CN101716271B - Chinese traditional medicine effective fraction composite used for curing coronary heart disease and preparation method thereof - Google Patents
Chinese traditional medicine effective fraction composite used for curing coronary heart disease and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese traditional medicine effective fraction composite used for curing coronary heart disease and a preparation method thereof. The Chinese traditional medicine effective fraction composite is prepared by the following steps of: taking radix pseudo-ginseng, teasel, trogopterus dung, licorice root, rhizoma cyperi (vinegar-fried), peach kernel, orange peel, fresh coriander, and vitamin C as raw materials; in a certain proportion, extracting part of medicines with alcohol for concentration; extracting part of medicines with acetum for concentration; and then combining the two parts of the medicines and diluting to obtain a liquid state preparation. The composite has the effects of blood activation and status dissolution, yang activation with aromatic herbs, compatibility of all the medicines, remarkable curative effect on the coronary heart disease, vitality supplement and auxiliary curing fostering; in addition, through preparing into the liquid state preparation capable of being taken directly, the composite is convenient for patients to take continuously with an effect of addressing both symptoms and root causes.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of compound preparation of treating coronary heart disease.
Background technology
Coronary atherosclerotic heart disease is called for short coronary heart disease, is meant that coronary atherosclerosis makes lumen of vessels narrow down, block, and causes myocardial ischemia, anoxia and the heart disease that causes.At present, the main medicine of treatment coronary heart disease has: nitrate esters medicine, anticoagulant,
-blocker, calcium ion antagonist, angiotensin converting enzyme inhibitor etc.Because coronary heart disease in fact also is a kind of chronic inflammation disease, practice result clinically shows, the western medicine refractory its, especially side effects of pharmaceutical drugs make the patient be difficult to take for a long time.In recent years along with the development of theory of Chinese medical science, part Chinese herbal medicine activating blood circulation to dissipate blood stasis, the character of aromatic herbs activating YANG and the application on treatment coronary heart disease thereof are admitted more and more.Because Chinese medicine contains many kinds of chemical constituents, the chemical constituent of the Chinese medicine compound of being made up of number flavor medicine is just complicated more, and this has determined them to have the effect of many target spots, especially is suitable for the coronary heart disease of cause of disease complicacy.That has promoted has NAOXINTONG, storax pill for treating coronary heart disease, tablet for promoting coronary circulation, a FUFANG DANSHEN PIAN etc.Also existing at present a plurality of patents disclose the important preparation that is used to treat coronary heart disease, but its prescription and effectiveness are different.The Effective Components of Chinese Herb and the mechanism of action are complicated; Exist compatibility relationship between the multiple medicine; The different drug combination possibly produce mutual reinforcement between, the mutual-assistance or effects such as mutual restraint between two drugs, the mutual-detoxication; The pools of traditional Chinese medicine of China is being contained the medicine and the prescription of many preciousnesses, and the effective prescription that wherein still has a large amount of can be used for to treat coronary heart disease remains to be excavated and development.But because the onset of treatment by Chinese herbs is slow, exist the inconvenient shortcoming of medication simultaneously, make that most of patients is difficult to persevere, can't obtain better therapeutic effect.
Summary of the invention
The objective of the invention is to provides a kind of and can effectively treat coronary heart disease to the existing deficiency of Chinese medicinal formulae, taking convenience, treating both the principal and secondary aspects of a disease, the compound Chinese medicinal preparation of the unification of recuperating.
Another object of the present invention provides the method for preparing of this medicine.
The present invention realizes above-mentioned purpose through following technical scheme:
A kind of effective ingredient in Chinese compositions that is used to treat coronary heart disease, the raw material of being made up of following weight constitutes:
The described compositions that is used to treat coronary heart disease, preferred following weight is formed:
The described compositions that is used to treat coronary heart disease is obtained by following method for preparing:
(1) Radix Notoginseng, Radix Dipsaci, Oletum Trogopterori, Radix Glycyrrhizae are pulverized, add alcoholic solution and decoct, filter and obtain filtrating, low-pressure distillation concentrates, and obtains concentrated solution.Digestion process 2-3h wherein, being concentrated into final volume is 100-300 part.
(2) Rhizoma Cyperi, Semen Persicae, Flos Carthami, Pericarpium Citri tangerinae, bright coriander, vitamin C are pulverized, added the acetic acid reflux, obtain filtrating after the filtration.Wherein acetum concentration is 8%-20%, and addition is 400-700 part, and the temperature of reflux is 60-85 ℃, and the time is 1.5-2h.
(3) merge above-mentioned concentrated solution and filtrating, thin up obtains liquid formulation.The final volume of liquid formulation is 800-1000 part.
Compared with prior art, the present invention has following beneficial effect:
(1) pharmaceutical composition provided by the present invention contains the composition of blood circulation promoting and blood stasis dispelling, aromatic herbs activating YANG, activating stagnated YANG; Its compatibility is particular about simultaneously, and mutual reinforcement between is complementary, the effect of many target spots; The also adjusting of vasoactive wall, the cardiac muscle when temperature of invigorating blood circulation is logical has significant effect to the treatment of coronary heart disease;
(2) pharmaceutical composition provided by the present invention has YIN nourishing and regulates the flow of vital energy, and augments vigour, and the pleasant effect of detoxifying plays important regulatory role to coronary heart disease patient's body, to support auxilliary the treatment;
(3) compositions provided by the present invention is the liquid formulation that can directly take, takes easyly, helps patient's continued treatment, is particularly suitable for the controlling of BIAO and BEN of this type of coronary heart disease chronic disease.
The specific embodiment
Below further specify technical scheme of the present invention through concrete embodiment.
Embodiment 1
Radix Notoginseng 60g, Radix Dipsaci 90g, Oletum Trogopterori 90g, Radix Glycyrrhizae 35g are pulverized, add alcoholic solution steaming and decocting 2.5h, filter rear filtrate and revolve in vacuum and steam on the appearance distillation to be concentrated into volume be about 100ml; In addition Rhizoma Cyperi (processed with vinegar) 80g, Semen Persicae 60g, Flos Carthami 45g, Pericarpium Citri tangerinae 75g, bright coriander 75g, vitamin C 0.5g are pulverized, add 10% acetum 600ml,, filter at 70 ℃ of following reflux 2h; Merge above-mentioned concentrated solution and filtrating, it is 1000ml that the adding drinking water makes final volume, obtains liquid formulation.
The liquid direct packaging of gained is the 60ml/ bottle, directly takes.1 bottle of every day or follow the doctor's advice, 1 month is a course of treatment.
Embodiment 2
Radix Notoginseng 50g, Radix Dipsaci 70g, Oletum Trogopterori 80g, Radix Glycyrrhizae 50g are pulverized, add alcoholic solution steaming and decocting 2.5h, filter rear filtrate and revolve in vacuum and steam on the appearance distillation to be concentrated into volume be about 100ml; In addition Rhizoma Cyperi (processed with vinegar) 65g, Semen Persicae 45g, Flos Carthami 35g, Pericarpium Citri tangerinae 65g, bright coriander 90g, vitamin C 1g are pulverized, add 10% acetum 600ml,, filter at 70 ℃ of following reflux 2h; Merge above-mentioned concentrated solution and filtrating, it is 1000ml that the adding drinking water makes final volume, obtains liquid formulation.
The liquid direct packaging of gained is the 60ml/ bottle, directly takes.1 bottle of every day or follow the doctor's advice, 1 month is a course of treatment.
Pharmaceutical composition provided by the present invention is through clinical observation, and is high to the treatment total effective rate of patients with coronary heart disease, below explains through data.
1, clinical disease classification:
Angina pectoris, myocardial infarction, arrhythmia, cardiac blood supply deficiency.
2, clinical data:
Patient's 156 examples, the age is at 41-86 between year, and male's 75 examples, women's 81 examples, the course of disease had 48 examples more than 10 years, and wherein there are 20 examples of two or more diseases simultaneously in 108 examples below 10 years.
3, diagnosis and criterion of therapeutical effect:
Diagnosis and criterion of therapeutical effect are so that " the clinical handbook of modern Chinese medicine is as the criterion.
4, Therapeutic Method:
The oral liquid formulation that is provided like embodiment 2 of patient, every day 1 time, each 60ml, 1 month is 1 course of treatment, 3 courses of treatment of continued treatment.
5, therapeutic effect:
6, model case
The * * of Tang, the woman 65 years old, suffered from cardiovascular disease 4 years; Be diagnosed as arrhythmia, show as nervous breathing hard, dizzy uncomfortable in chest; Fail to effect a radical cure the liquid formulation that the embodiment of the invention of taking medicine 2 is provided, clinical symptom disappearance after lasting 3 courses of treatment for many years; Electrocardioscopy is normal fully, follows the tracks of and follows up a case by regular visits to 3 years, does not see recurrence.
Claims (5)
1. effective ingredient in Chinese compositions that is used to treat coronary heart disease is characterized in that being processed by the raw material of following weight:
And its preparation method may further comprise the steps:
(1) Radix Notoginseng, Radix Dipsaci, Oletum Trogopterori, Radix Glycyrrhizae are pulverized, add alcoholic solution and decoct, filter and obtain filtrating, low-pressure distillation concentrates, and obtains concentrated solution;
(2) Rhizoma Cyperi (processed with vinegar), Semen Persicae, Flos Carthami, Pericarpium Citri tangerinae, bright coriander, vitamin C are pulverized, adding concentration is the acetic acid reflux of 8%-20%, obtains filtrating after the filtration;
(3) merge above-mentioned concentrated solution and filtrating, thin up obtains liquid formulation.
2. compositions according to claim 1 is characterized in that being processed by the raw material of following weight:
3. compositions according to claim 1 is characterized in that the said decoction process 2-3h of step in the method for preparing (1), and it is 100-300 part that distillation is concentrated into liquid volume.
4. compositions according to claim 1, the addition that it is characterized in that the described acetic acid of step in the method for preparing (2) is parts by volume 400-700 part, and the temperature of reflux is 60-85 ℃, and the time is 1.5-2h.
5. compositions according to claim 1 is characterized in that the described liquid formulation of step in the method for preparing (3) final volume after the water dilution is 800-1000 part.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009102136823A CN101716271B (en) | 2009-12-08 | 2009-12-08 | Chinese traditional medicine effective fraction composite used for curing coronary heart disease and preparation method thereof |
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| CN2009102136823A CN101716271B (en) | 2009-12-08 | 2009-12-08 | Chinese traditional medicine effective fraction composite used for curing coronary heart disease and preparation method thereof |
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| CN101716271A CN101716271A (en) | 2010-06-02 |
| CN101716271B true CN101716271B (en) | 2012-03-21 |
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| CN105708922A (en) * | 2016-01-28 | 2016-06-29 | 李庆升 | Capsule capable of dissolving thrombus |
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Address after: 510623 Guangdong city of Guangzhou province Tianhe District Zhujiang New City Jinsui Road Star International Building 17 floor tower Patentee after: YIPINHONG PHARMACY Co.,Ltd. Address before: 510623 Guangdong city of Guangzhou province Tianhe District Zhujiang New City Jinsui Road Star International Building 17 floor tower Patentee before: Guangdong Yipinhong Pharmacy Co.,Ltd. |
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Effective date of registration: 20221109 Address after: No.6 Dongbo Road, East District, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Patentee after: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Patentee after: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. Patentee after: Guangzhou Lianrui Pharmaceutical Co.,Ltd. Patentee after: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Patentee after: Euphorbia Biological Medicine Co.,Ltd. Patentee after: YIPINHONG PHARMACY Co.,Ltd. Address before: 510623 Guangdong city of Guangzhou province Tianhe District Zhujiang New City Jinsui Road Star International Building 17 floor tower Patentee before: YIPINHONG PHARMACY Co.,Ltd. |
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