CN104721882B - Application of the giant salamander mucus in soft tissue filling material is prepared - Google Patents
Application of the giant salamander mucus in soft tissue filling material is prepared Download PDFInfo
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- CN104721882B CN104721882B CN201510154466.1A CN201510154466A CN104721882B CN 104721882 B CN104721882 B CN 104721882B CN 201510154466 A CN201510154466 A CN 201510154466A CN 104721882 B CN104721882 B CN 104721882B
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- giant salamander
- salamander mucus
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- 210000003097 mucus Anatomy 0.000 title claims abstract description 46
- 238000011049 filling Methods 0.000 title claims abstract description 29
- 239000000463 material Substances 0.000 title claims abstract description 27
- 210000004872 soft tissue Anatomy 0.000 title claims abstract description 27
- 241000157862 Dicamptodontidae Species 0.000 title claims abstract 10
- 230000001954 sterilising effect Effects 0.000 claims description 14
- 238000000227 grinding Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 238000007710 freezing Methods 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 5
- 210000001835 viscera Anatomy 0.000 claims description 5
- 210000004204 blood vessel Anatomy 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 210000003205 muscle Anatomy 0.000 claims description 3
- 210000000936 intestine Anatomy 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims 1
- 238000002513 implantation Methods 0.000 abstract description 2
- 239000002504 physiological saline solution Substances 0.000 abstract description 2
- 208000026137 Soft tissue injury Diseases 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 241001415306 Cryptobranchidae Species 0.000 description 40
- 210000000813 small intestine Anatomy 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 238000012549 training Methods 0.000 description 4
- 241000269333 Caudata Species 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 241001253208 Andrias davidianus Species 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000009455 aseptic packaging Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 241000395633 Andrias japonicus Species 0.000 description 1
- 208000008081 Intestinal Fistula Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 244000227633 Ocotea pretiosa Species 0.000 description 1
- 235000004263 Ocotea pretiosa Nutrition 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000011013 aquamarine Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- -1 muscle Substances 0.000 description 1
- 230000002632 myometrial effect Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
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- 238000002360 preparation method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses application of the giant salamander mucus in soft tissue filling material is prepared, utilize the bond properties of giant salamander mucus, gel can be formed in physiological saline, and there is degradable and good biocompatibility, can as Soft-tissue operation implantation material, for filling cavity and the defect that soft tissue injury or lesion are caused, and the filler derives from giant salamander mucus, for natural constituents, security is good, with preferable application prospect.
Description
Technical field
The invention belongs to technical field of biological material, and in particular to application of the giant salamander mucus in soft tissue filling material is prepared.
Background technology
Giant salamander is commonly called as the giant salamander, is under the jurisdiction of Amphibia Caudata Yin Sai salamanders section, including 23 kinds of category, i.e. giant salamander category and hidden cheek salamander
Category, wherein giant salamander category again can be divided into Andrias japonicus and Chinese giant salamander, Andrias davidianus, be existing maximum, the most precious amphibian in the world, by
The United Nations is included in endangered species protection register, is national two classes protection aqua-marine life.Giant salamander fine and tender taste, delicious flavour,
Containing good protein, abundant amino acid and trace element, nutritive value is high, is described as " ginseng in water " and " soft Huang
Gold ".When giant salamander skin is by environmental stimuli, a large amount of white " milky "s, mucus with special odor can be secreted, are sent out through research
Main component is water (83-86%), protein (12%) in the mucus now secreted, and containing a small amount of polysaccharide (0.48%), is had
Antibacterial, it is anti-oxidant and antitumor the effects such as, cosmetic field is mainly used at present.Because the yield of giant salamander mucus is filled very much
Foot, repeats a large amount of collections, and its utilization rate is low.It would therefore be highly desirable to further be developed to the addition product of giant salamander mucus, giant salamander is improved
Comprehensive value.
The content of the invention
In view of this, an object of the present invention is the provision of giant salamander mucus answering in soft tissue filling material is prepared
With developing the new application of giant salamander mucus, and provide for soft tissue filling material new material.
1st, application of the giant salamander mucus in soft tissue filling material is prepared.
It is preferred that, the soft tissue is muscle, fat, blood vessel or internal organ.
It is preferred that, the internal organ are intestines.
It is preferred that, the preparation method of the soft tissue filling material freezes true for giant salamander mucus is frozen into solid, then
Sky, which is dried, removes moisture removal, then dry giant salamander mucus is crushed, and sterilizing is produced；
Or be dried in vacuo giant salamander mucus under conditions of temperature is not higher than 37 DEG C, then dry giant salamander mucus is crushed,
Sterilizing, is produced.
It is preferred that, the condition of the freezing is freezed in the case where temperature is not higher than -20 DEG C.
It is preferred that, the condition of the freezing is freezed in the case where temperature is -80 DEG C~-20 DEG C.
It is preferred that, the condition of the vacuum freezedrying is cold under the conditions of temperature is less than 20Pa less than -50 DEG C, vacuum
It is lyophilized dry at least 48 hours.
It is preferred that, the crushing is that ultramicro grinding to particle diameter is 300~1000 mesh.
It is preferred that, the sterilizing is 2~5 × 104The 60Co gamma-rays radiation sterilizations of Gy dosage.
The beneficial effects of the present invention are：The invention discloses giant salamander mucus answering in soft tissue filling material is prepared
Giant salamander mucus is derived from, the packing material, composition is natural, and security is good, can act as soft tissue filling material, such as muscle,
Fat, blood vessel or internal organ filling or plug-hole, and the reaction of good biocompatibility, no inflammation, without taking out after degradable, implantation,
Clinically it is with a wide range of applications.
Brief description of the drawings
In order that the purpose of the present invention, technical scheme and beneficial effect are clearer, the present invention provides drawings described below：
Fig. 1 is the inflammatory reaction result (A at detection heeling-in position：Surface observation；B：Cut at heeling-in position).
Embodiment
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail.It is unreceipted specific in embodiment
The experimental method of condition, generally according to normal condition or according to the condition proposed by manufacturer.
The collection of giant salamander mucus directly scrapes sassafras method using skin：Fresh and alive giant salamander is specially cleaned into body surface with clear water, removed
The impurity such as cast off a skin, be subsequently placed in dry box, giant salamander body surface is scraped with flat, until giant salamander body surface secretes a large amount of milkys
Mucus, scraping was collected in culture dish, made mucus thickness about 1cm in culture dish.The collection of giant salamander mucus can also use existing
Electrostimulation or etherization method collection, specific method see Publication No. 104223121A and 104206502A China specially
Profit.
Embodiment 1
The method that soft tissue filling material is prepared using giant salamander mucus, is comprised the following steps：The training of giant salamander mucus will be collected
Foster ware put -80 DEG C overnight it is frozen into solid, then with vacuum freeze drier vacuum be 19pa, temperature be -50 DEG C
Lower vacuum freezedrying 48 hours；Smash lyophilized giant salamander mucus to pieces rearmounted low-temperature submicron powder broken machine again and be crushed to 300 mesh, finally
With 5 × 104Gy dosage 60Co gamma-rays radiation sterilizations, obtain soft tissue filling material, aseptic packaging is standby.Wherein low-temperature grinding
Temperature is less than 37 DEG C, adds liquid nitrogen ultramicro grinding best results.
Embodiment 2
The method that soft tissue filling material is prepared using giant salamander mucus, is comprised the following steps：The training of giant salamander mucus will be collected
Foster ware put -20 DEG C overnight it is frozen into solid, then with vacuum freeze drier vacuum be 10pa, temperature be -70 DEG C
Lower vacuum freezedrying 56 hours；Smash lyophilized giant salamander mucus to pieces rearmounted low-temperature submicron powder broken machine again and be crushed to 500 mesh, finally
With 2 × 104Gy dosage 60Co gamma-rays radiation sterilizations, obtain soft tissue filling material, aseptic packaging is standby.Wherein low-temperature grinding
Temperature is less than 37 DEG C, adds liquid nitrogen ultramicro grinding best results.
Embodiment 3
The method that soft tissue filling material is prepared using giant salamander mucus, is comprised the following steps：The training of giant salamander mucus will be collected
Foster ware is directly put in vacuum drying chamber, 48h is dried under 37 DEG C of vacuum, then smash dry giant salamander mucus to pieces rearmounted low temperature ultra micro
Pulverizer is crushed to 1000 mesh, finally with 2 × 104Gy dosage 60Co gamma-rays radiation sterilizations, obtain soft tissue filling material, sterile
Package spare.Wherein the temperature of low-temperature grinding is less than 37 DEG C, adds liquid nitrogen ultramicro grinding best results.
Embodiment 4
The method that soft tissue filling material is prepared using giant salamander mucus, is comprised the following steps：The training of giant salamander mucus will be collected
Foster ware is directly put in vacuum drying chamber, 48h is dried under 20 DEG C of vacuum, then smash dry giant salamander mucus to pieces rearmounted low temperature ultra micro
Pulverizer is crushed to 800 mesh, finally with 2 × 104Gy dosage 60Co gamma-rays radiation sterilizations, obtain soft tissue filling material, sterile
Package spare.Wherein the temperature of low-temperature grinding is less than 37 DEG C, adds liquid nitrogen ultramicro grinding best results.
Embodiment 5
Degraded and biocompatibility test in vivo are carried out to soft tissue filling material prepared by giant salamander mucus, it is specific as follows：
Soft tissue filling material 50mg is taken to be placed in physiology 50ml physiological saline, stirring makes its gel, then takes KM mouse 6,
Gel liquid is placed in otch subendothelial, and away from otch, finally by myometrial suture.Sampling detection heeling-in position after 7 days
Inflammatory reaction, as a result as shown in Figure 1.As a result show, adhesive reacts in heeling-in position no inflammation.The drop at heeling-in position is detected again
Solution situation, as a result as shown in table 1.
Table 1,7 days degradation rates of heeling-in
| Mouse number | Mucus heeling-in amount (g) | Mucus surplus (g) | Degradation rate |
| 1 | 0.2017 | 0.0646 | 68% |
| 2 | 0.1864 | 0.0869 | 53.4% |
| 3 | 0.1965 | 0.0933 | 52.5% |
| 4 | 0.2144 | 0.1067 | 50.23% |
| 5 | 0.2005 | 0.0880 | 56.11% |
| 6 | 0.1950 | 0.0910 | 53.33% |
As a result show, the adhesive that giant salamander mucus is made is in the degradation rate of 7 days between 50.23%-68%.
Embodiment 6
The physiological pipeline filling test of soft tissue filling material is made in giant salamander mucus, is specially：Clip rat small intestine one
Section, it is long 8 centimeters, ligatured after discharging small intestine contents, one end ligation, other end insertion injection needle, make injection needle and injection
Device is connected.Then an aperture is pricked with another injection needle in intestinal wall, and this section of foraminate small intestine is immersed to the burning for filling water
In cup, air is pushed into syringe, small intestine is filled naturally, now because gas leakage has bubble generation at aperture.Determine that small intestine has
After aperture, small intestine is taken out from water, and soft tissue filling material prepared by a little embodiment 1~4 is sprinkled at aperture position, and
Smear uniform.After 1 minute, then the small intestine is immersed filled in the beaker of water, be pushed into air with syringe, small intestine is filled naturally
It is full of.As a result show, now no bubble is spilt from small intestine.As a result show, soft tissue prepared by the embodiment of the present invention 1~4 is filled out
The filling mending-leakage that material can be used for physiological pipeline is filled, can be used in including the filling such as intestinal fistula, blood vessel hole, tracheae hole.
Finally illustrate, preferred embodiment above is merely illustrative of the technical solution of the present invention and unrestricted, although logical
Cross above preferred embodiment the present invention is described in detail, it is to be understood by those skilled in the art that can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (9)
1. the application after the giant salamander mucus crushing dried, sterilizing in soft tissue filling material is prepared.
2. application according to claim 1, it is characterised in that：The soft tissue is muscle, fat, blood vessel or internal organ.
3. application according to claim 2, it is characterised in that：The internal organ are intestines.
4. the application according to any one of claim 1 ~ 3, it is characterised in that：The giant salamander mucus of the drying is crushed, sterilizing
Specific method for giant salamander mucus is frozen into solid, then vacuum freezedrying removes moisture removal, then by dry giant salamander mucus
Crush, sterilizing is produced；
Or be dried in vacuo giant salamander mucus under conditions of temperature is not higher than 37 DEG C, then dry giant salamander mucus is crushed, sterilizing,
Produce.
5. application according to claim 4, it is characterised in that：The condition of the freezing is to be not higher than in temperature at -20 DEG C
Freezing.
6. application according to claim 5, it is characterised in that it in temperature is -80 DEG C ~ -20 DEG C that the condition of the freezing, which is,
Lower freezing.
7. application according to claim 4, it is characterised in that the condition of the vacuum freezedrying be less than in temperature-
50 DEG C, vacuum be less than 20Pa under the conditions of be freeze-dried at least 48 hours.
8. application according to claim 4, it is characterised in that the crushing is that ultramicro grinding to particle diameter is 300 ~ 1000
Mesh.
9. application according to claim 4, it is characterised in that the sterilizing is 2 ~ 5 × 104The 60Co gamma-rays of Gy dosage
Radiation sterilization.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510154466.1A CN104721882B (en) | 2015-04-02 | 2015-04-02 | Application of the giant salamander mucus in soft tissue filling material is prepared |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510154466.1A CN104721882B (en) | 2015-04-02 | 2015-04-02 | Application of the giant salamander mucus in soft tissue filling material is prepared |
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| CN104721882A CN104721882A (en) | 2015-06-24 |
| CN104721882B true CN104721882B (en) | 2017-10-03 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066369A (en) * | 2016-11-16 | 2018-05-25 | 太鲵生物科技（天津）有限公司 | A kind of preparation method of giant salamander pituitary extract |
| CN106581736B (en) * | 2016-12-28 | 2020-04-21 | 安顺市四海农业科技开发有限公司 | Medical adhesive whose raw material is mucus on salamander body surface and preparation method |
| CN107412845B (en) * | 2017-08-10 | 2020-09-11 | 魏泓 | Giant salamander secretion biomembrane and preparation method and application thereof |
| CN108887364A (en) * | 2018-06-25 | 2018-11-27 | 贵阳学院 | The minimizing technology of mucus after a kind of giant salamander slaughter |
| EP3932436A4 (en) * | 2019-02-26 | 2022-12-07 | Stomatological Hospital of Chongquing Medical University | Medical adhesive, and manufacturing method therefor and use thereof |
| CN112169011A (en) * | 2019-07-05 | 2021-01-05 | 重庆医科大学附属口腔医院 | Medical adhesive for dense connective tissue |
| CN110559469B (en) * | 2019-02-26 | 2021-08-03 | 重庆医科大学附属口腔医院 | Medical adhesive |
| CN112107723B (en) * | 2019-06-20 | 2021-10-12 | 重庆医科大学附属口腔医院 | Medical water-based adhesive and using method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102335288A (en) * | 2010-07-20 | 2012-02-01 | 陕西理工学院 | Giant salamander skin mucus scalding ointment |
| CN103613654B (en) * | 2013-09-03 | 2016-01-06 | 张家界（中国）金驰大鲵生物科技有限公司 | Giant salamander mucus albumen, preparation method and the application in makeup |
| CN103829235B (en) * | 2014-01-11 | 2015-07-01 | 陕西理工学院 | Preparation method of giant salamander skin mucus whole powder |
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Address after: 405400 fourth floor, Kaizhou Avenue cinema, Hanfeng, Kaixian County, Chongqing Patentee after: Chongqing Changsheng lake fish bio Polytron Technologies Inc. Patentee after: Zhou Minghui Patentee after: Wei Hong Patentee after: Xing Mengqiu Address before: 405400 fourth floor, Kaizhou Avenue cinema, Hanfeng, Kaixian County, Chongqing Patentee before: CHONGQING KUIXU BIOLOGICAL SCIENCE & TECHNOLOGY Co.,Ltd. Patentee before: Zhou Minghui Patentee before: Wei Hong Patentee before: Xing Mengqiu |
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Effective date of registration: 20211215 Address after: 405400 fourth floor, Kaizhou Avenue cinema, Hanfeng, Kaixian County, Kaizhou District, Chongqing Patentee after: Chongqing Changsheng lake fish bio Polytron Technologies Inc. Patentee after: Zhou Minghui Patentee after: Xing Mengqiu Address before: 405400 fourth floor, Kaizhou Avenue cinema, Hanfeng, Kaixian County, Chongqing Patentee before: Chongqing Changsheng lake fish bio Polytron Technologies Inc. Patentee before: Zhou Minghui Patentee before: Wei Hong Patentee before: Xing Mengqiu |
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Inventor after: Shang Haitao Inventor after: Wang Ying Inventor after: Chen Bing Inventor after: Gou Qiang Inventor after: Xing Mengqiu Inventor after: Ge Liangpeng Inventor after: Zhou Minghui Inventor before: Shang Haitao Inventor before: Wang Ying Inventor before: Chen Bing Inventor before: Gou Qiang Inventor before: Wei Hong Inventor before: Xing Mengqiu Inventor before: Ge Liangpeng Inventor before: Zhou Minghui |
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