CN104758978B - Application of the giant salamander mucus in hemostatic material is prepared - Google Patents
Application of the giant salamander mucus in hemostatic material is prepared Download PDFInfo
- Publication number
- CN104758978B CN104758978B CN201510154852.0A CN201510154852A CN104758978B CN 104758978 B CN104758978 B CN 104758978B CN 201510154852 A CN201510154852 A CN 201510154852A CN 104758978 B CN104758978 B CN 104758978B
- Authority
- CN
- China
- Prior art keywords
- giant salamander
- salamander mucus
- hemostatic material
- mucus
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000003097 mucus Anatomy 0.000 title claims abstract description 40
- 239000000463 material Substances 0.000 title claims abstract description 27
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 24
- 241000157862 Dicamptodontidae Species 0.000 title claims abstract 8
- 230000001954 sterilising effect Effects 0.000 claims description 12
- 238000007710 freezing Methods 0.000 claims description 8
- 230000008014 freezing Effects 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- 230000005855 radiation Effects 0.000 claims description 6
- 239000012467 final product Substances 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 241000269331 Ambystoma Species 0.000 claims 1
- 230000000025 haemostatic effect Effects 0.000 abstract description 3
- 241001415306 Cryptobranchidae Species 0.000 description 37
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 241000700159 Rattus Species 0.000 description 5
- 238000009455 aseptic packaging Methods 0.000 description 4
- 230000023597 hemostasis Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000004643 material aging Methods 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000269333 Caudata Species 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 241001253208 Andrias davidianus Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000395633 Andrias japonicus Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000004263 Ocotea pretiosa Nutrition 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 244000009660 Sassafras variifolium Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229960005143 amobarbital sodium Drugs 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000011013 aquamarine Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000035617 depilation Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- BNHGKKNINBGEQL-UHFFFAOYSA-M sodium;5-ethyl-5-(3-methylbutyl)pyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CC(C)CCC1(CC)C(=O)NC(=O)[N-]C1=O BNHGKKNINBGEQL-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention discloses application of the giant salamander mucus in hemostatic material is prepared, using the bond properties of giant salamander mucus, the damage surface of a wound can be closed, therefore, it is possible to be used as hemostatic material；And the present invention obtains hemostatic material and derives from giant salamander mucus, is pure natural component, and security is good, and its haemostatic effect is good, is with a wide range of applications.
Description
Technical field
The invention belongs to technical field of biological material, and in particular to application of the giant salamander mucus in hemostatic material is prepared.
Background technology
Giant salamander is commonly called as the giant salamander, is under the jurisdiction of Amphibia Caudata Yin Sai salamanders section, including 23 kinds of category, i.e. giant salamander category and hidden cheek salamander
Category, wherein giant salamander category again can be divided into Andrias japonicus and Chinese giant salamander, Andrias davidianus, be existing maximum, the most precious amphibian in the world, by
The United Nations lists endangered species protection register in, is national two classes protection aqua-marine life.Giant salamander fine and tender taste, delicious flavour,
Containing good protein, abundant amino acid and trace element, nutritive value is high, is described as " ginseng in water " and " soft Huang
Gold ".When giant salamander skin is subject to environmental stimuli, a large amount of white " milky "s, the mucus with special odor can be secreted, be sent out through research
Main component is water (83-86%), protein (12%) in the mucus now secreted, and containing a small amount of polysaccharide (0.48%), is had
Antibacterial, it is anti-oxidant and antitumor the effects such as, cosmetic field is mainly used at present.Because the yield of giant salamander mucus is filled very much
Foot, repeats a large amount of collections, and its utilization rate is low.It would therefore be highly desirable to further be developed to the addition product of giant salamander mucus, giant salamander is improved
Comprehensive value.
The content of the invention
In view of this, an object of the present invention there are provided application of the giant salamander mucus in hemostatic material is prepared, and open
The new application of giant salamander mucus has been sent out, and for hemostatic material provides new material.
For achieving the above object, the present invention provides following technical scheme：
Application of the giant salamander mucus in hemostatic material is prepared.
Preferably, the preparation method of the hemostatic material is that giant salamander mucus is frozen into solid, then vacuum freezedrying
Moisture removal is removed, then dry giant salamander mucus is crushed, sterilizing is obtained final product；
Or giant salamander mucus is vacuum dried under conditions of temperature is not higher than 37 DEG C, then dry giant salamander mucus is crushed,
Sterilizing, obtains final product.
Preferably, the condition of the freezing is freezed in the case where temperature is not higher than -20 DEG C.
Preferably, the condition of the freezing is freezed in the case where temperature is for -80 DEG C~-20 DEG C.
Preferably, the condition of the vacuum freezedrying be temperature less than or equal to 50 DEG C, vacuum be less than 20Pa
Under the conditions of freeze-drying at least 48 hours.
Preferably, it is described to crush as ultramicro grinding to particle diameter is 300~1000 mesh.
Preferably, the sterilizing is 2~5 × 104The 60Co gamma-rays radiation sterilizations of Gy dosage.
The beneficial effects of the present invention are：The invention discloses application of the giant salamander mucus in hemostatic material is prepared, should be only
, in giant salamander mucus, composition is natural, and security is good, and haemostatic effect is good, and hemostatic material is spread in uniform in out for blood material source
The blood surface of a wound, pressing can stop blooding for 3 minutes, for clinical hemostasis provide new hemostatic material.
Specific embodiment
The preferred embodiments of the present invention will be described in detail below.The experiment of unreceipted actual conditions in embodiment
Method, generally according to normal condition or according to the condition proposed by manufacturer.
Sassafras method is directly scraped in the collection of giant salamander mucus using skin：Fresh and alive giant salamander is specially cleaned into body surface with clear water, is removed
The impurity such as cast off a skin, be subsequently placed in drying box, giant salamander body surface is scraped with flat, until giant salamander body surface secretes a large amount of milkys
Mucus, scraping was collected in culture dish, made mucus thickness about 1cm in culture dish.The collection of giant salamander mucus can also use existing
Electrostimulation or etherization method collection, specific method see Publication No. 104223121A and 104206502A China specially
Profit.
Embodiment 1
The method that hemostatic material is prepared using giant salamander mucus, is comprised the following steps：By collect giant salamander mucus culture dish put-
80 DEG C overnight make it be frozen into solid, then with vacuum freeze drier vacuum be 19pa, at temperature is -50 DEG C freezing it is true
Sky is dried 48 hours；Smash lyophilized giant salamander mucus to pieces rearmounted low-temperature submicron powder broken machine again and be crushed to 300 mesh, finally with 5 ×
104Gy dosage 60Co gamma-rays radiation sterilizations, obtain hemostatic material, and aseptic packaging is standby.Wherein the temperature of low-temperature grinding is less than 37
DEG C, add liquid nitrogen ultramicro grinding best results.
Embodiment 2
The method that hemostatic material is prepared using giant salamander mucus, is comprised the following steps：By collect giant salamander mucus culture dish put-
20 DEG C overnight make it be frozen into solid, then with vacuum freeze drier vacuum be 10pa, at temperature is -70 DEG C freezing it is true
Sky is dried 56 hours；Smash lyophilized giant salamander mucus to pieces rearmounted low-temperature submicron powder broken machine again and be crushed to 500 mesh, finally with 2 ×
104Gy dosage 60Co gamma-rays radiation sterilizations, obtain hemostatic material, and aseptic packaging is standby.Wherein the temperature of low-temperature grinding is less than 37
DEG C, add liquid nitrogen ultramicro grinding best results.
Embodiment 3
The method that hemostatic material is prepared using giant salamander mucus, is comprised the following steps：The culture dish for collecting giant salamander mucus is straight
Connect in putting vacuum drying chamber, 48h is dried under 37 DEG C of vacuum, then smash dry giant salamander mucus to pieces rearmounted low-temperature submicron powder broken machine
1000 mesh are crushed to, finally with 2 × 104Gy dosage 60Co gamma-rays radiation sterilizations, obtain hemostatic material, and aseptic packaging is standby.Its
The temperature of middle low-temperature grinding is less than 37 DEG C, adds liquid nitrogen ultramicro grinding best results.
Embodiment 4
The method that hemostatic material is prepared using giant salamander mucus, is comprised the following steps：The culture dish for collecting giant salamander mucus is straight
Connect in putting vacuum drying chamber, 48h is dried under 20 DEG C of vacuum, then smash dry giant salamander mucus to pieces rearmounted low-temperature submicron powder broken machine
800 mesh are crushed to, finally with 2 × 104Gy dosage 60Co gamma-rays radiation sterilizations, obtain hemostatic material, and aseptic packaging is standby.Wherein
The temperature of low-temperature grinding is less than 37 DEG C, adds liquid nitrogen ultramicro grinding best results.
Embodiment 5
The damage surface of a wound hemostasis experiment of hemostatic material, specially：Take Wistar rats 10, male and female half and half, body weight 250g
±20g；Every the 2 of rat back legs are divided into experimental group and control group respectively, before experiment, rat 30mg/kg abdominal cavities note is pressed into
The anesthesia of 2% amobarbital sodium water solution is penetrated, rat dorsal position is fixed, electricity consumption pushes away hair cutter by rat back leg inner side shaving, 8% sulphur
Change sodium depilation, Iodophor, volume fraction are 75% ethanol disinfection.Then the two back leg inside lines with scalpel in rat are cut
Mouthful, 30mm long, deep 3mm have blood to flow out；The hemostasis of the preparation of embodiment 1~4 is uniformly sprinkled after incision in experimental group cutting part
Material 0.5g, the gel to be formed then gently is touched with operation surgical forceps and otch is pulled to both sides, and bonding is firm, and haemostatic effect is bright
It is aobvious.Control group is covered in cutting part with gauze, and presses hemostasis in 3 minutes.
Finally illustrate, preferred embodiment above is merely illustrative of the technical solution of the present invention and unrestricted, although logical
Cross above preferred embodiment to be described in detail the present invention, it is to be understood by those skilled in the art that can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (6)
1. application of the giant salamander mucus in hemostatic material is prepared, it is characterised in that：The preparation method of the hemostatic material is will be big
Salamander mucus is frozen into solid, and then vacuum freezedrying removes moisture removal, then dry giant salamander mucus is crushed, and sterilizing is obtained final product；
Or giant salamander mucus is vacuum dried under conditions of temperature is not higher than 37 DEG C, then dry giant salamander mucus is crushed, sterilizing,
Obtain final product.
2. application according to claim 1, it is characterised in that：The condition of the freezing is not higher than at -20 DEG C in temperature
Freezing.
3. application according to claim 2, it is characterised in that the condition of the freezing be temperature be -80 DEG C ~ -20 DEG C
Lower freezing.
4. application according to claim 1, it is characterised in that the condition of the vacuum freezedrying be temperature be less than or
It is less than freeze-drying under the conditions of 20Pa at least 48 hours equal to 50 DEG C, vacuum.
5. application according to claim 1, it is characterised in that the crushing is that ultramicro grinding to particle diameter is 300 ~ 1000
Mesh.
6. application according to claim 1, it is characterised in that the sterilizing is 2 ~ 5 × 104The 60Co gamma-rays of Gy dosage
Radiation sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510154852.0A CN104758978B (en) | 2015-04-02 | 2015-04-02 | Application of the giant salamander mucus in hemostatic material is prepared |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510154852.0A CN104758978B (en) | 2015-04-02 | 2015-04-02 | Application of the giant salamander mucus in hemostatic material is prepared |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104758978A CN104758978A (en) | 2015-07-08 |
| CN104758978B true CN104758978B (en) | 2017-06-16 |
Family
ID=53641284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510154852.0A Expired - Fee Related CN104758978B (en) | 2015-04-02 | 2015-04-02 | Application of the giant salamander mucus in hemostatic material is prepared |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104758978B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106361776B (en) * | 2016-11-16 | 2024-03-19 | 张家界金姑大鲵开发有限公司 | Giant salamander mucus used for hemostasis |
| CN106581736B (en) * | 2016-12-28 | 2020-04-21 | 安顺市四海农业科技开发有限公司 | Medical adhesive taking giant salamander body surface mucus as raw material and preparation method thereof |
| CN109381731B (en) * | 2017-08-02 | 2021-04-13 | 长沙海润生物技术有限公司 | Medical biological dressing and preparation method thereof |
| CN107281535B (en) * | 2017-08-10 | 2020-09-15 | 魏泓 | Giant salamander secretion viscous biomembrane and preparation method and application thereof |
| CN107456599B (en) * | 2017-08-10 | 2020-09-01 | 魏泓 | Antibacterial giant salamander secretion biomembrane and preparation method and application thereof |
| CN107412845B (en) * | 2017-08-10 | 2020-09-11 | 魏泓 | Giant salamander secretion biomembrane and preparation method and application thereof |
| CN113727740A (en) * | 2019-02-26 | 2021-11-30 | 重庆医科大学附属口腔医院 | Medical adhesive and preparation method and application thereof |
| CN110755675A (en) * | 2019-12-10 | 2020-02-07 | 中国人民解放军陆军军医大学第一附属医院 | Composite biological paste capable of rapidly stopping bleeding and preparation method and application thereof |
| CN112121065A (en) * | 2020-10-09 | 2020-12-25 | 重庆医科大学附属口腔医院 | Medical styptic powder and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335288A (en) * | 2010-07-20 | 2012-02-01 | 陕西理工学院 | Giant salamander skin mucus scalding ointment |
| CN103829235A (en) * | 2014-01-11 | 2014-06-04 | 陕西理工学院 | Preparation method of giant salamander skin mucus whole powder |
-
2015
- 2015-04-02 CN CN201510154852.0A patent/CN104758978B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335288A (en) * | 2010-07-20 | 2012-02-01 | 陕西理工学院 | Giant salamander skin mucus scalding ointment |
| CN103829235A (en) * | 2014-01-11 | 2014-06-04 | 陕西理工学院 | Preparation method of giant salamander skin mucus whole powder |
Non-Patent Citations (1)
| Title |
|---|
| 中国大鲵营养成分和功能因子研究进展;耿敬章等;《氨基酸和生物资源》;20130630;第35卷(第2期);第9-12页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104758978A (en) | 2015-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104758978B (en) | Application of the giant salamander mucus in hemostatic material is prepared | |
| CN104815349B (en) | Adhesive prepared using giant salamander mucus and preparation method thereof | |
| CN102846698B (en) | Wall-broken radix tetrastigme oral decoction pieces | |
| CN104435743B (en) | A kind of preparation method of dendrobium candidum ultrafine powder | |
| CN103829235B (en) | Preparation method of giant salamander skin mucus whole powder | |
| CN104721882B (en) | Application of the giant salamander mucus in soft tissue filling material is prepared | |
| CN103637940B (en) | A kind of bath gel | |
| CN103393896B (en) | Traditional Chinese medicine formulation paris polyphylla direct-oral decoction piece for preventing and treating tumors | |
| CN104288180A (en) | Preparation method of pilose antler pure powder | |
| CN103349367A (en) | Traditional Chinese medicine used in health care bras | |
| CN108852951A (en) | A kind of moistening and cleaning skin composition and plant body wash | |
| CN107929120A (en) | The preparation method of water shield extracting solution and water shield repair Essence | |
| CN105520093B (en) | A kind of preparation method of garlic ultra micro nutrition full power | |
| CN105007988A (en) | Bioactive botanical compositions and uses thereof | |
| CN104069015A (en) | Eye cream containing plant extract | |
| CN107441479B (en) | Marine active peptide/chitin burn ointment for treating scald and preparation method thereof | |
| CN111450039A (en) | Mild and non-irritant moisturizing and anti-aging eye cream and preparation method thereof | |
| KR20160115285A (en) | Functional soap containing extract of Mulberry and manufacturing method of the same | |
| CN107823114A (en) | A kind of anti-acne skin care item containing sealwort stem cell extract | |
| CN107997985A (en) | Application of the deerskin polysaccharide in moisture-keeping cosmetics are prepared | |
| KR101075933B1 (en) | Sponge of manufacturing method for cleansing the skin | |
| KR101713115B1 (en) | Cosmetic composition containing the fermented extract of allium monanthum, allium scorodorpasum, allium tuberosum, allium fistulosum and scilla scilloides | |
| KR102072346B1 (en) | Cosmetic composition comprising fermented corn extract for skin moisture | |
| CN108451871A (en) | A kind of Chinese medicine shampoo and preparation method thereof | |
| CN104382781A (en) | Natural edible multifunctional cosmetic composition containing germinated brown rice |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 405400 fourth floor, Kaizhou Avenue cinema, Hanfeng, Kaixian County, Chongqing Patentee after: Chongqing Changsheng lake fish bio Polytron Technologies Inc. Patentee after: Zhou Minghui Patentee after: Wei Hong Patentee after: Xing Mengqiu Address before: 405400 fourth floor, Kaizhou Avenue cinema, Hanfeng, Kaixian County, Chongqing Patentee before: CHONGQING KUIXU BIOLOGICAL SCIENCE & TECHNOLOGY Co.,Ltd. Patentee before: Zhou Minghui Patentee before: Wei Hong Patentee before: Xing Mengqiu |
|
| CP01 | Change in the name or title of a patent holder | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220107 Address after: 405400 fourth floor, Kaizhou Avenue cinema, Hanfeng, Kaixian County, Kaizhou District, Chongqing Patentee after: Chongqing Changsheng lake fish bio Polytron Technologies Inc. Patentee after: Zhou Minghui Patentee after: Xing Mengqiu Address before: 405400 fourth floor, Kaizhou Avenue cinema, Hanfeng, Kaixian County, Chongqing Patentee before: Chongqing Changsheng lake fish bio Polytron Technologies Inc. Patentee before: Zhou Minghui Patentee before: Wei Hong Patentee before: Xing Mengqiu |
|
| TR01 | Transfer of patent right | ||
| CB03 | Change of inventor or designer information |
Inventor after: Shang Haitao Inventor after: Wang Ying Inventor after: Chen Bing Inventor after: Gou Qiang Inventor after: Xing Mengqiu Inventor after: Ge Liangpeng Inventor after: Zhou Minghui Inventor before: Shang Haitao Inventor before: Wang Ying Inventor before: Chen Bing Inventor before: Gou Qiang Inventor before: Wei Hong Inventor before: Xing Mengqiu Inventor before: Ge Liangpeng Inventor before: Zhou Minghui |
|
| CB03 | Change of inventor or designer information | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170616 |