CN101234137B - Drug for curing coronary disease - Google Patents
Drug for curing coronary disease Download PDFInfo
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- CN101234137B CN101234137B CN2007100552825A CN200710055282A CN101234137B CN 101234137 B CN101234137 B CN 101234137B CN 2007100552825 A CN2007100552825 A CN 2007100552825A CN 200710055282 A CN200710055282 A CN 200710055282A CN 101234137 B CN101234137 B CN 101234137B
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Abstract
A medicine for treating coronary heart disease, belonging to a field of medicine, which is composed of the Chinese medicinal materials with the following weight proportions: 0.2-3.2 portions of red ginseng, 0.6-9.6 portions of astragalus, 0.2-3.2 portions of panax notoginseng, 0.2-3.2 of portions safflower, 0.3-4.8 portions of Salvia miltiorrhiza Bge, 0.3-4.8 portions of antler glue, 0.3-4.8 portions of rosewood, 0.3-4.8 portions of sandalwood, 0.3-4.8 portions of barrenwort, 0.15-2.4 portions of leech and 0.3-4.8 portions of RhizomaChuanxiong. The preparation process of the medicine of the invention is as follows: extracting a clear paste from Salvia miltiorrhiza Bge, RhizomaChuanxiong, and sandalwood through alcohol extract method; extracting a clear paste from astragalus and barrenwortthrough water extract method; preparing the rest to be powders; and mixing the clear pastes and the powders to acquire the medicine of the invention. The medicine of the invention has the active effect of higher healing rate than the existing medicine, the accurate curative effect and raw materials of the medicine are common varieties. The preparation method of the invention belongs to a preparation technique of the conventional Chinese traditional medicine, which is of low cost in preparation and can satisfy the society requirements.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to treat the Chinese medicine of coronary heart disease.
Background technology
Coronary heart disease belongs to frequently-occurring disease, and still has the trend that continues to increase at present, though have now some treatment coronary heart disease in, western drug, cure rate is all lower, majority belongs to controlling symptoms to a certain extent, the medicine of mitigate the disease.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of coronary heart disease, overcome the existing medicine above shortcomings of treatment coronary heart disease.
The present invention is made up of the Chinese crude drug of following portions by weight ratio:
Radix Ginseng Rubra 0.2-3.2, Radix Astragali 0.6-9.6, Radix Notoginseng 0.2-3.2, Flos Carthami 0.2-3.2, Radix Salviae Miltiorrhizae 0.3-4.8, Colla cornus cervi 0.3-4.8, Lignum Dalbergiae Odoriferae 0.3-4.8, Lignum Santali Albi 0.3-4.8, Herba Epimedii 0.3-4.8, Hirudo 0.15-2.4, Rhizoma Chuanxiong 0.3-4.8.
Medicine material optimum feed stock consumption ratio of weight and number of the present invention is:
Radix Ginseng Rubra 0.8, the Radix Astragali 2.4, Radix Notoginseng 0.8, Flos Carthami 0.8, Radix Salviae Miltiorrhizae 1.2, Colla cornus cervi 1.2, Lignum Dalbergiae Odoriferae 1.2, Lignum Santali Albi 1.2, Herba Epimedii 1.2, Hirudo 0.6, Rhizoma Chuanxiong 1.2.
Medicine of the present invention is based on: the reinforce functional activities of the heart of Radix Ginseng Rubra, the Radix Astragali, the effect of the mind calming and mentality promoting are used to set upright, the regulating QI to relieve pain of Hirudo, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Radix Notoginseng, Lignum Dalbergiae Odoriferae, Lignum Santali Albi, the effect of blood circulation promoting and blood stasis dispelling is eliminating evil takes stopgap measures, the effect of the warming and activating heart-YANG of Herba Epimedii, Colla cornus cervi is in order to consolidate, it is collaborative mutually that three aspects are set upright, take stopgap measures, consolidated to above raw material, constitutes the new drug of a kind of curative effect apparently higher than existing medicaments for coronary disease.
The preparation method of medicine of the present invention is:
1, alcohol extraction prepares Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Lignum Santali Albi clear paste.
With above-mentioned three flavor crude drug alcohol reflux three times, concentration of alcohol (volume) 50% extracts 55-60 ℃ of temperature.Extracted 1.5 hours for the first time, filter, filtrate recycling ethanol, filtrate is concentrated into relative density 1.30 (55-60 ℃).Extracted 1.5 hours for the second time, filter.Extracted for the third time 2 hours, and filtered.Merge two, three times filtrate, be concentrated into 1.40 (55-60 ℃), and then with the first time extracting solution merge, mixing, the clear paste of making relative density 1.35-1.39 (55 ℃) is standby.
2, water is obtained through refining the Radix Astragali, Herba Epimedii clear paste fully.
The Radix Astragali, Herba Epimedii water are carried three times, are respectively to boil 3 hours, 2 hours, 2 hours.It is standby that extracting solution is condensed into the clear paste of relative density 1.35-1.39 (55 ℃).
3, preparation Radix Notoginseng, Radix Ginseng Rubra, Hirudo, Lignum Dalbergiae Odoriferae, Flos Carthami, Colla cornus cervi medicated powder.
It is standby that above-mentioned material is crushed to granularity 100-120 order with pharmaceutical industry disintegrating apparatus commonly used.
Above-mentioned alcohol extraction clear paste, water are put forward clear paste, crude drug powder mixes, stir, drying promptly gets active constituents of medicine of the present invention.It is encapsulated or add 5% starch film-making, every pastille 0.3g to pulverize the back.Perhaps add other pharmaceutical carriers and/or excipient, make other peroral dosage forms, promptly get medicine of the present invention.
Medicine of the present invention is oral medicine, and consumption is each pure medicine 1.5g, every day 3 times.
Good effect of the present invention is: cure rate is than existing medicine height, and determined curative effect, raw material are common kind, and preparation method belongs to conventional Chinese medicine preparation technology, and preparation cost is low, can satisfy social needs.
Comparison of therapeutic is given an example with concrete case.
Comparison of therapeutic.
Medicine of the present invention certain county institute of traditional Chinese medicine as institute in preparation use and contrast with taking Chinese patent medicine FUFANG DANSHEN PIAN patient, its process and result are:
Selecting at random and taking medicine 120 examples of the present invention is the treatment group, and it is matched group that 60 examples are taken FUFANG DANSHEN PIAN, all carries out items such as electrocardiogram, ultrasonic cardiography, blood fat before and after the treatment and checks, take in the treatment group of medicine of the present invention, produce effects 38 examples, effective 74 examples, total effective rate 93.33%.Matched group total effective rate 71.67% (P＜0.05).ECG curative effect, treatment group are produce effects 36 examples, effective 38 examples, total effective rate 58.33%.Matched group total effective rate 40.0% (P＜0.05).
Case for example.
The Hu Guozhu man lived in the worker of Songyuan City, Jilin Province Songyuan City agricultural bank in 46 years old.Suffer from coronary atherosclerotic heart disease and fatigue stable angina pectoris.On May 14th, 2003, the state of an illness added the treatment of reentry Qian Guo county institute of traditional Chinese medicine, took medicine of the present invention and reached the clinical recovery standard in 5 days, left hospital.
The refined celery woman of grandson lived Guo county post office dependents' district before the Songyuan City, Jilin Province in 73 years old.Suffer from coronary atherosclerotic heart disease and fatigue stable angina pectoris.Cardiac function II level, type 2 diabetes mellitus.Went into the treatment of Qian Guo county institute of traditional Chinese medicine on March 30th, 2003, take medicine of the present invention and reached the clinical recovery standard in 8 days, leave hospital.
The strong man in Tong sea lived in the Baicheng City Taobei District rail man of Jilin Province in 48 years old.Suffer from coronary atherosclerotic heart disease and fatigue stable angina pectoris, accidental premature ventricular beat.Went into the treatment of Qian Guo county institute of traditional Chinese medicine on March 13rd, 2002, take medicine of the present invention and reached the clinical recovery standard in 10 days, leave hospital.
The specific embodiment
Embodiment 1
Get Radix Salviae Miltiorrhizae 300g, Rhizoma Chuanxiong 300g, Lignum Santali Albi 300g, use alcohol reflux three times, concentration of alcohol (volume) 50% extracts 55-60 ℃ of temperature.Extracted 1.5 hours for the first time, filter, filtrate recycling ethanol, filtrate is concentrated into relative density 1.30 (55-60 ℃).Extracted 1.5 hours for the second time, filter.Extracted for the third time 2 hours, and filtered.Merge two, three times filtrate, be concentrated into 1.40 (55-60 ℃), and then with the first time extracting solution merge, mixing, the clear paste of making relative density 1.35-1.39 (55 ℃) is standby.
Get Radix Astragali 600g, Herba Epimedii 300g, water is carried three times, is respectively and boils 3 hours, 2 hours, 2 hours.It is standby that extracting solution is condensed into the clear paste of relative density 1.35-1.39 (55 ℃).
Get Radix Notoginseng 3200g, Radix Ginseng Rubra 3200g, Hirudo 2400g, Lignum Dalbergiae Odoriferae 4800g, Flos Carthami 3200g, Colla cornus cervi 4800g, standby with pharmaceutical industry disintegrating apparatus mixing commonly used or pulverize separately to granularity 100 order powder.
Above-mentioned alcohol extraction clear paste, water are put forward clear paste, crude drug powder mixes, stir, promptly get active constituents of medicine of the present invention.With mixture crushed after being dried 80 orders, encapsulated, every powder charge 0.3g, the packing capsule gets finished medicines.
Embodiment 2
Get Radix Salviae Miltiorrhizae 4800g, Rhizoma Chuanxiong 4800g, Lignum Santali Albi 4800g, with the process system alcohol extraction clear paste of embodiment 1.Get Radix Astragali 9600g, Herba Epimedii 4800g, carry clear paste with the process controlling the water circulation of embodiment 1.Get Radix Notoginseng 200g, Radix Ginseng Rubra 200g, Hirudo 150g, Lignum Dalbergiae Odoriferae 300g, Flos Carthami 200g, Colla cornus cervi 300g are crushed to 100 orders.Alcohol extraction clear paste, water are carried clear paste, crude drug powder mixing, and drying is crushed to 100 orders again, adds the starch of gained medicated powder weight 5%, by the pharmacy of existing film-making technology.The packing tablet gets tablet finished product of the present invention.
Embodiment 3
Get Radix Salviae Miltiorrhizae 1200g, Rhizoma Chuanxiong 1200g, Lignum Santali Albi 1200g, Radix Astragali 2400g, Herba Epimedii 1200g, Radix Notoginseng 800g, Radix Ginseng Rubra 800g, Hirudo 600g, Lignum Dalbergiae Odoriferae 1200g, Flos Carthami 800g, Colla cornus cervi 1200g.Pharmacy procedure is with embodiment 1.
Claims (2)
1. medicine for the treatment of coronary heart disease, it is characterized in that: the raw material by the following portions by weight ratio is formed, Radix Ginseng Rubra 0.2-3.2, Radix Astragali 0.6-9.6, Radix Notoginseng 0.2-3.2, Flos Carthami 0.2-3.2, Radix Salviae Miltiorrhizae 0.3-4.8, Colla cornus cervi 0.3-4.8, Lignum Dalbergiae Odoriferae 0.3-4.8, Lignum Santali Albi 0.3-4.8, Herba Epimedii 0.3-4.8, Hirudo 0.15-2.4, Rhizoma Chuanxiong 0.3-4.8.
2. according to a kind of medicine for the treatment of coronary heart disease of claim 1, it is characterized in that: raw materials used ratio of weight and number is Radix Ginseng Rubra 0.8, the Radix Astragali 2.4, Radix Notoginseng 0.8, Flos Carthami 0.8, Radix Salviae Miltiorrhizae 1.2, Colla cornus cervi 1.2, Lignum Dalbergiae Odoriferae 1.2, Lignum Santali Albi 1.2, Herba Epimedii 1.2, Hirudo 0.6, Rhizoma Chuanxiong 1.2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100552825A CN101234137B (en) | 2007-01-30 | 2007-01-30 | Drug for curing coronary disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100552825A CN101234137B (en) | 2007-01-30 | 2007-01-30 | Drug for curing coronary disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101234137A CN101234137A (en) | 2008-08-06 |
| CN101234137B true CN101234137B (en) | 2011-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100552825A Expired - Fee Related CN101234137B (en) | 2007-01-30 | 2007-01-30 | Drug for curing coronary disease |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703736B (en) * | 2009-11-13 | 2011-11-09 | 秦中文 | Chinese medicament for treating coronary disease |
| CN101947299B (en) * | 2010-09-08 | 2011-12-07 | 长春中医药大学 | Medicinal composition for treating coronary heart disease |
| CN102600255A (en) * | 2012-03-29 | 2012-07-25 | 周柳池 | Coronary disease treatment capsule |
| CN108379515B (en) * | 2018-05-14 | 2021-03-09 | 新疆维吾尔自治区阿克苏地区维吾尔医医院 | Medicine with angina pectoris treating effect and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1554397A (en) * | 2003-12-26 | 2004-12-15 | 济南永曜医药科技有限公司 | Pulse and channel drop pill and soft capsule and its preparing method |
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2007
- 2007-01-30 CN CN2007100552825A patent/CN101234137B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1554397A (en) * | 2003-12-26 | 2004-12-15 | 济南永曜医药科技有限公司 | Pulse and channel drop pill and soft capsule and its preparing method |
Non-Patent Citations (1)
| Title |
|---|
| 杜翌林等.中医治疗冠心病集析.《中医药学刊》.2005,第23卷(第3期),560-563. * |
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| CN101234137A (en) | 2008-08-06 |
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