CN104688839A - Preparation method of Suxiaoxintong sustained release tablets - Google Patents
Preparation method of Suxiaoxintong sustained release tablets Download PDFInfo
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- CN104688839A CN104688839A CN201310662690.2A CN201310662690A CN104688839A CN 104688839 A CN104688839 A CN 104688839A CN 201310662690 A CN201310662690 A CN 201310662690A CN 104688839 A CN104688839 A CN 104688839A
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Abstract
The invention discloses a preparation method of Suxiaoxintong sustained release tablets. The preparation method comprises the following steps: (1) weighing Szechuan lovage rhizome, tree peony bark and borneol by weight; (2) decocting Szechuan lovage rhizome with water, filtering the decoction, concentrating the filtrate into paste, adding ethanol for precipitation and pouring out the supernatant; (3) adding an ethanol water solution to soak tree peony bark, percolating tree peony bark with the ethanol water solution and collecting percolate; and (4) mixing the supernatant with the percolate, generating a precipitate, standing for 24 hours, pouring out the supernatant, recovering the supernatant at reduced pressure until paste is obtained, collecting the paste through water bath, drying and grinding the paste, adding borneol, mixing borneol with the powder uniformly to obtain a mixture, sieving the mixture, a filling agent, hydroxypropyl methylcellulose and a release rate regulating agent with a 60-mesh sieve and mixing the materials uniformly, adding proper amount of adhesive to prepare a soft material, carrying out sieving for granulation, drying the granules, arranging the granules and tabletting the granules. The Suxiaoxintong sustained release tablets are low in cost, are safe, take effect quickly, have good curative effects and are convenient to carry. The method has the advantages of few labor hours, high active ingredient transfer rate and improvement of the safety to operating personnel and is suitable for large-scale industrial production.
Description
Technical field
The invention belongs to Chinese drug preparation field, relate to the preparation method of quick-acting cardiac pain slow releasing tablet.
Background technology
Angina pectoris is commonly encountered diseases, the frequently-occurring disease of cardiovascular system, and its sickness rate is in rising trend in recent years, is the disease that people's life and quality of life are arrived in serious threat.Angina pectoris belongs to traditional Chinese medical science obstruction of qi in the chest and cardialgia category, and its morbidity Chang Yuxin, all dirty prosperity and decline of kidney,liver,spleen are relevant, and pathogenesis always belongs to evil numbness heart network, and QI and blood is smooth, channels stasis blocking, and heart network contraction is anxious, and heart arteries and veins is obstructed.The clinical syndrome being main manifestations with ictal chest pain that angina pectoris is coronary insufficiency, cardiac muscle transient ischemic anoxia sharply causes.
Be directed to the treatment of angina pectoris, SUXIAO JIUXIN WAN that current common medicine has " rescuing psychological treatment " and " cardioprotectant " Heart pill of Musk, therefore, await developing a kind of collection to nourish heart, protect the heart, fast-acting heart disease curing triple function, in the Chinese medicine preparation of one, gives prominence to its resisting coronary heart disease anginal atherosclerosis etiological treatment feature, control is laid equal stress on, and fundamentally alleviates patients with coronary heart disease misery.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of preparation method of quick-acting cardiac pain slow releasing tablet is provided.
Technical scheme of the present invention is summarized as follows:
A preparation method for quick-acting cardiac pain slow releasing tablet, comprises the steps:
(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;
(2) by Rhizoma Chuanxiong 4 quality soak by water twice doubly, first time 2.5h, second time 2h, filters, merges twice filtrate, and when being condensed into 50 DEG C, relative density is the cream of 1.20 ~ 1.25, adds the ethanol precipitate with ethanol three days with cream equimultiple, inclines and supernatant;
(3) Cortex Moutan adds the ethanol water immersion 24h that 3 quality concentration expressed in percentage by volume is doubly 90%, is the ethanol water percolation of 90%, collects Cortex Moutan 10 quality percolate doubly by concentration expressed in percentage by volume;
(4) percolate that supernatant step (2) obtained and step (3) obtain merges, produce precipitation, leave standstill 24h, incline and supernatant, be the cream of 1.29-1.31 65 DEG C of reclaim under reduced pressure to relative density during at 80 DEG C with rotating thin film, cream 20% ± 5% is received in water-bath two days, drying and crushing, add Borneolum Syntheticum mix homogeneously and obtain mixture, take the appropriate and filler 15-25 mass parts of mixture 300 mass parts, hypromellose 70-90 mass parts, rate of release regulator 3-8 mass parts, binding agent; Described mixture, filler, hypromellose and rate of release regulator are crossed 60 mesh sieve mixings, add binding agent soft material processed in right amount, cross 20 mesh sieves and granulate, 40-50 DEG C of drying, dry granule crosses 20 mesh sieve granulate, tabletting.
Described hypromellose is selected from HPMC K4M, hypromellose K15M or hypromellose K100M.
Described rate of release regulator is selected from carboxymethyl starch sodium or polyvinylpolypyrrolidone.
Described binding agent be selected from mass concentration be 3% polyvidone alcoholic solution or mass concentration be 3% ethyl cellulose alcoholic solution.
Described filler is microcrystalline Cellulose, calcium sulfate, lactose, polyvidone or amylum pregelatinisatum.
Advantage of the present invention
Quick-acting cardiac pain slow releasing tablet cost of the present invention is low, and safety is rapid-action, good effect, easy to carry.
Method of the present invention is few for its man-hour, and the effective ingredient rate of transform is high, improves the safety of operator, is suitable for the large production of industry.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further illustrated.
Embodiment 1
A preparation method for quick-acting cardiac pain slow releasing tablet, comprises the steps:
(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;
(2) by Rhizoma Chuanxiong 4 quality soak by water twice doubly, first time 2.5h, second time 2h, filters, merges twice filtrate, and when being condensed into 50 DEG C, relative density is the cream of 1.20, adds the ethanol precipitate with ethanol three days with cream equimultiple, inclines and supernatant;
(3) Cortex Moutan adds the ethanol water immersion 24h that 3 quality concentration expressed in percentage by volume is doubly 90%, is the ethanol water percolation of 90%, collects Cortex Moutan 10 quality percolate doubly by concentration expressed in percentage by volume;
(4) percolate that supernatant step (2) obtained and step (3) obtain merges, produce precipitation, leave standstill 24h, incline and supernatant, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.29, water-bath receives cream 20% in two days, drying and crushing, add Borneolum Syntheticum mix homogeneously and obtain mixture, take mixture 300 mass parts, HPMC K4M 80 mass parts, carboxymethyl starch sodium 5 mass parts, mass concentration be 3% appropriate and microcrystalline Cellulose 20 mass parts of polyvidone alcoholic solution;
Described mixture, microcrystalline Cellulose, HPMC K4M and carboxymethyl starch sodium are crossed 60 mesh sieve mixings, add the polyvidone alcoholic solution soft material processed in right amount that mass concentration is 3%, cross 20 mesh sieves and granulate, 45 DEG C of dryings, dry granule crosses 20 mesh sieve granulate, tabletting.
Embodiment 2
A preparation method for quick-acting cardiac pain slow releasing tablet, comprises the steps:
(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;
(2) by Rhizoma Chuanxiong 4 quality soak by water twice doubly, first time 2.5h, second time 2h, filters, merges twice filtrate, and when being condensed into 50 DEG C, relative density is the cream of 1.25, adds the ethanol precipitate with ethanol three days with cream equimultiple, inclines and supernatant;
(3) Cortex Moutan adds the ethanol water immersion 24h that 3 quality concentration expressed in percentage by volume is doubly 90%, is the ethanol water percolation of 90%, collects Cortex Moutan 10 quality percolate doubly by concentration expressed in percentage by volume;
(4) percolate that supernatant step (2) obtained and step (3) obtain merges, produce precipitation, leave standstill 24h, incline and supernatant, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.31, water-bath receives cream 25% in two days, drying and crushing, add Borneolum Syntheticum mix homogeneously and obtain mixture, take mixture 300 mass parts, hypromellose K15M70 mass parts, polyvinylpolypyrrolidone 8 mass parts, mass concentration be 3% appropriate and calcium sulfate 15 mass parts of ethyl cellulose alcoholic solution; Described mixture, calcium sulfate, hypromellose K15M and polyvinylpolypyrrolidone are crossed 60 mesh sieve mixings, add the ethyl cellulose alcoholic solution soft material processed in right amount that mass concentration is 3%, cross 20 mesh sieves and granulate, 40-50 DEG C of drying, dry granule crosses 20 mesh sieve granulate, tabletting.
Embodiment 3
A preparation method for quick-acting cardiac pain slow releasing tablet, comprises the steps:
(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;
(2) by Rhizoma Chuanxiong 4 quality soak by water twice doubly, first time 2.5h, second time 2h, filters, merges twice filtrate, and when being condensed into 50 DEG C, relative density is the cream of 1.25, adds the ethanol precipitate with ethanol three days with cream equimultiple, inclines and supernatant;
(3) Cortex Moutan adds the ethanol water immersion 24h that 3 quality concentration expressed in percentage by volume is doubly 90%, is the ethanol water percolation of 90%, collects Cortex Moutan 10 quality percolate doubly by concentration expressed in percentage by volume;
(4) percolate that supernatant step (2) obtained and step (3) obtain merges, produce precipitation, leave standstill 24h, incline and supernatant, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.31, water-bath receives cream 15% in two days, drying and crushing, add Borneolum Syntheticum mix homogeneously and obtain mixture, take mixture 300 mass parts, hypromellose K100M90 mass parts, polyvinylpolypyrrolidone 3 mass parts, mass concentration be 3% appropriate and lactose 25 mass parts of ethyl cellulose alcoholic solution; Described mixture, lactose, hypromellose K100M and polyvinylpolypyrrolidone are crossed 60 mesh sieve mixings, add the ethyl cellulose alcoholic solution soft material processed in right amount that mass concentration is 3%, cross 20 mesh sieves and granulate, 40-50 DEG C of drying, dry granule crosses 20 mesh sieve granulate, tabletting.
Claims (5)
1. a preparation method for quick-acting cardiac pain slow releasing tablet, comprises the steps:
(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;
(2) by Rhizoma Chuanxiong 4 quality soak by water twice doubly, first time 2.5h, second time 2h, filters, merges twice filtrate, and when being condensed into 50 DEG C, relative density is the cream of 1.20 ~ 1.25, adds the ethanol precipitate with ethanol three days with cream equimultiple, inclines and supernatant;
(3) Cortex Moutan adds the ethanol water immersion 24h that 3 quality concentration expressed in percentage by volume is doubly 90%, is the ethanol water percolation of 90%, collects Cortex Moutan 10 quality percolate doubly by concentration expressed in percentage by volume;
(4) percolate that supernatant step (2) obtained and step (3) obtain merges, produce precipitation, leave standstill 24h, incline and supernatant, be the cream of 1.29-1.31 65 DEG C of reclaim under reduced pressure to relative density during at 80 DEG C with rotating thin film, cream 20% ± 5% is received in water-bath two days, drying and crushing, add Borneolum Syntheticum mix homogeneously and obtain mixture, take the appropriate and filler 15-25 mass parts of mixture 300 mass parts, hypromellose 70-90 mass parts, rate of release regulator 3-8 mass parts, binding agent; Described mixture, filler, hypromellose and rate of release regulator are crossed 60 mesh sieve mixings, add binding agent soft material processed in right amount, cross 20 mesh sieves and granulate, 40-50 DEG C of drying, dry granule crosses 20 mesh sieve granulate, tabletting.
2. the preparation method of a kind of quick-acting cardiac pain slow releasing tablet according to claim 1, is characterized in that described hypromellose is selected from HPMC K4M, hypromellose K15M or hypromellose K100M.
3. the preparation method of a kind of quick-acting cardiac pain slow releasing tablet according to claim 1, is characterized in that described rate of release regulator is selected from carboxymethyl starch sodium or polyvinylpolypyrrolidone.
4. the preparation method of a kind of quick-acting cardiac pain slow releasing tablet according to claim 1, it is characterized in that described binding agent be selected from mass concentration be 3% polyvidone alcoholic solution or mass concentration be 3% ethyl cellulose alcoholic solution.
5. the preparation method of a kind of quick-acting cardiac pain slow releasing tablet according to claim 1, is characterized in that described filler is microcrystalline Cellulose, calcium sulfate, lactose, polyvidone or amylum pregelatinisatum.
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| CN201310662690.2A CN104688839A (en) | 2013-12-06 | 2013-12-06 | Preparation method of Suxiaoxintong sustained release tablets |
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| CN201310662690.2A CN104688839A (en) | 2013-12-06 | 2013-12-06 | Preparation method of Suxiaoxintong sustained release tablets |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368338A (en) * | 2001-02-05 | 2002-09-11 | 杨孟君 | Nano medicine 'Quick-acting Xintong' and its preparing process |
| CN101085072A (en) * | 2007-06-21 | 2007-12-12 | 复旦大学 | Sustained-release tablet containing folium crataegi total flavone |
| CN101856398A (en) * | 2009-04-10 | 2010-10-13 | 北京亚东生物制药有限公司 | Chinese medicinal composition for clearing heat and cooling blood, promoting blood circulation and stopping pain and preparation and detection method |
| CN102579572A (en) * | 2012-02-17 | 2012-07-18 | 李晓云 | Heart resurrection dripping pill production process |
-
2013
- 2013-12-06 CN CN201310662690.2A patent/CN104688839A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368338A (en) * | 2001-02-05 | 2002-09-11 | 杨孟君 | Nano medicine 'Quick-acting Xintong' and its preparing process |
| CN101085072A (en) * | 2007-06-21 | 2007-12-12 | 复旦大学 | Sustained-release tablet containing folium crataegi total flavone |
| CN101856398A (en) * | 2009-04-10 | 2010-10-13 | 北京亚东生物制药有限公司 | Chinese medicinal composition for clearing heat and cooling blood, promoting blood circulation and stopping pain and preparation and detection method |
| CN102579572A (en) * | 2012-02-17 | 2012-07-18 | 李晓云 | Heart resurrection dripping pill production process |
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Application publication date: 20150610 |