts, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 15 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 6 parts, Flos Farfarae 4 parts, Fructus Perillae 6 parts, acetaminophen 13 parts, semi-synthetic fatty acid glyceride 90 parts.
Preparation method is with embodiment 1.
Embodiment 6: the preparation of the suppository for the treatment of chill cold in children
Formula: Radix Bupleuri 32 parts, Radix Et Rhizoma Rhei 15 parts, Radix Scutellariae 20 parts, the Radix Paeoniae Alba 15 parts, the Rhizoma Pinelliae 20 parts, 28 parts, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 20 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 4 parts, Flos Farfarae 6 parts, Fructus Perillae 4 parts, acetaminophen 17 parts, semi-synthetic fatty acid glyceride 80 parts.
Preparation method is with embodiment 1.
Clinical data:
1. physical data:
The department of pediatrics of going to a doctor to 2014 Nian Lai institutes for 2012 observes infant 350 example of axil temperature more than 39 DEG C, it is divided at random treatment 1 group, treats 2 groups, treats 3 groups, treats 4 groups, treats 5 groups, treats 6 groups and matched group, often organize 50 examples, the age, sex, axil Wen Wendu etc. of seven groups are without significant difference.
2. observation index:
Observe the fever time after treatment.
3. Therapeutic Method:
Treat 1 group of suppository adopting the embodiment of the present invention 1 to prepare, 1-6 year child one time 1, fill in anal, if persistent fever or pain, can interval 4-6 hour repeated drug taking once, be no more than 4 in 24 hours; Treat 2 groups, treat 3 groups, treat 4 groups, treat 5 groups and treatment 6 groups of suppositorys adopting the embodiment of the present invention 2, embodiment 3, embodiment 4, embodiment 5 and embodiment 6 to prepare respectively, instructions of taking and dose are ruled together treatment 1 group.
Matched group adopts sulfanilamide or antibiotic to add antipyretic.
4. curative effect judging standard:
Cure: take medicine in latter 54 hours and bring down a fever completely;
Effective: to take medicine in latter 78 hours and bring down a fever completely;
Invalid: clinical symptoms is without being clearly better or increasing the weight of.
5. therapeutic outcome:
Observe therapeutic outcome, in table 1.
Table 1 therapeutic outcome
| Group | Number of cases | Cure | Effectively | Invalid | Total effective rate (%) |
| Treat 1 group | 50 | 43 | 6 | 1 | 98 |
| Treat 2 groups | 50 | 41 | 7 | 2 | 96 |
| Treat 3 groups | 50 | 42 | 6 | 2 | 96 |
| Treat 4 groups | 50 | 40 | 8 | 2 | 96 |
| Treat 5 groups | 50 | 41 | 8 | 1 | 98 |
| Treat 6 groups | 50 | 40 | 8 | 2 | 96 |
| Matched group | 50 | 38 | 6 | 6 | 88 |
As can be seen from Table 1, adopt suppository total effective rate of the present invention more than 96%, be obviously better than matched group, in process of clinical application, only having the infant of 1.2% to occur laxativeness, all there is not toxicity, side effect in other.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; any those skilled in the art of being familiar with are in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (9)
1. treating a suppository for chill cold in children, it is characterized in that, is be made up of the raw material of following weight portion:
Radix Bupleuri 25-35 part, Radix Et Rhizoma Rhei 12-25 part, Radix Scutellariae 12-25 part, Radix Paeoniae Alba 12-25 part, Rhizoma Pinelliae 12-25 part, Rhizoma Zingiberis Recens 25-35 part, Fructus Aurantii Immaturus 12-25 part, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 3-8 part, Flos Farfarae 3-8 part, Fructus Perillae 3-8 part, acetaminophen 10-20 part, substrate 80-90 part.
2. the suppository for the treatment of chill cold in children as claimed in claim 1, it is characterized in that, be made up of the raw material of following weight portion: Radix Bupleuri 28-32 part, Radix Et Rhizoma Rhei 15-20 part, Radix Scutellariae 15-20 part, Radix Paeoniae Alba 15-20 part, Rhizoma Pinelliae 15-20 part, Rhizoma Zingiberis Recens 28-32 part, Fructus Aurantii Immaturus 15-20 part, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 4-6 part, Flos Farfarae 4-6 part, Fructus Perillae 4-6 part, acetaminophen 13-17 part, substrate 80-90 part.
3. the suppository for the treatment of chill cold in children as claimed in claim 1, it is characterized in that, be made up of the raw material of following weight portion: Radix Bupleuri 30 parts, Radix Et Rhizoma Rhei 18 parts, Radix Scutellariae 18 parts, the Radix Paeoniae Alba 18 parts, the Rhizoma Pinelliae 18 parts, 30 parts, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 18 parts, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 5 parts, Flos Farfarae 5 parts, Fructus Perillae 5 parts, acetaminophen 15 parts, substrate 85 parts.
4. the suppository for the treatment of chill cold in children as claimed in claim 1, it is characterized in that, described substrate is selected from semi-synthetic fatty acid glyceride, cocoa butter, Myrj 45 or hydrogenated vegetable oil.
5. the suppository for the treatment of chill cold in children as claimed in claim 4, it is characterized in that, described substrate is semi-synthetic fatty acid glyceride.
6. the preparation method of the suppository of the treatment chill cold in children described in any one of claim 1 to 5, it is characterized in that, step is as follows:
(1) by Radix Bupleuri, Radix Et Rhizoma Rhei, Radix Scutellariae, the Radix Paeoniae Alba, the Rhizoma Pinelliae, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.), Flos Farfarae, Fructus Perillae mixing, decoct with water twice, merging filtrate, it is 1.2 that filtrate is concentrated into relative density, dry, pulverize, and sieves, and obtains Chinese medical concrete powder;
(2) acetaminophen is pulverized, sieved for subsequent use;
(3) by substrate heat fused, respectively the acetaminophen powder of the Chinese medical concrete powder of step (1) and step (2) is joined in the substrate after fusing, stirring and evenly mixing, pour in mould, be cooled to 35-40 DEG C, scrape mould, in 5-10 DEG C of cooling 10-20min, the demoulding, to obtain final product.
7. preparation method as claimed in claim 6, it is characterized in that, in step (1), the concrete operations of soak by water are: the water adding 8 times of quality carries out first time decoction, decocting time is 2h, filter, the water adding 6 times of quality in medicinal residues again carries out second time and decocts, and decocting time is 1.5h.
8. preparation method as claimed in claim 6, it is characterized in that, in step (1), baking temperature is 80 DEG C, adopts drying under reduced pressure.
9. preparation method as claimed in claim 6, is characterized in that, in step (1) and step (2), and equal mistake 100 mesh sieves after pulverizing.
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| CN104147063A (en) * | 2014-08-07 | 2014-11-19 | 江西九华药业有限公司 | Compound pediatric antipyretic suppository and preparation method thereof |
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| JP2008260695A (en) * | 2007-04-10 | 2008-10-30 | Nissei Bio Kk | Hepatopathy inhibitor |
| CN102847089A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation process of integration-type novel formulation of DACHAIHU decoction and a production method thereof |
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