CN1565601A - Application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy - Google Patents
Application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy Download PDFInfo
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Abstract
The invention discloses an application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy, which can be used for treating vascular nerve cephalalgia, cerebral thrombus, cerebrovascular angiosclerosis, coronary heart diseases, angina pectoris, hypertension, or asomnia, or common cold, or women's dysmenorrheal.
Description
Technical field
The present invention relates to supercritical CO
2The purposes of the Rhizoma Chuanxiong oil of extraction especially relates to its application in pharmaceutical field.
Background technology
Vascular headache comprises migraine, and bunch collection headache and non-migraine vascular headache are clinical very common headaches.
In recent years, HIS (the international association of having a headache) standard is pressed by many in the world developed countries, vascular headache has been carried out extensive Epidemiological study, to understand this disease to public health, individuality and influence of society, find the high-risk group simultaneously, to treating from now on and public health is given a clue.Survey result shows: vascular headache is a common high morbidity.In western countries, its prevalence is: the women 10～18%, and male 4～6% (as: American Women's 17.6%, the male 6%; France women 11.9%, the male 4%) and relevant with age, sex, socioeconomics: the women is many than the male, and youngster sees that prevalence rose since 12 years old, descended gradually later on up to 40 years old more.
China's vascular headache prevalence is about 985.2/10 ten thousand, and men and women's ratio is 1: 4, and 25～29 years old prevalence the highest (1927.4/10 ten thousand) is minimum below 10 years old, and land plateau is the high ill area of China, and is Central-South coastal minimum.Be grown up according to statistics and about 1/8 suffer from vascular headache, the whole world only developed country's vascular headache patient reaches 1.2 hundred million (attack times 1,400,000,000 times), wherein has at least 30% patient to go to a doctor.The nearest report of international Center for Disease Control (CDC) shows that the vascular headache prevalence has rising to become.Vascular headache becomes a social problem gradually, estimate according to U.S.'s vascular headache research, in United States citizen, serious vascular headache patient has 23,000,000, wherein 85% female patient and 82% male patient are with the functional handicap relevant with headache, wherein about 1/3 has serious hindrance maybe need lie up, and except dysfunction, more patient is owing to know very well family that outbreak may cause and burden on society and greatly alarmed all day.Vascular headache more has a strong impact on society except bring many miseries to the individual, in the U.S., delays work because vascular headache causes, and mistake is learned and lost above 100,000,000 dollars/year.Because the frequently-occurring and seriousness of vascular headache abroad, has been considered as it serious public health problem.
The morbidity machine of vascular headache is managed so far and be it be unclear that, may be relevant with heredity, endocrine, vascular factor, neurotransmitter, immune factor.At present, doctor trained in Western medicine to the Therapeutic Method of primary disease generally is: (one) prophylactic treatment: 1. adopt non-drug therapy; As avoid contacting risk factor, and correct dietary habit, improve sleep etc., curative effect only is about 30%.2. Drug therapy: commonly used have a calcium-channel antagonists (as flunarizine, Nimotop etc.), beta-blocker (as propranolol etc.), histamine receptor antagonists (as pizotifen, methyl-lysergic amide etc.), but curative effect is not satisfactory, only 50～70% is effective, and a lot of patients intermission of showing effect is longer, the long-term prescription prevention, and untoward reaction is more.Can cause drowsiness, weak, weight increase as pizotifen, methyl-lysergic amide causes behind the peritoneum and the fibrosis of lung etc.(2) stage of attack treatment: the cardinal symptom that occurs when the outbreak at patient as headache, feel sick, vomiting and adopt tranquilizer, antiemetic and analgesic, medicine commonly used is as stable, Ergotamine, aspirin.Though above-mentioned treatment has certain help to primary disease, but because the vascular headache patient itself has digestive functional disturbance, above-mentioned medicine needs through gastrointestinal absorption, drug absorption is bad so on the one hand, and most drug also can increase the weight of the gastrointestinal function obstacle, can cause nausea and vomiting, numb limbs and tense tendons pain, stomachache uncomfortable in chest as Ergotamine, and taboo person is a lot of.Aspirin can cause stomachache, vomiting and digestive tract hemorrhage.On the other hand, take tranquilizer medicine and analgesic for a long time and often cause psychological dependence, easily form drug dependence.
The traditional Chinese medical science is thought primary disease mainly due to liver, the heart, renal function imbalance, in addition due to wind, the stasis of blood, expectorant, the fire resistance network.Should make a clear distinction the cause of disease during treatment, because of disease executing controlled.Facts have proved: treatment by Chinese herbs primary disease safety and effectively, carrying out prophylactic treatment in the long catabasis, less untoward reaction can obviously alleviate attack degree.In also effective control of seizures of acute attack stage, the advantage of giving consideration to both the incidental and fundamental is arranged.And the Chinese medicine price is also lower, and every price of tablet of its 100mg of new drug sumatriptan (Sumatuiptan) of the treatment primary disease that at first goes on the market in Holland as nineteen ninety is 14 dollars.As seen the new Chinese medicine of research treatment vascular headache is very necessary.
Though can be used for the Chinese patent medicine of primary disease at present Tai Ji TONGTIAN KOUFUYE, ZHENNAONING JIAONANG, ZHENGTIAN WAN (Chinese medicine and western medicine compound preparation), Dachuanxiong oral liquid (granule), day relieving capsule, compound cavel capsule, blood-nourishing and brain-refreshing granules, dizzy pain stator etc. are arranged.But because the pattern of syndrome of primary disease is more, the specificity that has is not strong; More because above-mentioned kind still can not form competitive in the international market product.So more need to develop the Chinese patent medicine that active ingredient is clear, meet the treatment vascular headache of international market requirement.
Rhizoma Chuanxiong is the dry rhizome of Umbelliferae herbaceos perennial Rhizoma Chuanxiong, is that medical material is produced in famous river, is one of the most frequently used Chinese medicine of China, and it is the most frequently used in tcm prescription and the Chinese patent medicine, that export volume is big large medical material.The record of Ancient Times in China document, the Rhizoma Chuanxiong folk prescription is better to the migraine curative effect, and Chinese medicine thinks that primary disease is mainly due to liver, the heart, renal function imbalance, in addition due to wind, the stasis of blood, expectorant, the fire resistance network, should distinguish the cause of disease during treatment, execute because of card and control, thereby the Rhizoma Chuanxiong compound recipe is all used in medication mostly.According to clinical report: with Rhizoma Chuanxiong injection treatment and prevention of migraine case 67 examples, produce effects 25 examples, effective 37 examples, invalid 5 examples.Once a day, 10 times was 1 course of treatment to each intramuscular injection 2mL (quite crude drug 2g).To 36 routine patients wherein observed rheoencephalogram before and after the medication dynamically, find that this medicine injection does not have obvious dilating effect to cerebrovascular.Adopt Rhizoma Chuanxiong compound treatment migraine, matched group 50 examples, oral pizotifen, nimodipine, two groups through 2-3 course of therapy.The result: 50 routine effective percentage 82% are organized in treatment, and the matched group effective percentage is 60%.Clinical example shows, though no matter be Rhizoma Chuanxiong folk prescription Rhizoma Chuanxiong compound recipe to the migraine disease treatment effectively, but cure rate does not reach satisfied degree, particularly the Rhizoma Chuanxiong compound recipe all varies with each individual, because of disease executing controlled, it is used as a kind of Chinese patent medicine suitability for industrialized production, and unrealistic.
Rhizoma Chuanxiong oil is by the position with effective active components of extracting in the Rhizoma Chuanxiong.Because extracting method difference, its contained effective active components are also different.The traditional steam distillation of general employing, extraction ratio is also lower.Supercritical CO has appearred in recent years
2Extraction mainly contains effective constituent and effective site extraction ratio in Rhizoma Chuanxiong oil yield and Rhizoma Chuanxiong, i.e. Rhizoma Ligustici lactone extraction ratio, and total lactone extraction ratio all is higher than steam distillation far away.And have short, simple to operate, advantage such as temperature is low, no solvent is residual in the extract, environmental pollution is little of extraction time, be subjected to people's attention, its extraction results is also because of extraction conditions such as medical material granularity, extraction temperature, extracting pressure, CO
2Factors such as flow and extraction time are different and variant.Assay determination shows: use supercritical CO
2Its Main Ingredients and Appearance of Rhizoma Chuanxiong oil that extraction extracts is a ligustilide, and (ligustilide, 58.%), 3-butylidenephthalide (3-butylidene, phthalide 5.29%) and sabinene (sabinene, 6.08%) reach tens kinds of components such as other composition.Ligustilide and total lactone are that it mainly contains effective constituent and effective extract part, have ideal application prospect in the industrial preparation Chinese patent medicine.
Summary of the invention
The object of the invention is to provide a kind of employing supercritical CO
2The new application of Rhizoma Chuanxiong oil in pharmacy of extraction, the present invention has brought into play new medical application to the Chinese medicine Rhizoma Chuanxiong, has opened up a new application, adopts supercritical CO
2The Rhizoma Chuanxiong oil safety non-toxic of extraction, drug action is strong, and good prospect in medicine is arranged, and Rhizoma Chuanxiong abundant raw material, inexpensive, extraction process are simple, to make the Chinese patent medicine cost low, outlet profit height, and can be made into various dosage forms, meet clinical needs.
Concrete technical scheme of the present invention is as follows:
The invention is characterized in: supercritical CO
2The Rhizoma Chuanxiong oil of extraction is used with single or compound recipe mode in pharmacy, comprising:
The Rhizoma Chuanxiong compatibility Radix Angelicae Dahuricae, or Rhizoma Chuanxiong compatibility Ramulus Cinnamomi, or Rhizoma Chuanxiong compatibility Herba Schizonepetae, or Rhizoma Chuanxiong compatibility Rhizoma alpiniae chinensis, or Rhizoma Chuanxiong compatibility Herba Asari, or Rhizoma Chuanxiong compatibility Radix Saposhnikoviae, or Rhizoma Chuanxiong compatibility Roripa originally, or Rhizoma Chuanxiong compatibility Herba Menthae, or Rhizoma Chuanxiong compatibility Fructus Viticis, or Rhizoma Chuanxiong compatibility Flos Chrysanthemi, or Rhizoma Chuanxiong compatibility Radix Puerariae, or Rhizoma Chuanxiong compatibility Rhizoma Gastrodiae, or Rhizoma Chuanxiong compatibility (river) NIANXI, or Rhizoma Chuanxiong compatibility Radix Salviae Miltiorrhizae, or Rhizoma Chuanxiong compatibility Radix Notoginseng, or Rhizoma Chuanxiong compatibility Radix Angelicae Sinensis, or Rhizoma Chuanxiong compatibility red (in vain) Chinese herbaceous peony, or Rhizoma Chuanxiong compatibility Semen Ziziphi Spinosae, or Rhizoma Chuanxiong compatibility Fructus Gardeniae, or Rhizoma Chuanxiong compatibility Rhizoma Atractylodis, or Rhizoma Chuanxiong compatibility Borneolum Syntheticum, and Chuanxiong Chatiao San, pill of quenching dizziness, SHENGHUATANG, the various preparations of compound recipes such as SIWU TANG.
The preparation method of Rhizoma Chuanxiong oil of the present invention is as follows: get the Rhizoma Chuanxiong medicinal material drying, pulverize, cross 8 purposes sieve, use supercritical CO
2Extraction extracts warm 35-80 ℃, extracting pressure 12-40Mpa, CO
2Flow is counted 0.5-50kg/hr by every kilogram of Rhizoma Chuanxiong crude drug, and through separating still extraction 20-360 minute, separation reactor I: pressure is 6-30Mpa, temperature 18-50 ℃, separation reactor I I: pressure was 3-20Mpa, temperature 18-50 ℃; Collect the extract among separation reactor I or the separation reactor I I respectively, or, put in the volatile oil separator, leave standstill under the room temperature more than 1 hour, centrifugalize oil reservoir (more than 2000 rev/mins) the merging of the extract among separation reactor I or the separation reactor I I, the gained Rhizoma Chuanxiong oil is put in the brown bottle, and sealing is stored.
Supercritical CO of the present invention
2The Rhizoma Chuanxiong oil of extraction with its analgesia, calm, reduce drug action such as vascular resistance, cerebral blood flow increasing amount, antithrombotic formation and as the application in the medicine for the treatment of diseases such as angioneurotic headache, cerebral thrombosis, cerebrovascular sclerosis in preparation.Angioneurotic headache promptly comprises the migraine described in the traditional Chinese medical science, blood stasis, wind and cold, rheumatism, the headache of liver-yang type etc.
Supercritical CO of the present invention
2The Rhizoma Chuanxiong oil of extraction with drug action such as its coronary artery dilator, coronary blood flow increasing, reduction myocardial oxygen consumption, analgesia, blood pressure lowering as the application in the medicine for the treatment of diseases such as coronary heart disease, angina pectoris, arrhythmia, hypertension in preparation.Angina pectoris promptly comprises the described thoracic obstruction of the traditional Chinese medical science.
Supercritical CO of the present invention
2The Rhizoma Chuanxiong oil of extraction with drug action such as its calmness, hypnosis as the application in the medicine for preparing Cure for insomnia disease.
Supercritical CO of the present invention
2The Rhizoma Chuanxiong oil of extraction analgesicly waits drug action and as the application in the medicine for the treatment of the cold, fever disease in preparation with it.
Supercritical CO of the present invention
2Drug action such as the Rhizoma Chuanxiong oil of extraction is antibacterial with its analgesia, spasmolytic antitumor, antiinflammatory, activating blood circulation to dissipate blood stasis and as the application in preparing the medicine of diseases such as treating dysmenorrhes, puerperal abdonimal pain, gastric abscess, tumor.
Supercritical CO of the present invention
2The Rhizoma Chuanxiong oil of extraction is with soft capsule or hard capsule or drop pill or tablet or dispersible tablet or granule or oral liquid or suppository, oral administration or skin or mucosa or rectal administration.
Supercritical CO of the present invention
2The Rhizoma Chuanxiong oil of extraction also can according to clinical needs respectively with Radix Angelicae Sinensis oil or Radix Angelicae Dahuricae oil, or Borneolum Syntheticum is made patent medicine.
Supercritical CO of the present invention
2The taking dose of the Rhizoma Chuanxiong oil of extraction is 300-1500 milligram every day.
The invention has the advantages that:
1, the present invention has brought into play new medical application to the Chinese medicine Rhizoma Chuanxiong, has opened up a new application.
2, supercritical CO of the present invention
2The Rhizoma Chuanxiong oil safety non-toxic of extraction, drug action is strong, is shown with good prospect in medicine in advance.
3, supercritical CO of the present invention
2The Rhizoma Chuanxiong oil of extraction, its Rhizoma Chuanxiong abundant raw material, inexpensive, extraction process be simple, it is low to make the Chinese patent medicine cost, outlet profit height, and make various dosage forms, meet clinical needs.
4, supercritical CO of the present invention
2The Rhizoma Chuanxiong oil of extraction uses with single or compound recipe in pharmacy.
The specific embodiment:
Supercritical CO of the present invention
2The Rhizoma Chuanxiong oil of extraction has carried out pharmacodynamics test according to National Drug Administration's " specification requirement of study of tcm new drug " to Rhizoma Chuanxiong oil, and its result is as follows:
A, Rhizoma Chuanxiong oil can obviously improve the pain threshold of heat radiation rabbit headache animal model, reduce the positive cell number of nitroglycerin type rat headache animal model c-fos, c-jun gene expression, the content of nitroglycerin type headache rat plasma ET level in peripheral blood, 5-HT falls in the content of rising nitroglycerin type headache rat peripheral blood CGRP.Has the effect of treatment headache significantly.
B, Rhizoma Chuanxiong oil can prolong the incubation period of glacial acetic acid induced mice writhing response, reduce the number of times of writhing response, improve the pain threshold that mice stimulates hot plate.Has analgesic activity.
C, Rhizoma Chuanxiong oil can reduce the autonomic activities number of times of mice, prolong the length of one's sleep of pentobarbital sodium induced mice, increase the mice pentobarbital sodium threshold number of animals of sleep down.Has sedative-hypnotic effect.
D, Rhizoma Chuanxiong oil can reduce the plasma viscosity of rat blood stasis animal model, reduce the area of dog brain focal ischemia animal model cerebral ischemia, improve the brain local blood circulation, have function of promoting blood circulation to disperse blood clots.
E, Rhizoma Chuanxiong oil raise to rabbit body temperature due to the endotoxin significant reduction effect, and certain dose-effect effect trend is arranged, and its height, middle dosage group onset time is similar to antondin.
F, Rhizoma Chuanxiong oil have the trivial solution heat effect to beer yeast heating rat, and certain dose-effect effect trend is arranged, and high dose group onset time is similar to antondin.
According to the specification requirement of National Drug Administration's " specification requirement of study of tcm new drug " and Ministry of Public Health " new Chinese medicine toxicologic study guide ", Rhizoma Chuanxiong oil has been carried out rat long term toxicity test and Bealge dog long term toxicity test, the result is as follows:
1, rat oral gavage Rhizoma Chuanxiong oil 0.45ml/kg.d
-1, 0.225ml/kg.d
-1, 0.075ml/kg.d
-1, continuous 13 weeks; The animal appearance state is normal, and it is normal to ingest, and body weight is by Zhou Zengjia, and hematological indices, blood biochemical are learned index, system becomes celestial and main organs histopathologic examination, does not see that significant poison pair changes.Reversibility is observed, no abnormality seen.
2, the Bealge dog is irritated stomach Rhizoma Chuanxiong oil 0.3ml/kg.d
-1, 0.15ml/kg.d
-1, 0.05ml/kg.d
-1, continuous 13 weeks; Except that the indivedual dog vomitings of high dose group, anorexia, weight increase amplitude were less, other animal general state was normal, weight increase; urine is conventional; peripheral blood phase, bone marrow phase, blood parameters, electrocardiogram, system become celestial and pathological study, show no obvious abnormalities.Reversibility is observed, no abnormality seen.The Rhizoma Chuanxiong oil long term toxicity test shows: the dog stomach is had the stimulation no overt toxicity except that excessive.
Embodiment 1: the Rhizoma Chuanxiong oil soft capsule
New drug effect: analgesia, spasmolytic antitumor, antibacterial, the activating blood circulation to dissipate blood stasis of antiinflammatory.
Adapt to disease: treatment dysmenorrhes, puerperal abdonimal pain, gastric abscess, tumor.
Dosage: 300-1500 milligram.
The employing single is made.Get the Rhizoma Chuanxiong medicinal material drying, pulverize, cross 8 mesh sieves, use supercritical CO
2Extraction, 46 ℃ of extraction temperature, extracting pressure 25Mpa, CO
2Flow is counted 20kg/hr by every kilogram of Rhizoma Chuanxiong crude drug, through separating still extraction 100 minutes, respectively the extract of collecting is merged, puts in the volatile oil separator, left standstill centrifugalize oil reservoir (2000 rev/mins) under the room temperature 5 hours, the gained Rhizoma Chuanxiong oil is put in the brown bottle, and sealing is stored; Wherein: separation reactor I: pressure is 30 ℃ of 25Mpa, temperature, separation reactor I I: pressure is 20 ℃ of 10Mpa, temperature.
Through clinical observation, be 3-7 days the course of treatment, evident in efficacy.
Embodiment 2: the Rhizoma Chuanxiong oil tablet
New drug effect: calm, hypnosis
Dosage: Cure for insomnia disease
Adopt the adaptation disease: the 300-1500 milligram.
Make with compound recipe.Select the Rhizoma Chuanxiong oil of supercritical CO 2 extraction and Borneolum Syntheticum according to 1: the ratio of 1-500 is made.
Embodiment 3: Rhizoma Chuanxiong oil suppository
New drug effect: analgesic; Adapt to disease: treatment cold, fever disease
Dosage: 300-1500 milligram.
The employing compound recipe is made.Select the Rhizoma Chuanxiong oil of supercritical CO 2 extraction and Radix Angelicae Sinensis oil according to 1: the ratio of 0.1-30 is made.
Embodiment 4
Rhizoma Chuanxiong compatibility Radix Puerariae SHENGHUATANG
Dosage: 300-1500 milligram.
The employing compound recipe is made.Select supercritical CO
2The Rhizoma Chuanxiong oil of extraction and Radix Angelicae Sinensis oil are according to 1: the ratio of 0.1-30 is made.
Embodiment 5
Rhizoma Chuanxiong compatibility Herba Schizonepetae compound preparation
Adopt the adaptation disease: the 300-1500 milligram.
Make with compound recipe.Select supercritical CO
2The Rhizoma Chuanxiong oil of extraction and Borneolum Syntheticum are according to 1: the ratio of 1-500 is made.
The also optional supercritical CO of the present invention
2The Rhizoma Chuanxiong oil of extraction and Radix Angelicae Dahuricae oil are according to 1: the ratio of 0.1-20 is made compound recipe patent medicine.
The present invention has brought into play new medical application to the Chinese medicine Rhizoma Chuanxiong, has opened up a new application, adopts supercritical CO
2The Rhizoma Chuanxiong oil safety non-toxic of extraction, drug action is strong, and good prospect in medicine is arranged, and Rhizoma Chuanxiong abundant raw material, honest and clean, extraction process are simple, to make the Chinese patent medicine cost low, outlet profit height, and make various dosage forms, meet clinical needs.
Claims (12)
1, takes supercritical CO
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction is characterized in that: supercritical CO
2The Rhizoma Chuanxiong oil of extraction is used with single or compound recipe mode in pharmacy, comprising:
The Rhizoma Chuanxiong compatibility Radix Angelicae Dahuricae, or Rhizoma Chuanxiong compatibility Ramulus Cinnamomi, or Rhizoma Chuanxiong compatibility Herba Schizonepetae, or Rhizoma Chuanxiong compatibility Rhizoma alpiniae chinensis, or Rhizoma Chuanxiong compatibility Herba Asari, or Rhizoma Chuanxiong compatibility Radix Saposhnikoviae, or Rhizoma Chuanxiong compatibility Roripa originally, or Rhizoma Chuanxiong compatibility Herba Menthae, or Rhizoma Chuanxiong compatibility Fructus Viticis, or Rhizoma Chuanxiong compatibility Flos Chrysanthemi, or Rhizoma Chuanxiong compatibility Radix Puerariae, or Rhizoma Chuanxiong compatibility Rhizoma Gastrodiae, or Rhizoma Chuanxiong compatibility (river) NIANXI, or Rhizoma Chuanxiong compatibility Radix Salviae Miltiorrhizae, or Rhizoma Chuanxiong compatibility Radix Notoginseng, or Rhizoma Chuanxiong compatibility Radix Angelicae Sinensis, or Rhizoma Chuanxiong compatibility red (in vain) Chinese herbaceous peony, or Rhizoma Chuanxiong compatibility Semen Ziziphi Spinosae, or Rhizoma Chuanxiong compatibility Fructus Gardeniae, or Rhizoma Chuanxiong compatibility Rhizoma Atractylodis, or Rhizoma Chuanxiong compatibility Borneolum Syntheticum, and Chuanxiong Chatiao San, pill of quenching dizziness, SHENGHUATANG, the various preparations of compound recipes such as SIWU TANG.
2, the supercritical CO of taking of the present invention according to claim 1
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction, it is characterized in that: the preparation method of described Rhizoma Chuanxiong oil is as follows: get the Rhizoma Chuanxiong medicinal material drying, pulverize, cross 8 purposes sieve, use supercritical CO
2Extraction extracts warm 35-80 ℃, extracting pressure 12-40Mpa, CO
2Flow is counted 0.5-50kg/hr by every kilogram of Rhizoma Chuanxiong crude drug, and through separating still extraction 20-360 minute, separation reactor I: pressure is 6-30Mpa, temperature 18-50 ℃, separation reactor I I: pressure was 3-20Mpa, temperature 18-50 ℃; Collect the extract among separation reactor I or the separation reactor I I respectively, or, put in the volatile oil separator, leave standstill under the room temperature more than 1 hour, centrifugalize oil reservoir (more than 2000 rev/mins) the merging of the extract among separation reactor I or the separation reactor I I, the gained Rhizoma Chuanxiong oil is put in the brown bottle, and sealing is stored.
3, the supercritical CO of taking according to claim 1 and 2
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction is characterized in that: described supercritical CO
2The Rhizoma Chuanxiong oil of extraction with its analgesia, calm, reduce drug action such as vascular resistance, cerebral blood flow increasing amount, antithrombotic formation and as the application in the medicine for the treatment of diseases such as angioneurotic headache, cerebral thrombosis, cerebrovascular sclerosis in preparation.
4, the supercritical CO of taking according to claim 1 and 2
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction is characterized in that: described supercritical CO
2The Rhizoma Chuanxiong oil of extraction with drug action such as its coronary artery dilator, coronary blood flow increasing, reduction myocardial oxygen consumption, analgesia, blood pressure lowering as the application in the medicine for the treatment of diseases such as coronary heart disease, angina pectoris, arrhythmia, hypertension in preparation.
5, the supercritical CO of taking according to claim 1 and 2
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction is characterized in that: described supercritical CO
2The Rhizoma Chuanxiong oil of extraction with drug action such as its calmness, hypnosis as the application in the medicine for preparing Cure for insomnia disease.
6, the supercritical CO of taking according to claim 1 and 2
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction is characterized in that: described supercritical CO
2The Rhizoma Chuanxiong oil of extraction analgesicly waits drug action and as the application in the medicine for the treatment of the cold, fever disease in preparation with it.
7, the supercritical CO of taking according to claim 1 and 2
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction is characterized in that: described supercritical CO
2Drug action such as the Rhizoma Chuanxiong oil of extraction is antibacterial with its analgesia, spasmolytic antitumor, antiinflammatory, activating blood circulation to dissipate blood stasis and as the application in preparing the medicine of diseases such as treating dysmenorrhes, puerperal abdonimal pain, gastric abscess, tumor.
8, the supercritical CO of taking according to claim 1 and 2
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction is characterized in that: described supercritical CO
2The Rhizoma Chuanxiong oil of extraction is with soft capsule or hard capsule or drop pill or tablet or dispersant or granule or oral liquid state, oral administration or skin or mucosa or rectal administration.
9, the supercritical CO of taking according to claim 1 and 2
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction is characterized in that: described supercritical CO
2The taking dose of the Rhizoma Chuanxiong oil of extraction is 300-1500 milligram every day.
10, the supercritical CO of taking according to claim 1
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction is characterized in that: take supercritical CO
2The Rhizoma Chuanxiong oil of extraction and Radix Angelicae Sinensis oil are according to 1: the ratio of 0.1-30 is made patent medicine.
11, the supercritical CO of taking according to claim 1
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction is characterized in that: take supercritical CO
2The Rhizoma Chuanxiong oil of extraction and Radix Angelicae Dahuricae oil are according to 1: the ratio of 0.1-20 is made patent medicine.
12, the supercritical CO of taking according to claim 1
2The application of Rhizoma Chuanxiong oil in pharmacy of extraction is characterized in that: take supercritical CO
2The Rhizoma Chuanxiong oil of extraction and Borneolum Syntheticum are according to 1: the ratio of 1-500 is made patent medicine.
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| CN1857345B (en) * | 2005-05-08 | 2010-09-01 | 谢秀琼 | Hemicrania treating medicine composition and its preparing method |
| CN101214329B (en) * | 2008-01-04 | 2010-12-08 | 赵良田 | Medicament for expelling wind and relieving pain and preparation thereof |
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| CN102462753A (en) * | 2010-11-18 | 2012-05-23 | 中国科学院上海药物研究所 | Traditional Chinese medicine composition capable of treating cervical vertigo and preparation method thereof |
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