CN100496530C - Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method - Google Patents
Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method Download PDFInfo
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- CN100496530C CN100496530C CNB2004100185625A CN200410018562A CN100496530C CN 100496530 C CN100496530 C CN 100496530C CN B2004100185625 A CNB2004100185625 A CN B2004100185625A CN 200410018562 A CN200410018562 A CN 200410018562A CN 100496530 C CN100496530 C CN 100496530C
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- chinese medicine
- extract
- heart disease
- rhizoma chuanxiong
- semen
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- 239000000203 mixture Substances 0.000 title claims description 20
- 238000002360 preparation method Methods 0.000 title claims description 12
- 208000029078 coronary artery disease Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 29
- 208000004186 Pulmonary Heart Disease Diseases 0.000 claims abstract description 18
- 238000005516 engineering process Methods 0.000 claims abstract description 6
- 241000411851 herbal medicine Species 0.000 claims abstract description 5
- 238000002347 injection Methods 0.000 claims abstract description 4
- 239000007924 injection Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 37
- 210000000582 semen Anatomy 0.000 claims description 34
- 201000006306 Cor pulmonale Diseases 0.000 claims description 17
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
- FINHMKGKINIASC-UHFFFAOYSA-N Tetramethylpyrazine Chemical compound CC1=NC(C)=C(C)N=C1C FINHMKGKINIASC-UHFFFAOYSA-N 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000010828 elution Methods 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 239000012141 concentrate Substances 0.000 claims description 6
- 239000003208 petroleum Substances 0.000 claims description 6
- 239000011347 resin Substances 0.000 claims description 6
- 229920005989 resin Polymers 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical group O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 238000000746 purification Methods 0.000 claims description 4
- 238000000638 solvent extraction Methods 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 3
- 239000003292 glue Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229930013930 alkaloid Natural products 0.000 claims description 2
- 238000004458 analytical method Methods 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000006196 drop Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 3
- 229910052760 oxygen Inorganic materials 0.000 abstract description 3
- 239000001301 oxygen Substances 0.000 abstract description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract description 2
- 239000001569 carbon dioxide Substances 0.000 abstract description 2
- 241000801118 Lepidium Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000002815 pulmonary hypertension Diseases 0.000 description 4
- 229940097217 cardiac glycoside Drugs 0.000 description 3
- 239000002368 cardiac glycoside Substances 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 229930002534 steroid glycoside Natural products 0.000 description 3
- 238000011049 filling Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000790917 Dioxys <bee> Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000003177 cardiotonic effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- -1 drying Substances 0.000 description 1
- 238000004868 gas analysis Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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Abstract
The invention relates to Chinese traditional medicine technology field, it is a Chinese traditional medicine compound for curing pulmonary heart diseases. It includes Chinese herbal medicines lepidium seed, chuanxiong rhizome, its character lies in: the prescription is made up of 1-3 shares of lepidium seed or its extract, 1-2 shares of chuanxiong rhizome or its extract and proper quantity of accessories. Compared with current technology, the medicine reduces the carbon dioxide branch pressure, upgrades the effect of the high oxygen branch pressure, and supplements the blank of Chinese patent medicine injection solution for curing pulmonary heart diseases. It overcomes the deficiencies that the curative effect is low, and the side effect is large and not ideal. The investment is little, and the cost is low.
Description
[technical field]
The present invention relates to technical field of Chinese medicines, is a kind of Chinese medicine composition for the treatment of pulmonary heart disease and preparation method thereof.
[technical background]
Pulmonary heart disease is a kind of commonly encountered diseases, frequently-occurring disease.According to the whole nation 20,000,000 census of the populations, the average prevalence of pulmonary heart disease is 23.54%.The late mortality rate can reach 30%, and mainly to send out the patient be the old man, the old person back initiation pulmonary heart disease 90% or more of catching a cold.China has up to ten million chronic cardiopulmonary disease patients at present, so its control also is subject to people's attention day by day.The generation development and the pulmonary hypertension of this disease are closely related, if can effectively control pulmonary hypertension, obvious mitigation symptoms then, even avoid the acute attack of pulmonary heart disease.We are the distinguished veteran doctors of TCM proved recipe of decades, cure mainly the pulmonary heart disease pulmonary hypertension.Clinical and experimentation shows that Chinese medicine composition effective percentage of the present invention is 88.00%, obviously is better than general conventional medicine.From arterial blood gas analysis, have obvious reduction partial pressure of carbon dioxide, improve the effect of partial pressure of oxygen.
Clinically at present, Western medicine mainly is the medicine of conventional infection, anti-arrhythmia, and curative effect is slow, side effect is big and effect is undesirable, and Chinese patent medicine mainly relies on Drug therapys such as little Green Dragon mixture, and the injection product that still is not used in first aid occurs.What the Semen Lepidii (Semen Descurainiae) among the present invention had cardiotonic is the cardiac glycoside composition, and specific examples of such components promptly dissolves in alcohol water soluble again; The main effective ingredient of Rhizoma Chuanxiong is a biological species, wherein is mainly ligustrazine, and the very little water soluble of content is soluble in alcohol.Succeeding in developing of this medicine with filling up the blank that domestic treatment by Chinese herbs should disease, obtained great economic benefit and social benefit.
[summary of the invention]
The objective of the invention is provides a kind of Chinese medicine composition reasonable, that curative effect is fast, side effect is little, the pulmonary heart disease pulmonary hypertension is treated in realization of filling a prescription according to the rule and the mechanism of raw material of Chinese medicine.
For achieving the above object, design a kind of Chinese medicine composition for the treatment of pulmonary heart disease and preparation method thereof, comprise Chinese herbal medicine Semen Lepidii (Semen Descurainiae), Rhizoma Chuanxiong, it is characterized in that prescription is made up of Semen Lepidii (Semen Descurainiae) or 1～3 part of its extract, Rhizoma Chuanxiong or 1～2 part of its extract and appropriate amount of auxiliary materials by portion rate preparation; Rhizoma Chuanxiong can be substituted or Rhizoma Chuanxiong and Radix Salviae Miltiorrhizae Application of composite by other blood-activating stasis-removing kind medicines such as Radix Salviae Miltiorrhizaes; Contain the extract total cardiac glycoside position of Chinese herbal medicine Semen Lepidii (Semen Descurainiae) and the active ingredient ligustrazine of Chinese medicine Rhizoma Chuanxiong, the active ingredient ligustrazine of Rhizoma Chuanxiong can replace with the synthetic product; The prescription active ingredient is made of Semen Lepidii (Semen Descurainiae) total cardiac glycoside position and Rhizoma Chuanxiong total alkaloids position; Chinese medicine composition can be all dosage forms such as injection, tablet, capsule, drop pill; Following step of preparation process: the extraction process step of (1) Semen Lepidii (Semen Descurainiae) active ingredient: Semen Lepidii (Semen Descurainiae) → extraction → concentrate → analysing glue filtration → macroporous resin separates → concentrates → drying; At first get the Semen Lepidii (Semen Descurainiae) coarse crushing, defat with petroleum ether after squeezing is deoiled; Discard petroleum ether liquid, volatilizing medicinal residues kind petroleum ether with 70% ethanol is solvent extraction 2 times, and extracting solution reclaims ethanol, analyse glue, filter after water, 30%, 70% ethanol gradient elution are adopted in the macroporous resin separation and purification, collect 70% ethanol elution part, concentrate drying promptly.(2) the extraction process step of effective Chuanxiong component: Rhizoma Chuanxiong → 95% alcohol reflux extraction → recovery ethanol is to do → being dissolved in water → filtering → macroporous resin separation → concentrated → drying.After getting the Rhizoma Chuanxiong coarse crushing, be solvent extraction 2 times, reclaim ethanol to doing with 95% ethanol, add suitable quantity of water dissolving, filter after the macroporous resin separation and purification, first water is eluted to the reducing sugar reaction feminine gender, reuse 30% ethanol elution is collected 30% ethanol elution part, and concentrate drying promptly.(3) mix, will extract gained and appropriate amount of auxiliary materials mixing stirring in above-mentioned (1), (2) promptly.Compared with prior art, the invention obviously is better than general conventional medicine, has obvious reduction dioxy carbon dividing potential drop, improve the effect of partial pressure of oxygen, curative effect is fast, side effect is little, has filled up the blank that domestic treatment by Chinese herbs should disease, will obtain great economic benefit and social benefit, small investment, cost is low, is worthy of promotion and application.
[description of drawings]
Accompanying drawing 1 is a process chart of the present invention.
Referring to accompanying drawing, 1 is the extraction of Semen Lepidii (Semen Descurainiae) active ingredient; 2 is the extraction of effective Chuanxiong component; 3 is adjuvant; 4 is mixing granulation; 5 is dry; 6 is granulate; 7 is tabletting; 8 get finished product.The production technology of this technology is clearly to this professional people.
[specific embodiment]
The invention will be further described below in conjunction with accompanying drawing.
Example 1. tablets of the present invention
Get 1～2 part of 1～3 part of Semen Lepidii (Semen Descurainiae) or its extract, Rhizoma Chuanxiong or its extract, add right amount of auxiliary materials, granulate, drying, granulate, tabletting, promptly.
Claims (7)
1, a kind of Chinese medicine composition for the treatment of pulmonary heart disease comprises Chinese herbal medicine Semen Lepidii (Semen Descurainiae), Rhizoma Chuanxiong, it is characterized in that described compositions is made up of 1～3 part of Semen Lepidii extract (Semen Descurainiae extract), 1～2 part of Rhizoma Chuanxiong extract and appropriate amount of auxiliary materials by portion rate preparation;
The preparation technology of described Semen Lepidii extract (Semen Descurainiae extract) is: at first get the Semen Lepidii (Semen Descurainiae) coarse crushing, defat with petroleum ether after squeezing is deoiled; Discard petroleum ether liquid, medicinal residues are waved most petroleum ether, are solvent extraction 2 times with 70% ethanol, extracting solution reclaims ethanol, analyses glue, filters after the macroporous resin separation and purification, adopt water, 30%, 70% ethanol gradient elution, collect 70% ethanol elution part, concentrate drying promptly;
The preparation technology of described Rhizoma Chuanxiong extract is: after getting the Rhizoma Chuanxiong coarse crushing, with 95% ethanol is solvent extraction 2 times, reclaim ethanol to doing, add the suitable quantity of water dissolving, filter after the macroporous resin separation and purification, first water is eluted to the reducing sugar reaction feminine gender, reuse 30% ethanol elution, collect 30% ethanol elution part, concentrate drying promptly.
2, a kind of according to claim 1 Chinese medicine composition for the treatment of pulmonary heart disease is characterized in that Rhizoma Chuanxiong is substituted or Rhizoma Chuanxiong and Radix Salviae Miltiorrhizae Application of composite by Radix Salviae Miltiorrhizae.
3, a kind of according to claim 1 Chinese medicine composition for the treatment of pulmonary heart disease is characterized in that containing the total cardiac glycoside part of extract of Chinese herbal medicine Semen Lepidii (Semen Descurainiae) and the active ingredient ligustrazine of Chinese medicine Rhizoma Chuanxiong.
4, as a kind of Chinese medicine composition for the treatment of pulmonary heart disease as described in the claim 3, it is characterized in that the active ingredient ligustrazine of Chinese medicine Rhizoma Chuanxiong replaces with artificial composite.
5, a kind of according to claim 1 Chinese medicine composition for the treatment of pulmonary heart disease is characterized in that described compositions active ingredient partly is made of total cardiac glycoside part of Semen Lepidii (Semen Descurainiae) and Rhizoma Chuanxiong total alkaloids.
6, a kind of according to claim 1 Chinese medicine composition for the treatment of pulmonary heart disease is characterized in that Chinese medicine preparation is injection, tablet, capsule, drop pill.
7, as a kind of Chinese medicine composition preparation method for the treatment of pulmonary heart disease as described in claims 1, it is characterized in that comprising following step of preparation process: the extraction of (1) Semen Lepidii (Semen Descurainiae) active ingredient; (2) the extraction process step of effective Chuanxiong component; (3) mix, will extract gained and appropriate amount of auxiliary materials mixing stirring in above-mentioned (1), (2) promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100185625A CN100496530C (en) | 2004-05-21 | 2004-05-21 | Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100185625A CN100496530C (en) | 2004-05-21 | 2004-05-21 | Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1579489A CN1579489A (en) | 2005-02-16 |
| CN100496530C true CN100496530C (en) | 2009-06-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100185625A Expired - Lifetime CN100496530C (en) | 2004-05-21 | 2004-05-21 | Traditional Chinese medicinal composition for treating coronary heart disease and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100496530C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168818A (en) * | 2015-10-27 | 2015-12-23 | 戴礼礼 | Composition for treating acute stage of chronic pulmonary heart disease |
| CN114984087B (en) * | 2021-03-02 | 2023-04-25 | 天津中医药大学 | Traditional Chinese medicine composition, decoction and pharmaceutical composition, and preparation method and application thereof |
| CN113304187A (en) * | 2021-05-31 | 2021-08-27 | 勾大卉 | Composition for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof |
-
2004
- 2004-05-21 CN CNB2004100185625A patent/CN100496530C/en not_active Expired - Lifetime
Non-Patent Citations (2)
| Title |
|---|
| 复方葶苈注射液对野百合碱诱发大鼠肺心病急性发作期的急性时相蛋白影响. 熊旭东，王左.中国中医药科技，第2卷. 1999 |
| 复方葶苈注射液对野百合碱诱发大鼠肺心病急性发作期的急性时相蛋白影响. 熊旭东，王左.中国中医药科技，第2卷. 1999 * |
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| Publication number | Publication date |
|---|---|
| CN1579489A (en) | 2005-02-16 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SUZHOU YOUSEEN NEW MEDICINE EXPLOITATION CO., LTD. Free format text: FORMER OWNER: XUAN ZHENYU Effective date: 20140702 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 201203 PUDONG NEW AREA, SHANGHAI TO: 215123 SUZHOU, JIANGSU PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20140702 Address after: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215123 bio Nano Technology Park building 218 C30 Patentee after: SUZHOU YOUSEEN NEW DRUG R & D Co.,Ltd. Address before: 201203 Shanghai city Pudong New Area Yifeng 55 Lane Road, Room 302 No. 133 Hong Kong Liyuan spring Patentee before: Xuan Zhenyu |
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| CX01 | Expiry of patent term |
Granted publication date: 20090610 |