CN104800647A - Traditional Chinese medicine for treating vein stasis type infantile epilepsy and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating vein stasis type infantile epilepsy and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicinal materials: rust powder made of iron and acetic acid, Rubus parvifolius, Solanum dulcamara, uncaria lancifolia, pine leaf, common rush, star-flower lysimachia, Tanakaea omeiensis, Urtica angustifolia, Rhizoma typhonii, pagoda leaf, rootstock of Triarrhena sacchariflora (Maxim. ) Nakai, white sedge, Cardamine urbaniana, Caldamine leucantha (Tausch), Spiraea japonica, malachite and Phlomis mongolica. The invention has the beneficial effects that the traditional Chinese medicine provided by the invention has the advantages of definite medicine efficacy, low toxic and side effects and high long-term taking safety for infant patients, the damages to brain nervous functions are reduced, medicine resistance is not easily produced, and medicine dependence is relieved.

Description

A kind ofly treat Chinese medicine of stasis blocking venation type children epilepsy and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials medical material, particularly a kind ofly treating Chinese medicine of stasis blocking venation type children epilepsy and preparation method thereof.

Background technology

" epilepsy " or " epilepsy " that namely epilepsy is commonly called as, is the electric discharge of cerebral neuron paroxysmal abnormality, causes a kind of chronic disease of of short duration cerebral disorder.Due to the initial position of paradoxical discharge and the difference of transfer mode, the complicated clinical manifestation of epilepsy is various, can show as paroxysmal movement, sensation, autonomic nerve, consciousness and mental disorder.Epilepsy is found in all age group.Epilepsy in childhood sickness rate is comparatively grown up high, and with advancing age, epilepsy invasion rate decreases.Entering the geratic period (after 65 years old) increases due to cerebrovascular, senile dementia and neurodegenerative diseases, and epilepsy invasion rate is shown in rising again.The pathogenesis of epilepsy is very complicated.Imbalance between central nervous system stimulant and suppression causes epilepsy, and it is main relevant with the change of ion channel neurotransmitter and neurogliocyte

Because the physiological feature of child is different from adult, nervous function as child is not yet sound, cerebral cortex goes back imperfection to infracortical suppression, dynamic stereotype fails firmly to set up and process of intercentral inhibition goes down, therefore, children's just easily causes strong reaction for comparatively pinprick, and the impact of undesirable element is responsive especially especially to external world.Add the change of epineural, so epilepsy in childhood is different with adult in some aspects.Therefore, when treatment children epilepsy, select the medicine little to brain negative effect, multiple Western medicine should not be applied simultaneously as far as possible, general with a kind of, is no more than at most two kinds.Though western medicine and medical practitioners is controlling the advantage having it in epilepsy, excessively strong inhibitory action can damage cerebral nerve function, has obvious toxic-side effects.As carbamazepine, epilepsy amine etc., generally thoroughly can not effect a radical cure epilepsy, and side effect greatly, easily produce drug dependence, easily cause the side effect such as spirit depressing, dysnoesia.In addition, informal dress epilepsy Western medicine, easily causes drug resistance, wants to keep certain curative effect just must increase dosage, can cause more major injury.

In the traditional Chinese medical science, by epilepsy differentiation of symptoms and signs for classification of syndrome be following 5 kinds:

1, type of wind-phlegm blocking: patient often has the symptoms such as dizzy, uncomfortable in chest, weak, body part tic before outbreak; Suddenly fall during outbreak, obnubilation, convulsion with salivation, often with screaming and gatism; White and greasy fur, the many stringy and rolling pulse of arteries and veins.

2, type of intenseness of phlegm-fire: patient at ordinary times emotion irritability, vexed insomnia, expectoration is not smooth; Suddenly fall in a swoon during outbreak, convulsion with salivation, gnathospasma, or roar; Bitter taste and dryness in the mouth, constipation, red tongue, yellowish fur, stringy and rolling pulse number.

3, spleen emptiness and wet sputum type: patient has fatigue and weakness, the sense of discomfort such as uncomfortable in chest, dizzy on ordinary days; During outbreak, complexion is turned white, extreme cold of the limbs, and mind dusk is dim, and curling oneself up is on ground, or tic takes place frequently, sialemesis, and ululation is low timid; White and greasy fur, thready and rolling pulse.

4, resistance venation of becoming silted up type: this type epileptic has head to stagger along more, brain injury history, obstinate; There are the senses of discomfort such as headache, spirit depressing, numb limbs and tense tendons or facial numbness at ordinary times; During outbreak, symptom is more fixing, and local or whole body are twitched; Headache sense is often had after outbreak; Purplish tongue is dark or have ecchymosis, white and thin fur, hesitant pulse or stringy and tense pulse.

5, brain deficiency: epilepsy invasion is with the passing of time, lost in a reverie, with a haggard face dark and gloomy, insomnia, forgetful, cardiopalmus, has a dizzy spell, soreness of the waist and knees, spiritlessness and weakness; Thin and greasy fur, thready and weak pulse.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of and treats Chinese medicine of stasis blocking venation type children epilepsy and preparation method thereof, its treatment by Chinese herbs children epilepsy, has that drug effect is definite, toxic and side effects is low, infant can the advantage of safety clothes.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of stasis blocking venation type children epilepsy, comprising following raw medicinal material: Magnetite, Herba Rubi parvifolii, bittersweet, Ramulus Uncariae Cum Uncis, Folium Pini, Medulla Junci, Lysimachia trientaloides Hemsl., Tanakea omeiensis Nakai, urtica angustifolia, Rhizoma Typhonium Gigantei (Rhizoma Typhonii), Japanese pagodatree leaf, Triarrherca sacchariflora (Maxin.)Nakai, Folium Ledi Angusti, Cardamine urhaniana O.E.Schulz, Radix cardamines leucanthae, Ramulus Et folium Spiraeae Acuminatae, Malachitum and a string of bells hung round the neck.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows:

Magnetite 5 ~ 10 parts, Herba Rubi parvifolii 10 ~ 20 parts, bittersweet 10 ~ 15 parts, Ramulus Uncariae Cum Uncis 5 ~ 10 parts, Folium Pini 15 ~ 20 parts, Medulla Junci 10 ~ 15 parts, Lysimachia trientaloides Hemsl. 20 ~ 30 parts, Tanakea omeiensis Nakai 15 ~ 20 parts, urtica angustifolia 10 ~ 25 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 5 ~ 15 parts, Japanese pagodatree leaf 10 ~ 20 parts, Triarrherca sacchariflora (Maxin.)Nakai 15 ~ 25 parts, Folium Ledi Angusti 5 ~ 15 parts, Cardamine urhaniana O.E.Schulz 15 ~ 25 parts, Radix cardamines leucanthae 20 ~ 30 parts, Ramulus Et folium Spiraeae Acuminatae 10 ~ 20 parts, Malachitum 20 ~ 35 parts and a string of bells hung round the neck 15 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be as follows:

Magnetite 8 ~ 10 parts, Herba Rubi parvifolii 15 ~ 20 parts, bittersweet 12 ~ 15 parts, Ramulus Uncariae Cum Uncis 7 ~ 10 parts, Folium Pini 15 ~ 18 parts, Medulla Junci 12 ~ 15 parts, Lysimachia trientaloides Hemsl. 25 ~ 30 parts, Tanakea omeiensis Nakai 17 ~ 20 parts, urtica angustifolia 15 ~ 25 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 10 ~ 15 parts, Japanese pagodatree leaf 15 ~ 20 parts, Triarrherca sacchariflora (Maxin.)Nakai 20 ~ 25 parts, Folium Ledi Angusti 10 ~ 15 parts, Cardamine urhaniana O.E.Schulz 18 ~ 25 parts, Radix cardamines leucanthae 25 ~ 30 parts, Ramulus Et folium Spiraeae Acuminatae 15 ~ 20 parts, Malachitum 25 ~ 35 parts and a string of bells hung round the neck 20 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is most preferably as follows:

Magnetite 8 parts, Herba Rubi parvifolii 16 parts, bittersweet 12 parts, Ramulus Uncariae Cum Uncis 7 parts, Folium Pini 15 parts, Medulla Junci 15 parts, Lysimachia trientaloides Hemsl. 26 parts, Tanakea omeiensis Nakai 17 parts, urtica angustifolia 20 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 11 parts, Japanese pagodatree leaf 16 parts, Triarrherca sacchariflora (Maxin.)Nakai 21 parts, Folium Ledi Angusti 12 parts, Cardamine urhaniana O.E.Schulz 20 parts, Radix cardamines leucanthae 25 parts, Ramulus Et folium Spiraeae Acuminatae 16 parts, Malachitum 28 parts and a string of bells hung round the neck 21 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is most preferably as follows:

Magnetite 10 parts, Herba Rubi parvifolii 20 parts, bittersweet 15 parts, Ramulus Uncariae Cum Uncis 10 parts, Folium Pini 18 parts, Medulla Junci 12 parts, Lysimachia trientaloides Hemsl. 30 parts, Tanakea omeiensis Nakai 20 parts, urtica angustifolia 25 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 15 parts, Japanese pagodatree leaf 20 parts, Triarrherca sacchariflora (Maxin.)Nakai 25 parts, Folium Ledi Angusti 15 parts, Cardamine urhaniana O.E.Schulz 25 parts, Radix cardamines leucanthae 30 parts, Ramulus Et folium Spiraeae Acuminatae 20 parts, Malachitum 35 parts and a string of bells hung round the neck 25 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps,

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is oral liquid, its preparation method comprises the following steps,

The first step, by Magnetite, Herba Rubi parvifolii, bittersweet, Ramulus Uncariae Cum Uncis, Folium Pini Medulla Junci, Lysimachia trientaloides Hemsl. and Tanakea omeiensis Nakai mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

Beneficial effect of the present invention: Chinese medicine provided by the invention has that drug effect is definite, toxic and side effects is low, infant can the advantage taken of long-term safety, can reduce the damage to cerebral nerve function, not easily produce drug resistance, alleviate drug dependence.

Detailed description of the invention

Embodiments provide a kind of Chinese medicine for the treatment of stasis blocking venation type children epilepsy, it comprises Magnetite, Herba Rubi parvifolii, bittersweet, Ramulus Uncariae Cum Uncis, Folium Pini, Medulla Junci, Lysimachia trientaloides Hemsl., Tanakea omeiensis Nakai, urtica angustifolia, Rhizoma Typhonium Gigantei (Rhizoma Typhonii), Japanese pagodatree leaf, Triarrherca sacchariflora (Maxin.)Nakai, Folium Ledi Angusti, Cardamine urhaniana O.E.Schulz, Radix cardamines leucanthae, Ramulus Et folium Spiraeae Acuminatae, Malachitum and a string of bells hung round the neck.

In Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Magnetite: [another name] ferrum offspring powder (" Japan hanako materia medica "), the gorgeous powder of ferrum, ferrum frost (" detailed outline ").For the rust end generated after ferrum and acetic acid effect." Kaibao Bencao ": " salty in the mouth is flat, nontoxic." nourishing blood to tranquillize the mind, checking hyperfunction of the liver for relieving convulsion.Control blood deficiency, palpitation with fear, forgetful, epilepsy disease, Xuan tinea, proctoptosis anal fistula.[extracts] " Chinese medicine voluminous dictionary "

Herba Rubi parvifolii: [another name] enterprise shakes that thorn, wild Du Li, perpendicular rattan fire prunus mume (sieb.) sieb.et zucc. are stung, meal disappears and turns round, cuts field Fischer.For Rosaceae rubus fluffy Creeper Rubus hirsutus Thunb. [R.thunbergii Sieb.etZucc.], be used as medicine with root or leaf.Summer, autumn uproot, clean dry for subsequent use, the many using fresh herbs of leaf.Sweet, micro-hardship, flat.Leaf: antiinflammatory, synthetism.For severed finger.Root: dispelling, collateral-activating, heat clearing away is relieving convulsion.For infantile convulsion, bones and muscles pain due to rheumatism.[extracts] " national Chinese herbal medicine compilation "

Bittersweet: [another name] Fructus Solani Dulcamarae, pregnancy grass, Fructus Solani dulcamarae.Solanaceae is bittersweet Solanumdulcamara L., with all herbal medicine.Sweet, cold.Heat-clearing and toxic substances removing.[extracts] " national Chinese herbal medicine compilation "

Ramulus Uncariae Cum Uncis: [another name] Ramulus Uncariae macrophyllae [Yunnan].Rubiaceae Ramulus Uncariae Cum Uncis Uncaria LaevigataWal l., is used as medicine with the rattan of buckle.Sweet, be slightly cold.Heat clearing away suppressing the hyperactive liver, promoting blood circulation to restore menstrual flow.Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; Hypertension.[extracts] " in the whole nation Orpimentum (Auripigmentum) glossary of Herbs and Drugs "

Folium Pini: [another name] bristles Folium Pini, Folium Pini, illawarra mountain pine palpus, Folium Pini.Medical material Ji Yuan: be the needle of pinaceae plant Pinus armandi Franch-P. Komavovii Lavl., Pinus taiwanesis, Pinus massoniana Lamb, Pollen pini thunbergii, Pinus tabuliformis, pinus yunnanensis faranch, Pinus koraiensis etc.Bitter; Warm in nature.GUIXIN; Spleen channel.Dispeiling pathogenic wind and removing dampness; Killing parasites for relieving itching; Blood-promoting and mind-easing.Main air wets flaccidity syndrome and arthralgia syndrome; Foot gas; Eczema; Tinea; Rubella pruritus; Traumatic injury; Neurasthenia; Chronic nephritis; Hypertension.Preventing encephalitis, influenza.[extracts] " China's book on Chinese herbal medicine "

Medulla Junci: [another name] tiger's whiskers grass, red palpus, lampwick, Medulla Junci, jasper grass, water lampwick, ferrum lampwick, brave wine grass, bent dung grass, seedling are careless.For stem pith or the herb of rush family plant Medulla Junci.Sweet; Light; Be slightly cold.The heart; Lung; Small intestinal; Urinary bladder channel.Relieving stranguria by diuresis; Clearing heart fire.Main gonorrhea; Edema; Dysuria; Jaundice due to damp-heat; Dysphoria and insomnia; The nocturnal fretfulness in infants; Sore throat; Aphtha; Wound.[extracts] " China's book on Chinese herbal medicine "

Lysimachia trientaloides Hemsl.: [another name] infantile convulsion umbrella (" Guizhou side's medicine among the people collection "), Rhizoma Arisaematis (" Kweiyang medicinal herbs among the people "), public Cortex torricelliae tiliifoliae (" Guizhou medical herbs ").For root or the herb of the narrow leaf Herba lysimachiae capillipedis of Ofthe Primulaceae.The whole year can adopt." Kweiyang medicinal herbs among the people ": " pungent, temperature, nontoxic." dispel the wind, invigorate blood circulation.Dispelling the wind and dampness pathogens arthralgia pain, hemiplegia, traumatic injury, infantile convulsion.[extracts] " Chinese medicine voluminous dictionary "

Tanakea omeiensis Nakai: [another name] E Meiyan snows.For the herb of saxifragaceae plant Tanakea omeiensis Nakai.Salty; Cold.Liver Channel.Clearing away heat and relieving the wind syndrome.Main hyperpyrexia convulsion, infantile convulsion is twitched.[extracts] " China's book on Chinese herbal medicine "

Urtica angustifolia: [another name] stings pockmarks, small British nettle, Urtica angustifolia Fisch. ex Hornem..Urticaceae Urtica plant urtica angustifolia Urtica angustifolia Fisch. is with all herbal medicine.Xia Qiu gathers, using fresh herb or dry.Bitter, pungent, temperature.Slightly poisonous.Expelling wind for relieving convulsion, help digestion relieving constipation.For rheumatic arthritis, puerperal convulsion, infantile convulsion, poliomyelitis sequela, hypertension, dyspepsia, constipation; External controls urticaria from the beginning of, venom.[extracts] " national Chinese herbal medicine compilation "

Rhizoma Typhonium Gigantei (Rhizoma Typhonii): [another name] milk is attached (" Chinese medicinal herbal ") in vain, Cor Gigeriae Galli is attached (" traditional Chinese medicinal materials assortment discussion ") in vain.For the tuber of aroid Herba Typhonii gigantei.Autumn excavates tuber, removes residual stem, fibrous root, hits or to prune rough bark with bamboo knife, cleaning, dry." Traditional Chinese Medicine in Sichuan will ": " the large temperature of property, acrid-sweet flavor is poisonous." " Traditional Chinese Medicine in Sichuan will ": " enters stomach, liver two warp." dispel the wind expectorant, arresting convulsion, pain relieving.Control apoplectic aphasia, pained arthralgia due to stagnation of blood, migraine and general headache, sore throat swells and ache, scrofula, tetanus.[extracts] " Chinese medicine voluminous dictionary "

Japanese pagodatree leaf: be the blade of leguminous plant Chinese scholartree.Spring, summer gather, and dry." Japan hanako materia medica ": " flat, nontoxic." " must join book on Chinese herbal medicine ": " enters the sufficient bright warp of yin, yang of fainting." control infantile convulsion, high fever, hemorrhoidal hamorrhage, hematuria, hemorrhoid, scabies, eczema, furuncle swells.[extracts] " Chinese medicine voluminous dictionary "

Triarrherca sacchariflora (Maxin.)Nakai: [another name] wild reed, purple.For the herb of grass Miscanthus sacchariflorus (Maxim) Benth et Hook f.Sweet in the mouth; Cool in nature.Heat clearing and blood circulation promoting.A main emaciation due to blood disorder; Hectic fever; Puerpera loses blood thirsty; Toothache.[extracts] " China's book on Chinese herbal medicine "

Folium Ledi Angusti: be the leaf of ericad Folium Ledi Angusti.Bitter; Pungent; Cold nature.Liver; Stomach warp.Promoting blood flow to regulate menstruation; Preventing phlegm from forming and stopping coughing.Main menoxenia; Gastric ulcer; Cough ant phlegm.[extracts] " China's book on Chinese herbal medicine "

Cardamine urhaniana O.E.Schulz: [another name] Radix cardamines leucanthae, urban bittercress herb, Samantabhadra dish.For the root stock of crucifer Central China Hairy Bittercress.Micro-hardship; Pungent; Flat.Relieving cough and resolving phlegm; Promoting blood circulation and detumescence.Main pertussis; Chronic bronchitis; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix cardamines leucanthae: [another name] spends stone Caulis et Folium Brassicae junceae in vain.Cruciferae Cardamine hirsuta Linn platymiscium spends Cardamine hirsuta Linn Cardamine leucantha (Tausch) O.E.Schulz in vain, is used as medicine with root stock.Autumn excavates, and cleans, removes fibrous root, dry.Pungent, temperature.Spasmolytic antitussive, promoting blood circulation and stopping pain.For pertussis, traumatic injury.[extracts] " national Chinese herbal medicine compilation "

Ramulus Et folium Spiraeae Acuminatae: [another name] sharp leaf silk ball chrysanthemum, narrow leaf silk ball chrysanthemum.Rosaceae Ramulus Et folium Spiraeae Acuminatae Spiraeajaponica L.f.var.acuminata Franch., is used as medicine with Herb.Hardship, flat.Stimulate the menstrual flow, relieving constipation, diuresis.Cure mainly amenorrhea, menoxenia, constipation abdominal distention, dysuria.[extracts] " national Chinese herbal medicine compilation "

Malachitum: [another name] malachite green (Tang Materia Medica), stone commonplace (amplification on Canon of Materia Medica), green greatly (" detailed outline ").For the Ore of carbonate mineral malachite.Acid; Cold; Nontoxic.Return Liver Channel.Emeticly to eliminate the phlegm; Relieving convulsion; Sore.Main air expectorant is jammed; Faint with dizziness; Expectorant fan infantile convulsion; Chancre.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

A string of bells hung round the neck: [another name] 10000 years, lamb taro.For the joint that Balsaminaceae plant block joint Rhodiola dumulosa (Franch.) S.H.Fu basal part of stem expands.Pungent; Temperature.Expelling wind and removing dampness; Promoting blood circulation and stopping pain.Main anemofrigid cold; Throat moth; Rheumatic ostalgia; Amenorrhea; Fracture.[extracts] " China's book on Chinese herbal medicine "

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows:

Magnetite 5 ~ 10 parts, Herba Rubi parvifolii 10 ~ 20 parts, bittersweet 10 ~ 15 parts, Ramulus Uncariae Cum Uncis 5 ~ 10 parts, Folium Pini 15 ~ 20 parts, Medulla Junci 10 ~ 15 parts, Lysimachia trientaloides Hemsl. 20 ~ 30 parts, Tanakea omeiensis Nakai 15 ~ 20 parts, urtica angustifolia 10 ~ 25 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 5 ~ 15 parts, Japanese pagodatree leaf 10 ~ 20 parts, Triarrherca sacchariflora (Maxin.)Nakai 15 ~ 25 parts, Folium Ledi Angusti 5 ~ 15 parts, Cardamine urhaniana O.E.Schulz 15 ~ 25 parts, Radix cardamines leucanthae 20 ~ 30 parts, Ramulus Et folium Spiraeae Acuminatae 10 ~ 20 parts, Malachitum 20 ~ 35 parts and a string of bells hung round the neck 15 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be as follows:

Magnetite 8 ~ 10 parts, Herba Rubi parvifolii 15 ~ 20 parts, bittersweet 12 ~ 15 parts, Ramulus Uncariae Cum Uncis 7 ~ 10 parts, Folium Pini 15 ~ 18 parts, Medulla Junci 12 ~ 15 parts, Lysimachia trientaloides Hemsl. 25 ~ 30 parts, Tanakea omeiensis Nakai 17 ~ 20 parts, urtica angustifolia 15 ~ 25 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 10 ~ 15 parts, Japanese pagodatree leaf 15 ~ 20 parts, Triarrherca sacchariflora (Maxin.)Nakai 20 ~ 25 parts, Folium Ledi Angusti 10 ~ 15 parts, Cardamine urhaniana O.E.Schulz 18 ~ 25 parts, Radix cardamines leucanthae 25 ~ 30 parts, Ramulus Et folium Spiraeae Acuminatae 15 ~ 20 parts, Malachitum 25 ~ 35 parts and a string of bells hung round the neck 20 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material most preferably is as follows:

Magnetite 8 parts, Herba Rubi parvifolii 16 parts, bittersweet 12 parts, Ramulus Uncariae Cum Uncis 7 parts, Folium Pini 15 parts, Medulla Junci 15 parts, Lysimachia trientaloides Hemsl. 26 parts, Tanakea omeiensis Nakai 17 parts, urtica angustifolia 20 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 11 parts, Japanese pagodatree leaf 16 parts, Triarrherca sacchariflora (Maxin.)Nakai 21 parts, Folium Ledi Angusti 12 parts, Cardamine urhaniana O.E.Schulz 20 parts, Radix cardamines leucanthae 25 parts, Ramulus Et folium Spiraeae Acuminatae 16 parts, Malachitum 28 parts and a string of bells hung round the neck 21 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material most preferably is as follows:

Magnetite 10 parts, Herba Rubi parvifolii 20 parts, bittersweet 15 parts, Ramulus Uncariae Cum Uncis 10 parts, Folium Pini 18 parts, Medulla Junci 12 parts, Lysimachia trientaloides Hemsl. 30 parts, Tanakea omeiensis Nakai 20 parts, urtica angustifolia 25 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 15 parts, Japanese pagodatree leaf 20 parts, Triarrherca sacchariflora (Maxin.)Nakai 25 parts, Folium Ledi Angusti 15 parts, Cardamine urhaniana O.E.Schulz 25 parts, Radix cardamines leucanthae 30 parts, Ramulus Et folium Spiraeae Acuminatae 20 parts, Malachitum 35 parts and a string of bells hung round the neck 25 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps,

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is oral liquid, its preparation method comprises the following steps,

The first step, by Magnetite, Herba Rubi parvifolii, bittersweet, Ramulus Uncariae Cum Uncis, Folium Pini Medulla Junci, Lysimachia trientaloides Hemsl. and Tanakea omeiensis Nakai mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

Below adopt example to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet of the present invention

Get Magnetite 80g, Herba Rubi parvifolii 160g, bittersweet 120g, Ramulus Uncariae Cum Uncis 70g, Folium Pini 150g, Medulla Junci 150g, Lysimachia trientaloides Hemsl. 260g, Tanakea omeiensis Nakai 170g, urtica angustifolia 200g, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 110g, Japanese pagodatree leaf 160g, Triarrherca sacchariflora (Maxin.)Nakai 210g, Folium Ledi Angusti 120g, Cardamine urhaniana O.E.Schulz 200g, Radix cardamines leucanthae 250g, Ramulus Et folium Spiraeae Acuminatae 160g, Malachitum 280g and string of bells hung round the neck 210g.

Its preparation method comprises the steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.3 times, 0.15 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.05 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2 oral liquid of the present invention

Get Magnetite 100g, Herba Rubi parvifolii 200g, bittersweet 150g, Ramulus Uncariae Cum Uncis 100g, Folium Pini 180g, Medulla Junci 120g, Lysimachia trientaloides Hemsl. 300g, Tanakea omeiensis Nakai 200g, urtica angustifolia 250g, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 150g, Japanese pagodatree leaf 200g, Triarrherca sacchariflora (Maxin.)Nakai 250g, Folium Ledi Angusti 150g, Cardamine urhaniana O.E.Schulz 250g, Radix cardamines leucanthae 300g, Ramulus Et folium Spiraeae Acuminatae 200g, Malachitum 350g and string of bells hung round the neck 250g.

Its preparation method comprises the steps:

The first step, by Magnetite, Herba Rubi parvifolii, bittersweet, Ramulus Uncariae Cum Uncis, Folium Pini Medulla Junci, Lysimachia trientaloides Hemsl. and Tanakea omeiensis Nakai mixing, add relative to mixture 4 times amount determining alcohol be 60% alcohol reflux 3 times, each 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.31, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 times of water gagings, boils 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;

3rd step, the described mastic mixing that the first step, second step are obtained, 60 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 35 hours;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001; The time of described heat treated is 30 minutes, and temperature is 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

Toxicity test:

Acute toxicity testing:

Application NIH mice 60, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 30, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>32.9 crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 2.2g crude drug/day/people, adult body weight in 60KG, average dosage is 0.037g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 889 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test:

The tablet of the embodiment of the present invention 1 presses 10.78,20.35 and 33.48g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: the 90 routine the court out-patients in August, 2011 ~ in April, 2014, makes a definite diagnosis according to detailed and reliable outbreak medical history and EEC (electroencephalogram), brain mapping, brain CT detection and neurologic check by specialist.Be divided into treatment group and matched group at random.Treatment group 45 example, man 26 example, female 19 example, age 1-11 year, 5.7 ± 1.8 years old mean age, the course of disease 1 ~ 5 year, average course of disease 3.1 years, during morbidity: simple partial seizure 9 example, complex partial seizures 13 example, generalized seizures 18 example, myoclonic seizure 3 example, loses tension outbreak 2 example; Matched group 45 example, man 24 example, female 21 example; At 1 ~ 11 years old age, the mean age 5.9 ± 1.3, the course of disease 1 ~ 5 year, average course of disease 3.3 years, during morbidity: simple partial seizure 10 example, complex partial seizures 14 example, generalized seizures 17 example, myoclonic seizure 2 example, loses tension outbreak 2 example.

All trace in the outbreak intermission with EEC recording instrument before auxiliary examination two groups of patient treatments.All patients all makes brain mapping inspection, cerebral CT inspection and routine blood test, routine urinalysis, liver functional test.In 90 routine patients, EEC checks mile abnormality 26 example, abnormal 35 examples of moderate, Height Anomalies 29 example.Wherein treatment group: mile abnormality 13 example, abnormal 17 examples of moderate, Height Anomalies 15 example; Matched group: mile abnormality 13 example, abnormal 18 examples of moderate, Height Anomalies 14 example.The inspection of two groups of patient's brain mappings all shows exception.Routine blood test, routine urinalysis, liver function test are all within normal range.

Diagnostic criteria: doctor trained in Western medicine classification diagnosis presses the International Classification diagnostic criteria classification of ILAE (international epilepsy alliance) epilepsy in 1987, is divided into simple partial seizure, complex partial seizures, generalized seizures and other (as myoclonic seizure, losing tension outbreak).

Syndrome Differentiation of Traditional Chinese Medicine standard: resistance venation of becoming silted up type: this type epileptic has head to stagger along more, brain injury history, obstinate; There are the senses of discomfort such as headache, spirit depressing, numb limbs and tense tendons or facial numbness at ordinary times; During outbreak, symptom is more fixing, and local or whole body are twitched; Headache sense is often had after outbreak; Purplish tongue is dark or have ecchymosis, white and thin fur, hesitant pulse or stringy and tense pulse.

Case selection meets the diagnostic criteria of epilepsy International Classification and Syndrome Differentiation of Traditional Chinese Medicine is resistance venation type children epilepsy person of becoming silted up.

Therapeutic Method:

Treatment group: the tablet taking the embodiment of the present invention 1, child every day 3 times, each 3, one after each meal.It within 3 months, is 1 course for the treatment of.

Matched group: carbamazepine (Shanghai Sunve Pharmaceutical Co., Ltd., lot number H31020213), child every day 3 times, each 0.2g, one after each meal 3 months is 1 course for the treatment of.

Symptom curative effect judging standard: " new Chinese medicine guideline of clinical investigations " (first volume) it " principle is known in the clinical research of new Chinese medicine treatment epilepsy syndrome " issued with reference to Ministry of Public Health.Clinical recovery: outbreak controls 1 year completely, electroencephalogram recovers normal; Effective: seizure frequency reduces more than 75%, or show effect compare interval time with before treatment, prolongation more than half a year does not show effect, and electroencephalogram change is clearly better; Effective: seizure frequency reduces 50% ~ 75%, or outbreak symptom obviously alleviates, decreased duration more than 1/2, and electroencephalogram change take a favorable turn.Invalid: seizure frequency, degree, outbreak symptom, electroencephalogram are all without improvement or deterioration.Invalid: front and back symptom of taking medicine is without improvement.

Therapeutic outcome: before and after two groups of treatments, total effects is in table 1.

Before and after table 1 liang group treatment, Comparison of therapeutic is as follows:

	n	Clinical recovery	Effective	Effectively	Invalid	Total effective rate
							Treatment group	45	5	27	11	2	43(95.56％)
Matched group	45	0	12	24	9	36(80％)

Compare P < 0.05 with matched group total effective rate, treatment group is better than matched group.

Observation to brain mapping improves: treat front two groups of brain mappings and all show exception; Treatment group after treatment: 21 example displays are normal, and 24 examples are improved, and 0 example is unchanged; Matched group: 0 example display is normal, and 35 examples are improved, and 10 examples are unchanged.

The observation of untoward reaction: treatment group does not find untoward reaction; In matched group, 4 routine patients have inappetence, nauseating, tending to vomit, diarrhoea, and fatigue and weakness appears in 1 routine patient, happiness is sleeping drowsiness.

Model case: grandson, man, 7 years old, medical history 3 years, in August, 2012 is to our hospital, having head to wound history, at ordinary times paroxysmal headaches, is very with left side temple, time when sending out only, take analgesic completely invalid, during outbreak, whole body is twitched, severe headache, tongue with ecchymosis, white and thin fur, hesitant pulse.Be diagnosed as through various inspection: resistance venation of becoming silted up type epilepsy, take the tablet of the embodiment of the present invention 1, every day 3 times, each 3, one after each meal, take 1 first quarter moon, paroxysmal headaches disappears substantially, to take after 3 months every inspections such as electroencephalogram and recovers normal, clinical recovery, follows up a case by regular visits to 1 year, has no recurrence.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine for stasis blocking venation type children epilepsy, it is characterized in that, comprise following raw medicinal material: Magnetite, Herba Rubi parvifolii, bittersweet, Ramulus Uncariae Cum Uncis, Folium Pini, Medulla Junci, Lysimachia trientaloides Hemsl., Tanakea omeiensis Nakai, urtica angustifolia, Rhizoma Typhonium Gigantei (Rhizoma Typhonii), Japanese pagodatree leaf, Triarrherca sacchariflora (Maxin.)Nakai, Folium Ledi Angusti, Cardamine urhaniana O.E.Schulz, Radix cardamines leucanthae, Ramulus Et folium Spiraeae Acuminatae, Malachitum and a string of bells hung round the neck.

2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Magnetite 5 ~ 10 parts, Herba Rubi parvifolii 10 ~ 20 parts, bittersweet 10 ~ 15 parts, Ramulus Uncariae Cum Uncis 5 ~ 10 parts, Folium Pini 15 ~ 20 parts, Medulla Junci 10 ~ 15 parts, Lysimachia trientaloides Hemsl. 20 ~ 30 parts, Tanakea omeiensis Nakai 15 ~ 20 parts, urtica angustifolia 10 ~ 25 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 5 ~ 15 parts, Japanese pagodatree leaf 10 ~ 20 parts, Triarrherca sacchariflora (Maxin.)Nakai 15 ~ 25 parts, Folium Ledi Angusti 5 ~ 15 parts, Cardamine urhaniana O.E.Schulz 15 ~ 25 parts, Radix cardamines leucanthae 20 ~ 30 parts, Ramulus Et folium Spiraeae Acuminatae 10 ~ 20 parts, Malachitum 20 ~ 35 parts and a string of bells hung round the neck 15 ~ 25 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Magnetite 8 ~ 10 parts, Herba Rubi parvifolii 15 ~ 20 parts, bittersweet 12 ~ 15 parts, Ramulus Uncariae Cum Uncis 7 ~ 10 parts, Folium Pini 15 ~ 18 parts, Medulla Junci 12 ~ 15 parts, Lysimachia trientaloides Hemsl. 25 ~ 30 parts, Tanakea omeiensis Nakai 17 ~ 20 parts, urtica angustifolia 15 ~ 25 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 10 ~ 15 parts, Japanese pagodatree leaf 15 ~ 20 parts, Triarrherca sacchariflora (Maxin.)Nakai 20 ~ 25 parts, Folium Ledi Angusti 10 ~ 15 parts, Cardamine urhaniana O.E.Schulz 18 ~ 25 parts, Radix cardamines leucanthae 25 ~ 30 parts, Ramulus Et folium Spiraeae Acuminatae 15 ~ 20 parts, Malachitum 25 ~ 35 parts and a string of bells hung round the neck 20 ~ 25 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Magnetite 8 parts, Herba Rubi parvifolii 16 parts, bittersweet 12 parts, Ramulus Uncariae Cum Uncis 7 parts, Folium Pini 15 parts, Medulla Junci 15 parts, Lysimachia trientaloides Hemsl. 26 parts, Tanakea omeiensis Nakai 17 parts, urtica angustifolia 20 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 11 parts, Japanese pagodatree leaf 16 parts, Triarrherca sacchariflora (Maxin.)Nakai 21 parts, Folium Ledi Angusti 12 parts, Cardamine urhaniana O.E.Schulz 20 parts, Radix cardamines leucanthae 25 parts, Ramulus Et folium Spiraeae Acuminatae 16 parts, Malachitum 28 parts and a string of bells hung round the neck 21 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Magnetite 10 parts, Herba Rubi parvifolii 20 parts, bittersweet 15 parts, Ramulus Uncariae Cum Uncis 10 parts, Folium Pini 18 parts, Medulla Junci 12 parts, Lysimachia trientaloides Hemsl. 30 parts, Tanakea omeiensis Nakai 20 parts, urtica angustifolia 25 parts, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 15 parts, Japanese pagodatree leaf 20 parts, Triarrherca sacchariflora (Maxin.)Nakai 25 parts, Folium Ledi Angusti 15 parts, Cardamine urhaniana O.E.Schulz 25 parts, Radix cardamines leucanthae 30 parts, Ramulus Et folium Spiraeae Acuminatae 20 parts, Malachitum 35 parts and a string of bells hung round the neck 25 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and it comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is oral solutions, and its preparation method comprises the following steps:

The first step, by Magnetite, Herba Rubi parvifolii, bittersweet, Ramulus Uncariae Cum Uncis, Folium Pini Medulla Junci, Lysimachia trientaloides Hemsl. and Tanakea omeiensis Nakai mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is oral liquid, and preparation method comprises the following steps:

The first step, by Magnetite, Herba Rubi parvifolii, bittersweet, Ramulus Uncariae Cum Uncis, Folium Pini Medulla Junci, Lysimachia trientaloides Hemsl. and Tanakea omeiensis Nakai mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.