CN104784422A - Heat-clearing and toxicity-removing agent for treating rectal cancer - Google Patents

Abstract

The invention discloses a heat-clearing and toxicity-removing agent for treating rectal cancer. The heat-clearing and toxicity-removing agent is mainly prepared from the following raw medicinal materials in parts by mass: 10-15 parts of sculellaria barbata, 12-17 parts of scutellaria indica, 9-12 parts of paris polyphylla, 11-14 parts of rainbow conk, 10-15 parts of Chinese actinidia root, 8-14 parts of betel nut, 10-16 parts of fig, 11-17 parts of sweet wormwood, 10-13 parts of air potato, 13-16 parts of pericarpium arecae, 9-12 parts of spina gleditsiae, 12-14 parts of agar and 11-16 parts of phoenix-tail fern. The formula is prepared according to the principle of traditional Chinese medicine and has the effects of clearing away heat and toxic materials, replenishing qi to invigorate the spleen and promoting blood circulation to remove blood stasis, and the prepared product is exact in curative effect and safe to take and can achieve the effects of inhibiting development of focuses of patients suffering from rectal cancer and alleviating toxic and side effects of chemical therapy.

Description

A kind of formula for clearing heat and removing toxicity for the treatment of rectal cancer

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of formula for clearing heat and removing toxicity for the treatment of rectal cancer.

Background technology

Cancer between rectal cancer refers to from pectinate line to proctosigmoid intersection is one of modal malignant tumor of digestive tract.Rectal cancer position is low, is easily diagnosed by rectal touch and romanoscope.But because pelvic cavity is goed deep in its position, anatomy relationship is complicated, operation is not easily thorough, and Postoperative recurrent rate is high.China's rectal cancer age of onset median is at one's mid-40s.Adolescence's sickness rate has the trend of rising.Early rectal tumor majority is asymptomatic, occurs bowl evacuation habit change, hemafecia, bloody purulent stool, tenesmus, constipation, diarrhoea etc. time to a certain extent.Then stool is tapered, and then has late period defecation to block, even cachexia of becoming thin.Occur when invading the surrounding organs such as bladder, urethra, vagina that urinary tract infection symptom, vagina flow out liquid manure, sacrum portion and perineal position pain, lower limbs edema etc.Cancer in situ position is lower, and excrement block is comparatively hard, and cancerous protuberance is subject to the friction of excrement block and easily causes bleeding, and mostly is scarlet or kermesinus, mixed or invest excrement post surface and mistaken diagnosis " hemorrhoid " is hemorrhage with shaping feces.Because focus stimulates and the secondary infection of lump ulcer, constantly cause defecation reflex, be easily misdiagnosed as " bacillary dysentery " or " enteritis ".The growth of cancerous protuberance ring-type causes enteric cavity constriction, and Early manifestation is that excrement post attenuates, and Late manifestations is partial obstruction disease.

Publication No. CN 104083711 A(application number 201410270962.9) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of rectal cancer, raw material form: 10 parts, Semen Persicae, 10 parts, Flos Carthami, Radix Angelicae Sinensis 12 parts, Herba Salviae Chinensis 30 parts, Rhizoma Curcumae 15 parts, Squama Manis 15 parts, Radix Et Rhizoma Rhei 6 parts, Herba Scutellariae Barbatae 30 parts, Herba Hedyotidis Diffusae 30 parts.Publication No. CN 104491078 A(application number 201410718135.1) Chinese patent literature disclose a kind of Chinese medicinal tablet for the treatment of rectal cancer, consist of Herba Hedyotidis Diffusae 30 ~ 40 parts, Radix Angelicae Sinensis 10 ~ 25 parts, the Radix Astragali 20 ~ 40 parts, Herba Dianthi 30 ~ 40 parts, Fructus Caricae 10 ~ 18 parts, 5 ~ 20 parts, Semen Persicae, Ramulus Cinnamomi 15 ~ 25, Rhizoma Corydalis 10 ~ 20, Caulis Sargentodoxae 20 ~ 30, Herba Galii Teneri 10 ~ 25, Semen Platycladi 20 ~ 30 parts, Folium Isatidis 5 ~ 15 parts, 2 ~ 20 parts, Radix Glycyrrhizae, Caulis Akebiae 15 ~ 30 parts.Publication No. CN 104324091 A(application number 201410627817.1) Chinese patent literature disclose a kind of Chinese medicine formula for the treatment of rectal cancer, Herba Salviae Chinensis 10 parts-20 parts, Agkistrodon 10 parts-20 parts, Radix Astagali 10 parts-20 parts, Radix Notoginseng 10 parts-14 parts, Scolopendra 5 parts-15 parts, vine of Flos Lonicerae 4 parts-8 parts, Radix Et Rhizoma Rhei 5 parts-15 parts.

Current, doctor trained in Western medicine based on surgical operation, is aided with the Comprehensive Treatment of chemotherapy, radiotherapy to the treatment of rectal cancer, and these treatment meanss are all larger to human injury.The TCM investigation for the treatment of rectal cancer is still less at present, therefore needs the research strengthening this aspect.

Summary of the invention

For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare the formula for clearing heat and removing toxicity for the treatment of rectal cancer simply, safely and effectively.

Technical scheme of the present invention is:

Treat a formula for clearing heat and removing toxicity for rectal cancer, be prepared from primarily of following bulk drugs, be mass parts: Herba Scutellariae Barbatae 10-15, Herba Scutellariae indicae 12-17, Rhizoma Paridis 9-12, Coriolous Dersicolor (Fr.) Quel 11-14, macaque Radix pyri 10-15, Semen Arecae 8-14, Fructus Fici 10-16, Herba Artemisiae Annuae 11-17, Rhizoma Dioscoreae Bulbiferae 10-13, Pericarpium Arecae 13-16, Spina Gleditsiae 9-12, Eucheuma gelatinosum 12-14, Herba Pteridis Multifidae 11-16.

In preferred scheme, Herba Scutellariae Barbatae 11-14, Herba Scutellariae indicae 13-16, Rhizoma Paridis 10-11, Coriolous Dersicolor (Fr.) Quel 12-13, macaque Radix pyri 11-14, Semen Arecae 10-12, Fructus Fici 12-14, Herba Artemisiae Annuae 13-15, Rhizoma Dioscoreae Bulbiferae 11-12, Pericarpium Arecae 14-15, Spina Gleditsiae 10-11, Eucheuma gelatinosum 12.5-13.5, Herba Pteridis Multifidae 12-15.

Be more preferably, Herba Scutellariae Barbatae 12.5, Herba Scutellariae indicae 14.5, Rhizoma Paridis 10.5, Coriolous Dersicolor (Fr.) Quel 12.5, macaque Radix pyri 12.5, Semen Arecae 11, Fructus Fici 13, Herba Artemisiae Annuae 14, Rhizoma Dioscoreae Bulbiferae 11.5, Pericarpium Arecae 14.5, Spina Gleditsiae 10.5, Eucheuma gelatinosum 13, Herba Pteridis Multifidae 3.5.

Described a kind of formula for clearing heat and removing toxicity for the treatment of rectal cancer, be made into pharmaceutically acceptable decoction, its preparation method is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, Coriolous Dersicolor (Fr.) Quel, macaque Radix pyri, Herba Artemisiae Annuae, Rhizoma Dioscoreae Bulbiferae, Spina Gleditsiae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverize together with step (1) (2) made crude drug, load in penetrating bag, soak 20 minutes, then heat decoction, after big fire boiling, turn little fire decoct 25-35 minute (preferred, turn a little fire and decoct 27-33 minute; Be more preferably, turn little fire and decoct 30 minutes), take out penetrating bag, obtain medicinal liquid;

(4) Fructus Fici is picked clean, pulverize, add in step (3) made medicinal liquid, stir evenly, obtain decoction.

Described a kind of preparation method for the treatment of the formula for clearing heat and removing toxicity decoction of rectal cancer, step (3) amount of water is that doubly (preferred, amount of water is 6.5-7.5 times of total raw material medicine quality to the 6-8 of total raw material medicine quality; Be more preferably, amount of water is 7 times of total raw material medicine quality).

Described a kind of formula for clearing heat and removing toxicity for the treatment of rectal cancer, be made into pharmaceutically acceptable granule, its preparation method is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, macaque Radix pyri, Rhizoma Dioscoreae Bulbiferae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverize together with step (1) made crude drug, load in penetrating bag, the water soaking of totalling crude drug quality 7 times 20 minutes, then heats decoction, after big fire boiling, turn little fire to decoct, take out penetrating bag, obtain medicinal liquid, the penetrating bag that medicated powder is housed is put into non iron container again, add water and again decoct, merge twice and decoct gained medicinal liquid;

(4) Coriolous Dersicolor (Fr.) Quel, Fructus Fici, Herba Artemisiae Annuae and Spina Gleditsiae are picked clean, pulverize together with step (2) made crude drug, make medicated powder, and join in step (3) gained medicinal liquid, mixing, spraying dry, pulverize 140-220 mesh sieve and (preferably, pulverize 160-200 mesh sieve; Be more preferably, pulverized 180 mesh sieves), add starch slurry and sucrose soft material, the wet grain of system, dry, granulate, obtains granule.

Described a kind of preparation method for the treatment of the formula for clearing heat and removing toxicity granule of rectal cancer, step (3) turn little fire decocts 25-35 minute, and (preferred, 27-33 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 30 minutes).

Described a kind of formula for clearing heat and removing toxicity for the treatment of rectal cancer, be made into pharmaceutically acceptable electuary, its preparation method is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, Coriolous Dersicolor (Fr.) Quel, macaque Radix pyri, Fructus Fici, Herba Artemisiae Annuae, Rhizoma Dioscoreae Bulbiferae, Spina Gleditsiae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverize together with step (1) (2) made crude drug, load in penetrating bag, soak 20 minutes, then heat decoction, after big fire boiling, turn little fire decoct 25-35 minute (preferred, turn a little fire and decoct 27-33 minute; Be more preferably, turn little fire and decoct 30 minutes), take out penetrating bag, obtain medicinal liquid, the penetrating bag that medicated powder is housed is put into non iron container again, adds water and again decoct, merge twice and decoct gained medicinal liquid;

(4) by step (3) gained medicinal liquid, concentrate drying, pulverizes, makes powder, obtain electuary.

Described a kind of preparation method for the treatment of the formula for clearing heat and removing toxicity electuary of rectal cancer, step (4) pulverized 200-400 mesh sieve (preferred, to pulverize 300 mesh sieves).

Described a kind of formula for clearing heat and removing toxicity for the treatment of rectal cancer, be made into pharmaceutically acceptable pill, its preparation method is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, Coriolous Dersicolor (Fr.) Quel, macaque Radix pyri, Fructus Fici, Herba Artemisiae Annuae, Rhizoma Dioscoreae Bulbiferae, Spina Gleditsiae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverized 100-160 mesh sieve and (preferably, pulverized 120-140 mesh sieve together with step (1) (2) made crude drug; Be more preferably, pulverized 130 mesh sieves), make medicated powder;

(4) in step (3) made medicated powder, refined honey and water is added, pill block, ball bar, gradation, round, dry, obtain pill.

Described a kind of preparation method for the treatment of the formula for clearing heat and removing toxicity pill of rectal cancer, heavy 0.4-0.6g(is preferred for the every ball of step (4), the heavy 0.5g of every ball).

The Chinese medicinal formulae scientific formula that rectal cancer patient provided by the invention is taken, compatibility is rigorous, and preparation is simple.In addition, excellent results of the present invention also shows:

1, this prescription is according to the development of Chinese medicine principle, has the effects such as heat-clearing and toxic substances removing, replenishing QI to invigorate the spleen, blood circulation promoting and blood stasis dispelling;

2, products made thereby determined curative effect of the present invention, takes safety, can not only suppress the development of rectal cancer patient focus, also can alleviate the toxic and side effects of chemotherapy.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Herba Scutellariae Barbatae: base is former: be the herb of labiate Herba Scutellariae Barbatae.Nature and flavor: pungent are flat.Function cures mainly: heat clearing away, removing toxic substances, dissipating blood stasis, hemostasis, analgesic therapy.Control haematemesis, epistaxis, stranguria with blood, bloody dysentery, jaundice, have sore throat, lung abscess, furuncle, scrofula, sore, cancerous protuberance, traumatic injury knife injury, venom.

Herba Scutellariae indicae: base is former: be the whole herb with root of labiate Herba Scutellariae indicae.Nature and flavor: pungent, bitter are flat.Gui Jing: enter the heart, liver, lung meridian.Function cures mainly: dispel the wind, and invigorates blood circulation, removing toxic substances, pain relieving.Control traumatic injury, spit blood, hemoptysis, carbuncle, furunculosis, acute throat trouble, toothache.

Rhizoma Paridis: base is former: be the rhizome of liliaceous plant China Rhizoma Paridis.Nature and flavor: bitter, cold.Slightly poisonous.Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Epidemic encephalitis type B, stomachache, appendicitis, tuberculous lymphadenitis, tonsillitis, parotitis, mastitis, poisonous snake, insect-bite, sore swollen toxin.

Coriolous Dersicolor (Fr.) Quel: base is former: be the sporophore of On Polyporaceae Corilus versicolor Quel..Nature and flavor: sweet, light, be slightly cold.Gui Jing: liver, spleen, lung meridian.Function cures mainly: invigorating spleen to remove dampness, relieving cough and asthma, heat-clearing and toxic substances removing, antitumor.Main chronic active hepatitis, hepatitis interstitialis chronica, chronic bronchitis, infantile spasm bronchitis, laryngopharynx swelling and pain, kinds of tumors, rheumatoid arthritis, leukemia.

Macaque Radix pyri: base is former: be the root of Actinidiaceae plant Actinidia arguta Sieb.et Zucc.Nature and flavor: light are micro-puckery, flat.Function cures mainly: clearing away heat-damp and promoting diuresis, wind expelling stagnation removing, removing toxic substances and promoting subsidence of swelling, hemostasis.Main jaundice, dyspepsia, vomiting, rheumatic arthralgia, Alimentary Tract Cancer, carbuncle and ulcer furuncle, traumatic injury, traumatic hemorrhage, agalactia.

Semen Arecae: base is former: be the seed of babassu Semen Arecae.Nature and flavor: bitter, pungent, temperature.Gui Jing: return stomach, large intestine channel.Function cures mainly: killing insect and eliminating accumulation, sending down the abnormal ascending QI, row water, preventing the attack (or recurrence) of malaria.For cestode, ascarid, fasciolopsiasis buski, abdominal pain due to worm stagnation, stagnant dysentery, tenesmus, edema beriberi, malaria.

Fructus Fici: base is former: be the dry holder of moraceae plants Fructus Fici.Nature and flavor: sweet are flat.Gui Jing: lung, stomach, large intestine channel.Function cures mainly: invigorating the stomach and promoting bowel movement, subduing swelling and detoxicating.Control enteritis, dysentery, constipation, hemorrhoid, laryngalgia, carbuncle skin ulcer scabies, throat, appetizing anthelmintic.

Herba Artemisiae Annuae: base is former: be the herb of feverfew Herba Artemisiae Annuae or Herba Artemisiae annuae.Nature and flavor: bitter, acrid, cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: clearing away summer-heat, except steaming, and preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.

Rhizoma Dioscoreae Bulbiferae: base is former: be the tuber of Dioscoreaceae plant Dioscorea bulbifera L..Nature and flavor: bitter are flat.Gui Jing: lung, Liver Channel.Function cures mainly: removing heat from blood, pathogenic fire reducing, and disappear wart, removing toxic substances.Control haematemesis, epistaxis, sore throat, goiter, carbuncle sore scrofula.

Pericarpium Arecae: base is former: be the peel of babassu Semen Arecae.Nature and flavor: pungent, tepor.Gui Jing: return spleen, stomach, large intestine, small intestine meridian.Function cures mainly: therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.For retention of damp leading to blockage of QI, gastral cavity abdominal distention is vexed, defecates not well, edema distension, beriberi edema, dysuria.

Spina Gleditsiae: base is former: be the Spina jujubae of leguminous plant Fructus Gleditsia.Nature and flavor: pungent, temperature.Gui Jing: return liver, stomach warp.Function cures mainly: detumescence poison holding, evacuation of pus, parasite killing.For carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.

Eucheuma gelatinosum: base is former: be the frond of red tail feather colza plant Eucheuma gelatinosum.Nature and flavor: sweet are salty, cold, sliding, nontoxic.Gui Jing: liver, lung meridian.Function cures mainly: heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating, and laxation drives ascarid.Main enteritis, diarrhea, pyelonephritis, goiter, tumor, bleeding hemorrhoids, chronic constipation, ascarid is disease early.

Herba Pteridis Multifidae: base is former: be herb or the root of Pteridaceae plant Herba Pteridis Multifidae.Nature and flavor: light, micro-hardship, cold.Gui Jing: large intestine, the heart, Liver Channel.Function cures mainly: clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, subduing swelling and detoxicating.Main dysentery, has loose bowels, stranguria with turbid discharge, leukorrhagia, jaundice, furuncle swelling toxin, sore throat tonsillitis, lymphoid tuberculosis, parotitis, mastitis, high fever tic, snake bite and insect sting, and spit blood, epistaxis, hematuria, has blood in stool, traumatic hemorrhage.

embodiment 1treat a formula for clearing heat and removing toxicity for rectal cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Herba Scutellariae Barbatae 10 parts, Herba Scutellariae indicae 12 parts, Rhizoma Paridis 9 parts, Coriolous Dersicolor (Fr.) Quel 11 parts, macaque Radix pyri 10 parts, Semen Arecae 8 parts, Fructus Fici 10 parts, Herba Artemisiae Annuae 11 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Pericarpium Arecae 13 parts, Spina Gleditsiae 9 parts, Eucheuma gelatinosum 12 parts, Herba Pteridis Multifidae 11 parts.

Above-mentioned a kind of preparation method for the treatment of the formula for clearing heat and removing toxicity decoction of rectal cancer is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, Coriolous Dersicolor (Fr.) Quel, macaque Radix pyri, Herba Artemisiae Annuae, Rhizoma Dioscoreae Bulbiferae, Spina Gleditsiae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverize together with step (1) (2) made crude drug, load in penetrating bag, the water soaking of totalling crude drug quality 7 times 20 minutes, then heats decoction, after big fire boiling, turn little fire and decoct 30 minutes, take out penetrating bag, obtain medicinal liquid;

(4) Fructus Fici is picked clean, pulverize, add in step (3) made medicinal liquid, stir evenly, obtain decoction.

embodiment 2treat a formula for clearing heat and removing toxicity for rectal cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Herba Scutellariae Barbatae 15 parts, Herba Scutellariae indicae 17 parts, Rhizoma Paridis 12 parts, Coriolous Dersicolor (Fr.) Quel 14 parts, macaque Radix pyri 15 parts, Semen Arecae 14 parts, Fructus Fici 16 parts, Herba Artemisiae Annuae 17 parts, Rhizoma Dioscoreae Bulbiferae 13 parts, Pericarpium Arecae 16 parts, Spina Gleditsiae 12 parts, Eucheuma gelatinosum 14 parts, Herba Pteridis Multifidae 16 parts.

A kind of preparation method for the treatment of the formula for clearing heat and removing toxicity granule of rectal cancer is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, macaque Radix pyri, Rhizoma Dioscoreae Bulbiferae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverize together with step (1) made crude drug, load in penetrating bag, the water soaking of totalling crude drug quality 7 times 20 minutes, then heats decoction, after big fire boiling, turn little fire and decoct 30 minutes, take out penetrating bag, obtain medicinal liquid, the penetrating bag that medicated powder is housed is put into non iron container again, add water and again decoct, merge twice and decoct gained medicinal liquid;

(4) Coriolous Dersicolor (Fr.) Quel, Fructus Fici, Herba Artemisiae Annuae and Spina Gleditsiae are picked clean, pulverized 180 mesh sieves together with step (2) made crude drug, made medicated powder, and joined in step (3) gained medicinal liquid, mixing, spraying dry, pulverizes and sieves, and adds starch slurry and sucrose soft material, the wet grain of system, drying, granulate, obtains granule.

Model case: xxx, man, 40 years old.Main suit: occur that bowel habit changes the year before, gradually stool changes and increased frequency, and rear stool band blood, stomachache, abdominal distention, tenesmus sense, examination in hospital, is diagnosed as Anal canal cancer.After carry out chemotherapy, after chemotherapy 7 times, there is nausea and vomiting untoward reaction in patient, physical weakness, myasthenia of limbs, checks and obviously reduce before focus is comparatively.

After take a kind of formula for clearing heat and removing toxicity granule for the treatment of rectal cancer of the present embodiment gained, every day 2 times, each 6-10g, warm boiled water, 20 days courses for the treatment of.After taking a course for the treatment of, patient's appetite increases, and spirit takes a turn for the better, and after taking three courses for the treatment of, patient's extremity are strong, spirit is good, uncomfortable without abdominal pain and distension, and stool is normal, check, tumor disappearance, patient fully recovers, and consolidates and takes drug withdrawal after a course for the treatment of, follow up a case by regular visits in two years and do not recur.

embodiment 3treat a formula for clearing heat and removing toxicity for rectal cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Herba Scutellariae Barbatae 11 parts, Herba Scutellariae indicae 13 parts, Rhizoma Paridis 10 parts, Coriolous Dersicolor (Fr.) Quel 12 parts, macaque Radix pyri 11 parts, Semen Arecae 10 parts, Fructus Fici 12 parts, Herba Artemisiae Annuae 13 parts, Rhizoma Dioscoreae Bulbiferae 11 parts, Pericarpium Arecae 14 parts, Spina Gleditsiae 10 parts, Eucheuma gelatinosum 12.5 parts, Herba Pteridis Multifidae 12 parts.

A kind of preparation method for the treatment of the formula for clearing heat and removing toxicity electuary of rectal cancer is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, Coriolous Dersicolor (Fr.) Quel, macaque Radix pyri, Fructus Fici, Herba Artemisiae Annuae, Rhizoma Dioscoreae Bulbiferae, Spina Gleditsiae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverize together with step (1) (2) made crude drug, load in penetrating bag, soak 20 minutes, then heat decoction, after big fire boiling, turn little fire and decoct 30 minutes, take out penetrating bag, obtain medicinal liquid, the penetrating bag that medicated powder is housed is put into non iron container again, add water and again decoct, merge twice and decoct gained medicinal liquid;

(4) by step (3) gained medicinal liquid, concentrate drying, pulverized 300 mesh sieves, made powder, obtained electuary.

Model case: xxx, man, 56 years old.Stool surface band blood before half a year, or have bloody purulent stool and Mucous Stool, think it is bleeding hemorrhoids, pay attention to, after to have blood in stool improvement, rear stool attenuates, defecation is not smooth, and examination in hospital, is diagnosed as rectal cancer, carry out excision in hospital afterwards, and take a kind of formula for clearing heat and removing toxicity electuary for the treatment of rectal cancer of the present embodiment gained, adopt every day 2 times, each 5-10g, with warm boiled water, 20 days courses for the treatment of.After taking a course for the treatment of, patient experiences stable disease, wound healing is good, and without complication, after taking three courses for the treatment of, wounds heals, and reexamine focus is eliminated, and without metastasis, stool form is normal and smooth and easy, and patient fully recovers, and follows up a case by regular visits in two years and does not recur.

embodiment 4treat a formula for clearing heat and removing toxicity for rectal cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Herba Scutellariae Barbatae 14 parts, Herba Scutellariae indicae 16 parts, Rhizoma Paridis 11 parts, Coriolous Dersicolor (Fr.) Quel 13 parts, macaque Radix pyri 14 parts, Semen Arecae 12 parts, Fructus Fici 14 parts, Herba Artemisiae Annuae 15 parts, Rhizoma Dioscoreae Bulbiferae 12 parts, Pericarpium Arecae 15 parts, Spina Gleditsiae 11 parts, Eucheuma gelatinosum 13.5 parts, Herba Pteridis Multifidae 15 parts.

A kind of preparation method for the treatment of the formula for clearing heat and removing toxicity pill of rectal cancer is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, Coriolous Dersicolor (Fr.) Quel, macaque Radix pyri, Fructus Fici, Herba Artemisiae Annuae, Rhizoma Dioscoreae Bulbiferae, Spina Gleditsiae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverized 130 mesh sieves together with step (1) (2) made crude drug, make medicated powder;

(4) in step (3) made medicated powder, add refined honey and water, pill block, ball bar, gradation, round, dry, the heavy 0.5g of every ball, obtains pill.

Model case: xxx, female, 48 years old.Before three months, occur that times of defecation increases, every day 5-7 time, defecate rare, with tenesmus sense, occasionally have mucosanguineous feces, inappetence, examination in hospital, be diagnosed as rectal cancer.Patient is reluctant operation to accept chemotherapy and radiation.And take a kind of formula for clearing heat and removing toxicity pill for the treatment of rectal cancer of the present embodiment gained, and adopt every day 2 times, each 4-6 grain, with warm water delivery service, 20 days courses for the treatment of.After taking a course for the treatment of, patient defecate form improve, number of times reduce, appetite increase, after taking three courses for the treatment of, patient defecates normally, check, and lump obviously reduces, and after taking five courses for the treatment of, patient's form of defecating is normal, every day 1-2 time, lump disappears, and patient fully recovers, and follow up a case by regular visits in 1 year, patient is not recurred.

embodiment 5treat a formula for clearing heat and removing toxicity for rectal cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Herba Scutellariae Barbatae 12.5 parts, Herba Scutellariae indicae 14.5 parts, Rhizoma Paridis 10.5 parts, Coriolous Dersicolor (Fr.) Quel 12.5 parts, macaque Radix pyri 12.5 parts, Semen Arecae 11 parts, Fructus Fici 13 parts, Herba Artemisiae Annuae 14 parts, Rhizoma Dioscoreae Bulbiferae 11.5 parts, Pericarpium Arecae 14.5 parts, Spina Gleditsiae 10.5 parts, Eucheuma gelatinosum 13 parts, Herba Pteridis Multifidae 13.5 parts.

A kind of preparation method for the treatment of the formula for clearing heat and removing toxicity decoction of rectal cancer is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, Coriolous Dersicolor (Fr.) Quel, macaque Radix pyri, Herba Artemisiae Annuae, Rhizoma Dioscoreae Bulbiferae, Spina Gleditsiae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverize together with step (1) (2) made crude drug, load in penetrating bag, the water soaking of totalling crude drug quality 7 times 20 minutes, then heats decoction, after big fire boiling, turn little fire and decoct 30 minutes, take out penetrating bag, obtain medicinal liquid;

(4) Fructus Fici is picked clean, pulverize, add in step (3) made medicinal liquid, stir evenly, obtain decoction.

test example 1a kind of clinical practice for the treatment of the formula for clearing heat and removing toxicity (embodiment 5) of rectal cancer of gained of the present invention:

In October ,-2014 in January, 2012, in the rectal cancer patient that 4 inpatient departments are accepted for medical treatment, filter out 233 routine patients.Wherein women 121 example, male 112 example, age 40-65 year, 56.1 ± 4.3 years old mean age, course of disease 1-6, average course of disease 2.4 ± 0.5 years.Inclusive criteria: 1. without chemotherapy contraindication; 2. row chemotherapy carries out follow-up chemotherapy; 3. more than 3 months life cycle is estimated; 4. agree to participate in this research and written signature Informed Consent Form.Exclusion standard: 1. get rid of and have severe cardiac, liver, kidney diaseases patient; 2. serious dyscrasia patient is got rid of; 3. the patient of compliance difference is discharged.

Patient is divided into two groups at random, experimental group 140 example and matched group 93 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Matched group only adopts chemotherapy, and experimental group, on the basis of matched group, takes products obtained therefrom of the present invention, take every day twice (warm), each 350m1-500m1(adjusts to some extent depending on concrete condition), 20 days courses for the treatment of, period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.

Curative effect situation criterion: basic alleviate (CR): body constitution strengthens, and the discomforts such as digestion and defecation are obviously alleviated and alleviate, major lesions reduces about more than 70% or substantially disappear, and maintains more than 1 month without metastasis; Partial rcsponse (PR): body constitution strengthens, the discomforts such as digestion and defecation are obviously alleviated and alleviate, and CT examination pathological changes reduces about 50%, maintains more than 1 month; Basicly stable (SD): digestion and defecation etc. are uncomfortable without alleviating, and CT examination pathological changes reduces about 25%, or does not significantly reduce, and maintains more than 1 month; Invalid (PD): symptom and focus all without being clearly better or alleviating, even may worsen.Total effective rate=CR+PR+SD

Table 1 liang group patient treatment outcome

Through the treatment of four courses for the treatment of, two groups of patient treatment situations are as shown in table 1, and as seen from the table, the total effective rate of experimental group is 95.7%, the total effective rate 74.2% of matched group.The therapeutic effect of illustrative experiment group is better than matched group.And the incidence rate (43/140) of treatments period experimental group Chemotherapy in Patients untoward reaction is less than matched group (80/93).

The present invention selects Herba Scutellariae Barbatae heat-clearing and toxic substances removing, Herba Scutellariae indicae expelling wind and activating blood circulation, Rhizoma Paridis heat-clearing and toxic substances removing, Coriolous Dersicolor (Fr.) Quel invigorating spleen to remove dampness, macaque Radix pyri clearing away heat-damp and promoting diuresis, the capable water sending down the abnormal ascending QI of Semen Arecae, Fructus Fici invigorating the stomach and promoting bowel movement, Herba Artemisiae Annuae clearing away summer-heat, Rhizoma Dioscoreae Bulbiferae removing heat from blood pathogenic fire reducing, Pericarpium Arecae line water detumescence, Spina Gleditsiae evacuation of pus parasite killing, Eucheuma gelatinosum blood stasis-eliminating and stagnation-dissipating, Herba Pteridis Multifidae cooling blood for hemostasis, plurality of Chinese raw material shares, and can play the effects such as heat-clearing and toxic substances removing, replenishing QI to invigorate the spleen, blood circulation promoting and blood stasis dispelling.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. treat a formula for clearing heat and removing toxicity for rectal cancer, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Herba Scutellariae Barbatae 10-15, Herba Scutellariae indicae 12-17, Rhizoma Paridis 9-12, Coriolous Dersicolor (Fr.) Quel 11-14, macaque Radix pyri 10-15, Semen Arecae 8-14, Fructus Fici 10-16, Herba Artemisiae Annuae 11-17, Rhizoma Dioscoreae Bulbiferae 10-13, Pericarpium Arecae 13-16, Spina Gleditsiae 9-12, Eucheuma gelatinosum 12-14, Herba Pteridis Multifidae 11-16.

2. a kind of formula for clearing heat and removing toxicity for the treatment of rectal cancer as claimed in claim 1, it is characterized in that, Herba Scutellariae Barbatae 11-14, Herba Scutellariae indicae 13-16, Rhizoma Paridis 10-11, Coriolous Dersicolor (Fr.) Quel 12-13, macaque Radix pyri 11-14, Semen Arecae 10-12, Fructus Fici 12-14, Herba Artemisiae Annuae 13-15, Rhizoma Dioscoreae Bulbiferae 11-12, Pericarpium Arecae 14-15, Spina Gleditsiae 10-11, Eucheuma gelatinosum 12.5-13.5, Herba Pteridis Multifidae 12-15 is (preferred, Herba Scutellariae Barbatae 12.5, Herba Scutellariae indicae 14.5, Rhizoma Paridis 10.5, Coriolous Dersicolor (Fr.) Quel 12.5, macaque Radix pyri 12.5, Semen Arecae 11, Fructus Fici 13, Herba Artemisiae Annuae 14, Rhizoma Dioscoreae Bulbiferae 11.5, Pericarpium Arecae 14.5, Spina Gleditsiae 10.5, Eucheuma gelatinosum 13, Herba Pteridis Multifidae 13.5).

3. a kind of formula for clearing heat and removing toxicity for the treatment of rectal cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, Coriolous Dersicolor (Fr.) Quel, macaque Radix pyri, Herba Artemisiae Annuae, Rhizoma Dioscoreae Bulbiferae, Spina Gleditsiae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverize together with step (1) (2) made crude drug, load in penetrating bag, soak 20 minutes, then heat decoction, after big fire boiling, turn little fire decoct 25-35 minute (preferred, turn a little fire and decoct 27-33 minute; Be more preferably, turn little fire and decoct 30 minutes), take out penetrating bag, obtain medicinal liquid;

(4) Fructus Fici is picked clean, pulverize, add in step (3) made medicinal liquid, stir evenly, obtain decoction.

4. a kind of preparation method for the treatment of the formula for clearing heat and removing toxicity decoction of rectal cancer as claimed in claim 3, is characterized in that, step (3) amount of water be the 6-8 of total raw material medicine quality doubly (preferred, amount of water be the 6.5-7.5 of total raw material medicine quality doubly; Be more preferably, amount of water is 7 times of total raw material medicine quality).

5. a kind of formula for clearing heat and removing toxicity for the treatment of rectal cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, macaque Radix pyri, Rhizoma Dioscoreae Bulbiferae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverize together with step (1) made crude drug, load in penetrating bag, the water soaking of totalling crude drug quality 7 times 20 minutes, then heats decoction, after big fire boiling, turn little fire to decoct, take out penetrating bag, obtain medicinal liquid, the penetrating bag that medicated powder is housed is put into non iron container again, add water and again decoct, merge twice and decoct gained medicinal liquid;

(4) Coriolous Dersicolor (Fr.) Quel, Fructus Fici, Herba Artemisiae Annuae and Spina Gleditsiae are picked clean, pulverize together with step (2) made crude drug, make medicated powder, and join in step (3) gained medicinal liquid, mixing, spraying dry, pulverize 140-220 mesh sieve and (preferably, pulverize 160-200 mesh sieve; Be more preferably, pulverized 180 mesh sieves), add starch slurry and sucrose soft material, the wet grain of system, dry, granulate, obtains granule.

6. a kind of preparation method for the treatment of the formula for clearing heat and removing toxicity granule of rectal cancer as claimed in claim 5, is characterized in that, step (3) turn a little fire decoct 25-35 minute (preferred, turn a little fire and decoct 27-33 minute; Be more preferably, turn little fire and decoct 30 minutes).

7. a kind of formula for clearing heat and removing toxicity for the treatment of rectal cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable electuary, its preparation method is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, Coriolous Dersicolor (Fr.) Quel, macaque Radix pyri, Fructus Fici, Herba Artemisiae Annuae, Rhizoma Dioscoreae Bulbiferae, Spina Gleditsiae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverize together with step (1) (2) made crude drug, load in penetrating bag, soak 20 minutes, then heat decoction, after big fire boiling, turn little fire decoct 25-35 minute (preferred, turn a little fire and decoct 27-33 minute; Be more preferably, turn little fire and decoct 30 minutes), take out penetrating bag, obtain medicinal liquid, the penetrating bag that medicated powder is housed is put into non iron container again, adds water and again decoct, merge twice and decoct gained medicinal liquid;

(4) by step (3) gained medicinal liquid, concentrate drying, pulverizes, makes powder, obtain electuary.

8. a kind of preparation method for the treatment of the formula for clearing heat and removing toxicity electuary of rectal cancer as claimed in claim 7, is characterized in that, step (4) pulverized 200-400 mesh sieve (preferred, to pulverize 300 mesh sieves).

9. a kind of formula for clearing heat and removing toxicity for the treatment of rectal cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:

(1) get Testa Tritici to put into frying pan and heat, after smoldering, put into the Rhizoma Paridis picking clean impurity, constantly stir-fry, when to fry to Rhizoma Paridis be buff, add yellow wine and boil, pull out after well-done, removing Testa Tritici, dries in the air half-dried, and section, dries;

(2) get Semen Arecae and Pericarpium Arecae roguing, when boiling saturating to 6 one-tenth with rice vinegar, pull out, wrap up three layers with l Water Paper, put into fiery ash and burn to paper, take out, peel off paper;

(3) Herba Scutellariae Barbatae, Herba Scutellariae indicae, Coriolous Dersicolor (Fr.) Quel, macaque Radix pyri, Fructus Fici, Herba Artemisiae Annuae, Rhizoma Dioscoreae Bulbiferae, Spina Gleditsiae, Eucheuma gelatinosum and Herba Pteridis Multifidae remove impurity are cleaned, dry, pulverized 100-160 mesh sieve and (preferably, pulverized 120-140 mesh sieve together with step (1) (2) made crude drug; Be more preferably, pulverized 130 mesh sieves), make medicated powder;

(4) in step (3) made medicated powder, refined honey and water is added, pill block, ball bar, gradation, round, dry, obtain pill.

10. a kind of preparation method for the treatment of the formula for clearing heat and removing toxicity pill of rectal cancer as claimed in claim 9, is characterized in that, heavy 0.4-0.6g(is preferred for the every ball of step (4), the heavy 0.5g of every ball).