CN104706556A - Antiallergic composition and application thereof in cosmetics - Google Patents
Antiallergic composition and application thereof in cosmetics Download PDFInfo
- Publication number
- CN104706556A CN104706556A CN201510146830.XA CN201510146830A CN104706556A CN 104706556 A CN104706556 A CN 104706556A CN 201510146830 A CN201510146830 A CN 201510146830A CN 104706556 A CN104706556 A CN 104706556A
- Authority
- CN
- China
- Prior art keywords
- parts
- antiallergic composition
- antiseptic
- antioxidant
- phytantriol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 58
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 46
- 239000002537 cosmetic Substances 0.000 title claims abstract description 21
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims abstract description 50
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 50
- 241000628997 Flos Species 0.000 claims abstract description 49
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 27
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 27
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 27
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000004342 Benzoyl peroxide Substances 0.000 claims abstract description 25
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 25
- 229920002261 Corn starch Polymers 0.000 claims abstract description 25
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229930014669 anthocyanidin Natural products 0.000 claims abstract description 25
- 150000001452 anthocyanidin derivatives Chemical class 0.000 claims abstract description 25
- 235000008758 anthocyanidins Nutrition 0.000 claims abstract description 25
- 235000019400 benzoyl peroxide Nutrition 0.000 claims abstract description 25
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 25
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 25
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 25
- 239000008120 corn starch Substances 0.000 claims abstract description 25
- 239000011664 nicotinic acid Substances 0.000 claims abstract description 25
- 229960003512 nicotinic acid Drugs 0.000 claims abstract description 25
- 235000001968 nicotinic acid Nutrition 0.000 claims abstract description 25
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 25
- CGIHFIDULQUVJG-UHFFFAOYSA-N phytantriol Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)(O)C(O)CO CGIHFIDULQUVJG-UHFFFAOYSA-N 0.000 claims abstract description 25
- CGIHFIDULQUVJG-VNTMZGSJSA-N phytantriol Natural products CC(C)CCC[C@H](C)CCC[C@H](C)CCC[C@@](C)(O)[C@H](O)CO CGIHFIDULQUVJG-VNTMZGSJSA-N 0.000 claims abstract description 25
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 25
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 48
- 230000002421 anti-septic effect Effects 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 27
- 239000004471 Glycine Substances 0.000 claims description 24
- 239000009636 Huang Qi Substances 0.000 claims description 24
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 24
- 238000006277 sulfonation reaction Methods 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000006071 cream Substances 0.000 claims description 18
- 239000000839 emulsion Substances 0.000 claims description 18
- 238000010792 warming Methods 0.000 claims description 18
- 239000000470 constituent Substances 0.000 claims description 15
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 10
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 9
- 230000008020 evaporation Effects 0.000 claims description 9
- 238000001704 evaporation Methods 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 8
- 239000011787 zinc oxide Substances 0.000 claims description 5
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 4
- 208000010668 atopic eczema Diseases 0.000 abstract description 5
- 230000000172 allergic effect Effects 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 abstract description 3
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 abstract 1
- 244000042664 Matricaria chamomilla Species 0.000 abstract 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 abstract 1
- SAVLIIGUQOSOEP-UHFFFAOYSA-N N-octanoylglycine Chemical compound CCCCCCCC(=O)NCC(O)=O SAVLIIGUQOSOEP-UHFFFAOYSA-N 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 150000003890 succinate salts Chemical class 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 229940126673 western medicines Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 201000004624 Dermatitis Diseases 0.000 description 3
- 230000002052 anaphylactic effect Effects 0.000 description 3
- 210000005069 ears Anatomy 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 206010048768 Dermatosis Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 230000036783 anaphylactic response Effects 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 240000006409 Acacia auriculiformis Species 0.000 description 1
- OGGLGFFJQHOEMZ-UHFFFAOYSA-N C(C)O.[N+](=O)([O-])C1=C(C=CC(=C1)[N+](=O)[O-])Cl Chemical compound C(C)O.[N+](=O)([O-])C1=C(C=CC(=C1)[N+](=O)[O-])Cl OGGLGFFJQHOEMZ-UHFFFAOYSA-N 0.000 description 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical group OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 208000002029 allergic contact dermatitis Diseases 0.000 description 1
- 238000013528 artificial neural network Methods 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- -1 sulfonyl thioethylamine Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses an antiallergic composition and an application thereof in cosmetics. The antiallergic composition comprises the following components in parts by mass: 20-40 parts of flos lonicerae, 10-18 parts of chamomile, 8-13 parts of anthocyanidin, 5-10 parts of a salicylic acid, 8-6 parts of astragalus membranaceus, 2-5 parts of serine, 1-4 parts of phytantriol, 2-4 parts of corn starch sulfonated succinate, 1-1.8 parts of caprylyl glycine, 0.08-1.46 parts of a nicotinic acid, 0.3-1.2 parts of carboxymethyl cellulose, 1.2-3.5 parts of benzoyl peroxide, 0.5-1.1 parts of isopropyl myristate, 0-1 part of an antioxidant, and 0-3 parts of a preservative. The antiallergic composition is composed of traditional Chinese medicines and western medicines in proportion, so that the antiallergic composition is good in antiallergic effect, and can significantly improve the allergic symptoms of the skin after being applied in cosmetics.
Description
Technical field
The invention belongs to fine chemical product field, be specifically related to a kind of antiallergic composition and the application in cosmetics thereof.
Background technology
In recent years, along with the general lifting manipulation of people's living standard, the quickening of Regional City process, the decline of air quality, the easy allergic human population of China rises to about 5%-6% from 2% ~ 3% of the past., mostly there is close relationship this and environmental pollution, the change of dietary structure, the change of modern's body constitution and adding of competitive neural network pressure, and its key link is that the complexity interaction of gene and environment caused.In 1999, anaphylactic disease was classified as the disease of 21 century emphasis prevention and research by World Health Organization (WHO) (WHO).The unprecedentedly popular health resources of a lot of country of giving of anaphylactic disease brings huge financial burden and pressure, the whole world only allergy preparations this expenditure oneself more than 8,000,000,000 dollars.With regard to the treatment of anaphylactic disease, avoiding contact allergy former is one of the measure occurred that prevents disease, and adopts Drug therapy to be the Main Means effectively controlling anaphylaxis degree.
Skin allergy is dermatosis common at present, have a strong impact on the physical and mental health of people, when skin is subject to various stimulation as air of the cosmetics of untoward reaction, chemicals, pollen, some food, pollution etc., cause skin occur red and swollen, itch, peel and the abnormal phenomena such as allergic dermatitis.Inferior, rotten cosmetics, the cosmetics that zest is stronger and some drugs cosmetics, most typical cosmetic allergic contact dermatitis is that essence is irritated, and the cosmetics containing alcoholic content such as astringent lotion also can produce certain stimulation to skin.Other all can cause different stimulations to different skin as biochemical antiseptic, fruit acid etc.In recent years, the side effect of chemotherapy skin allergy manifests day by day, and there is side effect in existing medicine large, the problems such as development cost is high, difficulty is large, particularly therapeutic effect that is chronic for part, intractable anaphylaxis dermatosis is also unsatisfactory.Therefore skin allergy control and become the focus of research containing the development of new skin care item of antiallergic Chinese herbal medicine.
Summary of the invention
The invention provides a kind of antiallergic composition and the application in cosmetics thereof, this antiallergic composition adopts Chinese medicine Western medicine to proportion, and antiallergic effect is good, is applied in the allergic symptom that significantly can improve skin in cosmetics.
To achieve these goals, the technological means that the present invention adopts is:
A kind of antiallergic composition; component and each constituent mass number as follows: Flos Lonicerae 20 ~ 40 parts; Flos Matricariae chamomillae 10 ~ 18 parts; anthocyanidin 8 ~ 13 parts; salicylic acid 5 ~ 10 parts; the Radix Astragali 8 ~ 16 parts, serine 2 ~ 5 parts, phytantriol 1 ~ 4 part; corn starch sulfonation succinate 2 ~ 4 parts; capriloyl glycine 1 ~ 1.8 part, 0.08 ~ 1.46 part, nicotinic acid, carboxymethyl cellulose 0.3 ~ 1.2 part; benzoyl peroxide 1.2 ~ 3.5 parts; isopropyl myristate 0.5 ~ 1.1 part, 0 ~ 1 part, antioxidant, antiseptic 0 ~ 3 part.
Described antiseptic is at least one in zinc stearate, zinc oxide or aluminum chloride.
Described antioxidant is dibenzylatiooluene.
Described a kind of antiallergic composition; component and each constituent mass number are preferably as follows: Flos Lonicerae 25 ~ 35 parts; Flos Matricariae chamomillae 12 ~ 16 parts; anthocyanidin 10 ~ 12 parts; salicylic acid 6 ~ 8 parts; the Radix Astragali 10 ~ 15 parts, serine 3 ~ 4 parts, phytantriol 2 ~ 3 parts; corn starch sulfonation succinate 2 ~ 3 parts; capriloyl glycine 1.3 ~ 1.6 parts, 0.38 ~ 0.76 part, nicotinic acid, carboxymethyl cellulose 0.6 ~ 0.8 part; benzoyl peroxide 1.5 ~ 2.5 parts; isopropyl myristate 0.7 ~ 1.0 part, 0.2 ~ 0.8 part, antioxidant, antiseptic 0.5 ~ 2.2 part.
Described a kind of antiallergic composition, component and each constituent mass number are preferably as follows: Flos Lonicerae 20 ~ 30 parts, Flos Matricariae chamomillae 14 ~ 17 parts, anthocyanidin 10 ~ 13 parts, salicylic acid 7 ~ 9 parts, the Radix Astragali 11 ~ 13 parts, serine 3.6 ~ 3.85 parts, phytantriol 1.8 ~ 3.4 parts, corn starch sulfonation succinate 2.8 ~ 3 parts, capriloyl glycine 1.5 ~ 1.7 parts, 0.4 ~ 0.66 part, nicotinic acid, carboxymethyl cellulose 0.73 ~ 0.81 part, benzoyl peroxide 1.9 ~ 2.2 parts, isopropyl myristate 0.8 part, 0.39 ~ 0.64 part, antioxidant, antiseptic 1.3 ~ 1.8 parts.
Described a kind of antiallergic composition, component and each constituent mass number are preferably as follows: Flos Lonicerae 26.3 parts, Flos Matricariae chamomillae 15.8 parts; anthocyanidin 12 parts, salicylic acid 8 parts, the Radix Astragali 12 parts; serine 3.8 parts, phytantriol 2.7 parts, corn starch sulfonation succinate 2.9 parts; capriloyl glycine 1.6 parts, 0.46 part, nicotinic acid, carboxymethyl cellulose 0.77 part; benzoyl peroxide 2 parts; isopropyl myristate 0.8 part, 0.54 part, antioxidant, antiseptic 1.5 parts.
The described application of a kind of antiallergic composition in cosmetics.Antiallergic composition and conven-tional adjuvants are mixed and made into cream frost or emulsion.Comprise the steps:
1) by Flos Lonicerae, Flos Matricariae chamomillae, anthocyanidin, Radix Astragali mix homogeneously, the ratio adding 5 ~ 10mL water in the mixture of every 1g quality adds water, and is warming up to 80 ~ 90 DEG C, stirs 20 ~ 40min, and filter, filtrate evaporation and concentration, to 1/10th of original volume, obtains concentrated solution;
2) by step 1) concentrated solution that obtains mixes with salicylic acid, serine, phytantriol, corn starch sulfonation succinate, capriloyl glycine, nicotinic acid, carboxymethyl cellulose, benzoyl peroxide, isopropyl myristate; be warming up to 100 ~ 140 DEG C; stir; finally add antioxidant, antiseptic stirs, make cream frost shape or emulsion form.
The conven-tional adjuvants in any cosmetic field can be added in the process being prepared into cosmetics, common additives in cosmetics, such as essence, whitening composition (such as two sulfonyl thioethylamine), moisturizing ingredient (hyaluronate sodium), nutritional labeling (vitamin E, vitamin C etc.), the dosage form of preparation can be any common dosage forms of cosmetic field.
Beneficial effect:
A kind of antiallergic composition provided by the invention adopts Chinese medicine Western medicine to proportion, and antiallergic effect is good, and be applied in the allergic symptom that significantly can improve skin in cosmetics, decimal experimental result shows, antiallergic effective percentage is up to 99%.
Detailed description of the invention
Embodiment 1
A kind of antiallergic composition, component and each constituent mass number as follows: Flos Lonicerae 20 parts, Flos Matricariae chamomillae 10 parts; anthocyanidin 8 parts, salicylic acid 5 parts, the Radix Astragali 8 parts; serine 2 parts, phytantriol 1 part, corn starch sulfonation succinate 2 parts; capriloyl glycine 1 part, 0.08 part, nicotinic acid, carboxymethyl cellulose 0.3 part; benzoyl peroxide 1.2 parts; isopropyl myristate 0.5 part, antioxidant dibenzylatiooluene 0.1 part, antiseptic zinc stearate 0.3 part.
Antiallergic composition is made cream frost or emulsion.Comprise the steps:
1) by Flos Lonicerae, Flos Matricariae chamomillae, anthocyanidin, Radix Astragali mix homogeneously, the ratio adding 8mL water in the mixture of every 1g quality adds water, and is warming up to 90 DEG C, stirs 30min, and filter, filtrate evaporation and concentration, to 1/10th of original volume, obtains concentrated solution;
2) by step 1) concentrated solution that obtains mixes with salicylic acid, serine, phytantriol, corn starch sulfonation succinate, capriloyl glycine, nicotinic acid, carboxymethyl cellulose, benzoyl peroxide, isopropyl myristate; be warming up to 120 DEG C; stir; finally add antioxidant, antiseptic stirs, make cream frost shape or emulsion form.
Embodiment 2
A kind of antiallergic composition, component and each constituent mass number as follows: Flos Lonicerae 40 parts, Flos Matricariae chamomillae 18 parts; anthocyanidin 13 parts, salicylic acid 10 parts, the Radix Astragali 16 parts; serine 5 parts, phytantriol 4 parts, corn starch sulfonation succinate 4 parts; capriloyl glycine 1.8 parts, 1.46 parts, nicotinic acid, carboxymethyl cellulose 1.2 parts; benzoyl peroxide 3.5 parts; isopropyl myristate 1.1 parts, antioxidant dibenzylatiooluene 1 part, antiseptic zinc stearate 3 parts.
Antiallergic composition is made cream frost or emulsion.Comprise the steps:
1) by Flos Lonicerae, Flos Matricariae chamomillae, anthocyanidin, Radix Astragali mix homogeneously, the ratio adding 8mL water in the mixture of every 1g quality adds water, and is warming up to 90 DEG C, stirs 30min, and filter, filtrate evaporation and concentration, to 1/10th of original volume, obtains concentrated solution;
2) by step 1) concentrated solution that obtains mixes with salicylic acid, serine, phytantriol, corn starch sulfonation succinate, capriloyl glycine, nicotinic acid, carboxymethyl cellulose, benzoyl peroxide, isopropyl myristate; be warming up to 120 DEG C; stir; finally add antioxidant, antiseptic stirs, make cream frost shape or emulsion form.
Embodiment 3
A kind of antiallergic composition, component and each constituent mass number are preferably as follows: Flos Lonicerae 35 parts, Flos Matricariae chamomillae 16 parts; anthocyanidin 12 parts, salicylic acid 8 parts, the Radix Astragali 15 parts; serine 4 parts, phytantriol 3 parts, corn starch sulfonation succinate 3 parts; capriloyl glycine 1.6 parts, 0.76 part, nicotinic acid, carboxymethyl cellulose 0.8 part; benzoyl peroxide 2.5 parts; isopropyl myristate 1.0 parts, antioxidant dibenzylatiooluene 0.8 part, 2.2 parts, antiseptic aluminum chloride.
Antiallergic composition is made cream frost or emulsion.Comprise the steps:
1) by Flos Lonicerae, Flos Matricariae chamomillae, anthocyanidin, Radix Astragali mix homogeneously, the ratio adding 8mL water in the mixture of every 1g quality adds water, and is warming up to 90 DEG C, stirs 30min, and filter, filtrate evaporation and concentration, to 1/10th of original volume, obtains concentrated solution;
2) by step 1) concentrated solution that obtains mixes with salicylic acid, serine, phytantriol, corn starch sulfonation succinate, capriloyl glycine, nicotinic acid, carboxymethyl cellulose, benzoyl peroxide, isopropyl myristate; be warming up to 120 DEG C; stir; finally add antioxidant, antiseptic stirs, make cream frost shape or emulsion form.
Embodiment 4
A kind of antiallergic composition, component and each constituent mass number are preferably as follows: Flos Lonicerae 25 parts, Flos Matricariae chamomillae 12 parts; anthocyanidin 10 parts, salicylic acid 6 parts, the Radix Astragali 10 parts; serine 3 parts, phytantriol 2 parts, corn starch sulfonation succinate 2 parts; capriloyl glycine 1.3 parts, 0.38 part, nicotinic acid, carboxymethyl cellulose 0.6 part; benzoyl peroxide 1.5 parts; isopropyl myristate 0.7 part, antioxidant dibenzylatiooluene 0.2 part, 0.5 part, antiseptic aluminum chloride.
Antiallergic composition is made cream frost or emulsion.Comprise the steps:
1) by Flos Lonicerae, Flos Matricariae chamomillae, anthocyanidin, Radix Astragali mix homogeneously, the ratio adding 8mL water in the mixture of every 1g quality adds water, and is warming up to 90 DEG C, stirs 30min, and filter, filtrate evaporation and concentration, to 1/10th of original volume, obtains concentrated solution;
2) by step 1) concentrated solution that obtains mixes with salicylic acid, serine, phytantriol, corn starch sulfonation succinate, capriloyl glycine, nicotinic acid, carboxymethyl cellulose, benzoyl peroxide, isopropyl myristate; be warming up to 100 ~ 140 DEG C; stir; finally add antioxidant, antiseptic stirs, make cream frost shape or emulsion form.
Embodiment 5
A kind of antiallergic composition, component and each constituent mass number are preferably as follows: Flos Lonicerae 20 parts, Flos Matricariae chamomillae 17 parts; anthocyanidin 13 parts, salicylic acid 7 parts, the Radix Astragali 13 parts; serine 3.6 parts, phytantriol 3.4 parts, corn starch sulfonation succinate 3 parts; capriloyl glycine 1.7 parts, 0.66 part, nicotinic acid, carboxymethyl cellulose 0.81 part; benzoyl peroxide 2.2 parts; isopropyl myristate 0.8 part, antioxidant dibenzylatiooluene 0.64 part, antiseptic zinc oxide 1.8 parts.
Antiallergic composition is made cream frost or emulsion.Comprise the steps:
1) by Flos Lonicerae, Flos Matricariae chamomillae, anthocyanidin, Radix Astragali mix homogeneously, the ratio adding 8mL water in the mixture of every 1g quality adds water, and is warming up to 90 DEG C, stirs 30min, and filter, filtrate evaporation and concentration, to 1/10th of original volume, obtains concentrated solution;
2) by step 1) concentrated solution that obtains mixes with salicylic acid, serine, phytantriol, corn starch sulfonation succinate, capriloyl glycine, nicotinic acid, carboxymethyl cellulose, benzoyl peroxide, isopropyl myristate; be warming up to 100 ~ 140 DEG C; stir; finally add antioxidant, antiseptic stirs, make cream frost shape or emulsion form.
Embodiment 6
A kind of antiallergic composition, component and each constituent mass number are preferably as follows: Flos Lonicerae 30 parts, Flos Matricariae chamomillae 17 parts; anthocyanidin 10 parts, salicylic acid 9 parts, the Radix Astragali 11 parts; serine 3.85 parts, phytantriol 1.8 parts, corn starch sulfonation succinate 2.8 parts; capriloyl glycine 1.5 parts, 0.4 part, nicotinic acid, carboxymethyl cellulose 0.73 part; benzoyl peroxide 1.9 parts; isopropyl myristate 0.8 part, antioxidant dibenzylatiooluene 0.39 part, antiseptic zinc oxide 1.3 parts.
Antiallergic composition is made cream frost or emulsion.Comprise the steps:
1) by Flos Lonicerae, Flos Matricariae chamomillae, anthocyanidin, Radix Astragali mix homogeneously, the ratio adding 8mL water in the mixture of every 1g quality adds water, and is warming up to 90 DEG C, stirs 30min, and filter, filtrate evaporation and concentration, to 1/10th of original volume, obtains concentrated solution;
2) by step 1) concentrated solution that obtains mixes with salicylic acid, serine, phytantriol, corn starch sulfonation succinate, capriloyl glycine, nicotinic acid, carboxymethyl cellulose, benzoyl peroxide, isopropyl myristate; be warming up to 100 ~ 140 DEG C; stir; finally add antioxidant, antiseptic stirs, make cream frost shape or emulsion form.
Embodiment 7
A kind of antiallergic composition; component and each constituent mass number are preferably as follows: Flos Lonicerae 26.3 parts; Flos Matricariae chamomillae 15.8 parts; anthocyanidin 12 parts; salicylic acid 8 parts; the Radix Astragali 12 parts, serine 3.8 parts, phytantriol 2.7 parts; corn starch sulfonation succinate 2.9 parts; capriloyl glycine 1.6 parts, 0.46 part, nicotinic acid, carboxymethyl cellulose 0.77 part; benzoyl peroxide 2 parts; isopropyl myristate 0.8 part, antioxidant dibenzylatiooluene 0.54 part, antiseptic zinc oxide 1.5 parts.
Antiallergic composition is made cream frost or emulsion.Comprise the steps:
1) by Flos Lonicerae, Flos Matricariae chamomillae, anthocyanidin, Radix Astragali mix homogeneously, the ratio adding 8mL water in the mixture of every 1g quality adds water, and is warming up to 90 DEG C, stirs 30min, and filter, filtrate evaporation and concentration, to 1/10th of original volume, obtains concentrated solution;
2) by step 1) concentrated solution that obtains mixes with salicylic acid, serine, phytantriol, corn starch sulfonation succinate, capriloyl glycine, nicotinic acid, carboxymethyl cellulose, benzoyl peroxide, isopropyl myristate; be warming up to 100 ~ 140 DEG C; stir; finally add antioxidant, antiseptic stirs, make cream frost shape or emulsion form.
Antiallergic is tested:
Get body weight (20 ± 2) g mice, male and female half and half, random packet, be respectively blank group, chlorphenamine group, embodiment 1 ~ 7 group, often organize 10.According to dosage gastric infusion, blank group gives isometric(al) distilled water, administration every day 1 time, continuous 10 d.Administration the 5th d, by 3% 2,4-dinitrochlorobenzene ethanol coats mouse part skin (unhairing) sensitization (uniform areas).Last administration 0. 5 h uses 3% 2,4 again
-dinitrochlorobenzene is coated with auris dextra, and left ear contrasts.Put to death mice after 0. 5 h, cut two ears along auricle baseline, lay ears same position disk with the card punch of certain diameter, use electronic analytical balance precise weighing, using the difference of left and right auricle weight as delayed hypersensitivity value, be scaled antiallergic effective percentage, the results are shown in Table shown in 1.
Table 1
Claims (8)
1. an antiallergic composition; it is characterized in that component and each constituent mass number as follows: Flos Lonicerae 20 ~ 40 parts; Flos Matricariae chamomillae 10 ~ 18 parts; anthocyanidin 8 ~ 13 parts; salicylic acid 5 ~ 10 parts; the Radix Astragali 8 ~ 16 parts, serine 2 ~ 5 parts, phytantriol 1 ~ 4 part; corn starch sulfonation succinate 2 ~ 4 parts; capriloyl glycine 1 ~ 1.8 part, 0.08 ~ 1.46 part, nicotinic acid, carboxymethyl cellulose 0.3 ~ 1.2 part; benzoyl peroxide 1.2 ~ 3.5 parts; isopropyl myristate 0.5 ~ 1.1 part, 0 ~ 1 part, antioxidant, antiseptic 0 ~ 3 part.
2. a kind of antiallergic composition according to claim 1, is characterized in that: described antiseptic is at least one in zinc stearate, zinc oxide or aluminum chloride.
3. a kind of antiallergic composition according to claim 1, is characterized in that: described antioxidant is dibenzylatiooluene.
4. a kind of antiallergic composition according to claim 1, it is characterized in that: component and each constituent mass number as follows: Flos Lonicerae 25 ~ 35 parts, Flos Matricariae chamomillae 12 ~ 16 parts, anthocyanidin 10 ~ 12 parts, salicylic acid 6 ~ 8 parts, the Radix Astragali 10 ~ 15 parts, serine 3 ~ 4 parts, phytantriol 2 ~ 3 parts, corn starch sulfonation succinate 2 ~ 3 parts, capriloyl glycine 1.3 ~ 1.6 parts, 0.38 ~ 0.76 part, nicotinic acid, carboxymethyl cellulose 0.6 ~ 0.8 part, benzoyl peroxide 1.5 ~ 2.5 parts, isopropyl myristate 0.7 ~ 1.0 part, 0.2 ~ 0.8 part, antioxidant, antiseptic 0.5 ~ 2.2 part.
5. a kind of antiallergic composition according to claim 1, it is characterized in that: component and each constituent mass number as follows: Flos Lonicerae 20 ~ 30 parts, Flos Matricariae chamomillae 14 ~ 17 parts, anthocyanidin 10 ~ 13 parts, salicylic acid 7 ~ 9 parts, the Radix Astragali 11 ~ 13 parts, serine 3.6 ~ 3.85 parts, phytantriol 1.8 ~ 3.4 parts, corn starch sulfonation succinate 2.8 ~ 3 parts, capriloyl glycine 1.5 ~ 1.7 parts, 0.4 ~ 0.66 part, nicotinic acid, carboxymethyl cellulose 0.73 ~ 0.81 part, benzoyl peroxide 1.9 ~ 2.2 parts, isopropyl myristate 0.8 part, 0.39 ~ 0.64 part, antioxidant, antiseptic 1.3 ~ 1.8 parts.
6. a kind of antiallergic composition according to claim 1; it is characterized in that: component and each constituent mass number as follows: Flos Lonicerae 26.3 parts; Flos Matricariae chamomillae 15.8 parts; anthocyanidin 12 parts; salicylic acid 8 parts; the Radix Astragali 12 parts, serine 3.8 parts, phytantriol 2.7 parts; corn starch sulfonation succinate 2.9 parts; capriloyl glycine 1.6 parts, 0.46 part, nicotinic acid, carboxymethyl cellulose 0.77 part; benzoyl peroxide 2 parts; isopropyl myristate 0.8 part, 0.54 part, antioxidant, antiseptic 1.5 parts.
7. the application of a kind of antiallergic composition in cosmetics in claim 1 ~ 6 described in any one.
8. a kind of antiallergic composition according to claim 7 is applied in cosmetics, it is characterized in that: antiallergic composition is made cream frost or emulsion, comprise the steps:
1) by Flos Lonicerae, Flos Matricariae chamomillae, anthocyanidin, Radix Astragali mix homogeneously, the ratio adding 5 ~ 10mL water in the mixture of every 1g quality adds water, and is warming up to 80 ~ 90 DEG C, stirs 20 ~ 40min, and filter, filtrate evaporation and concentration, to 1/10th of original volume, obtains concentrated solution;
2) by step 1) concentrated solution that obtains mixes with salicylic acid, serine, phytantriol, corn starch sulfonation succinate, capriloyl glycine, nicotinic acid, carboxymethyl cellulose, benzoyl peroxide, isopropyl myristate; be warming up to 100 ~ 140 DEG C; stir; finally add antioxidant, antiseptic stirs, make cream frost shape or emulsion form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510146830.XA CN104706556A (en) | 2015-03-31 | 2015-03-31 | Antiallergic composition and application thereof in cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510146830.XA CN104706556A (en) | 2015-03-31 | 2015-03-31 | Antiallergic composition and application thereof in cosmetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104706556A true CN104706556A (en) | 2015-06-17 |
Family
ID=53406606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510146830.XA Pending CN104706556A (en) | 2015-03-31 | 2015-03-31 | Antiallergic composition and application thereof in cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104706556A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106277A (en) * | 2015-08-10 | 2015-12-02 | 广州钤诺生物科技有限公司 | Anti-allergy and anti-pruritus composite plant extract, and preparation method and application thereof |
| CN107823098A (en) * | 2017-12-08 | 2018-03-23 | 佛山实瑞先导材料研究院（普通合伙） | A kind of resisting skin allergy composition |
| CN109793697A (en) * | 2019-03-25 | 2019-05-24 | 韩兴旺 | A kind of Anti-allergic cosmetic composition and its preparation process containing plant active peptides |
| US10639300B2 (en) | 2016-04-12 | 2020-05-05 | Arturo Solis Herrera | Compositions and methods for treating nasal and paranasal mucosa diseases with nicotinic acetylcholine receptor agonists |
| CN111840118A (en) * | 2020-08-26 | 2020-10-30 | 惠州市蕙薏美生物科技有限公司 | Skin care preparation with hormone repairing face |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496772A (en) * | 2008-01-31 | 2009-08-05 | 姜宁 | Anti-aging allergy-releasing composition containing plant effective ingredient |
| CN103027867A (en) * | 2011-09-30 | 2013-04-10 | 天津市中科健新材料技术有限公司 | Finishing liquor applied on wet tissue and available for after-sun makeup removal and repair |
| CN103705426A (en) * | 2014-01-07 | 2014-04-09 | 梁云生 | Anti-allergic moisturizing composition with function of repairing skin barrier and external preparation thereof |
| CN103961276A (en) * | 2014-01-08 | 2014-08-06 | 片仔癀（上海）生物科技研发有限公司 | Anti-glycation cosmetic composition and anti-glycation cosmetics containing same |
| CN104185470A (en) * | 2012-03-19 | 2014-12-03 | 宝洁公司 | Superabsorbent polymers and silicone elastomer for use in skin care compositions |
-
2015
- 2015-03-31 CN CN201510146830.XA patent/CN104706556A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496772A (en) * | 2008-01-31 | 2009-08-05 | 姜宁 | Anti-aging allergy-releasing composition containing plant effective ingredient |
| CN103027867A (en) * | 2011-09-30 | 2013-04-10 | 天津市中科健新材料技术有限公司 | Finishing liquor applied on wet tissue and available for after-sun makeup removal and repair |
| CN104185470A (en) * | 2012-03-19 | 2014-12-03 | 宝洁公司 | Superabsorbent polymers and silicone elastomer for use in skin care compositions |
| CN103705426A (en) * | 2014-01-07 | 2014-04-09 | 梁云生 | Anti-allergic moisturizing composition with function of repairing skin barrier and external preparation thereof |
| CN103961276A (en) * | 2014-01-08 | 2014-08-06 | 片仔癀（上海）生物科技研发有限公司 | Anti-glycation cosmetic composition and anti-glycation cosmetics containing same |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106277A (en) * | 2015-08-10 | 2015-12-02 | 广州钤诺生物科技有限公司 | Anti-allergy and anti-pruritus composite plant extract, and preparation method and application thereof |
| CN105106277B (en) * | 2015-08-10 | 2018-11-13 | 广州钤诺生物科技有限公司 | A kind of antiallergic, antipruritic composite vegetables extractive and its preparation method and application |
| US10639300B2 (en) | 2016-04-12 | 2020-05-05 | Arturo Solis Herrera | Compositions and methods for treating nasal and paranasal mucosa diseases with nicotinic acetylcholine receptor agonists |
| CN107823098A (en) * | 2017-12-08 | 2018-03-23 | 佛山实瑞先导材料研究院（普通合伙） | A kind of resisting skin allergy composition |
| CN109793697A (en) * | 2019-03-25 | 2019-05-24 | 韩兴旺 | A kind of Anti-allergic cosmetic composition and its preparation process containing plant active peptides |
| CN111840118A (en) * | 2020-08-26 | 2020-10-30 | 惠州市蕙薏美生物科技有限公司 | Skin care preparation with hormone repairing face |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104706556A (en) | Antiallergic composition and application thereof in cosmetics | |
| Dharmananda | The Nature of Ginseng from Traditional Use to Modern Research | |
| CN102614102B (en) | Dandruff-removing medicinal composition and preparation method thereof | |
| CN103271346B (en) | Health-care food for relieving physical fatigue | |
| CN101690584A (en) | Functional food and medicine for clearing throat and preparation method thereof | |
| CN103463539A (en) | Drug for treating eczema, and preparation method and use thereof | |
| CN104187686A (en) | Health product for improving immunity | |
| Kulkarni et al. | Ginger supplementary therapy for iron absorption in iron deficiency anemia | |
| CN104825681A (en) | Traditional Chinese medicine composition for improving alimentary anemia | |
| Frost | Three popular medicinal mushroom supplements: A review of human clinical trials | |
| CN102430024B (en) | Traditional Chinese medicine composition, traditional Chinese medicinal preparation and traditional Chinese medicinal face mask | |
| CN103181561B (en) | Health food having effects of life cultivation and health preservation in autumn and preparation method thereof | |
| CN113398237B (en) | A kind of traditional Chinese medicine composition for antibacterial, antipruritic and antidandruff and preparation method thereof | |
| CN104800137B (en) | The applications of golden flower Flos Camelliae Japonicae extracts, preserving moisture and protecting skin composition and preparation method thereof | |
| Milind et al. | A Review on Aloe vera. | |
| CN105193650A (en) | Method for preparing ginseng and larix olgensis extract and application of ginseng and larix olgensis extract to aspect of cosmetics | |
| Kumar et al. | Safety and Toxicity of Botanical Medicines: A critical Appraisal | |
| CN100563467C (en) | Jelly of a kind of beauty treatment body-building and preparation method thereof | |
| CN107661272A (en) | Element shampoo | |
| CN108686157B (en) | Traditional Chinese medicine composition for preventing and treating blood stasis type nodules of breast, preparation method and pharmaceutical preparation thereof | |
| Stengler | The Natural Physician's Healing Therapies: Proven Remedies Medical Doctors Don't Know | |
| Ryabinina et al. | DEVELOPMENT OF CHEMICAL COMPOSITION OF TOPICAL DRUG FOR PSORIASIS THERAPY | |
| Wadnerwar et al. | A Critical Review on Haratala (An Arsenical Compound) | |
| Redfern | Improving acne, eczema and psoriasis in 30 days: Clear acne, eczema and psoriasis in 30 days: Healthy skin rehabilitation for the long term | |
| Rahman | Herbal drugs used in to cure different types of skin disorders |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150617 |
|
| RJ01 | Rejection of invention patent application after publication |