CN102973662A - Toothache treatment oral liquid and preparation method - Google Patents
Toothache treatment oral liquid and preparation method Download PDFInfo
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- CN102973662A CN102973662A CN 201210592075 CN201210592075A CN102973662A CN 102973662 A CN102973662 A CN 102973662A CN 201210592075 CN201210592075 CN 201210592075 CN 201210592075 A CN201210592075 A CN 201210592075A CN 102973662 A CN102973662 A CN 102973662A
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Abstract
The invention discloses a toothache treatment oral liquid and a preparation method. The preparation method comprises the following steps: (1) weighing long pepper, clove and borneol; (2) conducting reflux extraction on the long pepper with an ethanol water solution, filtering, recovering ethanol from the filtrate to obtain a thick extract, adding the ethanol water solution, mixing uniformly, standing, and conducting vacuum condensation to obtain an extract 1; (3) extracting clove oil from the clove by a steam distillation method to obtain an extract 2; (4) drying and crushing the extract 1, mixing the dried and crushed extract 1 with the extract 2 and the borneol, adding a lubricating agent and a corrigent, mixing and then tableting to form the toothache treatment oral liquid. The toothache treatment oral liquid prepared by the preparation method takes effects quickly, is convenient to take, has remarkable treatment effect, and can address both the symptoms and the root causes, so that the requirements of the majority of patients are met. According to the preparation method, the labor hour is short, and the transfer ratio of active ingredients is high.
Description
Technical field
The invention belongs to field of traditional Chinese, relate to particularly Traditional Chinese medicine for treating tooth-ache oral liquid and preparation method.
Background technology
Toothache is one of modal symptom of department of stomatology odontopathy, and it shows as red swelling of gingiva, meets caloric stimulation pain, buccal swelling etc.Toothache is caused dental pulp (dental nerve) to infect mostly by gingivitis, periodontitis, decayed tooth or jackknifing tooth caused.Toothache belongs to the external reaction of tooth defect, might be that the gingiva around dental caries, dental pulp or the canine tooth is infected, and slight crack appears in premolar teeth also can cause toothache.
At present, being used for medicine such as ibuprofen, the acetaminophen etc. of Traditional Chinese medicine for treating tooth-ache, mainly is symptomatic treatment, can alleviate pain at period in a medicine, and can not carry out etiological treatment for its basic reason.
Summary of the invention
The Traditional Chinese medicine for treating tooth-ache oral liquid that the purpose of this invention is to provide a kind for the treatment of both the principal and secondary aspects of a disease.
Second purpose of the present invention provides the preparation method of Traditional Chinese medicine for treating tooth-ache oral liquid.
Technical scheme of the present invention is summarized as follows:
The preparation method of Traditional Chinese medicine for treating tooth-ache oral liquid comprises the steps:
(1) by weight taking by weighing Fructus Piperis Longi, Flos Caryophylli and Borneolum Syntheticum for the ratio of 20-80: 1-20: 1-10;
(2) Fructus Piperis Longi is added reflux, extract, in the ethanol water that volumetric concentration is 60%-95%, the addition of described ethanol water is 2-5 times of described Fructus Piperis Longi quality, extract 2-5 time, the each extraction 1-5 hour, filter, filtrate is merged, Recycled ethanol during to 70-90 ℃ relative density be the thick extractum of 1.1-1.3, the volumetric concentration that adds suitable Fructus Piperis Longi weight 1-5 times is 95% ethanol water, mixing, left standstill 5-15 hour, and got supernatant, relative density is the extract 1 of 1.0-1.2 when being evaporated to 70-90 ℃;
(3) described Flos Caryophylli was got extract 2 in 1-10 hour with the extraction by steam distillation Oleum Caryophylli;
(4) extract 1, extract 2 and Borneolum Syntheticum are mixed to get mixture, add described mixture quality 10-50 distilled water doubly, 0.1-5 correctives doubly, mixing is made oral liquid.
Described correctives is sucrose, xylose, lactose, xylitol, sorbitol, mannitol, sucralose, stevioside or saccharin sodium.
The Traditional Chinese medicine for treating tooth-ache oral liquid of said method preparation.
Advantage of the present invention:
The oral liquid of method of the present invention preparation, rapid-action, taking convenience, evident in efficacy, treating both the principal and secondary aspects of a disease, thus can satisfy the demand of extensive patients.The man-hour of preparation method is few, and the effective ingredient rate of transform is high.
The specific embodiment
The present invention is further illustrated below in conjunction with the specific embodiment.
Embodiment 1
The preparation method of Traditional Chinese medicine for treating tooth-ache oral liquid comprises the steps:
(1) be that 43: 18: 7 ratio takes by weighing Fructus Piperis Longi, Flos Caryophylli and Borneolum Syntheticum by weight;
(2) Fructus Piperis Longi being added volumetric concentration is reflux, extract, in 90% the ethanol water, the addition of described ethanol water is 3 times of described Fructus Piperis Longi quality, extracts 3 times, extracts 3 hours at every turn, filter, filtrate is merged, and relative density is 1.2 thick extractum during Recycled ethanol to 75 ℃, and the volumetric concentration that adds 1 times of suitable Fructus Piperis Longi weight is 95% ethanol water, mixing, left standstill 13 hours, and got supernatant, relative density is 1.1 extract 1 when being evaporated to 80 ℃;
(3) described Flos Caryophylli was got extract 2 in 5 hours with the extraction by steam distillation Oleum Caryophylli;
(4) extract 1, extract 2 and Borneolum Syntheticum are mixed to get mixture, add the distilled water of 30 times of described mixture qualities, 5 times sucrose, mixing is made oral liquid.The 10ml/ bottle.
Embodiment 2
The preparation method of Traditional Chinese medicine for treating tooth-ache oral liquid comprises the steps:
(1) be that 20: 1: 1 ratio takes by weighing Fructus Piperis Longi, Flos Caryophylli and Borneolum Syntheticum by weight;
(2) Fructus Piperis Longi being added volumetric concentration is reflux, extract, in 60% the ethanol water, the addition of described ethanol water is 5 times of described Fructus Piperis Longi quality, extracts 2 times, extracts 5 hours at every turn, filter, filtrate is merged, and relative density is 1.3 thick extractum during Recycled ethanol to 70 ℃, and the volumetric concentration that adds 1 times of suitable Fructus Piperis Longi weight is 95% ethanol water, mixing, left standstill 5 hours, and got supernatant, relative density is 1.2 extract 1 when being evaporated to 70 ℃;
(3) described Flos Caryophylli was got extract 2 in 1 hour with the extraction by steam distillation Oleum Caryophylli;
(4) extract 1, extract 2 and Borneolum Syntheticum are mixed to get mixture, add the distilled water of 10 times of described mixture qualities, 5 times xylose, mixing is made oral liquid.
Substitute respectively xylose in the present embodiment with lactose, xylitol, sorbitol, mannitol or sucralose, also can be prepared into corresponding Traditional Chinese medicine for treating tooth-ache oral liquid.The 10ml/ bottle.
Embodiment 3
The preparation method of Traditional Chinese medicine for treating tooth-ache oral liquid comprises the steps:
(1) be that 80: 20: 10 ratio takes by weighing Fructus Piperis Longi, Flos Caryophylli and Borneolum Syntheticum by weight;
(2) Fructus Piperis Longi being added volumetric concentration is reflux, extract, in 95% the ethanol water, the addition of described ethanol water is 2 times of described Fructus Piperis Longi quality, extracts 5 times, extracts 1 hour at every turn, filter, filtrate is merged, and relative density is 1.1 thick extractum during Recycled ethanol to 90 ℃, and the volumetric concentration that adds 5 times of suitable Fructus Piperis Longi weight is 95% ethanol water, mixing, left standstill 15 hours, and got supernatant, relative density is 1.0 extract 1 when being evaporated to 90 ℃;
(3) described Flos Caryophylli was got extract 2 in 10 hours with the extraction by steam distillation Oleum Caryophylli;
(4) extract 1, extract 2 and Borneolum Syntheticum are mixed to get mixture, add the distilled water of 50 times of described mixture qualities, 0.1 times correctives, mixing is made oral liquid.The 10ml/ bottle.
Stevioside with in the alternative present embodiment of saccharin sodium also can be prepared into corresponding Traditional Chinese medicine for treating tooth-ache oral liquid.
Embodiment 4
Pharmacological evaluation
Traditional Chinese medicine for treating tooth-ache oral liquid to the embodiment of the invention 1 has carried out the pharmacological action observation of mice analgesia with antiinflammatory.The result shows that the Traditional Chinese medicine for treating tooth-ache oral liquid 3.2ml/kg of the embodiment of the invention 1 is oral to have obvious analgesic activity to mice acetic acid twisting, hot plate induced pain, and its analgesia rate is 70%, and the threshold of pain doubles above; 0.8,1.6ml/kg all can obviously suppress mice auricular concha, rat paw inflammation and mouse peritoneum permeability; 1.6,3.2ml/kg has inhibitory action to mice gingiva persistence inflammation, can significantly improve mice and take the photograph the material amount, so point out this medical instrument that stronger analgesia and anti-inflammatory activity are arranged.
Alternative has been measured the Traditional Chinese medicine for treating tooth-ache oral liquid of embodiment 1 to the minimum inhibitory concentration (MIC) of the 4 strain antibacterials such as escherichia coli with Plating; simultaneously with cow-bezoar bolus for clearing away heat of the upper part of the body in contrast medicine compare the result and show; pharmaceutical preparation of the present invention is except having analgesia, antiinflammation; extracorporeal bacteria inhibitor test also all has inhibitory action to staphylococcus aureus, escherichia coli, Candida albicans, and its minimum bacteriostasis concentration is higher than contrast medicine cow-bezoar bolus for clearing away heat of the upper part of the body.
The oral liquid that experiment showed, embodiment 2 or embodiment 3 preparations has the effect similar to the oral liquid of embodiment 1 preparation.
Claims (3)
1. the preparation method of Traditional Chinese medicine for treating tooth-ache oral liquid is characterized in that comprising the steps:
(1) by weight taking by weighing Fructus Piperis Longi, Flos Caryophylli and Borneolum Syntheticum for the ratio of 20-80: 1-20: 1-10;
(2) Fructus Piperis Longi is added reflux, extract, in the ethanol water that volumetric concentration is 60%-95%, the addition of described ethanol water is 2-5 times of described Fructus Piperis Longi quality, extract 2-5 time, the each extraction 1-5 hour, filter, filtrate is merged, Recycled ethanol during to 70-90 ℃ relative density be the thick extractum of 1.1-1.3, the volumetric concentration that adds suitable Fructus Piperis Longi weight 1-5 times is 95% ethanol water, mixing, left standstill 5-15 hour, and got supernatant, relative density is the extract 1 of 1.0-1.2 when being evaporated to 70-90 ℃;
(3) described Flos Caryophylli was got extract 2 in 1-10 hour with the extraction by steam distillation Oleum Caryophylli;
(4) extract 1, extract 2 and Borneolum Syntheticum are mixed to get mixture, add described mixture quality 10-50 distilled water doubly, 0.1-5 correctives doubly, mixing is made oral liquid.
2. method according to claim 1 is characterized in that described correctives is sucrose, xylose, lactose, xylitol, sorbitol, mannitol, sucralose, stevioside or saccharin sodium.
3. the Traditional Chinese medicine for treating tooth-ache oral liquid of the method for one of claim 1-2 preparation.
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| CN 201210592075 CN102973662A (en) | 2012-12-29 | 2012-12-29 | Toothache treatment oral liquid and preparation method |
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| CN 201210592075 CN102973662A (en) | 2012-12-29 | 2012-12-29 | Toothache treatment oral liquid and preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688838A (en) * | 2013-12-06 | 2015-06-10 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of Suxiaoxintong oral liquid |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688838A (en) * | 2013-12-06 | 2015-06-10 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of Suxiaoxintong oral liquid |
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Application publication date: 20130320 |