CN107006651A - The preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag and its health preserving tea of preparation - Google Patents
The preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag and its health preserving tea of preparation Download PDFInfo
- Publication number
- CN107006651A CN107006651A CN201710246491.1A CN201710246491A CN107006651A CN 107006651 A CN107006651 A CN 107006651A CN 201710246491 A CN201710246491 A CN 201710246491A CN 107006651 A CN107006651 A CN 107006651A
- Authority
- CN
- China
- Prior art keywords
- motherwort
- delicacies
- life
- tea bag
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses the preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag and its health preserving tea of preparation, specific prepare comprises the following steps：（1）Prepare the raw material Chinese herbal medicine of eight delicacies with motherwort health preserving tea；（2）Raw material Chinese herbal medicine obtains thick paste after extraction；（3）Pharmaceutically acceptable auxiliary material is added to thick paste, pill is made, the mixture for then adding the insoluble type cellulose acetate of water and ethyl cellulose carries out film coating, acupuncture aperture on subsequent pill after coating, through drying, dispense to filter paper bag, produce ball formula eight delicacies with motherwort life-nourishing tea bag.This product allows effective ingredient not only to be breathed freely by acupuncture aperture and can delay Slow release, solves existing tea bag and typically brews after 1 time just tedious, need to discard the technical problem of tea grounds.
Description
Technical field
The present invention relates to traditional Chinese medicine health field, more specifically to a kind of ball formula eight delicacies with motherwort life-nourishing tea bag
Preparation method and its health preserving tea of preparation.
Background technology
In 20 end of the centurys, the final conclusion of global medical field free discussion is：Best medical science is not the medical science reached a cure, but
Make one not sick medical science.The starting point of the traditional Chinese medicine " preventiveing treatment of disease " in preventing and treating inferior health is primarily directed to the people of disease " be intended to ", i.e.,：
On the one hand, it is healthy and strong by reposing, makes its state of getting well：On the other hand, by early intervention, inferior health can be prevented to disease
Disease transformation.Can be by supplementing qi and blood in the form of tea-drinking due to using tcm methodses to choose Chinese medicine material, foster essence consolidates to realize
In the regulation of essence in body, improve constitution, so that the external manifestation symptom of inferior health is eliminated, the problem of solving inferior health,
Therefore, Tea containing traditional Chinese medicine turns into focus of concern and the object pursued, and a large amount of different types of Tea containing traditional Chinese medicine systems also occurs in the market
Product.
The bubble drink of tea bag is more convenient quick, and no loose tea bubble drink needs to be particular about tea set, skill of making tea, tea ceremony tea like that
The time in road, therefore pursued deeply by people.Chinese traditional herbs are the health protection tea of main component, the female eight delicacies tea bag of such as benefit, four
Thing drink tea bag, three plain soup tea bags etc. turn into the new highlight in major markets.However, this bag with health-caring function
General simply crushing or the decocting and concentrating that carried out to formula of making tea enters bag, does not consider how fully to extract effective in medicine
Composition, other has the Chinese herbal medicine of niff or taste, it is difficult to make tea bag, moreover, tea bag is typically all
Brew and just discard tea grounds after 1 time.Because this tealeaves is rubbed in processing and manufacturing by cutting, leaf cell, shape have been sufficiently destroyed
Into the tiny sheet of graininess or shape, effective content in tealeaves is easy to be leached when brewing to be come.Therefore, tea bag
It can not meet and can comfortably sample tea when convenient, be healthy and strong while having effects that to take care of health.
The content of the invention
The technical problem to be solved in the present invention is that the drawbacks described above for prior art is beneficial there is provided a kind of ball formula eight delicacies
The preparation method of female life-nourishing tea bag and its health preserving tea of preparation.The present invention uses the insoluble type coating material of water, especially necessarily
The cellulose acetate of ratio and the mixture of ethyl cellulose, the coating material are coated on the surface of medicinal substances extract, and with
Effective ingredient tight adhesion together, makes medical surfaces have to several layers of fish tail and waterproof layer, then the pin on fish tail and waterproof layer
Stomata is pierced, due to coating material water-insoluble, effective ingredient is not only breathed freely but also can be slowly released by acupuncture aperture
Medicine is put, existing tea bag is solved and typically brews after 1 time just tedious, the technical problem of tea grounds need to be discarded.This product exists
Meet easily meanwhile, it is capable to allow people cosily to sample tea, be healthy and strong while having effects that to take care of health.
The technical solution adopted for the present invention to solve the technical problems is：
First purpose of the present invention is to provide a kind of preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag, specific to make
It is standby to comprise the following steps：
(1) the raw material Chinese herbal medicine of eight delicacies with motherwort health preserving tea is prepared；
(2) raw material Chinese herbal medicine obtains thick paste after extraction；
(3) pharmaceutically acceptable auxiliary material is added to thick paste, pill is made, then add the insoluble type cellulose acetate of water
Film coating is carried out with the mixture of ethyl cellulose, then acupuncture aperture on pill after coating, through drying, packing to filter
Paper bag, produces ball formula eight delicacies with motherwort life-nourishing tea bag.
Preferably, the eight delicacies with motherwort health preserving tea is made up of the component of following parts by weight：20-30 parts of motherwort, Radix Codonopsis
5-8 parts, 5-8 parts of rhizoma atractylodis macrocephalae, 5-8 parts of Poria cocos, 2.5-5 parts of radix glycyrrhizae, 10-15 parts of Radix Angelicae Sinensis, 5-10 parts of the root of herbaceous peony, wine fry Ligusticum wallichii 5-10
Part, 10-15 parts of prepared rhizome of rehmannia；
The extraction process of the step (2) is as follows：
(2.1) rhizoma atractylodis macrocephalae, Radix Angelicae Sinensis, wine fry Ligusticum wallichii and use supercritical CO2Extraction extracts volatile oil；
(2.2) motherwort is extracted using water extract-alcohol precipitation, through the purifying motherwort total life of acid cation exchange resin post
Alkaloids；
(2.3) Radix Codonopsis, radix glycyrrhizae, the root of herbaceous peony extract total glycosides using decocting method；
(2.4) prepared rhizome of rehmannia extracts Dihuang polysaccharide using water extraction and alcohol precipitation method.
Preferably, the extracting process of volatile oil is as follows in the step (2.1)：Rhizoma atractylodis macrocephalae, Radix Angelicae Sinensis, wine is taken to fry Rhizoma Chuanxiong power
Broken, 10 mesh sieves excessively, use supercritical CO2Extraction, extraction temperature is 40-75 DEG C, and extracting pressure is 15-38Mpa, CO2Flow presses every thousand
Gram Ligusticum wallichii crude drug is calculated as 10-45kg/hr, is extracted 30-300 minutes by separating still, separating still I：Pressure is 6-30Mpa, temperature
For 18-50 DEG C, separating still II：Pressure is that 3-20Mpa, temperature are 18-50 DEG C；The extraction of separating still I or separating still II is collected respectively
Thing is taken, is merged, is placed in volatilization oil eliminator, stands more than 2 hours at room temperature, oil reservoir is centrifuged, rotating speed is 2500 revs/min
Clock, the volatile oil of gained is placed in stand-by in brown bottle.
Preferably, the volatile oil that the step (2.1) obtains adds the absolute ethyl alcohol dissolving of 1-3 times of volume, is volatilized
Oily ethanol；Beta-schardinger dextrin of the weight for 6-20 times of oil volume of volatilization is weighed, the water of 15-40 times of beta-schardinger dextrin weight is added, mixed
Close uniform, obtain the beta-schardinger dextrin aqueous solution, under 150 revs/min of rotating speed, slowly add and volatilize to the beta-schardinger dextrin aqueous solution
Oily ethanol, after addition is finished, continues to stir 1.5 hours, refrigerates 12 hours, filtering will filter to obtain thing low temperature drying at 45 DEG C,
Produce volatile oil clathrate compound.
Preferably, the extracting method of motherwort total alkaloid is as follows in the step (2.2)：Motherwort is crushed, added
6-8 times is measured distilled water, and ethanol is added under agitation makes alcohol content be 40-80%, and heating and refluxing extraction 4-8 hours, filtration takes filter
Liquid reclaims ethanol, and pH to 2-3 is adjusted with hydrochloric acid, filtration, acid cation exchange resin post on filtrate, after exchange resin be washed with water to
Water elution pH6-7, is discarded, and is continued the ethanol containing ammonia using pH value as 9-10 and is eluted to alkaloid extraction completely, collection is washed
De- liquid, is reclaimed after ethanol, is concentrated and dried, is obtained Total alkaloids extract.
Preferably, the extracting method of total glycosides is as follows described in the step (2.3)：Radix Codonopsis, radix glycyrrhizae, root of herbaceous peony chopping are taken, plus
The water of 10 times of weight, soaks 0.5-2h, decocts 1-2 hours, and filtering, the dregs of a decoction add the water of 8 times of weight of medicinal material, decocts 1 hour,
Decoction is filtered out, and is concentrated under reduced pressure into semifluid.
Preferably, the extracting method of Dihuang polysaccharide is as follows in the step (2.4)：The water that prepared rhizome of rehmannia plus 6 times are measured,
100 DEG C of extraction 1.5h, filtering, the dregs of a decoction add the water of 6 times of amounts to extract 1.5h at 100 DEG C again, and filtering, merging filtrate is concentrated into quite
Make alcohol content up to 75% in crude drug 0.3g/mL, plus ethanol stirring, alcohol precipitation is stayed overnight, suction filtration, takes precipitation to be dissolved in water, and adjusts pH extremely
8.5, room temperature is placed, centrifugation takes supernatant concentration to thick paste, is dried under reduced pressure and produces.
Preferably, step (3) are comprised the following steps that：
(3.1) supplementary product starch paste, cellulose acetate and ethyl cellulose are taken；
(3.2) it is thick that motherwort total alkaloid, total glycosides and the Dihuang polysaccharide merging for taking step (2.2)-(2.4) to extract are made
Cream, adds gelatinized corn starch and is tentatively mixed, then is made a diameter of 0.3-0.5cm piller, 40 DEG C of dryings 0.5 hour, after drying
The volatile oil that is obtained again with step (2.1) of pill mix, particle is fully absorbed volatile oil, pill be made；Then vinegar is added
Acid cellulose and ethyl cellulose carry out film coating 2-4 times in seed-coating machine；Acupuncture aperture on subsequent pill after coating,
Acupuncture number in each ball is 10-20, through drying, dispenses to filter paper bag, produces ball formula eight delicacies with motherwort life-nourishing tea bag.
Preferably, the consumption of gelatinized corn starch described in the step (3.2) is motherwort total alkaloid, total glycosides and Dihuang polysaccharide
Merge the 15% of the thick paste weight being made；The consumption of the cellulose acetate and ethyl cellulose is the pill after absorption volatile oil
The 30% of weight, cellulose acetate and ethyl cellulose usage ratio are 1：(1-3).
Second object of the present invention is also to provide a kind of ball formula eight delicacies with motherwort life-nourishing tea bag, by ball as described above
The preparation method of formula eight delicacies with motherwort life-nourishing tea bag is prepared.
Implement the preparation method and its health preserving tea of preparation of the ball formula eight delicacies with motherwort life-nourishing tea bag of the present invention, with following
Beneficial effect：
(1) coating material has three kinds, respectively stomach dissolution type coating material, and enteric solubility coating material and the insoluble type of water are coated material
Material, the insoluble type coating material of present invention use water, the mixture of especially a certain proportion of cellulose acetate and ethyl cellulose,
The coating material is coated on to the surface of medicinal substances extract, and together with effective ingredient tight adhesion, makes medical surfaces
Have to several layers of fish tail and waterproof layer, then the acupuncture air-vent on fish tail and waterproof layer, due to coating material water-insoluble, there is medicine
Effect composition can not only be breathed freely by acupuncture aperture but also can delay Slow release, solved existing tea bag and typically brewed after 1 time just
It is tedious, the technical problem of tea grounds need to be discarded.This product is being met easily meanwhile, it is capable to allow people cosily to sample tea, simultaneously
Have effects that to take care of health and be healthy and strong.
(2) present invention takes into full account difference of the active component of each taste Chinese herbal medicine in tea side in species, structure, physicochemical property
On the basis of different, said extracted technique is optimized, drug effect is significantly improved；In addition, also by selecting appropriate sustained-release matrix
Material (water-insoluble coating material), controls the appropriate consumption of auxiliary material, slow-releasing pill is made, be user in health preserving tea of taking after mixing it with water
During, the active ingredient in tea side slowly discharges, and to reach that tea perfume is fresher naturally, mouthfeel is full abundant, color is yellowish green bright
Bright effect.
(3) in addition, the ball formula eight delicacies with motherwort life-nourishing tea bag for preparing of the present invention, drinks by long-time, with filling blood,
Adjust effect of menstruation.It is main to take into full account the active component of each taste Chinese herbal medicine in tea side in species, structure, physics and chemistry by the present invention
On the basis of qualitative difference, Different Extraction Method and different solvents are respectively adopted classification extraction is carried out to bulk drug, to
Reduce consumption while, significantly improve drug effect, make the formula have it is excellent fill blood, adjust menstruation effect.
(4) speed ratio of ball formula eight delicacies with motherwort life-nourishing tea bag insoluble drug release within four hours relatively relaxes, and makes tea perfume
It is fresher naturally, mouthfeel is full abundant, color is yellowish green bright, and four hours do not change, and comes accordingly, with respect to existing tea bag
Say, overcome after tea bag only soaks once, the defect that tea flavour is had a greatly reduced quality.In addition, inventor has found, cellulose acetate and second
Release yet its important effect of the amount of mixture ratio of base cellulose to whole tea side, is not that random addition can be played
The function of the release of tea flavour is controlled very well, can only be (1 in preferable amount:3), its effect is only relatively good.The present invention's
The key looked good, smell good and taste good of health preserving tea of the present invention is also achieved in coating material selection and the distribution of consumption, has the formula
Excellent slow release effect.
Embodiment
Below, with reference to embodiment, the present invention is described further：
In the present invention, if not refering in particular to, all part, percentage are unit of weight, equipment and raw material for being used etc.
It is commercially available or commonly used in the art.Method in following embodiments, is the normal of this area unless otherwise instructed
Rule method.
A kind of ball formula eight delicacies with motherwort life-nourishing tea bag of the present invention is prepared by the component of following parts by weight through granulating process
Form：25 parts of motherwort, 6 parts of Radix Codonopsis, 8 parts of rhizoma atractylodis macrocephalae, 7 parts of Poria cocos, 4 parts of radix glycyrrhizae, 13 parts of Radix Angelicae Sinensis, 8 parts of the root of herbaceous peony, wine fry Ligusticum wallichii 8
Part, 13 parts of prepared rhizome of rehmannia.
The pharmacological action of each Chinese herbal medicine is as follows：
Motherwort：For the fresh of labiate motherwort Leonurus japonicus Houtt. or dry overground part
Point.It is bitter, pungent, it is slightly cold.Channel tropism Return liver, pericardium channel.Major function promoting blood circulation for regulating menstruation, inducing diuresis to remove edema.For irregular menstruation, dysmenorrhoea, warp
Close, lochiorrhagia, oedema oliguria；Acute nephritis edema.
Radix Codonopsis：For the root of Campanulaceae Radix Codonopsis.It is sweet, it is mild-natured.Have tonifying middle-Jiao and Qi, quench the thirst, strengthening spleen and tonifying lung, blood-nourishing life
Tianjin.For spleen-lung Qi deficiency, eat less and tired, false asthma cough, insufficiency of vital energy and blood, sallow complexion, palpitation, injury thirst, interior heat disappears
Yearningly.
Rhizoma atractylodis macrocephalae：For feverfew bighead atractylodes rhizome Atractylodes macrocephala Koidz. dry rhizome.Nature and flavor
Bitter Wen Xinlie, has eliminating dampness, changes the effect of turbid, analgesic.
Poria cocos：For On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf dry sclerotia.It is sweet, light, put down.Channel tropism
The thoughts of returning home, lung, spleen, kidney channel.Major function clearing damp and promoting diuresis, invigorating the spleen calming heart.For oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool
Diarrhea, confused and worried, insomnia of palpitating with fear.
Radix glycyrrhizae：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza
Inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L. dry root.It is sweet, put down.The channel tropism thoughts of returning home, lung, spleen, stomach
Through.Major function is invigorated the spleen and benefited qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, burnout is weary
Power, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Radix Angelicae Sinensis：For umbelliferae angelica Angelica sinensis (Oliv.) Diels dry root.Sweet, acrid, warm.
Channel tropism Return liver, the heart, the spleen channel.Major function replenishing and activating blood, menstruction regulating and pain relieving relaxes bowel.For blood deficiency chlorosis, dizziness palpitaition, the moon
Through uncomfortable, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.
For closed dysmenorrhea, arthralgia pain due to rheumatism, injury from falling down.
The root of herbaceous peony：For the dry root of ranunculaceae plant Chinese herbaceous peony.Bitter, acid, is slightly cold.Return liver, the spleen channel.The moon is held back in blood-nourishing, and soft liver relieves pain,
Pinggan Yang.Smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, stomachache, four limbs contraction pain, blood deficiency chlorosis, the moon
Through uncomfortable, spontaneous perspiration, night sweat.
Wine fries Ligusticum wallichii：Creeping stem pungent, warm channel tropism Return liver, courage, the pericardium channel of samphire Ligusticum wallichii.With promoting blood circulation row
The work(of gas, wind-expelling pain-stopping.Damaged for irregular menstruation, Amenorrhea, dysmenorrhoea caused by the blood stasis stagnation of the circulation of vital energy, and postpartum stasis of blood, bruise
Wound, sore swell and ache curative etc. are demonstrate,proved.
Prepared rhizome of rehmannia：For scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch. fresh or dried root.
The thoughts of returning home, liver and kidney channel.Major function fresh rehmannia root：Clearing heat and promoting fluid, cool blood, hemostasis.For consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, hair spot hair
Rash, spits blood, bleeding from five sense organs or subcutaneous tissue, abscess of throat.
The health preserving tea property of medicine is analyzed：Tea side adds motherwort to form with four things and four gentleman, cultivated land, Radix Angelicae Sinensis, the root of herbaceous peony, the thing of Ligusticum wallichii four
Promoting blood circulation for regulating menstruation, Radix Codonopsis, Poria cocos, the bighead atractylodes rhizome, the gentleman of radix glycyrrhizae four replenish qi to invigorate the spleen；It is pure then solely cloudy not long with four things, it is pure then lonely with four gentleman
Sun is not given birth to, and two sides share, then qi and blood has the benefit of mediation, then close motherwort blood-activating and qi-promoting, there is the work(of tonifying yin.All medicines play tonifying Qi altogether
Blood, adjusts the work(of menstruation.
In the embodiment of the present invention, each embodiment, the ball formula eight delicacies with motherwort life-nourishing tea bag of comparative example, it is prepared
Method comprises the following steps：
(1) raw material is prepared according to the parts by weight；
(2) take rhizoma atractylodis macrocephalae, Radix Angelicae Sinensis, wine to fry Ligusticum wallichii to crush, cross 10 mesh sieves, use supercritical CO2Extraction, extraction temperature is 40-
75 DEG C, extracting pressure is 15-38Mpa, CO2Flow is calculated as 10-45kg/hr by every kilogram of Ligusticum wallichii crude drug, is extracted by separating still
30-300 minutes, separating still I：Pressure is that 6-30Mpa, temperature are 18-50 DEG C, separating still II：Pressure is that 3-20Mpa, temperature are
18-50℃；The extract of separating still I or separating still II is collected respectively, is merged, and is placed in volatilization oil eliminator, 2 are stood at room temperature
More than hour, oil reservoir is centrifuged, rotating speed is 2500 revs/min, the volatile oil of gained is placed in stand-by in brown bottle.Take volatilization
Oil adds the absolute ethyl alcohol dissolving of 1-3 times of volume, obtains volatile oil ethanol；Weigh weight for volatilization 6-20 times of oil volume β-
Cyclodextrin, adds the water of 15-40 times of beta-schardinger dextrin weight, well mixed, obtains the beta-schardinger dextrin aqueous solution, in 150 revs/min of rotating speed
Under clock, volatile oil ethanol slowly is added to the beta-schardinger dextrin aqueous solution, after addition is finished, continues to stir 1.5 hours, refrigeration
12 hours, filtering will filter to obtain thing low temperature drying at 45 DEG C, produce volatile oil clathrate compound.
(3) motherwort is crushed, adds 6-8 times and measure distilled water, ethanol is added under agitation makes alcohol content be 40-80%,
Heating and refluxing extraction 4-8 hours, filtration, takes filtrate recycling ethanol, and acid cation on pH to 2-3, filtration, filtrate is adjusted with hydrochloric acid
Resin is washed with water to water elution pH6-7 after exchange resin column, exchange, is discarded, and the ammoniacal liquor ethanol continued using pH value as 9-10 is molten
Liquid is eluted to alkaloid and extracts complete, collects eluent, reclaims after ethanol, is concentrated and dried, obtains Total alkaloids extract.
(4) water of Radix Codonopsis, radix glycyrrhizae, root of herbaceous peony chopping, plus 10 times of weight is taken, 0.5-2h is soaked, decocts 1-2 hours, filtering, medicine
Slag adds the water of 8 times of weight of medicinal material, decocts 1 hour, decoction is filtered out, and is concentrated under reduced pressure into semifluid.
(5) prepared rhizome of rehmannia is added to the water of 6 times of amounts, 1.5h, filtering are extracted at 100 DEG C, the dregs of a decoction add the water of 6 times of amounts at 100 DEG C again
1.5h is extracted, is filtered, merging filtrate, be concentrated into makes alcohol content up to 75%, alcohol equivalent to crude drug 0.3g/mL, plus ethanol stirring
Heavy suction filtration takes precipitation to be dissolved in water overnight, adjusts pH to 8.5, places room temperature, and centrifugation takes supernatant concentration to thick paste, decompression is dry
It is dry to produce.
(6) supplementary product starch paste, cellulose acetate and ethyl cellulose are taken；The motherwort for taking step (3), (4)-(5) to extract
Total alkaloid, total glycosides and Dihuang polysaccharide merge the thick paste being made, and add gelatinized corn starch and are tentatively mixed, then a diameter of 0.3- is made
0.5cm piller, 40 DEG C of dryings 0.5 hour, the volatile oil that dried pill is obtained with step (2) again is mixed, and makes particle complete
Hypersorption volatile oil, is made pill；Then add cellulose acetate and ethyl cellulose carries out film coating 2-4 in seed-coating machine
It is secondary；Acupuncture number in acupuncture aperture on subsequent pill after coating, each ball is 10-20, through drying, packing to filter paper
Bag, produces ball formula eight delicacies with motherwort life-nourishing tea bag.
Embodiment 1-3, comparative example 1-3
Table 1：Embodiment 1-3, comparative example 1-3 ratio of adjuvant tables
Experimental example
1st, the sense organ evaluation and test of health preserving tea：
Sense organ evaluation and test is carried out to ball formula eight delicacies with motherwort life-nourishing tea bag prepared by embodiment 1-3, respectively Example 1,2,3
20 grams of gained ball formula eight delicacies with motherwort life-nourishing tea bag, successively labeled as B, C, D；160 grams of normal-temperature waters are separately added into, are stirred,
Health preserving tea is made；The eight delicacies with motherwort tea bag of conventional commercial is taken simultaneously, numbering is A, take the blind mode commented, examined with reference in table 2
Requirement is commented, sensory review's test is carried out to each money tea-drinking, test table data are evaluated in effective 32 parts of collection, to soup look, fragrance, taste
Taste, the average mark of overall four key factor total scores carry out statistical analysis.
The ball formula eight delicacies with motherwort life-nourishing tea bag of table 2 evaluates table
From table 2 it can be seen that ball formula eight delicacies with motherwort life-nourishing tea bag contrasts commercially available tea bag obtained by embodiment 1,2,3,
Tea perfume is fresher naturally, mouthfeel is full abundant, and color is yellowish green bright, ball formula eight delicacies with motherwort health bag obtained by embodiment 1,2,3
Making tea the fraction on fragrance and flavour and three indexs of color will be apparently higher than commercially available tea bag, and its final score is 83 points
More than, and commercially available tea bag final score is 60.
2nd, the tonifying Qi and blood of health preserving tea, the test and appraisal of menstruation regulating effect
By ball formula eight delicacies with motherwort life-nourishing tea bag made from the embodiment 1-3 of preparation and commercially available eight delicacies with motherwort tea bag
Be respectively issued to 100 women (100 women have nervous, and fatigue and weak, Hypomenorrhea, color is light, and on the face color spot deposition,
It is dull sallow) use, 100 women take ball formula eight delicacies with motherwort life-nourishing tea bag in the same manner, drink daily, continuously
Drink three months.Every group of embodiment has 25 womens, and drinking person holds according to the sensation of oneself to menses situation and face
Face improves situation and scored, and scoring uses ten point system, and 1 point is worst, and 5 points moderate, and 10 points are best, and score more high effect is more
Good, menses situation, which improves, includes hyper-menorrhea, and the menstrual cycle is normal, full of energy；Facial appearance, which improves situation, includes color spot
Desalination, the colour of skin highlights ruddy；Using effect evaluation result such as table 3.
The embodiment 1-3 test results of table 3
Tester drinks 1-3 of embodiment of the present invention ball formula eight delicacies with motherwort health bag bubble it can be seen from data in upper table
After tea, relative to comparative example (commercially available eight delicacies with motherwort tea bag), its menses situation and color spot desalination degree have preferable improvement,
Hyper-menorrhea is embodied in, the menstrual cycle is normal, the state of mind improves and increased the glossiness of skin, ruddy degree, color
Spot is desalinated.Especially, the auxiliary material proportion of embodiment 2, it improves menses situation and color spot desalination degree best results, average
More than 8.6.It can be seen that, it fills blood for tea side of the invention, adjusts menstruation effect preferable；Tea is mainly taken into full account by the present invention
In side on the basis of difference of the active component of each taste Chinese herbal medicine in species, structure, physicochemical property, said extracted technique is entered
Row optimization, to reduce consumption while, significantly improve drug effect, make the formula have it is excellent fill blood, adjust menstruation effect.
3rd, the measure that health preserving tea release influences on liquor color, fragrance, flavour, overall quality
Method of testing is as follows, by ball formula eight delicacies with motherwort health bag made from the embodiment 2 and comparative example 1-3 of preparation
The 200g that makes tea adds 1600ml warm water (37 DEG C), respectively with 0.5 hour, 1 hour, 2 hours, 4 hours sampling 100ml, gives respectively
Six people are drunk, and everyone evaluates health preserving tea when 0.5 hour, 1 hour, 2 hours, 4 hours are drunk in each stage respectively
In the soup look of tea, fragrance, flavour, overall four key factors are evaluated.Effect assessment result such as table 4.
The test result of the embodiment 2 of table 4 and comparative example 1-3
The ball formula eight delicacies with motherwort life-nourishing tea bag of the present invention can be about completely dissolved in or so four hours, and from table
Middle data are visible, the ball formula eight delicacies with motherwort life-nourishing tea bag of embodiment 2 its soup look, fragrance, flavour and whole within four hours
From the point of view of body-sensing, very high scoring is respectively provided with, illustrates ball formula eight delicacies with motherwort life-nourishing tea bag insoluble drug release within four hours
Speed ratio relatively relax, make tea perfume fresher naturally, mouthfeel is full abundant, color is yellowish green bright, and four hours do not change, because
This, for existing tea bag, overcomes after tea bag only soaks once, the defect that tea flavour is had a greatly reduced quality.
The cellulose acetate of comparative example 1 and embodiment 2：The usage ratio of ethyl cellulose is identical, preparation method phase
Together, difference is that the content of gelatinized corn starch is different, is 30%；Gelatinized corn starch can preferably be mixed with medicine, be made as filler
Piller, but inventor has found, the shaping of the consumption of gelatinized corn starch to whole pill plays an important role, and is not random addition energy
Fine shaping is enough played, ultimately results in that coating is not smooth, effective ingredient, which can not be stablized, to be discharged, from data, contrast
The ball formula eight delicacies with motherwort life-nourishing tea bag of embodiment 1 within four hours from the point of view of its soup look, fragrance, flavour and overall feeling,
Can not stably it discharge, can only be in preferable amount (15%), its effect is only relatively good.
Comparative example 2-3 is identical with the gelatinized corn starch consumption of embodiment 2, and preparation method is identical, and difference is acetate fiber
Element：The ratio consumption of ethyl cellulose is not in the present invention 1：Within (1-3), as a result find, its insoluble drug release effect is unsatisfactory,
Show as making tea flavour rate of release substantially increase, soup look and fragrance are all discharged quickly, make tea flavour thicken, it is difficult to enter
Mouthful.Further illustrate, the color, smell and taste of health preserving tea of the present invention are achieved in the selection of coating material and the distribution of consumption of the invention
Various key, makes the formula have excellent slow release effect.
It will be apparent to those skilled in the art that technical scheme that can be as described above and design, make other various
It is corresponding to change and deformation, and all these change and deformation should all belong to the protection domain of the claims in the present invention
Within.
Claims (10)
1. the preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag, it is characterised in that specific prepare comprises the following steps：
（1）Prepare the raw material Chinese herbal medicine of eight delicacies with motherwort health preserving tea；
（2）Raw material Chinese herbal medicine obtains thick paste after extraction；
（3）Pharmaceutically acceptable auxiliary material is added to thick paste, pill is made, the insoluble type cellulose acetate of water and second is then added
The mixture of base cellulose carries out film coating, then acupuncture aperture on pill after coating, through drying, packing to filter paper
Bag, produces ball formula eight delicacies with motherwort life-nourishing tea bag.
2. the preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag according to claim 1, it is characterised in that the eight delicacies
Beneficial mother's health preserving tea is made up of the component of following parts by weight：20-30 parts of motherwort, 5-8 parts of Radix Codonopsis, 5-8 parts of rhizoma atractylodis macrocephalae, Poria cocos 5-
8 parts, 2.5-5 parts of radix glycyrrhizae, 10-15 parts of Radix Angelicae Sinensis, 5-10 parts of the root of herbaceous peony, wine fry 5-10 parts of Ligusticum wallichii, 10-15 parts of prepared rhizome of rehmannia；
The step（2）Extraction process it is as follows：
（2.1）The rhizoma atractylodis macrocephalae, Radix Angelicae Sinensis, wine fry Ligusticum wallichii and use supercritical CO2Extraction extracts volatile oil；
（2.2）The motherwort is extracted using water extract-alcohol precipitation, purifies motherwort total alkaloid through acid cation exchange resin post；
（2.3）The Radix Codonopsis, radix glycyrrhizae, the root of herbaceous peony extract total glycosides using decocting method；
（2.4）The prepared rhizome of rehmannia extracts Dihuang polysaccharide using water extraction and alcohol precipitation method.
3. the preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag according to claim 2, it is characterised in that the step
（2.1）The extracting process of middle volatile oil is as follows：Take rhizoma atractylodis macrocephalae, Radix Angelicae Sinensis, wine to fry Ligusticum wallichii to crush, cross 10 mesh sieves, use supercritical CO2Extraction
Take, extraction temperature is 40-75 DEG C, and extracting pressure is 15-38Mpa, CO2Flow is calculated as 10-45kg/ by every kilogram of Ligusticum wallichii crude drug
Hr, is extracted 30-300 minutes, separating still I by separating still：Pressure is that 6-30Mpa, temperature are 18-50 DEG C, separating still II：Pressure
It it is 18-50 DEG C for 3-20Mpa, temperature；The extract of separating still I or separating still II is collected respectively, is merged, and is placed in volatile oil separation
In device, more than 2 hours are stood at room temperature, oil reservoir is centrifuged, rotating speed is 2500 revs/min, and the volatile oil of gained is placed in into palm fibre
It is stand-by in color bottle.
4. the preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag according to claim 3, it is characterised in that the step
（2.1）Obtained volatile oil adds the absolute ethyl alcohol dissolving of 1-3 times of volume, obtains volatile oil ethanol；It is volatilization to weigh weight
The beta-schardinger dextrin of 6-20 times of oil volume, adds the water of 15-40 times of beta-schardinger dextrin weight, is well mixed, obtains beta-schardinger dextrin water-soluble
Liquid, under 150 revs/min of rotating speed, slowly adds volatile oil ethanol to the beta-schardinger dextrin aqueous solution, after addition is finished, after
Continuous stirring 1.5 hours, is refrigerated 12 hours, and filtering will filter to obtain thing low temperature drying at 45 DEG C, produce volatile oil clathrate compound.
5. the preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag according to claim 2, it is characterised in that the step
（2.2）The extracting method of middle motherwort total alkaloid is as follows：Motherwort is crushed, 6-8 times is added and measures distilled water, is added under agitation
Entering ethanol makes alcohol content be 40-80%, and heating and refluxing extraction 4-8 hours, filtration takes filtrate recycling ethanol, pH to 2- is adjusted with hydrochloric acid
3, filtration, the upper acid cation exchange resin post of filtrate, resin is washed with water to water elution pH6-7 after exchange, is discarded, continuation with
PH value is eluted to alkaloid for 9-10 ethanol containing ammonia and extracts complete, collects eluent, reclaims after ethanol, is concentrated and dried,
Obtain Total alkaloids extract.
6. the preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag according to claim 2, it is characterised in that the step
（2.3）Described in total glycosides extracting method it is as follows：The water of Radix Codonopsis, radix glycyrrhizae, root of herbaceous peony chopping, plus 10 times of weight is taken, 0.5-2h is soaked,
Decoct 1-2 hours, filtering, the dregs of a decoction add the water of 8 times of weight of medicinal material, decoct 1 hour, decoction is filtered out, and is concentrated under reduced pressure into semi-fluid
Body.
7. the preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag according to claim 2, it is characterised in that the step
（2.4）The extracting method of middle Dihuang polysaccharide is as follows：By prepared rhizome of rehmannia plus 6 times of water measured, 1.5h is extracted at 100 DEG C, is filtered, the dregs of a decoction are again
Plus the water of 6 times of amounts extracts 1.5h at 100 DEG C, filtering, merging filtrate is concentrated into and stirred equivalent to crude drug 0.3g/mL, plus ethanol
Make alcohol content up to 75%, alcohol precipitation is stayed overnight, suction filtration, takes precipitation to be dissolved in water, adjust pH to 8.5, place room temperature, centrifugation takes supernatant dense
Thick paste is reduced to, is dried under reduced pressure and produces.
8. the preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag according to claim 2, it is characterised in that the step
（3）Comprise the following steps that：
（3.1）Take supplementary product starch paste, cellulose acetate and ethyl cellulose；
（3.2）Take step（2.2）-（2.4）The motherwort total alkaloid of extraction, total glycosides and Dihuang polysaccharide merge the thick paste being made,
Add gelatinized corn starch tentatively to be mixed, then be made a diameter of 0.3-0.5cm piller, 40 DEG C of dryings 0.5 hour, dried ball
Agent again with step（2.1）Obtained volatile oil mixing, makes particle fully absorb volatile oil, pill is made；Then acetic acid is added fine
Dimension element and ethyl cellulose carry out film coating 2-4 times in seed-coating machine；Acupuncture aperture on subsequent pill after coating, each
Acupuncture number in ball is 10-20, through drying, dispenses to filter paper bag, produces ball formula eight delicacies with motherwort life-nourishing tea bag.
9. the preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag according to claim 7, it is characterised in that the step
（3.2）Described in gelatinized corn starch consumption be motherwort total alkaloid, total glycosides and Dihuang polysaccharide merge the thick paste weight that is made
15%；The consumption of the cellulose acetate and ethyl cellulose is 30% of the pill weight after absorption volatile oil, cellulose acetate
It is 1 with ethyl cellulose usage ratio：（1-3）.
10. a kind of ball formula eight delicacies with motherwort life-nourishing tea bag, it is characterised in that as the ball formula as described in claim any one of 1-9
The preparation method of eight delicacies with motherwort life-nourishing tea bag is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710246491.1A CN107006651A (en) | 2017-04-15 | 2017-04-15 | The preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag and its health preserving tea of preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710246491.1A CN107006651A (en) | 2017-04-15 | 2017-04-15 | The preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag and its health preserving tea of preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107006651A true CN107006651A (en) | 2017-08-04 |
Family
ID=59448048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710246491.1A Pending CN107006651A (en) | 2017-04-15 | 2017-04-15 | The preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag and its health preserving tea of preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107006651A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2558221Y (en) * | 2002-07-19 | 2003-07-02 | 王恩平 | Formed compound tea |
| CN1456548A (en) * | 2003-03-21 | 2003-11-19 | 毛友昌 | Process for extracting leonuridine from fresh motherwort and leonuridine preparation |
| CN1565601A (en) * | 2003-07-04 | 2005-01-19 | 成都永泽药物研究开发有限责任公司 | Application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy |
| CN101402691A (en) * | 2008-11-17 | 2009-04-08 | 河南中医学院 | Preparation method for prepared rehmannia root polysaccharide |
| CN104173503A (en) * | 2014-07-25 | 2014-12-03 | 北京汉典制药有限公司 | Preparation method of traditional Chinese medicine granules, traditional Chinese medicine granules prepared by same and use of traditional Chinese medicine granules |
| CN106177143A (en) * | 2016-08-22 | 2016-12-07 | 上海典实医疗科技有限公司 | Bazhen yimu pills, bazhen yimu wan and preparation method thereof |
-
2017
- 2017-04-15 CN CN201710246491.1A patent/CN107006651A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2558221Y (en) * | 2002-07-19 | 2003-07-02 | 王恩平 | Formed compound tea |
| CN1456548A (en) * | 2003-03-21 | 2003-11-19 | 毛友昌 | Process for extracting leonuridine from fresh motherwort and leonuridine preparation |
| CN1565601A (en) * | 2003-07-04 | 2005-01-19 | 成都永泽药物研究开发有限责任公司 | Application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy |
| CN101402691A (en) * | 2008-11-17 | 2009-04-08 | 河南中医学院 | Preparation method for prepared rehmannia root polysaccharide |
| CN104173503A (en) * | 2014-07-25 | 2014-12-03 | 北京汉典制药有限公司 | Preparation method of traditional Chinese medicine granules, traditional Chinese medicine granules prepared by same and use of traditional Chinese medicine granules |
| CN106177143A (en) * | 2016-08-22 | 2016-12-07 | 上海典实医疗科技有限公司 | Bazhen yimu pills, bazhen yimu wan and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 张奇: "《军用药物制剂工程学》", 30 April 2012, 北京理工大学出版社 * |
| 程磬基，等: "《家庭实用药茶》", 30 June 2004, 上海科学技术出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2009133998A1 (en) | Medicinal plants extract using processing of herbal medicine and composition of skin external application comprising the same | |
| CN103690853B (en) | A kind ofly treat Chinese medicine preparation of wet rotten type tinea pedis and preparation method thereof | |
| CN103860969A (en) | Traditional Chinese medicine for increasing weight | |
| CN105496917A (en) | Herba centellae anti-wrinkling face cream and preparation method thereof | |
| CN105918946B (en) | Jujube-wolfberry liver-nourishing composition, granules and preparation method thereof | |
| CN103536838B (en) | A kind of Chinese medicine preparation for the treatment of threatened abortion and preparation method thereof | |
| CN103550721B (en) | There is the Chinese medicine composition of the sleeping effect of blood pressure lowering and the medicated pillow containing said composition | |
| CN105232911A (en) | Traditional Chinese medicine composition | |
| CN104998061A (en) | Traditional Chinese medicine formula for treating cold uterus and infertility and preparation method thereof | |
| CN105343593A (en) | Spica prunellae health oral liquid capable of decreasing blood pressure and blood lipid as well as preparation method of spica prunellae health oral liquid | |
| CN104705456A (en) | Plant composite herbal tea and preparation method thereof | |
| CN112316066B (en) | Jasmine flower-containing traditional Chinese medicine brown sugar capable of soothing nerves and helping sleep and preparation method thereof | |
| CN101574509A (en) | Agerasia preparation | |
| CN101129576A (en) | Bolus of eight delicacies with motherwort | |
| CN103656197B (en) | The Chinese medicine composition of kidney tonifying and enriching blood and preparation method | |
| CN106367297A (en) | Vinegar koji block for sun vinegar | |
| CN106344480A (en) | Whitening and freckle-removing traditional Chinese medicine facial mask without toxic or side effect, and preparation method of traditional Chinese medicine facial mask | |
| CN107006651A (en) | The preparation method of ball formula eight delicacies with motherwort life-nourishing tea bag and its health preserving tea of preparation | |
| CN105616984A (en) | Crinkle-removing beauty cream containing herba leonurus and preparation method thereof | |
| CN105663700A (en) | Wrinkle resistance and beauty treatment cream making method and beauty treatment cream thereof | |
| CN102091254B (en) | Traditional Chinese medicine composition for relieving swelling after cosmetic surgery and preparation method thereof | |
| CN105343502A (en) | Health-care oral liquid capable of improving immunity | |
| CN104840773A (en) | Traditional Chinese medicine composition for treating vertebral artery type cervical spondylopathy and method for preparing same | |
| CN104958666A (en) | Preparation method of gynecological disease treatment oral preparation | |
| CN106922906A (en) | The preparation method of the thing of ball formula four drink life-nourishing tea bag and its health preserving tea of preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170804 |
|
| RJ01 | Rejection of invention patent application after publication |