CN104688631A - Moisturizer for sensitive skin and preparation method thereof - Google Patents
Moisturizer for sensitive skin and preparation method thereof Download PDFInfo
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- CN104688631A CN104688631A CN201510146728.XA CN201510146728A CN104688631A CN 104688631 A CN104688631 A CN 104688631A CN 201510146728 A CN201510146728 A CN 201510146728A CN 104688631 A CN104688631 A CN 104688631A
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Abstract
The invention discloses a moisturizer for sensitive skin and a preparation method thereof. The components and the mass fractions of each component are as follows, 8-20 parts of deacetylation chitin, 5-15 parts of chamomile, 6-10 parts of citric acid, 2-6 parts of carboxymethyl chitosan, 1-6 parts of astragalus membranaceus, 3-6 parts of wool fat, 1-4 parts of sesame oil, 2-7 parts of corn starch sulfonation succinate, 2-5.8 parts of caprylyl glycine, 0.08-0.46 part of methyl hydroxypropyl cellulose, 0.3-2.3 parts of carbamide, 1.5-3.5 parts of benzoyl peroxide, 1.5-3.1 parts of isopropyl myristate, 0-1 part of antioxidant, 0-3 parts of preservative, 1-4 parts of palmitoyl hydroxylation wheat protein, 3-8 parts of atractylodes macrocephala koidz, 3-5 parts of oleum menthae, 0.05-1.2 parts of phthalic anhydride and 60-70 parts of water. The moisturizer for the sensitive skin can form a protective film on the skin surface layer effectively to enhance the anti-allergy capacity of the skin.
Description
Technical field
The invention belongs to skincare product field, be specifically related to a kind of sensitive skin emollient cream and preparation method thereof.
Background technology
Sensitive skin is the skin condition that a kind of height does not tolerate, be vulnerable to the excitation of various factors and produce twinge, burn, the multiple-factor syndrome of the subjective symptom such as tight, pruritus, skin appearance is normal or with slight desquamation, erythema and drying.Sensitive skin and " skin allergy " are two different concepts, and skin allergy is a kind of allergy, after entering body by allergen, body is impelled to produce corresponding antibody, cause antigen antibody reaction, show as the clinical objective signs such as erythema, pimple, welt, often accompany pruritus.And sensitive skin normally reduces the toleration stimulated, occur that a series of abnormal sensory reacts, mostly lack objective sign, although its genesis mechanism is not very clear, generally believe without immunity or irritated mechanism.
In recent years, along with the general lifting manipulation of people's living standard, the quickening of Regional City process, the decline of air quality, the easy allergic human population of China rises to about 5%-6% from 2% ~ 3% of the past., mostly there is close relationship this and environmental pollution, the change of dietary structure, the change of modern's body constitution and adding of competitive neural network pressure, and its key link is that the complexity interaction of gene and environment caused.In 1999, anaphylactic disease was classified as the disease of 21 century emphasis prevention and research by World Health Organization (WHO) (WHO).The unprecedentedly popular health resources of a lot of country of giving of anaphylactic disease brings huge financial burden and pressure, the whole world only allergy preparations this expenditure oneself more than 8,000,000,000 dollars.With regard to the treatment of anaphylactic disease, avoiding contact allergy former is one of the measure occurred that prevents disease, and adopts Drug therapy to be the Main Means effectively controlling anaphylaxis degree.
The requirement of sensitive skin to cosmetics is higher, inferior, rotten cosmetics, the cosmetics that zest is stronger and some drugs cosmetics, most typical cosmetic allergic contact dermatitis is that essence is irritated, and the cosmetics containing alcoholic content such as astringent lotion also can produce certain stimulation to skin.Other all can cause different stimulations to different skin as biochemical antiseptic, fruit acid etc.Therefore the development of sensitive skin skin care item has become the focus of research.
Summary of the invention
The invention provides a kind of sensitive skin emollient cream, gentleness does not stimulate, and effectively form protecting film at skin surface, life-time service obviously can strengthen the antiallergic ability of skin.
To achieve these goals, the technological means that the present invention adopts is:
A kind of sensitive skin emollient cream, component and each constituent mass number as follows: chitosan 8 ~ 20 parts, Flos Matricariae chamomillae 5 ~ 15 parts, citric acid 6 ~ 10 parts, carboxymethyl chitosan 2 ~ 6 parts, the Radix Astragali 1 ~ 6 part, lanoline 3 ~ 6 parts, Oleum sesami 1 ~ 4 part, corn starch sulfonation succinate 2 ~ 7 parts, capriloyl glycine 2 ~ 5.8 parts, methylhydroxypropylcellulose 0.08 ~ 0.46 part, 0.3 ~ 2.3 part, carbamide, benzoyl peroxide 1.5 ~ 3.5 parts, isopropyl myristate 1.5 ~ 3.1 parts, 0 ~ 1 part, antioxidant, antiseptic 0 ~ 3 part, palmityl hydroxylation wheat protein 1 ~ 4 part, the Rhizoma Atractylodis Macrocephalae 3 ~ 8 parts, Oleum menthae 3 ~ 5 parts, phthalic anhydride 0.05 ~ 1.2 part, 60 ~ 70 parts, water.
Described antiseptic is zinc stearate or zinc oxide.
Described antioxidant is dibenzylatiooluene.
Also comprise 1 ~ 8 part, Folium Bambusae, vitamin E 2 ~ 4 parts.
A kind of sensitive skin emollient cream, component and each constituent mass number are preferably as follows: chitosan 12 ~ 18 parts, Flos Matricariae chamomillae 7 ~ 11 parts, citric acid 6 ~ 8 parts, carboxymethyl chitosan 4 ~ 5 parts, the Radix Astragali 3 ~ 5 parts, lanoline 4 ~ 6 parts, Oleum sesami 2 ~ 3 parts, corn starch sulfonation succinate 3 ~ 5 parts, capriloyl glycine 3 ~ 4.8 parts, methylhydroxypropylcellulose 0.18 ~ 0.25 part, 0.9 ~ 1.6 part, carbamide, benzoyl peroxide 2.2 ~ 3.1 parts, isopropyl myristate 1.8 ~ 2.5 parts, 0 ~ 1 part, antioxidant, antiseptic 0 ~ 1 part, palmityl hydroxylation wheat protein 2 ~ 3 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 6 parts, Oleum menthae 4 ~ 5 parts, phthalic anhydride 0.35 ~ 0.7 part, 3 ~ 6 parts, Folium Bambusae, vitamin E 3 parts, 65 parts, water.
A kind of sensitive skin emollient cream, component and each constituent mass number are preferably: chitosan 15 parts, Flos Matricariae chamomillae 9 parts, citric acid 7 parts, carboxymethyl chitosan 4.5 parts, the Radix Astragali 4 parts, lanoline 5 parts, Oleum sesami 2.5 parts, corn starch sulfonation succinate 3.5 parts, capriloyl glycine 3.8 parts, methylhydroxypropylcellulose 0.2 part, 1.1 parts, carbamide, benzoyl peroxide 2.8 parts, isopropyl myristate 2.2 parts, 0.1 part, antioxidant, antiseptic 0.1 part, palmityl hydroxylation wheat protein 2.5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Oleum menthae 4.5 parts, phthalic anhydride 0.5 part, 4.5 parts, Folium Bambusae, vitamin E 3 parts, 65 parts, water.
The preparation method of sensitive skin emollient cream, comprises the steps:
1) by Flos Matricariae chamomillae, the Rhizoma Atractylodis Macrocephalae, Radix Astragali mixed grinding powdering, add citric acid, Oleum sesami and Oleum menthae, stir, mix homogeneously obtains component A;
2) chitosan, carboxymethyl chitosan, corn starch sulfonation succinate, methylhydroxypropylcellulose, carbamide, lanoline, capriloyl glycine, benzoyl peroxide, isopropyl myristate, palmityl hydroxylation wheat protein, phthalic anhydride are mixed with water, be warming up to 100 ~ 140 DEG C, stir 20 ~ 50min, be cooled to 20 DEG C, obtain B component;
3) B component is joined in component A, be warming up to 60 ~ 80 DEG C, add antioxidant, antiseptic stirs, make cream frost shape and namely obtain sensitive skin emollient cream.
Step 2) in be warming up to 120 DEG C, stir 30min.
70 DEG C are warming up in step 3).
Beneficial effect:
Sensitive skin emollient cream provided by the invention, gentleness does not stimulate, and effectively form protecting film at skin surface, life-time service obviously can strengthen the antiallergic ability of skin.
Detailed description of the invention
Embodiment 1
A kind of sensitive skin emollient cream; component and each constituent mass number as follows: chitosan 20 parts; Flos Matricariae chamomillae 15 parts, citric acid 10 parts, carboxymethyl chitosan 6 parts; the Radix Astragali 6 parts; lanoline 6 parts, Oleum sesami 4 parts, corn starch sulfonation succinate 7 parts; capriloyl glycine 5.8 parts; methylhydroxypropylcellulose 0.46 part, 2.3 parts, carbamide, benzoyl peroxide 3.5 parts; isopropyl myristate 3.1 parts; palmityl hydroxylation wheat protein 1 part, the Rhizoma Atractylodis Macrocephalae 8 parts, Oleum menthae 5 parts; phthalic anhydride 1.2 parts, 60 parts, water.。
Preparation method, comprises the steps:
1) by Flos Matricariae chamomillae, the Rhizoma Atractylodis Macrocephalae, Radix Astragali mixed grinding powdering, add citric acid, Oleum sesami and Oleum menthae, stir, mix homogeneously obtains component A;
2) chitosan, carboxymethyl chitosan, corn starch sulfonation succinate, methylhydroxypropylcellulose, carbamide, lanoline, capriloyl glycine, benzoyl peroxide, isopropyl myristate, palmityl hydroxylation wheat protein, phthalic anhydride are mixed with water, be warming up to 120 DEG C, stir 30min, be cooled to 20 DEG C, obtain B component;
3) B component is joined in component A, be warming up to 70 DEG C, make cream frost shape and namely obtain sensitive skin emollient cream.
Embodiment 2
A kind of sensitive skin emollient cream, component and each constituent mass number as follows: chitosan 8 parts, Flos Matricariae chamomillae 5 parts, citric acid 6 parts, carboxymethyl chitosan 2 parts, the Radix Astragali 1 part, lanoline 3 parts, Oleum sesami 1 part, corn starch sulfonation succinate 2 parts, capriloyl glycine 2 parts, methylhydroxypropylcellulose 0.08 part, 0.3 part, carbamide, benzoyl peroxide 1.5 parts, isopropyl myristate 1.5 parts, antioxidant dibenzylatiooluene 1 part, antiseptic zinc stearate 3 parts, palmityl hydroxylation wheat protein 4 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, Oleum menthae 3 parts, phthalic anhydride 1.2 parts, 70 parts, water.
Preparation method, comprises the steps:
1) by Flos Matricariae chamomillae, the Rhizoma Atractylodis Macrocephalae, Radix Astragali mixed grinding powdering, add citric acid, Oleum sesami and Oleum menthae, stir, mix homogeneously obtains component A;
2) chitosan, carboxymethyl chitosan, corn starch sulfonation succinate, methylhydroxypropylcellulose, carbamide, lanoline, capriloyl glycine, benzoyl peroxide, isopropyl myristate, palmityl hydroxylation wheat protein, phthalic anhydride are mixed with water, be warming up to 120 DEG C, stir 30min, be cooled to 20 DEG C, obtain B component;
3) B component is joined in component A, be warming up to 70 DEG C, add antioxidant, antiseptic stirs, make cream frost shape and namely obtain sensitive skin emollient cream.
Embodiment 3
A kind of sensitive skin emollient cream, component and each constituent mass number as follows: chitosan 18 parts, Flos Matricariae chamomillae 11 parts, citric acid 8 parts, carboxymethyl chitosan 5 parts, the Radix Astragali 5 parts, lanoline 6 parts, Oleum sesami 3 parts, corn starch sulfonation succinate 5 parts, capriloyl glycine 4.8 parts, methylhydroxypropylcellulose 0.25 part, 1.6 parts, carbamide, benzoyl peroxide 3.1 parts, isopropyl myristate 2.5 parts, antioxidant dibenzylatiooluene 1 part, antiseptic zinc oxide 1 part, palmityl hydroxylation wheat protein 2 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Oleum menthae 5 parts, phthalic anhydride 0.7 part, 6 parts, Folium Bambusae, vitamin E 3 parts, 65 parts, water.
Preparation method, comprises the steps:
1) by Flos Matricariae chamomillae, the Rhizoma Atractylodis Macrocephalae, Radix Astragali mixed grinding powdering, add citric acid, Oleum sesami and Oleum menthae, stir, mix homogeneously obtains component A;
2) chitosan, carboxymethyl chitosan, corn starch sulfonation succinate, methylhydroxypropylcellulose, carbamide, lanoline, capriloyl glycine, benzoyl peroxide, isopropyl myristate, palmityl hydroxylation wheat protein, phthalic anhydride are mixed with water, be warming up to 120 DEG C, stir 30min, be cooled to 20 DEG C, obtain B component;
3) B component is joined in component A, be warming up to 70 DEG C, add antioxidant, antiseptic stirs, make cream frost shape and namely obtain sensitive skin emollient cream.
Embodiment 4
A kind of sensitive skin emollient cream, component and each constituent mass are preferably as follows: chitosan 12 parts, Flos Matricariae chamomillae 7 parts, citric acid 6 parts, carboxymethyl chitosan 4 parts, the Radix Astragali 3 parts, lanoline 4 parts, Oleum sesami 2 parts, corn starch sulfonation succinate 3 parts, capriloyl glycine 3 parts, methylhydroxypropylcellulose 0.18 part, 0.9 part, carbamide, benzoyl peroxide 2.2 parts, isopropyl myristate 1.8 parts, antioxidant dibenzylatiooluene 0 part, antiseptic zinc oxide 0 part, palmityl hydroxylation wheat protein 2 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, Oleum menthae 4 parts, phthalic anhydride 0.35 part, 3 parts, Folium Bambusae, vitamin E 3 parts, 65 parts, water.
Preparation method, comprises the steps:
1) by Flos Matricariae chamomillae, the Rhizoma Atractylodis Macrocephalae, Radix Astragali mixed grinding powdering, add citric acid, Oleum sesami and Oleum menthae, stir, mix homogeneously obtains component A;
2) chitosan, carboxymethyl chitosan, corn starch sulfonation succinate, methylhydroxypropylcellulose, carbamide, lanoline, capriloyl glycine, benzoyl peroxide, isopropyl myristate, palmityl hydroxylation wheat protein, phthalic anhydride are mixed with water, be warming up to 120 DEG C, stir 30min, be cooled to 20 DEG C, obtain B component;
3) B component is joined in component A, be warming up to 70 DEG C, add antioxidant, antiseptic stirs, make cream frost shape and namely obtain sensitive skin emollient cream.
Embodiment 5
A kind of sensitive skin emollient cream, component and each constituent mass number are: chitosan 15 parts, Flos Matricariae chamomillae 9 parts, citric acid 7 parts, carboxymethyl chitosan 4.5 parts, the Radix Astragali 4 parts, lanoline 5 parts, Oleum sesami 2.5 parts, corn starch sulfonation succinate 3.5 parts, capriloyl glycine 3.8 parts, methylhydroxypropylcellulose 0.2 part, 1.1 parts, carbamide, benzoyl peroxide 2.8 parts, isopropyl myristate 2.2 parts, antioxidant dibenzylatiooluene 0.1 part, antiseptic zinc stearate 0.1 part, palmityl hydroxylation wheat protein 2.5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Oleum menthae 4.5 parts, phthalic anhydride 0.5 part, 4.5 parts, Folium Bambusae, vitamin E 3 parts, 65 parts, water.
Preparation method, comprises the steps:
1) by Flos Matricariae chamomillae, the Rhizoma Atractylodis Macrocephalae, Radix Astragali mixed grinding powdering, add citric acid, Oleum sesami and Oleum menthae, stir, mix homogeneously obtains component A;
2) chitosan, carboxymethyl chitosan, corn starch sulfonation succinate, methylhydroxypropylcellulose, carbamide, lanoline, capriloyl glycine, benzoyl peroxide, isopropyl myristate, palmityl hydroxylation wheat protein, phthalic anhydride are mixed with water, be warming up to 120 DEG C, stir 30min, be cooled to 20 DEG C, obtain B component;
3) B component is joined in component A, be warming up to 70 DEG C, add antioxidant, antiseptic stirs, make cream frost shape and namely obtain sensitive skin emollient cream.
Antiallergic is tested:
Get body weight (20 ± 2) g mice, male and female half and half, random packet, be respectively blank group, chlorphenamine group, embodiment 1 ~ 5 group, often organize 10.According to dosage gastric infusion, blank group gives isometric(al) distilled water, administration every day 1 time, continuous 10 d.Administration the 5th d, by 3% 2,4-dinitrochlorobenzene ethanol coats mouse part skin (unhairing) sensitization (uniform areas).Last administration 0. 5 h uses 2, the 4-dinitrochlorobenzene of 3% to be coated with auris dextra again, and left ear contrasts.Put to death mice after 0. 5 h, cut two ears along auricle baseline, lay ears same position disk with the card punch of certain diameter, use electronic analytical balance precise weighing, using the difference of left and right auricle weight as delayed hypersensitivity value, be scaled antiallergic effective percentage, the results are shown in Table shown in 1.
Clinical trial: select sensitive skin men and women, random packet, be respectively blank group, certain brand emollient cream commercially available, embodiment 1 ~ 5 group, often organize 6, men and women half and half, first observe Different Individual to the anaphylaxis of different material, then respectively its long-term follow investigated, smear the present invention lubricate frost one month, three months, again carry out anaphylactogen stimulation after half a year, 1 year, observe dermoreaction, the results are shown in Table 1.
Table 1
Claims (9)
1. sensitive skin emollient cream, it is characterized in that component and each constituent mass number as follows: chitosan 8 ~ 20 parts, Flos Matricariae chamomillae 5 ~ 15 parts, citric acid 6 ~ 10 parts, carboxymethyl chitosan 2 ~ 6 parts, the Radix Astragali 1 ~ 6 part, lanoline 3 ~ 6 parts, Oleum sesami 1 ~ 4 part, corn starch sulfonation succinate 2 ~ 7 parts, capriloyl glycine 2 ~ 5.8 parts, methylhydroxypropylcellulose 0.08 ~ 0.46 part, 0.3 ~ 2.3 part, carbamide, benzoyl peroxide 1.5 ~ 3.5 parts, isopropyl myristate 1.5 ~ 3.1 parts, 0 ~ 1 part, antioxidant, antiseptic 0 ~ 3 part, palmityl hydroxylation wheat protein 1 ~ 4 part, the Rhizoma Atractylodis Macrocephalae 3 ~ 8 parts, Oleum menthae 3 ~ 5 parts, phthalic anhydride 0.05 ~ 1.2 part, 60 ~ 70 parts, water.
2. a kind of sensitive skin emollient cream according to claim 1, is characterized in that: described antiseptic is zinc stearate or zinc oxide.
3. a kind of sensitive skin emollient cream according to claim 1, is characterized in that: described antioxidant is dibenzylatiooluene.
4. a kind of sensitive skin emollient cream according to claim 1, is characterized in that: also comprise 1 ~ 8 part, Folium Bambusae, vitamin E 2 ~ 4 parts.
5. a kind of sensitive skin emollient cream according to claim 4, it is characterized in that: component and each constituent mass number as follows: chitosan 12 ~ 18 parts, Flos Matricariae chamomillae 7 ~ 11 parts, citric acid 6 ~ 8 parts, carboxymethyl chitosan 4 ~ 5 parts, the Radix Astragali 3 ~ 5 parts, lanoline 4 ~ 6 parts, Oleum sesami 2 ~ 3 parts, corn starch sulfonation succinate 3 ~ 5 parts, capriloyl glycine 3 ~ 4.8 parts, methylhydroxypropylcellulose 0.18 ~ 0.25 part, 0.9 ~ 1.6 part, carbamide, benzoyl peroxide 2.2 ~ 3.1 parts, isopropyl myristate 1.8 ~ 2.5 parts, 0 ~ 1 part, antioxidant, antiseptic 0 ~ 1 part, palmityl hydroxylation wheat protein 2 ~ 3 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 6 parts, Oleum menthae 4 ~ 5 parts, phthalic anhydride 0.35 ~ 0.7 part, 3 ~ 6 parts, Folium Bambusae, vitamin E 3 parts, 65 parts, water.
6. a kind of sensitive skin emollient cream according to claim 5, it is characterized in that: component and each constituent mass number as follows: chitosan 15 parts, Flos Matricariae chamomillae 9 parts, citric acid 7 parts, carboxymethyl chitosan 4.5 parts, the Radix Astragali 4 parts, lanoline 5 parts, Oleum sesami 2.5 parts, corn starch sulfonation succinate 3.5 parts, capriloyl glycine 3.8 parts, methylhydroxypropylcellulose 0.2 part, 1.1 parts, carbamide, benzoyl peroxide 2.8 parts, isopropyl myristate 2.2 parts, 0.1 part, antioxidant, antiseptic 0.1 part, palmityl hydroxylation wheat protein 2.5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Oleum menthae 4.5 parts, phthalic anhydride 0.5 part, 4.5 parts, Folium Bambusae, vitamin E 3 parts, 65 parts, water.
7. the preparation method of a kind of sensitive skin emollient cream according to claim 1, is characterized in that comprising the steps:
1) by Flos Matricariae chamomillae, the Rhizoma Atractylodis Macrocephalae, Radix Astragali mixed grinding powdering, add citric acid, Oleum sesami and Oleum menthae, stir, mix homogeneously obtains component A;
2) chitosan, carboxymethyl chitosan, corn starch sulfonation succinate, methylhydroxypropylcellulose, carbamide, lanoline, capriloyl glycine, benzoyl peroxide, isopropyl myristate, palmityl hydroxylation wheat protein, phthalic anhydride are mixed with water, be warming up to 100 ~ 140 DEG C, stir 20 ~ 50min, be cooled to 20 DEG C, obtain B component;
3) B component is joined in component A, be warming up to 60 ~ 80 DEG C, add antioxidant, antiseptic stirs, make cream frost shape and namely obtain sensitive skin emollient cream.
8. the preparation method of a kind of sensitive skin emollient cream according to claim 7, is characterized in that: step 2) in be warming up to 120 DEG C, stir 30min.
9. the preparation method of a kind of sensitive skin emollient cream according to claim 7, is characterized in that: be warming up to 70 DEG C in step 3).
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919711A (en) * | 2014-04-14 | 2014-07-16 | 郑州市嘉蓓丽生物科技有限公司 | Oolong anti-aging whitening cream and preparation method thereof |
| CN104042529A (en) * | 2014-07-09 | 2014-09-17 | 广州丹奇日用化工厂有限公司 | Anti-allergic cosmetic composition and preparation method thereof |
| CN104434747A (en) * | 2014-10-13 | 2015-03-25 | 金日制药（中国）有限公司 | Face cream with anti-aging function and preparation method of face cream |
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- 2015-03-31 CN CN201510146728.XA patent/CN104688631A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919711A (en) * | 2014-04-14 | 2014-07-16 | 郑州市嘉蓓丽生物科技有限公司 | Oolong anti-aging whitening cream and preparation method thereof |
| CN104042529A (en) * | 2014-07-09 | 2014-09-17 | 广州丹奇日用化工厂有限公司 | Anti-allergic cosmetic composition and preparation method thereof |
| CN104434747A (en) * | 2014-10-13 | 2015-03-25 | 金日制药（中国）有限公司 | Face cream with anti-aging function and preparation method of face cream |
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