CN104740305A - Prescription with effects of nourishing kidney and reducing turbidity and preparation method thereof - Google Patents

Abstract

The invention discloses a prescription with effects of nourishing kidney and reducing turbidity and a preparation method thereof. Each dose of the traditional Chinese medicine is prepared from the following raw medicinal materials by weight: 6-15g of raw Chinese rhubarb, 9-12g of radix aconiti lateralis preparata, 9-12g of sundried ginseng and 9-15g of sealwort. The method can prepare the raw medicinal materials into decoction, granules or capsules. The prescription has very good curative effect on chronic renal failure, and is safe and effective in long-term treatment.

Description

There is prescription of kidney tonifying the turbid descending effect and preparation method thereof

Technical field

The invention belongs to the medicine preparation field with health-care effect, be specifically related to a kind of to there is prescription of kidney tonifying the turbid descending effect and preparation method thereof.

Background technology

Chronic renal failure (CRF) refers to that a variety of causes causes chronic progressive external Renal lesion, cause the obvious atrophy of kidney, can not maintain basic function, clinical appearance is with metabolite retention, water, electrolyte, acid base imbalance, each system involvement of whole body is the clinical syndrome of main manifestations.

Because the course of disease of chronic renal failure is very long, so a lot of problem may be there is over the course for the treatment of, therefore in order to the raising treatment effect of maximum possible, reduce the harm of chronic renal failure, for patients with chronic renal failure, the nursery work carrying out chronic renal failure is very important.

Radix Aconiti Lateralis Preparata is the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx..The first tenday period of a month in the last ten-days period in June to August excavate, and removing parent root, fibrous root and silt, practise and claim " mud Radix Aconiti Lateralis Preparata ", floats, boil, the method such as stir-fry reduces toxicity, title " Radix Aconiti Lateralis Preparata " after concocting through salting, water.It has recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, and by wind-cold damp pathogen, for YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.

Informal voucher is joined, a kind of rare mushroom bacterium eating medicine dual-purpose, and mushroom body constitution is tough, fragrant taste, deliciousness are tasty and refreshing, nutritious.Informal voucher ginseng (Radix Ginseng) be often referred to sun-dried Radix Ginseng, for Araliaceae for many years draft plant man ginseng root, main product in Jilin, Liaoning, Heilungkiang etc.The polysaccharide (SPG) extracted from schizophyllum commune, can stimulate mononuclear phagocyte system active, have significant defense effectiveness, have inhibitory action to tumor to chronic bacterial infection; The organic acid of its mycelia submerged fermentation output, is widely used in the aspects such as food, medical industry and biochemistry.

Summary of the invention

The object of the present invention is to provide and a kind of there is prescription of kidney tonifying the turbid descending effect and preparation method thereof, to chronic kidney hypofunction, there is extraordinary curative effect.This prescription kidney tonifying the turbid descending effect is obvious, and to health without any detrimental effect, prolonged application is safe and effective.

For achieving the above object, the present invention adopts following technical scheme:

There is the prescription of kidney tonifying the turbid descending effect, often pay Chinese medicine and adopt the crude drug of following weight ratio to make:

Radix Et Rhizoma Rhei 6-15g, Radix Aconiti Lateralis Preparata 9-12g, informal voucher ginseng 9-12g, Rhizoma Polygonati 9-15g.

The described prescription with kidney tonifying the turbid descending effect, the weight proportion of each crude drug is:

Radix Et Rhizoma Rhei 8-10g, Radix Aconiti Lateralis Preparata 9-10g, informal voucher ginseng 9-11g, Rhizoma Polygonati 13-15g.

The described prescription with kidney tonifying the turbid descending effect, the weight proportion of each crude drug is:

Radix Et Rhizoma Rhei 9g, Radix Aconiti Lateralis Preparata 9g, informal voucher ginseng 9g, Rhizoma Polygonati 15g.

The described prescription with kidney tonifying the turbid descending effect, the weight proportion of each crude drug is:

Radix Et Rhizoma Rhei 10 g, Radix Aconiti Lateralis Preparata 10g, informal voucher ginseng 11g, Rhizoma Polygonati 13g.

The described prescription with kidney tonifying the turbid descending effect, the dosage form of described prescription is the one in decoction, capsule or granule.

The dosage form of described prescription is decoction.

The preparation method of decoction comprises the following steps:

In crude drug, add tap water to submergence medicine 2 ~ 3cm, soak 30 minutes; Then after Radix Aconiti Lateralis Preparata is decocted first 30 minutes, add Rhizoma Polygonati, informal voucher ginseng decocts 30 minutes again, finally add Radix Et Rhizoma Rhei and decoct leaching medicine juice after 10 minutes; Add tap water again to submergence medicine 2cm, decoct leaching medicine juice after 25 minutes; Merge twice medicinal liquid, obtain decoction.

The preparation method of capsule or granule comprises the following steps:

1) first get Radix Et Rhizoma Rhei, Radix Aconiti Lateralis Preparata, informal voucher ginseng, Rhizoma Polygonati by weight, after soaking by material-water ratio 1:3-1:5, decoct 2 times, decoct 1.5h at every turn, merge 2 decocting liquids, filter, it is 1.5 ~ 2 that filtrate is concentrated into relative density;

2) after filtrate being let cool, adopt decoction and alcohol sedimentation technique, slowly add ethanol while stirring and make alcohol content reach 50wt%-60wt%, airtight cold preservation 24h, gets supernatant, reclaims ethanol, obtained extractum;

3) dextrin is added, dry, make granule, filled capsules or make granule.

The described application with the prescription of kidney tonifying the turbid descending effect, for the preparation of the medicine for the treatment of chronic kidney hypofunction.

The advantage of decoction absorbs soon, and drug effect plays rapidly, and can add and subtract with disease according to the change of the state of an illness, can embody the characteristic of differentiation of tcm fully.But along with the develop rapidly of society science and technology, the quickening of rhythm of life, the decocting for Chinese herbal medicine time is grown, be inconvenient to carry and be difficult to the shortcomings such as entrance manifests gradually, and therefore in order to adapt to the demand of society and clinical treatment, the different dosage form such as capsule, granule arises at the historic moment.

Chinese medicine granules refers to and is coordinated with suitable adjuvant by the prepared slices of Chinese crude drugs through Processing methods and the granular formulations made, and not only volume is little for it, and take, easy to carry.But effect of effect of Chinese medicine granules and traditional decoct has indifference, at present still without final conclusion.Traditional decoction, owing to being close to decoct, is considered to more meet tcm characteristic, and Chinese medicine granules adopts is remerge after point decocting, but how its clinical efficacy still needs to be probed into.Chinese medicine itself is containing a lot of chemical compositions, and close after decocting and will inevitably cause, between composition, chemical reaction occurs, presumable precipitation, the precipitation had, even also can produce new material.

Chinese medicine capsules refer to by Chinese medicine or add proper auxiliary materials through purifying, concentrated after dry pulverize or make granule etc., be then filled in Capsules.Its advantage is easy to swallow, the bitterness also can covered and stink, but its in the process made after the kinds of processes such as to withdraw deposit, concentrate, whether drug effect can change, and still needs exploration.

In sum, no matter Chinese medicine is decoction, granule or capsule, have respective advantage and shortcoming, should not take a part for the whole, lump together, main or curative effect clinically and sick Man's Demands separately will be seen, and many differences are still existed for the result of study of dosage form due to current home and abroad, be therefore necessary the clinical efficacy further going to further investigate various dosage form, only ensureing that, under clinical efficacy affirmative and similar prerequisite, the exploitation of TCM modern preparations is just meaningful.

beneficial effect of the present invention is:

1, prescription of the present invention has significant kidney tonifying the turbid descending effect, and Radix Et Rhizoma Rhei, Radix Aconiti Lateralis Preparata, informal voucher ginseng, Rhizoma Polygonati press certain mass than composite, have extraordinary curative effect to chronic kidney hypofunction;

2, decoction made by prescription of the present invention, and curative effect is better than granule, capsule, and the advantage of decoction absorbs soon, and drug effect plays rapidly, and can add and subtract with disease according to the change of the state of an illness, can embody the characteristic of differentiation of tcm fully; This experimental studies results shows, decoction group, groups of grains, Capsules group all can improve CRF rat RBC and HB content, reduce creatinine, blood urea nitrogen and urine protein, suppress renal interstitial fibroblastic Proliferative Activated, illustrate that three all has the effect of obviously treatment CRF, and with decoction group best results.Trace it to its cause, kinds of processes such as withdrawing deposit, concentrate may be passed through with capsule in the process made as mentioned above, cause the loss of some effective ingredient of medicine, destruction etc.; Granule effect is good not as decoction, may divide to decoct with granule and close, chemical reaction cannot occur relevant between medicine.

Detailed description of the invention

The present invention's the following example further illustrates the present invention, but protection scope of the present invention is not limited to the following example.

embodiment 1

The present embodiment makes medicament by disposable for total for the gavage of 8 weeks dose.

1) first the prepared slices of Chinese crude drugs (Radix Et Rhizoma Rhei 216g, Radix Aconiti Lateralis Preparata 216g, informal voucher ginseng 216g, Rhizoma Polygonati 360g) were added 5L water soaking after 2 hours, decoct 2 times, decoct 1.5h at every turn, merge 2 decocting liquids, filter, it is about 2 that filtrate is concentrated into relative density;

2) after filtrate lets cool, adopt decoction and alcohol sedimentation technique, slowly add ethanol while stirring and make alcohol content reach 50%, airtight cold preservation 24h, gets supernatant, reclaims ethanol, obtained extractum; Add appropriate dextrin afterwards, dry, make granule, make 1000g, filled capsules, capsule 0.42g/ grain.

medicament the present invention obtained carries out drug efficacy study

1, experimental program:

(1). modeling: 5/6 nephrectomy modeling renal failure model is adopted to rat;

(2). random packet: normal group, sham operated rats, model group, matched group, treatment group (comprising decoction group, Capsules group, groups of grains);

(3). administration: postoperative 4 weeks, treatment group is respectively to give Yishenjiangzhuofang decoction, capsule, granule gavage; Matched group gives NIAODUQING gavage; Normal group, sham operated rats and model group give normal saline gavage respectively; Administration time is 8 weeks;

(4). verifying the curative effect of Yishenjiangzhuofang treatment chronic kidney hypofunction by observing the index such as routine blood test, kidney merit, comparing the Different therapeutical effect of the party's decoction, capsule, granule three groups simultaneously.

, experimental result: curative effect: Yishenjiangzhuofang decoction group is best, Capsules group and groups of grains no statistical significance, Capsules group, groups of grains and NIAODUQING group also no significant difference.Although the curative effect of Capsules group does not have decoction group good, at least proving that Capsules group treatment chronic kidney hypofunction also has certain curative effect, is the clinical experimental basis carried out Yishenjiangzhuofang capsule formulation and provide certain.Concrete data are as follows:

The experimental result of routine blood test (erythrocyte (RBC), hemoglobin (HB)) respectively organized by table 1

Note: blank group compares with sham operated rats, P > 0.05, no difference of science of statistics;

▲ comparing with blank group, P < 0.05, has significant difference;

▼, ●, ★ compare with model group, and P < 0.05, has significant difference;

▼ compares with groups of grains, Capsules group, and P < 0.05, has significant difference;

▼ compares with NIAODUQING group, and P < 0.05, has significant difference;

★ with ● compare, P > 0.05, no difference of science of statistics.

As can be known from the results of Table 1: compared with blank group, sham operated rats RBC counting, HB content no significant difference (P > 0.05), model group RBC counting, HB content obviously reduce (P < 0.05); Compared with model group, decoction group, groups of grains, Capsules group RBC counting, HB content obviously raise (P < 0.05); Compared with NIAODUQING group, decoction group RBC counts, HB content obviously raises (P < 0.05), and groups of grains, Capsules group RBC counting, HB content raise not obvious (> 0.05); Compared with groups of grains, decoction group RBC counts, HB content obviously raises (P < 0.05), Capsules group RBC counting, HB content no significant difference (P > 0.05); Compared with Capsules group, decoction group RBC counts, HB content obviously raises (P < 0.05).As can be seen from interpretation of result: Yishenjiangzhuofang can improve CRF rat RBC counting, HB content, and decoction group curative effect is better than groups of grains, Capsules group.

The experimental result of serum creatinine (Scr), blood urea nitrogen (BUN) respectively organized by table 2

Note: blank group compares with sham operated rats, P > 0.05, no difference of science of statistics.

▲ comparing with blank group, P < 0.05, has significant difference.

▼, ●, ★ compare with model group, and P < 0.05, has significant difference.

▼ compares with groups of grains, Capsules group, and P < 0.05, has significant difference.

▼ compares with NIAODUQING group, and P < 0.05, has significant difference.

★ with ● compare, P > 0.05, no difference of science of statistics.

As can be known from the results of Table 2: compared with blank group, sham operated rats Scr, BUN no significant difference (P > 0.05), model group Scr, BUN obviously raise (P < 0.05); Compared with model group, decoction group, groups of grains, Capsules group Scr, BUN obviously reduce (P < 0.05); Compared with NIAODUQING group, decoction group Scr, BUN obviously reduce (P < 0.05), groups of grains, Capsules group Scr, BUN no significant difference (> 0.05); Compared with groups of grains, decoction group Scr, BUN obviously reduce (P < 0.05), Capsules group Scr, BUN no significant difference (P > 0.05); Compared with Capsules group, decoction group Scr, BUN obviously reduce (P < 0.05).As can be seen from interpretation of result: Yishenjiangzhuofang can reduce CRF rat Scr, BUN content, and decoction group curative effect is better than groups of grains, Capsules group.

embodiment 2

Have the prescription of kidney tonifying the turbid descending effect, the weight proportion of each crude drug is:

Radix Et Rhizoma Rhei 9g, Radix Aconiti Lateralis Preparata 9g, informal voucher ginseng 9g, Rhizoma Polygonati 15g, make decoction; Effect is best, and is better than creatinine to the effect reducing blood urea nitrogen.

Every day 2 times, sooner or later 40 minutes after meal decoction being taken warmly.

embodiment 3

Have the prescription of kidney tonifying the turbid descending effect, the weight proportion of each crude drug is:

Radix Et Rhizoma Rhei 10 g, Radix Aconiti Lateralis Preparata 10g, informal voucher ginseng 11g, Rhizoma Polygonati 13g; Make decoction.

Every day 2 times, sooner or later 40 minutes after meal decoction being taken warmly.

The foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.

Claims (9)

1. there is the prescription of kidney tonifying the turbid descending effect, it is characterized in that: often pay Chinese medicine and adopt the crude drug of following weight ratio to make: Radix Et Rhizoma Rhei 6-15g, Radix Aconiti Lateralis Preparata 9-12g, informal voucher ginseng 9-12g, Rhizoma Polygonati 9-15g.

2. the prescription with kidney tonifying the turbid descending effect according to claim 1, is characterized in that: the weight proportion of each crude drug is: Radix Et Rhizoma Rhei 8-10g, Radix Aconiti Lateralis Preparata 9-10g, informal voucher ginseng 9-11g, Rhizoma Polygonati 13-15g.

3. the prescription with kidney tonifying the turbid descending effect according to claim 1, is characterized in that: the weight proportion of each crude drug is: Radix Et Rhizoma Rhei 9g, Radix Aconiti Lateralis Preparata 9g, informal voucher ginseng 9g, Rhizoma Polygonati 15g.

4. the prescription with kidney tonifying the turbid descending effect according to claim 1, is characterized in that: the weight proportion of each crude drug is:

Radix Et Rhizoma Rhei 10 g, Radix Aconiti Lateralis Preparata 10g, informal voucher ginseng 11g, Rhizoma Polygonati 13g.

5. the prescription with kidney tonifying the turbid descending effect according to claim 1-4, is characterized in that: the dosage form of described prescription is the one in decoction, capsule or granule.

6. the prescription with kidney tonifying the turbid descending effect according to claim 5, is characterized in that: the dosage form of described prescription is decoction.

7. prepare a prescription as claimed in claim 5 with kidney tonifying the turbid descending effect, it is characterized in that: the preparation method of decoction comprises the following steps:

In crude drug, add tap water to submergence medicine 2 ~ 3cm, soak 30 minutes; Then after Radix Aconiti Lateralis Preparata is decocted first 30 minutes, add Rhizoma Polygonati, informal voucher ginseng decocts 30 minutes again, finally add Radix Et Rhizoma Rhei and decoct leaching medicine juice after 10 minutes; Add tap water again to submergence medicine 2cm, decoct leaching medicine juice after 25 minutes; Merge twice medicinal liquid, obtain decoction.

8. prepare a method for the prescription as claimed in claim 5 with kidney tonifying the turbid descending effect, it is characterized in that: the preparation method of capsule or granule comprises the following steps:

1) first get Radix Et Rhizoma Rhei, Radix Aconiti Lateralis Preparata, informal voucher ginseng, Rhizoma Polygonati by weight, after soaking by material-water ratio 1:3-1:5, decoct 2 times, decoct 1.5h at every turn, merge 2 decocting liquids, filter, it is 1.5 ~ 2 that filtrate is concentrated into relative density;

2) after filtrate being let cool, adopt decoction and alcohol sedimentation technique, slowly add ethanol while stirring and make alcohol content reach 50wt%-60wt%, airtight cold preservation 24h, gets supernatant, reclaims ethanol, obtained extractum;

3) dextrin is added, dry, make granule, filled capsules or make granule.

9. the application with the prescription of kidney tonifying the turbid descending effect according to claim 1-4, is characterized in that: for the preparation of the medicine for the treatment of chronic kidney hypofunction.