CN104688838A - Preparation method of Suxiaoxintong oral liquid - Google Patents
Preparation method of Suxiaoxintong oral liquid Download PDFInfo
- Publication number
- CN104688838A CN104688838A CN201310662565.1A CN201310662565A CN104688838A CN 104688838 A CN104688838 A CN 104688838A CN 201310662565 A CN201310662565 A CN 201310662565A CN 104688838 A CN104688838 A CN 104688838A
- Authority
- CN
- China
- Prior art keywords
- oral liquid
- parts
- preparation
- time
- mixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of Suxiaoxintong oral liquid. The preparation method comprises the following steps: (1) weighing 401 parts by weight of Szechuan lovage rhizome, 240 parts by weight of tree peony bark and 26 parts by weight of borneol; and (2) carrying out heating reflux extraction on Szechuan lovage rhizome and tree peony bark twice with three times of ethanol water solution at a volume concentration of 90-99% by mass, 2.5 hours for the first time and 2 hours for the second time, filtering the extracting solutions, mixing filtrates obtained twice, recovering the filtrates at reduced pressure at 65 DEG C with a rotary film until paste with relative density of 1.15-1.20 at 80 DEG C is obtained, collecting 20+/-5% of the paste, drying and grinding the paste, adding borneol, mixing borneol with the powder uniformly to obtain a mixture, adding distilled water with mass being 10-50 times that of the mixture and a flavoring agent with mass being 0.1-5 times that of the mixture and mixing the materials uniformly, thus preparing the oral liquid. The Suxiaoxintong oral liquid is low in cost, is safe, takes effect quickly, has good curative effects and is convenient to carry. The method has the advantages of few labor hours, high active ingredient transfer rate and improvement of the safety to operating personnel and is suitable for large-scale industrial production.
Description
Technical field
The invention belongs to Chinese drug preparation field, relate to the preparation method of quick-acting cardiac pain oral liquid.
Background technology
Angina pectoris is commonly encountered diseases, the frequently-occurring disease of cardiovascular system, and its sickness rate is in rising trend in recent years, is the disease that people's life and quality of life are arrived in serious threat.Angina pectoris belongs to traditional Chinese medical science obstruction of qi in the chest and cardialgia category, and its morbidity Chang Yuxin, all dirty prosperity and decline of kidney,liver,spleen are relevant, and pathogenesis always belongs to evil numbness heart network, and QI and blood is smooth, channels stasis blocking, and heart network contraction is anxious, and heart arteries and veins is obstructed.The clinical syndrome being main manifestations with ictal chest pain that angina pectoris is coronary insufficiency, cardiac muscle transient ischemic anoxia sharply causes.
Be directed to the treatment of angina pectoris, SUXIAO JIUXIN WAN that current common medicine has " rescuing psychological treatment " and " cardioprotectant " Heart pill of Musk, therefore, await developing a kind of collection to nourish heart, protect the heart, fast-acting heart disease curing triple function, in the Chinese medicine preparation of one, gives prominence to its resisting coronary heart disease anginal atherosclerosis etiological treatment feature, control is laid equal stress on, and fundamentally alleviates patients with coronary heart disease misery.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of preparation method of quick-acting cardiac pain oral liquid is provided.
Technical scheme of the present invention is summarized as follows:
A preparation method for quick-acting cardiac pain oral liquid, comprises the steps:
(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;
(2) by Rhizoma Chuanxiong and Cortex Moutan by 3 quality volumetric concentration be doubly the ethanol water heating and refluxing extraction twice of 90-99%, first time 2.5h, second time 2h, filter, merge twice filtrate, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.15-1.20, receive cream 20% ± 5%.Drying and crushing, adds Borneolum Syntheticum mix homogeneously and obtains mixture, adds described mixture quality 10-50 distilled water doubly, and 0.1-5 correctives doubly, mixing, makes oral liquid.
Described correctives is preferably sucrose, xylose, lactose, xylitol, sorbitol, mannitol, sucralose, stevioside or saccharin sodium.
Advantage of the present invention
Quick-acting cardiac pain oral liquid cost of the present invention is low, and safety is rapid-action, good effect, easy to carry.
Method of the present invention is few for its man-hour, and the effective ingredient rate of transform is high, improves the safety of operator, is suitable for the large production of industry.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further illustrated.
Embodiment 1
A preparation method for quick-acting cardiac pain oral liquid, comprises the steps:
(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;
(2) by Rhizoma Chuanxiong and Cortex Moutan by 3 quality volumetric concentration be doubly 95% ethanol water heating and refluxing extraction twice, first time 2.5h, second time 2h, filter, merge twice filtrate, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.15, receive cream 25%.Drying and crushing, adds Borneolum Syntheticum mix homogeneously and obtains mixture, adds the distilled water of described mixture quality 30 times, the sucrose of 1 times, and mixing, makes oral liquid.
Substitute the sucrose in the present embodiment with lactose, xylitol, sorbitol or mannitol, other same the present embodiment, also can prepare corresponding oral liquid.
Embodiment 2
A preparation method for quick-acting cardiac pain oral liquid, comprises the steps:
(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;
(2) by Rhizoma Chuanxiong and Cortex Moutan by 3 quality volumetric concentration be doubly 90% ethanol water heating and refluxing extraction twice, first time 2.5h, second time 2h, filter, merge twice filtrate, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.17, receive cream 20%.Drying and crushing, adds Borneolum Syntheticum mix homogeneously and obtains mixture, adds the distilled water of described mixture quality 10 times, the stevioside of 0.1 times, and mixing, makes oral liquid.
Substitute the stevioside in the present embodiment with sucralose or saccharin sodium, other same the present embodiment, also can prepare corresponding oral liquid.
Embodiment 3
A preparation method for quick-acting cardiac pain oral liquid, comprises the steps:
(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;
(2) by Rhizoma Chuanxiong and Cortex Moutan by 3 quality volumetric concentration be doubly 99% ethanol water heating and refluxing extraction twice, first time 2.5h, second time 2h, filter, merge twice filtrate, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.20, receive cream 15%.Drying and crushing, adds Borneolum Syntheticum mix homogeneously and obtains mixture, adds the distilled water of described mixture quality 50 times, the xylose of 5 times, and mixing, makes oral liquid.
Claims (2)
1. a preparation method for quick-acting cardiac pain oral liquid, is characterized in that comprising the steps:
(1) take by weight: Rhizoma Chuanxiong 401 parts, Cortex Moutan 240 parts and Borneolum Syntheticum 26 parts;
(2) by Rhizoma Chuanxiong and Cortex Moutan by 3 quality volumetric concentration be doubly the ethanol water heating and refluxing extraction twice of 90-99%, first time 2.5h, second time 2h, filter, merge twice filtrate, with rotating thin film 65 DEG C of reclaim under reduced pressure at 80 DEG C time relative density be the cream of 1.15-1.20, receive cream 20% ± 5%.Drying and crushing, adds Borneolum Syntheticum mix homogeneously and obtains mixture, adds described mixture quality 10-50 distilled water doubly, and 0.1-5 correctives doubly, mixing, makes oral liquid.
2. the preparation method of a kind of quick-acting cardiac pain oral liquid according to claim 1, is characterized in that described correctives is sucrose, xylose, lactose, xylitol, sorbitol, mannitol, sucralose, stevioside or saccharin sodium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310662565.1A CN104688838A (en) | 2013-12-06 | 2013-12-06 | Preparation method of Suxiaoxintong oral liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310662565.1A CN104688838A (en) | 2013-12-06 | 2013-12-06 | Preparation method of Suxiaoxintong oral liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104688838A true CN104688838A (en) | 2015-06-10 |
Family
ID=53336662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310662565.1A Pending CN104688838A (en) | 2013-12-06 | 2013-12-06 | Preparation method of Suxiaoxintong oral liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104688838A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626129A (en) * | 2003-12-11 | 2005-06-15 | 天津天士力制药股份有限公司 | Medicine for treating obstruction of qi in the chest and heartache |
| CN1730044A (en) * | 2005-08-03 | 2006-02-08 | 包头市千年健药物研究开发有限公司 | Process for preparing quick-acting spray for cardiac pain |
| CN1742829A (en) * | 2005-10-09 | 2006-03-08 | 北京亚东生物制药有限公司 | Dripping pill for treating coronary heart disease and preparing method |
| CN102973662A (en) * | 2012-12-29 | 2013-03-20 | 天津中新药业集团股份有限公司第六中药厂 | Toothache treatment oral liquid and preparation method |
-
2013
- 2013-12-06 CN CN201310662565.1A patent/CN104688838A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626129A (en) * | 2003-12-11 | 2005-06-15 | 天津天士力制药股份有限公司 | Medicine for treating obstruction of qi in the chest and heartache |
| CN1730044A (en) * | 2005-08-03 | 2006-02-08 | 包头市千年健药物研究开发有限公司 | Process for preparing quick-acting spray for cardiac pain |
| CN1742829A (en) * | 2005-10-09 | 2006-03-08 | 北京亚东生物制药有限公司 | Dripping pill for treating coronary heart disease and preparing method |
| CN102973662A (en) * | 2012-12-29 | 2013-03-20 | 天津中新药业集团股份有限公司第六中药厂 | Toothache treatment oral liquid and preparation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102048895B (en) | Pure traditional Chinese medicine preparation for treating dilated cardiomyopathy | |
| CN101181350A (en) | Technique for preparing fufang danshen pian | |
| CN103784503A (en) | Traditional Chinese medicine formula used for resisting cardia-cerebrovascular disease and preparation method of soft capsule | |
| CN101085071A (en) | Traditional Chinese medicinal composition containing red sage root and haw and its preparation | |
| CN1785284A (en) | Medicinal composition containing flowery knotwood root | |
| CN104435243A (en) | Traditional Chinese medicine composition for treating jaundice | |
| CN1565601A (en) | Application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy | |
| CN113197804A (en) | Plant repair factor and application thereof | |
| CN104257947A (en) | Pharmaceutical composition for treating low fever caused by gynecological operation | |
| CN104688838A (en) | Preparation method of Suxiaoxintong oral liquid | |
| CN104688841A (en) | Preparation method of Suxiaoxintong granules | |
| CN101244123A (en) | Novel technique for preparing pseudo-ginseng red sage root lozenge | |
| CN104688840A (en) | Preparation method of Suxiaoxintong capsules | |
| CN104688837A (en) | Preparation method of Suxiaoxintong tablets | |
| CN101085070B (en) | Traditional Chinese medicinal composition containing notoginseng and haw and its preparation | |
| CN103169797B (en) | Traditional Chinese medicine hypotensive paste | |
| CN105194121A (en) | External solution for treating onychomycosis | |
| CN101658636A (en) | Chinese medical composition for treating coronary heart disease | |
| CN105434264A (en) | Motherwort-herb toothpaste | |
| CN102210763B (en) | Chinese medicinal composition for promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain and preparation method thereof | |
| CN108272705A (en) | A kind of anti-inflammatory and antalgic maintenance composition | |
| CN102526511B (en) | Chinese medicinal composition for treating hypertension | |
| CN104688839A (en) | Preparation method of Suxiaoxintong sustained release tablets | |
| CN101053615B (en) | Medicinal composition for treating bone fracture and injury and its preparation method | |
| CN1046284A (en) | The new preparation method that toothache is peaceful |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150610 |