CN104888073A - Traditional Chinese medicine for treating liver-kidney yin deficiency type dizziness and preparation method - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating liver-kidney yin deficiency type dizziness and a preparation method. The traditional Chinese medicine comprises raw materials as follows: Japanese snailseed roots, walnut kernels, camellia, roots and rhizomes of Canton fairybells, cyrtomium rhizome, leaves of Japanese pagodatree, pine among the Indian Bread, Lysimachia insignis Hemsl, seeds of Chinese milkvetch, common leafflower herb, sessile stemona roots, broadleaf holly leaves, Indian rorippa herb, barbed skullcap herb, oriental stephania roots, herb of geminate speedwell, Silene conoidea and rhizome of whorledleaf solomonseal. The traditional Chinese medicine has the benefits of definite curative effect on liver-kidney yin deficiency type dizziness, high pertinence, fast effect, little toxic and side effects and low relapse rate.

Description

A kind ofly treat the dizzy Chinese medicine of liver-kidney yin deficiency and preparation method

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to and a kind ofly treating the dizzy Chinese medicine of liver-kidney yin deficiency and preparation method.

Background technology

Dizzy be human body to the orientation of spatial relationship or para equilibrium, be a kind of self or outdoor scene illusion of movement or hallucination.During outbreak, most of patients sensation surrounding is in rotation, and swinging depending on thing or rocking (his innervation is dizzy) appears in small number of patients; Also can have from rotating, toppling over, rise and fall or rocking in certain plane (from dynamic dizzy).Can be divided into patients with vestibular system vertigo (true vertigo) and non-patients with vestibular system vertigo (giddy) clinically, the cause of disease is more complicated.

The traditional Chinese medical science is thought, dizzyly can be caused by wind, expectorant, void, therefore has the saying such as " calm do not do dizzy ", " dizziness must be caused by phlegm ", " dizziness must be due to deficiency ".Dizzyly refer to blurring of vision or dark and dim eyesight; Swoon and refer to self-induction health or external scene rotary oscillation, astasia.The two often occurs simultaneously, therefore is referred to as dizzy.Slight dizzy person closes order and namely stops.The dizzy person of severe as boat by bus, or with nausea and vomiting, nervously to perspire, even limbs deflection is for the symptom such as falling.Dizzy is the common a kind of symptom of middle-aged and elderly people.It can be caused by the various diseases in modern medicine, as Menieres disease, vestibulum auris internae and lost infection, vestibulum auris internae neuritis, hypertension, hypotension, anemia, diabetes, leukopenia, cerebral arteriosclerosis, neurosis etc.

At present, be usually used in the dizzy medicine for the treatment of and mainly contain the medicines such as phenothiazines, antihistaminic class, hyoscyami class, ubiquity can not symptomatic treatment, and effective percentage is low, and take effect slow, side effect is many, easily the shortcoming such as recurrence.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind ofly to treat the dizzy Chinese medicine of liver-kidney yin deficiency and preparation method, and Chinese medicine of the present invention has definite curative effect to liver-kidney yin deficiency is dizzy, with strong points, instant effect, toxic and side effects are little and relapse rate is low.

In order to solve the problems of the technologies described above, the invention provides and a kind ofly treat the dizzy Chinese medicine of liver-kidney yin deficiency, each raw medicinal material of described Chinese medicine comprises: Radix cocculi laurifolii, semen juglandis, Flos Camelliae Japonicae, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Osmundae, Japanese pagodatree leaf, Lignum Poria, Herba Lysimachiae Insignis, Semen astragali sinici, Herba Phyllanthi Urinariae, the Radix Stemonae, Folium Ligustri pubescentis, Herba Rorippae, Herba Scutellariae Barbatae, Radix Stephaniae Cepharanthae, Herba veronicae, Herba Silenes conoideae and Rhizoma Polygonati Verticillati.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix cocculi laurifolii 15 ~ 25 parts, semen juglandis 20 ~ 30 parts, Flos Camelliae Japonicae 8 ~ 18 parts, Radix et Rhizoma Dispori Cantoniensis 10 ~ 20 parts, Rhizoma Osmundae 5 ~ 15 parts, Japanese pagodatree leaf 20 ~ 30 parts, Lignum Poria 16 ~ 26 parts, Herba Lysimachiae Insignis 10 ~ 20 parts, Semen astragali sinici 20 ~ 30 parts, Herba Phyllanthi Urinariae 15 ~ 25 parts, the Radix Stemonae 6 ~ 16 parts, Folium Ligustri pubescentis 23 ~ 33 Fen, Herba Rorippae 14 ~ 24 parts, Herba Scutellariae Barbatae 10 ~ 20 parts, Radix Stephaniae Cepharanthae 30 ~ 40 parts, Herba veronicae 10 ~ 20 parts, Herba Silenes conoideae 23 ~ 33 parts and Rhizoma Polygonati Verticillati 15 ~ 25 parts

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix cocculi laurifolii 17 ~ 22 parts, semen juglandis 20 ~ 25 parts, Flos Camelliae Japonicae 10 ~ 15 parts, Radix et Rhizoma Dispori Cantoniensis 12 ~ 17 parts, Rhizoma Osmundae 8 ~ 13 parts, Japanese pagodatree leaf 23 ~ 28 parts, Lignum Poria 19 ~ 24 parts, Herba Lysimachiae Insignis 13 ~ 18 parts, Semen astragali sinici 22 ~ 27 parts, Herba Phyllanthi Urinariae 15 ~ 20 parts, the Radix Stemonae 8 ~ 13 parts, Folium Ligustri pubescentis 26 ~ 31 Fen, Herba Rorippae 17 ~ 22 parts, Herba Scutellariae Barbatae 11 ~ 16 parts, Radix Stephaniae Cepharanthae 32 ~ 37 parts, Herba veronicae 15 ~ 20 parts, Herba Silenes conoideae 25 ~ 30 parts and Rhizoma Polygonati Verticillati 18 ~ 23 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix cocculi laurifolii 20 parts, semen juglandis 22 parts, Flos Camelliae Japonicae 14 parts, Radix et Rhizoma Dispori Cantoniensis 13 parts, Rhizoma Osmundae 12 parts, Japanese pagodatree leaf 24 parts, Lignum Poria 22 parts, Herba Lysimachiae Insignis 15 parts, Semen astragali sinici 26 parts, Herba Phyllanthi Urinariae 17 parts, the Radix Stemonae 12 parts, Folium Ligustri pubescentis 28 Fen, Herba Rorippae 20 parts, Herba Scutellariae Barbatae 12 parts, Radix Stephaniae Cepharanthae 35 parts, Herba veronicae 15 parts, Herba Silenes conoideae 30 parts and Rhizoma Polygonati Verticillati 19 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix cocculi laurifolii 18 parts, semen juglandis 24 parts, Flos Camelliae Japonicae 12 parts, Radix et Rhizoma Dispori Cantoniensis 16 parts, Rhizoma Osmundae 10 parts, Japanese pagodatree leaf 27 parts, Lignum Poria 20 parts, Herba Lysimachiae Insignis 16 parts, Semen astragali sinici 24 parts, Herba Phyllanthi Urinariae 20 parts, the Radix Stemonae 9 parts, Folium Ligustri pubescentis 30 Fen, Herba Rorippae 18 parts, Herba Scutellariae Barbatae 15 parts, Radix Stephaniae Cepharanthae 33 parts, Herba veronicae 18 parts, Herba Silenes conoideae 28 parts and Rhizoma Polygonati Verticillati 22 parts.

Wherein, when the dosage form of described Chinese medicine is for during containing tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion Radix cocculi laurifolii, semen juglandis, Flos Camelliae Japonicae, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Osmundae and Japanese pagodatree leaf, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Lignum Poria, Herba Lysimachiae Insignis, Semen astragali sinici, Herba Phyllanthi Urinariae, the Radix Stemonae and Folium Ligustri pubescentis are mixed in proportion, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water soaking 3-8 hour of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water soaking 3-8 hour of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

Wherein, when the dosage form of described Chinese medicine is glucose injection, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to liver-kidney yin deficiency is dizzy, with strong points, instant effect, toxic and side effects are little and relapse rate is low.

Detailed description of the invention

The invention provides and a kind ofly treat the dizzy Chinese medicine of liver-kidney yin deficiency, its raw medicinal material comprises: Radix cocculi laurifolii, semen juglandis, Flos Camelliae Japonicae, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Osmundae, Japanese pagodatree leaf, Lignum Poria, Herba Lysimachiae Insignis, Semen astragali sinici, Herba Phyllanthi Urinariae, the Radix Stemonae, Folium Ligustri pubescentis, Herba Rorippae, Herba Scutellariae Barbatae, Radix Stephaniae Cepharanthae, Herba veronicae, Herba Silenes conoideae and Rhizoma Polygonati Verticillati.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Radix cocculi laurifolii: [another name] Radix Inulae, Niu Muxiang, JINSUOSHI, purple back of the body JINSUOSHI, Radix Ilicis Asprellae potato, cocculi, brill Lignum Poria, Caulis Cocculi Trilobi, Lignum Aquilariae Resinatum, silver-colored key, plate south root, white mountain sweet potato, Jasminum nervosum Lour, Radix Cocculi Orbiculati, circle rattan root, Cardiospermum halicacabum, Rhizoma Dioscoreae Nipponicae, Pan Gufeng, oolong, large Radix Stephaniae Tetrandrae, Lantian Radix Stephaniae Tetrandrae.[source] medical material Ji Yuan: be the root of menispermaceous plants Radix cocculi laurifolii and hair Radix cocculi laurifolii.Latin plant animal mineral name: Cocculus orbiculatus (L.) DC.[nature and flavor] are bitter; Pungent; Cold.[return through] bladder; Kidney; Spleen; Lung meridian.[function cures mainly] expelling wind and removing dampness; Dredge the meridian passage; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Edema; Urine leaching pain; Amenorrhea; Traumatic injury; Laryngopharynx swelling and pain; Sore swollen toxin; Eczema; Venom.[extracts] " China's book on Chinese herbal medicine "

Semen juglandis: [another name] Rana limnocharis, the Semen Juglandis stalks of rice, wheat, etc., Semen Juglandis, Semen Juglandis.[source] medical material Ji Yuan: be the kernel of juglandaceae plant Semen Juglandis.Latin plant animal mineral name: Juglans regia L. [J.orientis Dode; J.sinensis (C.DC.) Dode].[nature and flavor] are sweet; Puckery; Warm in nature.[return through] kidney; Liver; Lung meridian.[function cures mainly] tonifying the kidney to consolidate the essence; Warming the lung Dingchuan; Loosening bowel to relieve constipation.Main lumbago flaccidity of the lower limbs; Frequent micturition; The enuresis; Sexual impotence; Seminal emission; Chronic cough dyspnea with rapid and short breath; Dryness of the intestine constipation; Stranguria caused by urinary stone and skin infection scrofula.[extracts] " China's book on Chinese herbal medicine "

Flos Camelliae Japonicae: [another name] Man Yangluo tree, mound Flos Camelliae Japonicae, black tea flower, mound flower, twist with the fingers red, the resistance to winter.[source] medical material Ji Yuan: be the flower of plant of theaceae Flos Camelliae Japonicae.Latin plant animal mineral name: Camellia japonica L.[nature and flavor] are sweet; Bitter; Pungent; Puckery; Cool.[return through] liver; Lung meridian.[function cures mainly] cooling blood for hemostasis; Dissipating blood stasis; Repercussive swells.Main haematemesis; Epistaxis; Hemoptysis; Have blood in stool; Hemorrhoidal bleeding; Red dysentery; Stranguria with blood; Metrorrhagia; Leukorrhagia; Scald; Injury from falling down.[extracts] " China's book on Chinese herbal medicine "

Radix et Rhizoma Dispori Cantoniensis: [another name] Radix Alangii, Folium Bambusae seven, Radix chloranthi japonici, Hystrix hodgsoni seven, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Panacis Japonici, Rhizoma Tupistrae Chinensis, Rhizoma dispori flaventis, Bletilla striata (Thunb.ex A.Murray)Rchb.f. medicine, bamboo root, bamboo are loose, Rhizoma Polygonati Cirrhifolii, Radix Streptopi Simplicis, the umbrella of falling bamboo.[source] medical material Ji Yuan: be the root and rhizome of liliaceous plant cantonese fairy bells.[nature and flavor] bitter in the mouth; Pungent; Cool in nature.[function cures mainly] wind-damp dispelling; Relaxing muscles and tendons to promote blood circulation; Heat clearing away expelling phlegm for arresting cough.Main air arthralgia chiefly caused by damp pathogen is demonstrate,proved; Joint lumbago and skelalgia; Traumatic injury; Fracture; Asthenia; Osteopyrexia and fever; Pulmonary tuberculosis is spat blood; Cough due to lung-heat; Burn and scald.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Osmundae: [another name] only Luo, pass through joint, pass through canal, hundred, tiger volume, the flat membrane inside the rush stalk, pass through, pass through in, canal is female, pass through clock, uncle celery, medicine canal, bronze bell, primary duckweed, happy algae, careless Caput Circi cyanei, primary medicine, medicine algae, Herba Pteridis Multifidae, Herba pteridii latiusculi common vetch dish root, cyrtomium fortunei, Herba potentillae fulgentis, bracken cyrtomium fortunei.[source] medical material Ji Yuan: be rhizome and the petiole residual base of Dryopteridaceae plant dryopteris crassirhizoma.[nature and flavor] are bitter; Puckery; Be slightly cold; Slightly poisonous.[return through] liver; Stomach warp.[function cures mainly] parasite killing; Heat clearing away; Removing toxic substances; Cooling blood for hemostasis.Main anemopyretic cold; Warm skin eruption; Spit blood; Hemoptysis; Epistaxis; Have blood in stool; Metrorrhagia; Dysentery; The intestinal parasitic diseases such as leukorrhagia and hook, ascarid, cestode.[extracts] " China's book on Chinese herbal medicine "

Japanese pagodatree leaf: [source] medical material Ji Yuan: be the leaf of leguminous plant Chinese scholartree Sphora japonica L..Latin plant animal mineral name: Sphora japonica L.[nature and flavor] bitter in the mouth; Property is put down.[return through] liver; Stomach warp.[function cures mainly] purging liver-fire; Removing pathogenic heat from blood and toxic substance from the body; Removing dampness and killing parasites.Main pediatric epilepsy scared; High fever; Hemorrhoidal hamorrhage; Hematuria; Hemorrhoid; Eczema; Scabies; Carbuncle skin ulcer furuncle swells.[extracts] " China's book on Chinese herbal medicine "

Lignum Poria: [another name] yellow pine joint, Lignum Pini Nodi, Fu Shenxin, Poria cum Radix Pini's heart wood, poria wood.[source] medical material Ji Yuan: be the Radix Pini massonianae in the middle of On Polyporaceae poria cocos sclerotium.Latin plant animal mineral name: Poria cocos (Schw.) Wolf. [Pavhyma cocos Fr.].[nature and flavor] are sweet; Property is put down.[return through] liver; Heart channel.[function cures mainly] suppressing the hyperactive liver is calmed the nerves.Main palpitation with fear is forgetful; Apoplexy language is not smoothgoing; Beriberi is had a cramp.[extracts] " China's book on Chinese herbal medicine "

Herba Lysimachiae Insignis: [another name] Herba Oxalidis Griffithii, SANYE Herba Phyllanthi Urinariae, three leaves, joint GUFENG, separate poisonous weeds, traumatic injury Mus.[source] medical material Ji Yuan: be herb or the root of Ofthe Primulaceae SANYE Rhizoma et radix valerianae.Latin plant animal mineral name: Radix et Herba Lysimachiae Insignis.[nature and flavor] are pungent; Bitter; Warm in nature.[function cures mainly] dispelling wind and removing obstruction in the collateral; Promoting flow of QI and blood.Main air pain of dampness syndrome; Epigastric pain; Treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Semen astragali sinici: [another name] Fructus Tribuli, careless Fructus Tribuli.[source] medical material Ji Yuan: be the seed of leguminous plant Herba Astragali Melilotoidis (Herba Astragali Sinici).Latin plant animal mineral name: Astragalus sinicus L.[nature and flavor] are pungent; Cool.[return through] Liver Channel.[function cures mainly] dispelling pathogenic wind for improving eyesight.Main conjunctival congestion and swelling pain.[extracts] " China's book on Chinese herbal medicine "

Herba Phyllanthi Urinariae: [another name] star show grass, Pilus Caprae seu Ovis are careless.[source] medical material Ji Yuan: be the herb of pinkwort Herba Phyllanthi Urinariae.Latin plant animal mineral name: Sagina saginoides (L.) Karsten [Sper-gula saginoides L. ".[nature and flavor] are light; Property is put down.[function cures mainly] endogenous wind stopping relieving convulsion; Clearing away heat-damp and promoting diuresis.Main tetanus; Jaundice.[extracts] " China's book on Chinese herbal medicine "

The Radix Stemonae: [another name] Radix Stemonae, white also, beautiful vertical bamboo flute, arrow shaft, medicine of coughing, Radix Stemonae, wild Radix Asparagi, hundred milk, the nine clumps of roots, nine worm roots, a brood of tiger, 99 roots, hundred, mountain, cattle lice ghost, medicine louse medicine.[source] medical material Ji Yuan: be the root of Stemonaceae plant Radix Stemonae, Radix stemonae japonicae and radix stemonae tuberosae.[nature and flavor] are sweet; Bitter; Tepor.[return through] lung meridian.[function cures mainly] nourishing the lung to arrest cough; Parasite killing delousing.Main new chronic cough is coughed; Pulmonary tuberculosis; Pertussis; Enterobiasis; Body louse; Tinea scabies.[extracts] " China's book on Chinese herbal medicine "

Folium Ligustri pubescentis: [another name] little white beeswax, bitterness are loose, Folium Ilicis.[source] medical material Ji Yuan: be the leaf of Oleaceae plants Ligustrum japonicum Thunb..Gather and store: annual or multiple, autumn gathers, using fresh herb or dry.[nature and flavor] are bitter; Micro-sweet; Cool in nature.Return Liver Channel.[function cures mainly] clearing away liver-fire; Relieving heat toxin.The main vertigo; Acute catarrhal conjunctivitis; Mouth is lean; Tooth is evil; Innominate toxic swelling; Burn due to hot liquid or fire.[extracts] " China's book on Chinese herbal medicine "

Herba Rorippae: [another name] peppery rice dish, sarson, pool Pueraria lobota dish, Herba Rorippae, Radix Loxostigmatis griffithii, Carnis Gallus domesticus dish, Tian Gecai, Herba Rorippae, wild potherb mustard, wild mustard grass, wild herbs, barbarea, Du Gencai, chervil, spun gold pod.[source] medical material Ji Yuan: be that thing Herba Rorippae and the herb without lobe Han are planted by ten Zi Hua sections.[nature and flavor] acrid in the mouth; Bitter; Slightly warm in nature.[return through] lung; Liver Channel.[function cures mainly] expelling phlegm for arresting cough; Induce sweat cold expelling; Promoting blood circulation and detoxication; Dampness removing jaundice eliminating.Main cough phlegm dyspnea; Cold, fever; Measles is sent out not smooth thoroughly; Rheumatic arthralgia; Laryngopharynx swelling and pain; Furuncle carbuncle; Dermatitis rhus; Amenorrhea; Traumatic injury; Jaundice; Edema.[extracts] " China's book on Chinese herbal medicine "

Herba Scutellariae Barbatae: [another name] narrow leaf Herba Scutellariae indicae, Aleuritopteris argentea (Gmel.) Fee, purple connect grass and head is careless, toothbrush is careless, water Korea Spro letter, small stream limit Radix Scutellariae, Herba Carpesii Divaricati, wild Spica Prunellae, say careless youngster, partly to flower, inclined head grass, Rabdosia stracheyi(Benth.ex Hook.f.)Hara[Plectranthus stracheyi Benth.ex Hook.f., scutllaria indica, small size India skullcap, narrow leaf India skullcap.[source] medical material Ji Yuan: be the herb of labiate Herba Scutellariae Barbatae.[nature and flavor] acrid in the mouth; Bitter; Cold in nature.[return through] returns lung; Liver; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Dissipating blood stasis stops blooding; Inducing diuresis to remove edema.Main pyretic toxicity carbuncle; Have sore throat; Lung abscess; Intestinal carbuncle; Scrofula; Venom; Traumatic injury; Spit blood; Epistaxis; Stranguria with blood; Edema; Ascites and cancer.[extracts] " China's book on Chinese herbal medicine "

Radix Stephaniae Cepharanthae: [another name] BAIYAO, BAIYAO root, Stephania cepharatha Hayata.[source] medical material Ji Yuan: be the tuber of menispermaceous plants Radix Stephaniae Cepharanthae.[nature and flavor] toil; Cool; Mild toxicity.[return through] spleen; Lung; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Wind-expelling pain-stopping; Cooling blood for hemostasis.Main laryngopharynx swelling and pain; Pyretic toxicity carbuncle; Rheumatic arthralgia; Stomachache; Dysentery; Spit blood; Epistaxis; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Herba veronicae: [another name] Canis familiaris L. ovum grass, two pearl grass, two copper hammer, Herba Microtis taiwanianae, ovum grass, stone patch, dish kidney, Jiang Juncao, Herba veronicae arvensis.[source] medical material Ji Yuan: be the herb of goatweed Herba veronicae.Latin plant animal mineral name: Veronica didyma Tenore.[nature and flavor] sweet in the mouth; Light; Cool in nature.[return through] returns liver; Kidney channel.[function cures mainly] replenishing kidney, strengthening waist; Removing toxic substances and promoting subsidence of swelling.Main lumbago due to renal deficiency; Hernia; Painful and swollen testis; Women leucorrhea; Carbuncle.[extracts] " China's book on Chinese herbal medicine "

Herba Silenes conoideae: [another name] Coelogyne barbata Eriff., incense burner grass, rice crock, Flos Mume bottle, noodles dish, Pericarpium Citri Reticulatae dish, wooden dipper are chewed, Radix Betae, wheat Punica granatum L., oil bottle dish, Radix Rumicis Japonici, red not English dish, Hu Ping Cai, wheat dishes made from scrambled eggs, Fructus Seu Herba Pubescentis; Physalis minima L.; Bottle & Can flower.[source] medical material Ji Yuan: be the herb of pinkwort Herba Silenes conoideae.[nature and flavor] are sweet; Micro-hardship; Cool in nature.[return through] heart; Liver Channel.[function cures mainly] yin nourishing; Heat clearing away; Blood-arresting catamenia-regulating.Main haematemesis; Epistaxis; Chronic consumptive disease is coughed; Spitting of blood; Hematuria; Menoxenia.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Polygonati Verticillati: [another name] smelly youngster ginseng, hang.[source] medical material Ji Yuan: be the rhizome of liliaceous plant P. veriicillatum and Xinjiang Rhizoma Polygonati.[nature and flavor] are sweet; Micro-hardship; Cool.[function cures mainly] spleen reinforcing lung moistening; Nourishing the liver; Removing toxicity for eliminating carbuncles.Main weakness of the spleen and stomach; Lung-dryness syndrome due to deficiency of YIN; Cough dry pharynx; Excessive rising of liver-YANG; Have a dizzy spell; Sore, carbuncle and painful swelling.[extracts] " China's book on Chinese herbal medicine "

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix cocculi laurifolii 15 ~ 25 parts, semen juglandis 20 ~ 30 parts, Flos Camelliae Japonicae 8 ~ 18 parts, Radix et Rhizoma Dispori Cantoniensis 10 ~ 20 parts, Rhizoma Osmundae 5 ~ 15 parts, Japanese pagodatree leaf 20 ~ 30 parts, Lignum Poria 16 ~ 26 parts, Herba Lysimachiae Insignis 10 ~ 20 parts, Semen astragali sinici 20 ~ 30 parts, Herba Phyllanthi Urinariae 15 ~ 25 parts, the Radix Stemonae 6 ~ 16 parts, Folium Ligustri pubescentis 23 ~ 33 Fen, Herba Rorippae 14 ~ 24 parts, Herba Scutellariae Barbatae 10 ~ 20 parts, Radix Stephaniae Cepharanthae 30 ~ 40 parts, Herba veronicae 10 ~ 20 parts, Herba Silenes conoideae 23 ~ 33 parts and Rhizoma Polygonati Verticillati 15 ~ 25 parts

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix cocculi laurifolii 17 ~ 22 parts, semen juglandis 20 ~ 25 parts, Flos Camelliae Japonicae 10 ~ 15 parts, Radix et Rhizoma Dispori Cantoniensis 12 ~ 17 parts, Rhizoma Osmundae 8 ~ 13 parts, Japanese pagodatree leaf 23 ~ 28 parts, Lignum Poria 19 ~ 24 parts, Herba Lysimachiae Insignis 13 ~ 18 parts, Semen astragali sinici 22 ~ 27 parts, Herba Phyllanthi Urinariae 15 ~ 20 parts, the Radix Stemonae 8 ~ 13 parts, Folium Ligustri pubescentis 26 ~ 31 Fen, Herba Rorippae 17 ~ 22 parts, Herba Scutellariae Barbatae 11 ~ 16 parts, Radix Stephaniae Cepharanthae 32 ~ 37 parts, Herba veronicae 15 ~ 20 parts, Herba Silenes conoideae 25 ~ 30 parts and Rhizoma Polygonati Verticillati 18 ~ 23 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix cocculi laurifolii 20 parts, semen juglandis 22 parts, Flos Camelliae Japonicae 14 parts, Radix et Rhizoma Dispori Cantoniensis 13 parts, Rhizoma Osmundae 12 parts, Japanese pagodatree leaf 24 parts, Lignum Poria 22 parts, Herba Lysimachiae Insignis 15 parts, Semen astragali sinici 26 parts, Herba Phyllanthi Urinariae 17 parts, the Radix Stemonae 12 parts, Folium Ligustri pubescentis 28 Fen, Herba Rorippae 20 parts, Herba Scutellariae Barbatae 12 parts, Radix Stephaniae Cepharanthae 35 parts, Herba veronicae 15 parts, Herba Silenes conoideae 30 parts and Rhizoma Polygonati Verticillati 19 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix cocculi laurifolii 18 parts, semen juglandis 24 parts, Flos Camelliae Japonicae 12 parts, Radix et Rhizoma Dispori Cantoniensis 16 parts, Rhizoma Osmundae 10 parts, Japanese pagodatree leaf 27 parts, Lignum Poria 20 parts, Herba Lysimachiae Insignis 16 parts, Semen astragali sinici 24 parts, Herba Phyllanthi Urinariae 20 parts, the Radix Stemonae 9 parts, Folium Ligustri pubescentis 30 Fen, Herba Rorippae 18 parts, Herba Scutellariae Barbatae 15 parts, Radix Stephaniae Cepharanthae 33 parts, Herba veronicae 18 parts, Herba Silenes conoideae 28 parts and Rhizoma Polygonati Verticillati 22 parts.

Wherein, when the dosage form of described Chinese medicine is for during containing tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion Radix cocculi laurifolii, semen juglandis, Flos Camelliae Japonicae, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Osmundae and Japanese pagodatree leaf, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Lignum Poria, Herba Lysimachiae Insignis, Semen astragali sinici, Herba Phyllanthi Urinariae, the Radix Stemonae and Folium Ligustri pubescentis are mixed in proportion, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water soaking 3-8 hour of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water soaking 3-8 hour of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

Wherein, when the dosage form of described Chinese medicine is glucose injection, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: containing tablet

Get Radix cocculi laurifolii 180g, semen juglandis 240g, Flos Camelliae Japonicae 120g, Radix et Rhizoma Dispori Cantoniensis 160g, Rhizoma Osmundae 100g, Japanese pagodatree leaf 270g, Lignum Poria 200g, Herba Lysimachiae Insignis 160g, Semen astragali sinici 240g, Herba Phyllanthi Urinariae 200g, Radix Stemonae 90g, Folium Ligustri pubescentis 300g, Herba Rorippae 180g, Herba Scutellariae Barbatae 150g, Radix Stephaniae Cepharanthae 330g, Herba veronicae 180g, Herba Silenes conoideae 280g and Rhizoma Polygonati Verticillati 220g;

Its preparation method comprises the following steps:

The first step, is mixed in proportion Radix cocculi laurifolii, semen juglandis, Flos Camelliae Japonicae, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Osmundae and Japanese pagodatree leaf, and with the dissolve with ethanol of the determining alcohol 90%% of 5 times relative to the mixture quality obtained, reflux was extracted after 3 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 90% of 3 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.1g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Lignum Poria, Herba Lysimachiae Insignis, Semen astragali sinici, Herba Phyllanthi Urinariae, the Radix Stemonae and Folium Ligustri pubescentis are mixed in proportion, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 95% of 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water soaking of 3 times 6 hours relative to the mixture quality obtained, and heating decoction 2 hours, filters; By filtering residue again with the water soaking of 2 times 4 hours relative to the mixture quality obtained, heating decoction 1 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.1 times, the microcrystalline Cellulose of 0.08 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.03 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

Embodiment 2: glucose injection

Get Radix cocculi laurifolii 200g, semen juglandis 220g, Flos Camelliae Japonicae 140g, Radix et Rhizoma Dispori Cantoniensis 130g, Rhizoma Osmundae 120g, Japanese pagodatree leaf 240g, Lignum Poria 220g, Herba Lysimachiae Insignis 150g, Semen astragali sinici 260g, Herba Phyllanthi Urinariae 170g, Radix Stemonae 120g, Folium Ligustri pubescentis 280g, Herba Rorippae 200g, Herba Scutellariae Barbatae 120g, Radix Stephaniae Cepharanthae 350g, Herba veronicae 150g, Herba Silenes conoideae 300g and Rhizoma Polygonati Verticillati 190g;

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 4 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 7 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 0.5 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 35g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.2g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.22 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Toxicity test:

Acute toxicity testing: application mice 70, male and female half and half, body weight 20 ~ 28g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, fasting 12 hours before experiment, the Traditional Chinese medicine lozenge agent prepared by embodiments of the invention 1 is dissolved in water, (concentration is 7.30g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.5 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage is of the present invention containing tablet LD50>36.5 crude drug/kg, and every day, maximum dosage-feeding was 73.0 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.107g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 24g) oral administration gavage Chinese medicine of the present invention is 682 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 of the present invention presses 13.12,19.03 and 37.45g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight containing tablet to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 100 routine cases are my Out-patient Department or inpatient, male 46 people, women 54 people, 22 ~ 63 years old age.Wherein, Menieres disease 18 example, vestibulum auris internae neuritis 14 example, hypertension 25 example, hypotension 14 example, arteriosclerosis 6 example, cerebroma 5 example, cerebral thrombosis 9 example and anemia 9 example is accompanied.Be divided into treatment group and matched group at random, wherein treatment group 50 people, male 22 people, women 28 people, 24 ~ 62 years old age; Wherein, Menieres disease 9 example, vestibulum auris internae neuritis 7 example, hypertension 13 example, hypotension 7 example, arteriosclerosis 3 example, cerebroma 2 example, cerebral thrombosis 4 example and anemia 5 example is accompanied.Matched group 50 people, male 24 people, women 26 people, 22 ~ 63 years old age; Wherein, Menieres disease 9 example, vestibulum auris internae neuritis 7 example, hypertension 12 example, hypotension 7 example, arteriosclerosis 3 example, cerebroma 3 example, cerebral thrombosis 5 example and anemia 4 example is accompanied.Two groups of ages, sex, the course of disease, diseased region, clinical manifestation and equal not statistically significants of coincident with severity degree of condition comparing difference (p>0.05).

Diagnostic criteria:

The diagnosis of all patients meets diagnostic criteria dizzy in doctor trained in Western medicine " neurological ", determine diagnostic criteria with reference to State Administration of Traditional Chinese Medicine's " disease of tcm Standardization of diagnosis and curative effect ": 1, have a dizzy spell, rotate depending on thing, the lighter closes order and namely stops simultaneously, severe one, as ship by bus, very then holds down; 2, nausea and vomiting can be accompanied, nystagmus, Hiccough and deaf, sweating, pale complexion etc.; 3, chronic onset increases the weight of gradually, or Acute onset, or recurrent exerbation; 4, measuring blood pressure, pigment of having a blood test, red blood cell count(RBC), electric audiometry, brainstem evoked potential, sheet taken the photograph by electronystagmogram and cervical vertebra x line, and all patients all check through the necessity such as electrocardiogram, CT, MRI; 5, should note getting rid of tumor, serious blood disease and increased intracranial pressure disease etc.

Syndrome Differentiation of Traditional Chinese Medicine standard: liver-kidney yin deficiency: main symptom: dizzy, very inviolent, brains sky is dizzy.Accompanied symptoms: tinnitus, soreness of the waist and knees, irritable, dysphoria with feverish sensation in the chest palms and soles, hectic fever sweating, menoxenia; Red tongue, the few or no fur of tongue, thready and rapid pulse.

Therapeutic Method:

Treatment group: give the embodiment of the present invention 1 containing tablet every day 3 times, each 31 week was 1 course for the treatment of, took 2 courses for the treatment of continuously;

Matched group: oral QIJU DIHUANG WAN (Tongrentang) big honeyed pills 1 ball, 2 times on the one, 7 days was 1 course for the treatment of, was used in conjunction 2 courses for the treatment of.

Curative effect judging standard: with reference to State Administration of Traditional Chinese Medicine " Chinese medical disease Standardization of diagnosis and curative effect ".Recovery from illness: vertigo symptoms and relevant sign disappear, and auxiliary examination is normal, follows up a case by regular visits to and does not recur for 1 year; Take a turn for the better: vertigo symptoms is obviously alleviated, and auxiliary examination is improved, and follows up a case by regular visits to and has slight onset of vertigo half a year; Invalid: vertigo symptoms is without improvement, and auxiliary examination is without improvement.

Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result is see table 1 and table 2.As can be seen from Table 1, adopt treatment by Chinese herbs liver-kidney yin deficiency of the present invention dizzy, relative to matched group on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs liver-kidney yin deficiency of the present invention dizzy, relative to matched group, treatment the course for the treatment of on significantly shorten.

A table 1 liang group treats two groups of comparitive study (example) after 2 weeks respectively:

Group	n	Recovery from illness	Take a turn for the better	Invalid	Effectively total
						Treatment group	50	32(64％)	16(32％)	2(4％)	48(96％)
Matched group	50	21(42％)	21(42％)	8(16％)	42(84％)

Number and cure rate comparative example (%) is cured stage by stage after a table 2 liang group treats 2 weeks respectively

Group	Treat 5 days	Treat 10 days	Treat 14 days
				Treatment group (cure rate)	6(12％)	26(52％)	32(64％)
Matched group (cure rate)	2(4％)	16(32％)	21(42％)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect and the advantage that not easily recurs.

Concrete case: high mountain, male, 58 years old.Because of dizzy, tinnitus is admitted to hospital, and through various inspections such as CT, is diagnosed as dizzy.According to traditional Chinese medical science classical symptom: dizzy, very inviolent, brains sky is dizzy.Tinnitus, soreness of the waist and knees, irritable, dysphoria with feverish sensation in the chest palms and soles, hectic fever sweating, red tongue, no fur, thready and rapid pulse, is diagnosed as liver-kidney yin deficiency dizzy further.Give Chinese medicine embodiment of the present invention 1 containing tablet every day 3 times, each 3, treat after 12 days, vertigo symptoms and relevant sign disappear, and follow up a case by regular visits to and do not recur for 1 year, fully recover.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat the dizzy Chinese medicine of liver-kidney yin deficiency for one kind, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Radix cocculi laurifolii, semen juglandis, Flos Camelliae Japonicae, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Osmundae, Japanese pagodatree leaf, Lignum Poria, Herba Lysimachiae Insignis, Semen astragali sinici, Herba Phyllanthi Urinariae, the Radix Stemonae, Folium Ligustri pubescentis, Herba Rorippae, Herba Scutellariae Barbatae, Radix Stephaniae Cepharanthae, Herba veronicae, Herba Silenes conoideae and Rhizoma Polygonati Verticillati.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix cocculi laurifolii 15 ~ 25 parts, semen juglandis 20 ~ 30 parts, Flos Camelliae Japonicae 8 ~ 18 parts, Radix et Rhizoma Dispori Cantoniensis 10 ~ 20 parts, Rhizoma Osmundae 5 ~ 15 parts, Japanese pagodatree leaf 20 ~ 30 parts, Lignum Poria 16 ~ 26 parts, Herba Lysimachiae Insignis 10 ~ 20 parts, Semen astragali sinici 20 ~ 30 parts, Herba Phyllanthi Urinariae 15 ~ 25 parts, the Radix Stemonae 6 ~ 16 parts, Folium Ligustri pubescentis 23 ~ 33 parts, Herba Rorippae 14 ~ 24 parts, Herba Scutellariae Barbatae 10 ~ 20 parts, Radix Stephaniae Cepharanthae 30 ~ 40 parts, Herba veronicae 10 ~ 20 parts, Herba Silenes conoideae 23 ~ 33 parts and Rhizoma Polygonati Verticillati 15 ~ 25 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix cocculi laurifolii 17 ~ 22 parts, semen juglandis 20 ~ 25 parts, Flos Camelliae Japonicae 10 ~ 15 parts, Radix et Rhizoma Dispori Cantoniensis 12 ~ 17 parts, Rhizoma Osmundae 8 ~ 13 parts, Japanese pagodatree leaf 23 ~ 28 parts, Lignum Poria 19 ~ 24 parts, Herba Lysimachiae Insignis 13 ~ 18 parts, Semen astragali sinici 22 ~ 27 parts, Herba Phyllanthi Urinariae 15 ~ 20 parts, the Radix Stemonae 8 ~ 13 parts, Folium Ligustri pubescentis 26 ~ 31 parts, Herba Rorippae 17 ~ 22 parts, Herba Scutellariae Barbatae 11 ~ 16 parts, Radix Stephaniae Cepharanthae 32 ~ 37 parts, Herba veronicae 15 ~ 20 parts, Herba Silenes conoideae 25 ~ 30 parts and Rhizoma Polygonati Verticillati 18 ~ 23 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix cocculi laurifolii 20 parts, semen juglandis 22 parts, Flos Camelliae Japonicae 14 parts, Radix et Rhizoma Dispori Cantoniensis 13 parts, Rhizoma Osmundae 12 parts, Japanese pagodatree leaf 24 parts, Lignum Poria 22 parts, Herba Lysimachiae Insignis 15 parts, Semen astragali sinici 26 parts, Herba Phyllanthi Urinariae 17 parts, the Radix Stemonae 12 parts, Folium Ligustri pubescentis 28 Fen, Herba Rorippae 20 parts, Herba Scutellariae Barbatae 12 parts, Radix Stephaniae Cepharanthae 35 parts, Herba veronicae 15 parts, Herba Silenes conoideae 30 parts and Rhizoma Polygonati Verticillati 19 parts.

5. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix cocculi laurifolii 18 parts, semen juglandis 24 parts, Flos Camelliae Japonicae 12 parts, Radix et Rhizoma Dispori Cantoniensis 16 parts, Rhizoma Osmundae 10 parts, Japanese pagodatree leaf 27 parts, Lignum Poria 20 parts, Herba Lysimachiae Insignis 16 parts, Semen astragali sinici 24 parts, Herba Phyllanthi Urinariae 20 parts, the Radix Stemonae 9 parts, Folium Ligustri pubescentis 30 Fen, Herba Rorippae 18 parts, Herba Scutellariae Barbatae 15 parts, Radix Stephaniae Cepharanthae 33 parts, Herba veronicae 18 parts, Herba Silenes conoideae 28 parts and Rhizoma Polygonati Verticillati 22 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion Radix cocculi laurifolii, semen juglandis, Flos Camelliae Japonicae, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Osmundae and Japanese pagodatree leaf, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Lignum Poria, Herba Lysimachiae Insignis, Semen astragali sinici, Herba Phyllanthi Urinariae, the Radix Stemonae and Folium Ligustri pubescentis are mixed in proportion, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water soaking 3-8 hour of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water soaking 3-8 hour of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is glucose injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion Radix cocculi laurifolii, semen juglandis, Flos Camelliae Japonicae, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Osmundae and Japanese pagodatree leaf, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Lignum Poria, Herba Lysimachiae Insignis, Semen astragali sinici, Herba Phyllanthi Urinariae, the Radix Stemonae and Folium Ligustri pubescentis are mixed in proportion, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water soaking 3-8 hour of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water soaking 3-8 hour of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is glucose injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.