CN100496530C - Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method - Google Patents
Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method Download PDFInfo
- Publication number
- CN100496530C CN100496530C CNB2004100185625A CN200410018562A CN100496530C CN 100496530 C CN100496530 C CN 100496530C CN B2004100185625 A CNB2004100185625 A CN B2004100185625A CN 200410018562 A CN200410018562 A CN 200410018562A CN 100496530 C CN100496530 C CN 100496530C
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- CN
- China
- Prior art keywords
- chinese medicine
- extract
- heart disease
- rhizoma chuanxiong
- semen
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000000203 mixture Substances 0.000 title claims description 20
- 238000002360 preparation method Methods 0.000 title claims description 12
- 208000029078 coronary artery disease Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 29
- 208000004186 Pulmonary Heart Disease Diseases 0.000 claims abstract description 18
- 238000005516 engineering process Methods 0.000 claims abstract description 6
- 241000411851 herbal medicine Species 0.000 claims abstract description 5
- 238000002347 injection Methods 0.000 claims abstract description 4
- 239000007924 injection Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 37
- 210000000582 semen Anatomy 0.000 claims description 34
- 201000006306 Cor pulmonale Diseases 0.000 claims description 17
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
- FINHMKGKINIASC-UHFFFAOYSA-N Tetramethylpyrazine Chemical compound CC1=NC(C)=C(C)N=C1C FINHMKGKINIASC-UHFFFAOYSA-N 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000010828 elution Methods 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 239000012141 concentrate Substances 0.000 claims description 6
- 239000003208 petroleum Substances 0.000 claims description 6
- 239000011347 resin Substances 0.000 claims description 6
- 229920005989 resin Polymers 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical group O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 238000000746 purification Methods 0.000 claims description 4
- 238000000638 solvent extraction Methods 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 3
- 239000003292 glue Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229930013930 alkaloid Natural products 0.000 claims description 2
- 238000004458 analytical method Methods 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000006196 drop Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 3
- 229910052760 oxygen Inorganic materials 0.000 abstract description 3
- 239000001301 oxygen Substances 0.000 abstract description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract description 2
- 239000001569 carbon dioxide Substances 0.000 abstract description 2
- 241000801118 Lepidium Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000002815 pulmonary hypertension Diseases 0.000 description 4
- 229940097217 cardiac glycoside Drugs 0.000 description 3
- 239000002368 cardiac glycoside Substances 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 229930002534 steroid glycoside Natural products 0.000 description 3
- 238000011049 filling Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000790917 Dioxys <bee> Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000003177 cardiotonic effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- -1 drying Substances 0.000 description 1
- 238000004868 gas analysis Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100185625A CN100496530C (en) | 2004-05-21 | 2004-05-21 | Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100185625A CN100496530C (en) | 2004-05-21 | 2004-05-21 | Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1579489A CN1579489A (en) | 2005-02-16 |
CN100496530C true CN100496530C (en) | 2009-06-10 |
Family
ID=34581843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100185625A Expired - Lifetime CN100496530C (en) | 2004-05-21 | 2004-05-21 | Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method |
Country Status (1)
Country | Link |
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CN (1) | CN100496530C (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105168818A (en) * | 2015-10-27 | 2015-12-23 | 戴礼礼 | Composition for treating acute stage of chronic pulmonary heart disease |
CN114984087B (en) * | 2021-03-02 | 2023-04-25 | 天津中医药大学 | Traditional Chinese medicine composition, decoction and pharmaceutical composition, and preparation method and application thereof |
CN113304187A (en) * | 2021-05-31 | 2021-08-27 | 勾大卉 | Composition for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof |
-
2004
- 2004-05-21 CN CNB2004100185625A patent/CN100496530C/en not_active Expired - Lifetime
Non-Patent Citations (2)
Title |
---|
复方葶苈注射液对野百合碱诱发大鼠肺心病急性发作期的急性时相蛋白影响. 熊旭东,王左.中国中医药科技,第2卷. 1999 |
复方葶苈注射液对野百合碱诱发大鼠肺心病急性发作期的急性时相蛋白影响. 熊旭东,王左.中国中医药科技,第2卷. 1999 * |
Also Published As
Publication number | Publication date |
---|---|
CN1579489A (en) | 2005-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SUZHOU YOUSEEN NEW MEDICINE EXPLOITATION CO., LTD. Free format text: FORMER OWNER: XUAN ZHENYU Effective date: 20140702 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 201203 PUDONG NEW AREA, SHANGHAI TO: 215123 SUZHOU, JIANGSU PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20140702 Address after: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215123 bio Nano Technology Park building 218 C30 Patentee after: SUZHOU YOUSEEN NEW DRUG R & D Co.,Ltd. Address before: 201203 Shanghai city Pudong New Area Yifeng 55 Lane Road, Room 302 No. 133 Hong Kong Liyuan spring Patentee before: Xuan Zhenyu |
|
CX01 | Expiry of patent term |
Granted publication date: 20090610 |