CN103054958A - Yatongting granule and preparation method thereof - Google Patents
Yatongting granule and preparation method thereof Download PDFInfo
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- CN103054958A CN103054958A CN 201210592133 CN201210592133A CN103054958A CN 103054958 A CN103054958 A CN 103054958A CN 201210592133 CN201210592133 CN 201210592133 CN 201210592133 A CN201210592133 A CN 201210592133A CN 103054958 A CN103054958 A CN 103054958A
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Abstract
The invention discloses a Yatongting granule and a preparation method thereof. The preparation method comprises the following steps: step 1, weighing long pepper, clove and borneol; step 2, adding the long pepper in aqueous alcohol for refluxing extraction and filtering, then recycling alcohol to obtain a dense extract, adding the aqueous alcohol in the dense extract, and after uniform mixing and standing, and extracting supernatant liquid for concentration under reduced pressure to obtain an extractive 1; step 3, extracting clove oil from the clove by a steam distillation method to obtain an extractive 2; and step 4, drying the extractive 1 and then mixing the dried extractive 1 with the extractive 2 and the borneol to obtain a mixture, adding sucrose, starch or dextrin 1-5 times the mass of the mixture for uniform mixing, and then carrying out granulation and drying to obtain the Yatongting granules. The granules prepared by the method are quick in action, convenient in use and effective in treatment, and has the effect of treating both symptoms and root causes of disease, thereby satisfying the demands of patients; and through the adoption of the preparation method, the working hours are few, and the transfer rate of effective components is high.
Description
Technical field
The invention belongs to field of traditional Chinese, relate to particularly Traditional Chinese medicine for treating tooth-ache granule and preparation method.
Background technology
Toothache is one of modal symptom of department of stomatology odontopathy, and it shows as red swelling of gingiva, meets caloric stimulation pain, buccal swelling etc.Toothache is caused dental pulp (dental nerve) to infect mostly by gingivitis, periodontitis, decayed tooth or jackknifing tooth caused.Toothache belongs to the external reaction of tooth defect, might be that the gingiva around dental caries, dental pulp or the canine tooth is infected, and slight crack appears in premolar teeth also can cause toothache.
At present, being used for medicine such as ibuprofen, the acetaminophen etc. of Traditional Chinese medicine for treating tooth-ache, mainly is symptomatic treatment, can alleviate pain at period in a medicine, and can not carry out etiological treatment for its basic reason.
Summary of the invention
The Traditional Chinese medicine for treating tooth-ache granule that the purpose of this invention is to provide a kind for the treatment of both the principal and secondary aspects of a disease.
Second purpose of the present invention provides the preparation method of Traditional Chinese medicine for treating tooth-ache granule.
Technical scheme of the present invention is summarized as follows:
The preparation method of Traditional Chinese medicine for treating tooth-ache granule comprises the steps:
(1) by weight taking by weighing Fructus Piperis Longi, Flos Caryophylli and Borneolum Syntheticum for the ratio of 20-80: 1-20: 1-10;
(2) Fructus Piperis Longi is added reflux, extract, in the ethanol water that volumetric concentration is 60%-95%, the addition of described ethanol water is 2-5 times of described Fructus Piperis Longi quality, extract 2-5 time, the each extraction 1-5 hour, filter, filtrate is merged, Recycled ethanol during to 70-90 ℃ relative density be the thick extractum of 1.1-1.3, the volumetric concentration that adds suitable Fructus Piperis Longi weight 1-5 times is 95% ethanol water, mixing, left standstill 5-15 hour, and got supernatant, relative density is the extract 1 of 1.0-1.2 when being evaporated to 70-90 ℃;
(3) described Flos Caryophylli was got extract 2 in 1-10 hour with the extraction by steam distillation Oleum Caryophylli;
(4) with extract 1 drying, and be mixed to get mixture with extract 2 and Borneolum Syntheticum, add described mixture quality 1-5 sucrose, starch or dextrin mixing doubly, granulate, be drying to obtain.
The Traditional Chinese medicine for treating tooth-ache granule of said method preparation.
Advantage of the present invention:
The granule of method of the present invention preparation, rapid-action, taking convenience, evident in efficacy, treating both the principal and secondary aspects of a disease, thus can satisfy the demand of extensive patients.The man-hour of preparation method is few, and the effective ingredient rate of transform is high.
The specific embodiment
The present invention is further illustrated below in conjunction with the specific embodiment.
Embodiment 1
(1) be that 43: 18: 7 ratio takes by weighing Fructus Piperis Longi, Flos Caryophylli and Borneolum Syntheticum by weight;
(2) Fructus Piperis Longi being added volumetric concentration is reflux, extract, in 90% the ethanol water, the addition of described ethanol water is 3 times of described Fructus Piperis Longi quality, extracts 3 times, extracts 3 hours at every turn, filter, filtrate is merged, and relative density is 1.2 thick extractum during Recycled ethanol to 75 ℃, and the volumetric concentration that adds 1 times of suitable Fructus Piperis Longi weight is 95% ethanol water, mixing, left standstill 13 hours, and got supernatant, relative density is 1.1 extract 1 when being evaporated to 80 ℃;
(3) described Flos Caryophylli was got extract 2 in 5 hours with the extraction by steam distillation Oleum Caryophylli;
(4) with extract 1 drying, and be mixed to get mixture with extract 2 and Borneolum Syntheticum, add sucrose, the mixing of 3 times of described mixture qualities, granulate, be drying to obtain.The 10g/ bag.
Embodiment 2
(1) be that 20: 1: 1 ratio takes by weighing Fructus Piperis Longi, Flos Caryophylli and Borneolum Syntheticum by weight;
(2) Fructus Piperis Longi being added volumetric concentration is reflux, extract, in 60% the ethanol water, the addition of described ethanol water is 5 times of described Fructus Piperis Longi quality, extracts 2 times, extracts 5 hours at every turn, filter, filtrate is merged, and relative density is 1.3 thick extractum during Recycled ethanol to 70 ℃, and the volumetric concentration that adds 1 times of suitable Fructus Piperis Longi weight is 95% ethanol water, mixing, left standstill 5 hours, and got supernatant, relative density is 1.2 extract 1 when being evaporated to 70 ℃;
(3) described Flos Caryophylli was got extract 2 in 1 hour with the extraction by steam distillation Oleum Caryophylli;
(4) with extract 1 drying, and be mixed to get mixture with extract 2 and Borneolum Syntheticum, add the starch mixing of 1 times of described mixture quality, granulate, be drying to obtain.The 10g/ bag.
Embodiment 3
(1) be that 80: 20: 10 ratio takes by weighing Fructus Piperis Longi, Flos Caryophylli and Borneolum Syntheticum by weight;
(2) Fructus Piperis Longi being added volumetric concentration is reflux, extract, in 95% the ethanol water, the addition of described ethanol water is 2 times of described Fructus Piperis Longi quality, extracts 5 times, extracts 1 hour at every turn, filter, filtrate is merged, and relative density is 1.1 thick extractum during Recycled ethanol to 90 ℃, and the volumetric concentration that adds 5 times of suitable Fructus Piperis Longi weight is 95% ethanol water, mixing, left standstill 15 hours, and got supernatant, relative density is 1.0 extract 1 when being evaporated to 90 ℃;
(3) described Flos Caryophylli was got extract 2 in 10 hours with the extraction by steam distillation Oleum Caryophylli;
(4) with extract 1 drying, and be mixed to get mixture with extract 2 and Borneolum Syntheticum, add 5 times of dextrin mixings of described mixture quality, granulate, be drying to obtain.The 10g/ bag.
Embodiment 4
Pharmacological evaluation
Traditional Chinese medicine for treating tooth-ache granule to the embodiment of the invention 1 has carried out the pharmacological action observation of mice analgesia with antiinflammatory.The result shows that the Traditional Chinese medicine for treating tooth-ache granule 3.2g/kg of the embodiment of the invention 1 is oral to have obvious analgesic activity to mice acetic acid twisting, hot plate induced pain, and its analgesia rate is 70%, and the threshold of pain doubles above; 0.8,1.6g/kg all can obviously suppress mice auricular concha, rat paw inflammation and mouse peritoneum permeability; 1.6,3.2g/kg has inhibitory action to mice gingiva persistence inflammation, can significantly improve mice and take the photograph the material amount, so point out this medical instrument that stronger analgesia and anti-inflammatory activity are arranged.
Alternative has been measured the Traditional Chinese medicine for treating tooth-ache granule of embodiment 1 to the minimum inhibitory concentration (MIC) of the 4 strain antibacterials such as escherichia coli with Plating; simultaneously with cow-bezoar bolus for clearing away heat of the upper part of the body in contrast medicine compare the result and show; pharmaceutical preparation of the present invention is except having analgesia, antiinflammation; extracorporeal bacteria inhibitor test also all has inhibitory action to staphylococcus aureus, escherichia coli, Candida albicans, and its minimum bacteriostasis concentration is higher than contrast medicine cow-bezoar bolus for clearing away heat of the upper part of the body.
The granule that experiment showed, embodiment 2 or embodiment 3 preparations has effect like the Particle Phase with embodiment 1 preparation.
Claims (2)
1. the preparation method of Traditional Chinese medicine for treating tooth-ache granule is characterized in that comprising the steps:
(1) by weight taking by weighing Fructus Piperis Longi, Flos Caryophylli and Borneolum Syntheticum for the ratio of 20-80: 1-20: 1-10;
(2) Fructus Piperis Longi is added reflux, extract, in the ethanol water that volumetric concentration is 60%-95%, the addition of described ethanol water is 2-5 times of described Fructus Piperis Longi quality, extract 2-5 time, the each extraction 1-5 hour, filter, filtrate is merged, Recycled ethanol during to 70-90 ℃ relative density be the thick extractum of 1.1-1.3, the volumetric concentration that adds suitable Fructus Piperis Longi weight 1-5 times is 95% ethanol water, mixing, left standstill 5-15 hour, and got supernatant, relative density is the extract 1 of 1.0-1.2 when being evaporated to 70-90 ℃;
(3) described Flos Caryophylli was got extract 2 in 1-10 hour with the extraction by steam distillation Oleum Caryophylli;
(4) with extract 1 drying, and be mixed to get mixture with extract 2 and Borneolum Syntheticum, add described mixture quality 1-5 sucrose, starch or dextrin mixing doubly, granulate, be drying to obtain.
2. the Traditional Chinese medicine for treating tooth-ache granule of the method for claim 1 preparation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210592133 CN103054958A (en) | 2012-12-29 | 2012-12-29 | Yatongting granule and preparation method thereof |
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| CN 201210592133 CN103054958A (en) | 2012-12-29 | 2012-12-29 | Yatongting granule and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688841A (en) * | 2013-12-06 | 2015-06-10 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of Suxiaoxintong granules |
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- 2012-12-29 CN CN 201210592133 patent/CN103054958A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688841A (en) * | 2013-12-06 | 2015-06-10 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of Suxiaoxintong granules |
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Application publication date: 20130424 |