CN104688841A - Preparation method of Suxiaoxintong granules - Google Patents

Abstract

The invention discloses a preparation method of Suxiaoxintong granules. The preparation method comprises the following steps: (1) weighing 401 parts by weight of Szechuan lovage rhizome, 240 parts by weight of tree peony bark and 26 parts by weight of borneol; and (2) carrying out heating reflux extraction on Szechuan lovage rhizome and tree peony bark twice with three times of ethanol water solution at a volume concentration of 90-99% by mass, 2.5 hours for the first time and 2 hours for the second time, filtering the extracting solutions, mixing filtrates obtained twice, recovering the filtrates at reduced pressure at 65 DEG C with a rotary film until paste with relative density of 1.15-1.20 at 80 DEG C is obtained, collecting 20+/-5% of the paste, drying and grinding the paste, adding borneol, mixing borneol with the powder uniformly to obtain a mixture, adding sucrose, starch or dextrin with mass being 1-5 times that of the mixture, mixing the materials uniformly, granulating the mixture and drying the granules, thus obtaining the Suxiaoxintong granules. The Suxiaoxintong granules are low in cost, are safe, take effect quickly, have good curative effects and are convenient to carry. The method has the advantages of few labor hours, high active ingredient transfer rate and improvement of the safety to operating personnel and is suitable for large-scale industrial production.

Description

The preparation method of quick-acting cardiac pain granule

Technical field

The invention belongs to Chinese drug preparation field, relate to the preparation method of quick-acting cardiac pain granule.

Background technology

Angina pectoris is commonly encountered diseases, the frequently-occurring disease of cardiovascular system, and its sickness rate is in rising trend in recent years, is the disease that people's life and quality of life are arrived in serious threat.Angina pectoris belongs to traditional Chinese medical science obstruction of qi in the chest and cardialgia category, and its morbidity Chang Yuxin, all dirty prosperity and decline of kidney,liver,spleen are relevant, and pathogenesis always belongs to evil numbness heart network, and QI and blood is smooth, channels stasis blocking, and heart network contraction is anxious, and heart arteries and veins is obstructed.The clinical syndrome being main manifestations with ictal chest pain that angina pectoris is coronary insufficiency, cardiac muscle transient ischemic anoxia sharply causes.

Be directed to the treatment of angina pectoris, SUXIAO JIUXIN WAN that current common medicine has " rescuing psychological treatment " and " cardioprotectant " Heart pill of Musk, therefore, await developing a kind of collection to nourish heart, protect the heart, fast-acting heart disease curing triple function, in the Chinese medicine preparation of one, gives prominence to its resisting coronary heart disease anginal atherosclerosis etiological treatment feature, control is laid equal stress on, and fundamentally alleviates patients with coronary heart disease misery.

Summary of the invention

The object of the invention is to overcome the deficiencies in the prior art, a kind of preparation method of quick-acting cardiac pain granule is provided.

Technical scheme of the present invention is summarized as follows:

A preparation method for quick-acting cardiac pain granule, comprises the steps:

(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;

(2) by Rhizoma Chuanxiong and Cortex Moutan by 3 quality volumetric concentration be doubly the ethanol water heating and refluxing extraction twice of 90-99%, first time 2.5h, second time 2h, filter, merge twice filtrate, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.15-1.20, receive cream 20% ± 5%.Drying and crushing, adds Borneolum Syntheticum mix homogeneously and obtains mixture, adds described mixture quality 1-5 sucrose, starch or dextrin mixing doubly, granulates, be drying to obtain.

Advantage of the present invention

Quick-acting cardiac pain granule cost of the present invention is low, and safety is rapid-action, good effect, easy to carry.

Method of the present invention is few for its man-hour, and the effective ingredient rate of transform is high, improves the safety of operator, is suitable for the large production of industry.

Detailed description of the invention

Below in conjunction with detailed description of the invention, the present invention is further illustrated.

Embodiment 1

A preparation method for quick-acting cardiac pain granule, comprises the steps:

(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;

(2) by Rhizoma Chuanxiong and Cortex Moutan by 3 quality volumetric concentration be doubly 95% ethanol water heating and refluxing extraction twice, first time 2.5h, second time 2h, filter, merge twice filtrate, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.15, receive cream 25%.Drying and crushing, adds Borneolum Syntheticum mix homogeneously and obtains mixture, adds the sucrose mixing of described mixture quality 3 times, granulates, be drying to obtain.

Embodiment 2

A preparation method for quick-acting cardiac pain granule, comprises the steps:

(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;

(2) by Rhizoma Chuanxiong and Cortex Moutan by 3 quality volumetric concentration be doubly 90% ethanol water heating and refluxing extraction twice, first time 2.5h, second time 2h, filter, merge twice filtrate, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.17, receive cream 20%.Drying and crushing, adds Borneolum Syntheticum mix homogeneously and obtains mixture, adds the starch mixing of described mixture quality 1 times, granulates, be drying to obtain.

Embodiment 3

A preparation method for quick-acting cardiac pain granule, comprises the steps:

(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;

(2) by Rhizoma Chuanxiong and Cortex Moutan by 3 quality volumetric concentration be doubly 99% ethanol water heating and refluxing extraction twice, first time 2.5h, second time 2h, filter, merge twice filtrate, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.20, receive cream 15%.Drying and crushing, adds Borneolum Syntheticum mix homogeneously and obtains mixture, adds the dextrin mixing of described mixture quality 5 times, granulates, be drying to obtain.

Claims (1)

1. a preparation method for quick-acting cardiac pain granule, comprises the steps:

(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;

(2) by Rhizoma Chuanxiong and Cortex Moutan by 3 quality volumetric concentration be doubly the ethanol water heating and refluxing extraction twice of 90-99%, first time 2.5h, second time 2h, filter, merge twice filtrate, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.15-1.20, receive cream 20% ± 5%.Drying and crushing, adds Borneolum Syntheticum mix homogeneously and obtains mixture, adds described mixture quality 1-5 sucrose, starch or dextrin mixing doubly, granulates, be drying to obtain.