CN104740680B - 一种镁基生物材料组合物及其制备方法与应用 - Google Patents
一种镁基生物材料组合物及其制备方法与应用 Download PDFInfo
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- CN104740680B CN104740680B CN201510080356.5A CN201510080356A CN104740680B CN 104740680 B CN104740680 B CN 104740680B CN 201510080356 A CN201510080356 A CN 201510080356A CN 104740680 B CN104740680 B CN 104740680B
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- magnesium
- magnesia
- hydroxyapatite
- sucrose
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- 239000000203 mixture Substances 0.000 title claims abstract description 61
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims abstract description 47
- 239000011777 magnesium Substances 0.000 title claims abstract description 47
- 229910052749 magnesium Inorganic materials 0.000 title claims abstract description 47
- 239000012620 biological material Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title description 7
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 143
- 239000007788 liquid Substances 0.000 claims abstract description 74
- 239000000395 magnesium oxide Substances 0.000 claims abstract description 72
- 229930006000 Sucrose Natural products 0.000 claims abstract description 58
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 58
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims abstract description 47
- 235000019796 monopotassium phosphate Nutrition 0.000 claims abstract description 47
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 46
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 46
- 239000000843 powder Substances 0.000 claims abstract description 45
- 239000002738 chelating agent Substances 0.000 claims abstract description 36
- 239000000463 material Substances 0.000 claims abstract description 31
- 239000007864 aqueous solution Substances 0.000 claims abstract description 22
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 15
- 239000004568 cement Substances 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 13
- 239000005720 sucrose Substances 0.000 claims description 57
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 46
- 229910019142 PO4 Inorganic materials 0.000 claims description 24
- 239000010452 phosphate Substances 0.000 claims description 24
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 24
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims description 12
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 11
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 9
- 239000001103 potassium chloride Substances 0.000 claims description 9
- 235000011164 potassium chloride Nutrition 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- 235000001014 amino acid Nutrition 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 230000007547 defect Effects 0.000 claims description 4
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- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 3
- 239000004472 Lysine Substances 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
- 235000009697 arginine Nutrition 0.000 claims description 3
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- 235000018417 cysteine Nutrition 0.000 claims description 3
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- 235000013922 glutamic acid Nutrition 0.000 claims description 3
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- 239000004471 Glycine Substances 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- 235000003704 aspartic acid Nutrition 0.000 claims description 2
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- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 abstract description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract description 2
- 230000008439 repair process Effects 0.000 abstract description 2
- 235000013681 dietary sucrose Nutrition 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 abstract 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 abstract 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
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- 230000000052 comparative effect Effects 0.000 description 21
- 238000002347 injection Methods 0.000 description 17
- 239000007924 injection Substances 0.000 description 17
- 238000003756 stirring Methods 0.000 description 15
- 229910052586 apatite Inorganic materials 0.000 description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 12
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 12
- 206010061218 Inflammation Diseases 0.000 description 10
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- CMXPERZAMAQXSF-UHFFFAOYSA-M sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate;1,8-dihydroxyanthracene-9,10-dione Chemical compound [Na+].O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O.CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC CMXPERZAMAQXSF-UHFFFAOYSA-M 0.000 description 6
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- 239000011574 phosphorus Substances 0.000 description 4
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- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical group [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 4
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Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
编号 | 组分加入顺序 | 细胞增殖率 |
实施例1 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 119.6% |
实施例2 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 98.2% |
实施例3 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 93.7% |
实施例4 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 93.3% |
实施例5 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 101.5% |
实施例6 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 91.4% |
实施例7 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 89.7% |
实施例8 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 95.7% |
实施例9 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 97.3% |
实施例10 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 87.5% |
实施例11 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 90.3% |
实施例12 | 氧化镁、磷酸二氢钾+固化液+蔗糖、羟基磷灰石、金属螯合剂 | 93.4% |
对比例1 | 氧化镁、磷酸二氢钾、蔗糖、羟基磷灰石、金属螯合剂+固化液 | 60.4% |
对比例2 | 氧化镁、磷酸二氢钾、羟基磷灰石、蔗糖+固化液(水) | 51.2% |
样本 | 平均记分 | 反应类型 |
极性溶剂浸提实施例1浆体 | 0 | 无 |
非极性溶剂浸提实施例1浆体 | 0.2 | 极轻微 |
极性溶剂浸提对比例2浆体 | 0.3 | 轻微 |
非极性溶剂浸提对比例2浆体 | 0.6 | 轻度 |
阳性对照 | 6 | 重度 |
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