CN104689082A - External used medicine for treating prostatic calculus - Google Patents
External used medicine for treating prostatic calculus Download PDFInfo
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- CN104689082A CN104689082A CN201510158547.9A CN201510158547A CN104689082A CN 104689082 A CN104689082 A CN 104689082A CN 201510158547 A CN201510158547 A CN 201510158547A CN 104689082 A CN104689082 A CN 104689082A
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Abstract
The invention discloses external used medicine for treating prostatic calculus. The external used medicine aims to treat prostatic calculus. The external used medicine for treating prostatic calculus is characterized by comprising mole cricket, oriental grape roots, artemisia sieversiana Willd., lotus stamen, passion flower, stachys geobombycis, Buchnera cruciata Ham., caulis et folium plucheae, cannabis leaves, cedar leaves, bulbophyllum inconspicuum maxim and euryale ferox. Clinical experiments show that the external used medicine has the advantages of being good in curative effect, high in safety, and worth of clinic application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of external used medicine for the treatment of calculus of prostate.
Background technology
Calculus of prostate refer to the calculus formed in prostata tissue or acinus, different from the calculus rested in prostatic urethra, do not belong to lithangiuria.Calculus of prostate with organic starch sample body for core, corpora amylacea is made up of the epithelial cell come off and prostatic secretion, tradition thinks that above-mentioned corpora amylacea blocks the conduit of prostatic acini, during prostatic secretion secondary infection in acinus, the mucosa of acinus will be inflamed change, the inorganic salts such as calcium phosphate contained in prostate are made to form crystallization, being deposited on corpora amylacea from level to level forms calculus, but apply anti-inflammatory drug in actual clinical, only can alleviate prostatitic symptom, calculus process can not be delayed.Research in recent years shows, calculus of prostate acinar epithelia lining disappears, infiltrate between acinus and have a kind of basophilia inflammatory cluster of grains, this kind of inflammatory cluster of grains has reunion characteristic, then cell infiltration and fibrosis is stimulated, cause the Prostate gland stroma also fibrosis around calculus, cause the depositions such as inorganic salt, protein, cholesterol, citric acid.
At present, the treatment of calculus of prostate there is no effective Therapeutic Method, in general, asymptomatic sufferer is taked to appease more, to the patient of the chronic prostatitis syndrome shape that occurs together, take medicine antiinflammatory symptomatic treatment, and can only modus operandi be taked for middle severe patient.
Chinese medicine fossil treatment (as treating stranguria Huashi Tang: Endothelium Corneum Gigeriae Galli, Herba Lysimachiae, Spora Lygodii, Herba Salviae Chinensis, Folium Pyrrosiae, Semen Abutili, Natrii Sulfas, LIUYI SAN, Ramulus Cinnamomi, Poria) is for lithangiuria (stranguria caused by urinary stone) successful, but because calculus of prostate are present in prostata tissue or acinus, all there is difference in essence with the lithangiuria be present in urinary tract in nature in lesion locations and calculus, therefore the Therapeutic Method of above-mentioned relieving stranguria by diuresis is for calculus of prostate poor effect.And treat the medicine (as Qianlieshu pill: Radix Rehmanniae Preparata, Semen Coicis, Semen Benincasae, Fructus Corni, Rhizoma Dioscoreae, Cortex Moutan, Rhizoma Atractylodis, Semen Persicae, Rhizoma Alismatis, Poria, Ramulus Cinnamomi, Radix Aconiti Lateralis Preparata, Semen Allii Tuberosi, Herba Epimedii, Radix Glycyrrhizae) of chronic prostatitis, prostatic hyperplasia, only inflammatory symptoms can be solved, can not control or alleviate the further formation of calculus, remain a kind of palliative treatment.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the external used medicine of the little treatment calculus of prostate of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of external used medicine for the treatment of calculus of prostate, it is characterized in that being prepared from by the crude drug of following weight proportion: Gryllotalpa 1 ~ 3 part, smelly Herba Artemisiae 3 ~ 12 parts, Herba Passiflorae Caeruleae 3 ~ 12 parts, Stachys geobombycis C. Y. Wu 2 ~ 5 parts, 12 ~ 20 parts, plumage arrow, Herba Bulbophylli inconspicui 3 ~ 12 parts, Creeper root 12 ~ 20 parts, goldenrain tree sweet-scented osmanthus 12 ~ 20 parts, HUOMAYE 1 ~ 2 part, Stamen Nelumbinis 12 ~ 20 parts, Folium Cunninghamiae lanceolatae 1 ~ 5 part, 10 ~ 25 parts, Gorgon fruit.
Chinese medicine of the present invention is prepared from by the raw material of following optimum weight part proportioning: Gryllotalpa 2 parts, smelly Herba Artemisiae 12 parts, Herba Passiflorae Caeruleae 12 parts, Stachys geobombycis C. Y. Wu 5 parts, 15 parts, plumage arrow, Herba Bulbophylli inconspicui 12 parts, Creeper root 15 parts, goldenrain tree sweet-scented osmanthus 15 parts, HUOMAYE 1 part, Stamen Nelumbinis 15 parts, Folium Cunninghamiae lanceolatae 2 parts, 20 parts, Gorgon fruit.
Wherein said: Gryllotalpa, for the adult of Gryllotalpidae insecticide Gryllotalpa Gryllotalpa africana Palisot et Beaurois or large Gryllotalpa G. unispina Saussure is all.Nature and flavor are salty, cold.Return bladder, large intestine, small intestine meridian.Function cures mainly: inducing diuresis to remove edema.Smelly Herba Artemisiae is the herb of labiate Hemerocallis citrina Baroni Herba Rabdosiae glaucocalycis Rabdosia sculponeata (Vaniot) Hara.Acrid in the mouth; Warm in nature.Function cures mainly: regulate the flow of vital energy; Dampness removing; Removing toxic substances.Herba Passiflorae Caeruleae, is Passifloraceae Passiflora plant Herba Passiflorae Caeruleae Passiflora caerulea L., is used as medicine with root, Teng Heguo.Nature and flavor are bitter, temperature.Function cures mainly: expelling wind and removing dampness, promoting blood circulation and stopping pain.Stachys geobombycis C. Y. Wu, for Scarabeidae insecticide Korea scarab beetle Holotrichia diomphalia Bates or A. Corpulenta A-grade in the first class nomala carpulenta Motsch. is used as medicine with larva body.Salty, tepor.Function cures mainly: removing blood stasis with potent drugs blood, reducing swelling and alleviating pain, improving eyesight.Plumage arrow is the herb of goatweed Ramulus Euonymi (Herba Buchnerae cruciatae) Buchnera cruciatas Hamilt..Lightly seasoned; Micro-hardship; Cool in nature.Function cures mainly: heat-clearing and toxic substances removing; Cooling blood for hemostasis.Creeper root is the root of vitaceae Pueraria lobota Bud.Nature and flavor are sweet, flat.Function cures mainly: nourishing qi and blood, reuniting the fractured tendons and bones, longue meat.Goldenrain tree sweet-scented osmanthus is stem and leaf or the root of feverfew fetid marsh fleabane Pluchea indica (L.) Less..Nature and flavor sweet in the mouth; Slightly warm in nature.Function cures mainly: warming the stomach goes to amass; The hard eliminating stagnation of software; Expelling wind and removing dampness.HUOMAYE is the leaf of moraceae plants Fructus Cannabis Cannabis sativa L..Return lung; Bladder; Large intestine channel.Function cures mainly: preventing the attack (or recurrence) of malaria of relievining asthma; Removing toxic substances parasite killing.Stamen Nelumbinis is the dry stamen of nymphaeaceae plant lotus Nelumbo nucifera Gaertn..Nature and flavor are sweet, puckery, flat.Return through GUIXIN, kidney channel.Function cures mainly: reinforcing the kindey to control nocturnal emission.Herba Bulbophylli inconspicui is the orchid family Bulbophyllum platymiscium Herba Bulbophylli inconspicui Bulbophyllum inconspicuum Maxim., with all herbal medicine.Sweet, light, cool.Function cures mainly: nourishing YIN and clearing away heat, preventing phlegm from forming and stopping coughing.Folium Cunninghamiae lanceolatae is the leaf of taxodiaceae plant China fir Cunninghamia lanceolata (Lamb.) Hook..Nature and flavor are pungent; Slightly warm in nature.Function cures mainly: dispel the wind; Reduce phlegm; Invigorate blood circulation; Removing toxic substances.Gorgon fruit is the dry mature kernal of nymphaeaceae plant Gorgon euryale Euryale ferox Salisb..Nature and flavor are sweet, puckery, flat.Gui Jing returns spleen, kidney channel.Function cures mainly: supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, damp eliminating leukorrhagia stopping.
Compared with prior art, the present invention has following characteristics:
1, from " calculus of prostate acinus infiltrates basophilia inflammatory cluster of grains; so then stimulate cell infiltration, fibrosis, deposition " this inwardness starts with, not take Chinese Traditional Medicine " fossil calculus " means, solve the problem of its " reunion " from core;
2, get Gryllotalpa in prescription, smelly Herba Artemisiae is monarch drug: Gryllotalpa has very strong tissue penetration, walk to alter power strong, and it is little compared with other insect medicine for mucous membrane irritation, laboratory research shows that Gryllotalpa water logging agent (1:4) can make inflammatory cluster of grains loosen in vitro, and its mechanism of action is relevant with enzymolysis.Smelly Herba Artemisiae water extract 12.5mg/kg topical application all has obvious inhibitory action to Oleum Tiglii induced mice auricle acute exudative inflammation, and action intensity, higher than prednisolone acetate, also has the subcutaneous granulation tissue hyperplasia of cotton balls induced mice and shows inhibitory action.Gryllotalpa, smelly both Herba Artemisiaes coordinate the tack that effectively can reduce basophilia inflammatory cluster of grains, make its easier dismission, eliminate existing fiber laydown;
3, get Herba Passiflorae Caeruleae, Creeper root, Stachys geobombycis C. Y. Wu minister assistant Gryllotalpa, increase local blood confession, alleviate acinus mucosal inflammation and change, the interacinous cell infiltration of antagonism and fibrosis;
4, get plumage arrow, the clear excess-heat of Herba Bulbophylli inconspicui, clearind deficient heat minister help smelly Herba Artemisiae; The sodium oxalacetate raised in plumage arrow decoct has the effect regulating extracellular environment abnormal metabolism; And the antagonism of its hemostatic capability prevents Drug Prepared from Insects from moving blood too;
5, goldenrain tree sweet-scented osmanthus root extract can reduce and oozes out and hypertrophy, contributes to preventing inflammatory granule from gathering further, reduces probability after recurring therapies;
6, Gorgon fruit and heavy dose of Stamen Nelumbinis water decoction can reduce local skin stimulates;
7, Folium Cunninghamiae lanceolatae and HUOMAYE contribute to increasing transdermal absorption factor, and non-stimulated for local, and HUOMAYE also has slight local anesthesia effect, alleviate the stimulation of Drug Prepared from Insects;
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Gryllotalpa 2 parts, smelly Herba Artemisiae 12 parts, Herba Passiflorae Caeruleae 12 parts, Stachys geobombycis C. Y. Wu 5 parts, Creeper root 15 parts, 15 parts, plumage arrow, Herba Bulbophylli inconspicui 12 parts, goldenrain tree sweet-scented osmanthus 15 parts, HUOMAYE 1 part, Stamen Nelumbinis 15 parts, Folium Cunninghamiae lanceolatae 2 parts, 20 parts, Gorgon fruit.
The preparation method of embodiment 1 is: Gryllotalpa, Creeper root, smelly Herba Artemisiae, Herba Passiflorae Caeruleae, Stachys geobombycis C. Y. Wu, plumage arrow, Herba Bulbophylli inconspicui, goldenrain tree sweet-scented osmanthus, HUOMAYE, Folium Cunninghamiae lanceolatae, Stamen Nelumbinis, Gorgon fruit mixing and water adding are decocted secondary, each 1 hour, extracting solution filters, and merges, gets gauze deg and spread on Zhongji acupoint.
The finished product that this kind of preparation method is prepared is liquid, and inconvenience stores, and also described filtered solution can be condensed into thick paste, drying under reduced pressure, pulverize 150 mesh sieves, becomes fine powder.During use, Zhongji acupoint is adjusted to stick use gained fine powder water tune/vinegar.The extraction process preparing scheme Raw medicine due to above-mentioned two kinds is identical, is therefore only the change in finished product physical behavior, and pharmacology, drug effect are identical.
Embodiment 2, crude drug weight proportion: Gryllotalpa 1 part, smelly Herba Artemisiae 3 parts, Herba Passiflorae Caeruleae 3 parts, Stachys geobombycis C. Y. Wu 2 parts, 12 parts, plumage arrow, Creeper root 12 parts, goldenrain tree sweet-scented osmanthus 12 parts, HUOMAYE 1 part, Stamen Nelumbinis 12 parts, Herba Bulbophylli inconspicui 3 parts, Folium Cunninghamiae lanceolatae 1 part, 10 parts, Gorgon fruit.
Embodiment 3, crude drug weight proportion: Gryllotalpa 2 parts, smelly Herba Artemisiae 12 parts, Herba Passiflorae Caeruleae 12 parts, Stachys geobombycis C. Y. Wu 5 parts, 15 parts, plumage arrow, Creeper root 15 parts, goldenrain tree sweet-scented osmanthus 15 parts, HUOMAYE 1 part, Stamen Nelumbinis 15 parts, Herba Bulbophylli inconspicui 12 parts, Folium Cunninghamiae lanceolatae 2 parts, 20 parts, Gorgon fruit.
Embodiment 4, crude drug weight proportion: Gryllotalpa 3 parts, smelly Herba Artemisiae 12 parts, Herba Passiflorae Caeruleae 12 parts, Stachys geobombycis C. Y. Wu 2 parts, 20 parts, plumage arrow, Creeper root 20 parts, goldenrain tree sweet-scented osmanthus 20 parts, HUOMAYE 2 parts, Stamen Nelumbinis 20 parts, Herba Bulbophylli inconspicui 12 parts, Folium Cunninghamiae lanceolatae 5 parts, 25 parts, Gorgon fruit.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) by Folium Cunninghamiae lanceolatae, HUOMAYE, smelly Herba Artemisiae, Herba Bulbophylli inconspicui with vapor distillation extract volatile oil for subsequent use, medicinal residues are continued to employ;
(2) mixed with the medicinal residues of step 1 gained in Gryllotalpa, Creeper root, Stamen Nelumbinis, Herba Passiflorae Caeruleae, Stachys geobombycis C. Y. Wu, plumage arrow, goldenrain tree sweet-scented osmanthus, Gorgon fruit and add 8 times amount soak by water and decoct with water secondary, each 1 hour, extracting solution filters, and merges;
(3) the extracting solution concentrating under reduced pressure of step 2 gained is concentrated solution, and under concentrated solution 25 DEG C of conditions, relative density is 1.16; Under agitation, in concentrated solution, add 95% ethanol, make ethanol content to 70%, under 0 ~ 4 DEG C of cold preservation, static 24 hours, get supernatant liquid filtering, filtrate recycling ethanol, and under being concentrated into 25 DEG C of conditions, relative density is 1.35, obtains thick paste;
(4) volatile oil of step 1 gained is sprayed in step 3 gained thick paste, mixing, subpackage.
During use, gained thick paste Zhongji acupoint in step 4 is sticked use.
In order to easy to use, can add water-soluble base glycerol and sodium lauryl sulfate by gained thick paste in step 4, heating in water bath fusing evenly, then adds fat-soluble substrate monoglyceride, paraffin, vaseline, and heating in water bath fusing makes evenly.Being spread evenly across after slightly cold on cotton, is 5cm × 60cm by trimming, is affixed on pressure sensitive adhesive, obtained acupoint adhesive plaster.Above-described acupoint adhesive plaster preparation technology also can use existing preparation method in prior art.
The efficient combination of said medicine, coordinates mutually, effectively reach the object controlling calculus of prostate state of an illness progress, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: in February, 2012 ~ in February, 2014 is diagnosed as " calculus of prostate ", and AP roentgenograms display prostatic high density shadow diameter is less than patient 98 example of 1cm.35 ~ 68 years old age, 57 years old mean age.Wherein occur together prostatic hyperplasia have 67 example.
1.1.2 diagnostic criteria: B ultrasonic prompting prostate visits and strong echo light group, rear accompanying sound shadow or without sound shadow, or AP roentgenograms and inspection show as the high density shadow of prostatic pit shape.
1.1.3 divide into groups: patient be divided into matched group, soak group and stick group.Matched group 30 example, soak group 32 example, sticks group 36 example.Compare on age, the state of an illness, the course of disease, the prostatic hyperplasia that whether occurs together before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 Therapeutic Method: matched group directed toward bacteria is cultivated and antibiotic drug sensitive result of the test selects antibiotic, mainly based on quinolones.Soak group applies Zhongji acupoint, every day twice with gained medicinal liquid in the embodiment of the present invention 1 or the damping of medicated powder water.Stick group to stick with gained thick paste Zhongji acupoint in the embodiment of the present invention 3, every day twice.Three groups of treatments are 4 weeks the course for the treatment of.
1.2.2 criterion of therapeutical effect: 1. fully recover: clinical subjective symptoms disappears, B ultrasonic 2 times (or more than 2 times) check prostate acoustic image without exception; 2. take a turn for the better: subjective symptoms disappears or alleviates, and B ultrasonic check calculus of prostate reduce or reduce; 3. invalid: clinical symptoms is not improved, and B ultrasonic check calculus quantity and volume are without change.
1.2.3 stop treatment after 12 months, recovery from illness and effectively patient check B ultrasonic, for relapse criteria, calculate relapse rate with " B ultrasonic check calculus of prostate increase or increase ".
1.2.4 statistical analysis: SPSS 16.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
Comparitive study after 2.1 3 groups of patient treatment 4W: see the following form,
| Group | Number of cases | Recovery from illness | Improve | Invalid | Effective percentage | Cure rate |
| Matched group | 30 | 1 | 18 | 11 | 63.33% | 3.33% |
| Soak group | 32 | 7 | 21 | 4 | 87.50% | 21.88% |
| Stick group | 36 | 9 | 22 | 5 | 86.11% | 25.00% |
Soak group organizes total effective rate apparently higher than matched group (χ with sticking
2=4.93, P<0.05; χ
2=4.62, P<0.05); And soak group organizes cure rate also apparently higher than matched group, (χ with sticking
2=4.74, P<0.05; χ
2=5.98, P<0.05).
Recurrence after 2.2 3 groups of patient treatment 12m: relapse rate is respectively matched group 47.37%(9/19), soak group 10.71%(5/28) and stick group 16.13%(5/31), soak group and stick group recurrence be starkly lower than matched group, (χ
2=4.71, P<0.05; χ
2=5.70, P<0.05).
2.3 3 groups of adverse reactions of patients incidence rates compare: in treatment, obviously relevant to medicine untoward reaction does not all appear in three groups of patients.
3. conclusion.
This result of study shows, use soak group of the present invention and stick group treatment calculus of prostate cure rate, total effective rate all apparently higher than the matched group of simple antiinflammatory, and relapse rate is low in 1 year, illustrate that pharmaceutical composition of the present invention has effective, that safety is higher advantage in calculus of prostate treatment, and action target spot is not anti-inflammatory, antibacterial treatment.
Claims (2)
1. treat the external used medicine of calculus of prostate for one kind, it is characterized in that, crude drug is: Gryllotalpa 1 ~ 3 part, smelly Herba Artemisiae 3 ~ 12 parts, Herba Passiflorae Caeruleae 3 ~ 12 parts, Stachys geobombycis C. Y. Wu 2 ~ 5 parts, 12 ~ 20 parts, plumage arrow, Creeper root 12 ~ 20 parts, goldenrain tree sweet-scented osmanthus 12 ~ 20 parts, HUOMAYE 1 ~ 2 part, Stamen Nelumbinis 12 ~ 20 parts, Herba Bulbophylli inconspicui 3 ~ 12 parts, Folium Cunninghamiae lanceolatae 1 ~ 5 part, 10 ~ 25 parts, Gorgon fruit.
2. a kind of external used medicine for the treatment of calculus of prostate according to claim 1, it is characterized in that, crude drug is: Gryllotalpa 2 parts, smelly Herba Artemisiae 12 parts, Herba Passiflorae Caeruleae 12 parts, Stachys geobombycis C. Y. Wu 5 parts, 15 parts, plumage arrow, Creeper root 15 parts, goldenrain tree sweet-scented osmanthus 15 parts, HUOMAYE 1 part, Stamen Nelumbinis 15 parts, Herba Bulbophylli inconspicui 12 parts, Folium Cunninghamiae lanceolatae 2 parts, 20 parts, Gorgon fruit.
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|---|---|---|---|
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109045188A (en) * | 2018-10-12 | 2018-12-21 | 广州市暖能新能源科技有限公司 | A kind of Chinese herbal medicine hot compress paste of establishing-Yang waist support and preparation method thereof |
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| CN102302566A (en) * | 2011-08-05 | 2012-01-04 | 刘翠传 | Dampness-eliminating and stasis-removing capsules |
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2015
- 2015-04-07 CN CN201510158547.9A patent/CN104689082A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008239564A (en) * | 2007-03-28 | 2008-10-09 | Toyo Shinyaku:Kk | Agent for preventing renal/ureteral stone formation |
| CN102302566A (en) * | 2011-08-05 | 2012-01-04 | 刘翠传 | Dampness-eliminating and stasis-removing capsules |
Non-Patent Citations (1)
| Title |
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| 郭军等: "《前列腺疾病治疗特效方》", 30 June 2010 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109045188A (en) * | 2018-10-12 | 2018-12-21 | 广州市暖能新能源科技有限公司 | A kind of Chinese herbal medicine hot compress paste of establishing-Yang waist support and preparation method thereof |
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Application publication date: 20150610 |