CN104666815A - Saliva-engendering and thirst slaking medicament for gestational diabetes mellitus and preparation method thereof - Google Patents
Saliva-engendering and thirst slaking medicament for gestational diabetes mellitus and preparation method thereof Download PDFInfo
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Abstract
The invention discloses saliva-engendering and thirst slaking medicament for gestational diabetes mellitus. The medicament is mainly prepared from the following medicinal raw materials in parts by weight: 6-12 parts of caltrops, 10-20 parts of mung bean hulls, 6-9 parts of water melonseeds, 8-12 parts of glossy privet fruits, 9-15 parts of circium japonicum, 5-10 parts of dogwood, 10-20 parts of roots of kudzu vines, 9-15 parts of rhizoma anemarrhenae, 8-14 parts of poria cocos, 6-12 parts of fermented soybeans, 7-12 parts of morinda officinalis, 5-10 parts of rhizoma alismatis, 6-12 parts of poria cocos, 8-12 parts of seeds of cowherb, 9-12 parts of leonurus, 7-12 parts of cacumen biotae and 5-8 parts of endothelium corneum gigeriae galli (grinding and mixing). The medicament can be prepared into various forms which are stable in component, and the curative effect is ensured. The formula disclosed by the invention has the functions of inducing diuresis and detoxifying, tonifying the liver and kidney, engendering saliva and slaking thirst, tonifying spleen and quieting the heart, invigorating stomach and promoting digestion and the like. The medicament disclosed by the invention is wide in medicine source, is a pure traditional Chinese medicine preparation, and the prepared product is good in curative effect, safe and free of any toxic and side effects.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of gestational diabetes promoting the production of body fluid to quench thirst medicament and preparation method thereof.
Background technology
Diabetes are one group take hyperglycemia as the metabolic disease of feature caused by defect of insulin secretion or insulin action obstacle.Persistent high blood sugar and long-term metabolic are disorderly etc. can cause body tissue's organ, particularly eye, kidney, cardiovascular and neural infringement and dysfunction thereof and exhaustion.Severe patient can cause dehydration, the acute complications such as electrolyte disturbance and acid base imbalance ketoacidosis and Hyperosmotic coma.Gestational diabetes, also known as pregnancy associated with diabetes, refers to that appearance merges pregnant disease on the basis of original diabetes, or for developing into the situation of diabetes after latent diabetes, gestation before gestation.Belong to high risk pregnancy, all have larger harm to female youngster.Be applied to clinical from insulin, diabetes pregnant and lying-in women and neonatal mortality thereof all significantly decline.But the clinical course of pregnant and lying-in women's diabetes is more complicated, mother and baby's mortality rate is still higher so far, has caused the attention of medical profession.Gestational diabetes is that pregnancy duration finds or the hyperglycemia in various degree caused by impaired glucose tolerance and diabetes in various degree of morbidity.According to its definition, namely this paradiabetes has existed before comprising gestation but pregnancy duration is just diagnosed and 2 classes that occur along with trimester of pregnancy, while it both comprised diabetes, comprise impaired glucose tolerance again and fasting glucose is bad.Some patients i.e. diagnosing diabetes or impaired glucose tolerance before gestation, after gestation, sustainable existence or Progressive symmetric erythrokeratodermia increase the weight of.Patients with Gestational Diabetes Mellitus, great majority point puerperium blood sugar recoveries are normal, so Patients with Gestational Diabetes Mellitus all again will detect blood glucose or carry out glucose tolerance test 6 weeks puerperal, to be divided into the bad and euglycemia of diabetes, impaired glucose tolerance, fasting glucose.Pregnancy associated with diabetes treatment with western method adopts insulin, and diabetics about has 90% need use insulin in trimester of pregnancy, and the alone diet control of all the other patients is enough.Daily insulinize: use of exogenous insulin generally selects intermediate-acting insulins to mix in 2:1 ratio with short-acting insulin, gives 2/3 of accumulated dose during breakfast.Inject remaining 1/3 dosage during dinner (or remaining mixt amount to be injected respectively, namely inject short-acting insulin during dinner, inject intermediate-acting insulins before sleeping, to reduce the generation of Nocturnal hypoglycemia.I.e. so-called " day three " injection treatment).In addition, also have Pregnant Women to need to add during lunch with short-acting insulin, thus form " day four " injection treatment.
Publication number CN 104042974 A(application number 201410248966.7) Chinese patent literature disclose the Chinese medicine for the treatment of diabetes, former medicine composition has Herba Schizonepetae 9-15 part, Ramulus Cinnamomi 5-10 part, Radix Achyranthis Bidentatae 5-15 part, Radix Paeoniae Rubra 6-12 part, Olibanum 5-15 part, Folium Artemisiae Argyi 10-15 part, Indigo Naturalis 10-15 part, Squama Manis 3-9 part, Herba Artemisiae Anomalae 10-15 part, Semen Platycladi 6-15 part, Talcum 10-20 part, Scolopendra 3-5 part, Semen Phaseoli 10-20 part, Semen Coicis 10-20 part, Rhizomadioscoreae 10-20 part, Fructus Lycii 10-20 part, Rhizoma Polygonati 10-20 part.Publication number CN 103751344 A(application number 201410037776.0) Chinese patent literature disclose treatment diabetes medicine, primary raw material has Radix Aconiti Lateralis Preparata 5 ~ 15 parts, Cortex Cinnamomi 1 ~ 5 part, Radix Morindae Officinalis 5 ~ 15 parts.Publication number CN 103599381 A(application number 201310504101.8) Chinese patent literature disclose treatment diabetes Chinese medicine, it is by weight portion Rhizoma Atractylodis 20 ~ 60, weight portion Rhizoma Alismatis 20 ~ 60, weight portion Radix Puerariae 20 ~ 50, weight portion Herba Dendrobii 5 ~ 15, weight portion Radix Astragali 25 ~ 55, weight portion Radix Salviae Miltiorrhizae 10 ~ 30, weight portion Radix Scrophulariae 5 ~ 15, weight portion Radix Ophiopogonis 20 ~ 40, weight portion Rhizoma Dioscoreae 10 ~ 30, weight portion Ramulus Euonymi 20 ~ 40, making of the weight portion Radix Rehmanniae 10 ~ 30.
At present, though Chinese medicine has about the formula for the treatment of diabetes, but almost do not have for the formula of Patients with Gestational Diabetes Mellitus, the research of this respect has wide Research Prospects, thus, there is the traditional Chinese medical science formula needing to work out a kind of immunotherapy targeted autoantibody gestational diabetes, ensure that curative effect is safe and reliable, without any side effects to mother and baby.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of gestational diabetes promoting the production of body fluid to quench thirst medicament and preparation method thereof taking safety, stable curative effect.
Technical scheme of the present invention is:
Gestational diabetes promoting the production of body fluid to quench thirst medicament, is prepared from primarily of following bulk drugs, is weight portion: Fructus Tribuli 6-12, Testa Phaseoli radiati 10-20, Semen Citrulli 6-9, Fructus Ligustri Lucidi 8-12, Radix Cirsii Japonici 9-15, Fructus Corni 5-10, Radix Puerariae 10-20, Rhizoma Anemarrhenae 9-15, Poria 8-14, Semen Sojae Preparatum 6-12, Radix Morindae Officinalis 7-12, Rhizoma Alismatis 5-10, Poria 6-12, Semen Vaccariae 8-12, Herba Leonuri 9-12, Cacumen Platycladi 7-12, Endothelium Corneum Gigeriae Galli (grind into powder and take after mixing it with water) 5-8.
In preferred scheme, Fructus Tribuli 7-11, Testa Phaseoli radiati 12-18, Semen Citrulli 7-8, Fructus Ligustri Lucidi 9-11, Radix Cirsii Japonici 11-13, Fructus Corni 6-9, Radix Puerariae 12-18, Rhizoma Anemarrhenae 11-13, Poria 9-13, Semen Sojae Preparatum 8-10, Radix Morindae Officinalis 9-10, Rhizoma Alismatis 6-9, Poria 8-10, Semen Vaccariae 9-11, Herba Leonuri 10-11, Cacumen Platycladi 8-11, Endothelium Corneum Gigeriae Galli (grind into powder and take after mixing it with water) 6-7.
Be more preferably, Fructus Tribuli 9, Testa Phaseoli radiati 15, Semen Citrulli 7.5, Fructus Ligustri Lucidi 10, Radix Cirsii Japonici 12, Fructus Corni 7.5, Radix Puerariae 15, the Rhizoma Anemarrhenae 12, Poria 11, Semen Sojae Preparatum 9, Radix Morindae Officinalis 9.5, Rhizoma Alismatis 7.5, Poria 9, Semen Vaccariae 10, Herba Leonuri 10.5, Cacumen Platycladi 9.5, Endothelium Corneum Gigeriae Galli (grind into powder and take after mixing it with water) 6.5.
The preparation method of described gestational diabetes promoting the production of body fluid to quench thirst medicament decoction is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, be placed in steamer steam 10-20 minute (preferred, steam 12-18 minute; More be added with choosing, steam 15 minutes), take out, dry in the air cool;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry, grind into powder;
(4) by other crude drug except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, decontamination, clean, with step (2) made crude drug, be placed in marmite together, add the water soaking of boiled crude drug quality 7 times after 20 minutes, be heated to boiling, continue 10 minutes, a turn little fire boils 20-40 minute, and (preferred, a turn little fire boils 25-35 minute; Be more preferably, turn little fire and boil 30 minutes), filter, collect filtrate;
(5) while hot step (1) and (3) made crude drug are added in step (4) made filtrate together with mature vinegar, stir, obtain decoction.
The preparation method of described gestational diabetes promoting the production of body fluid to quench thirst medicament decoction, the amount of step (5) mature vinegar is the 0.5-1.0 of Endothelium Corneum Gigeriae Galli quality doubly (preferred, the amount of mature vinegar is 0.8 times of Endothelium Corneum Gigeriae Galli quality).
The preparation method of described powder is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, be placed in steamer steam 10-20 minute (preferred, steam 12-18 minute; More be added with choosing, steam 15 minutes), take out, dry in the air cool;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry in the air cool;
(4) by other medical material decontaminations except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, clean, dry together with step (1) (2) (3) made crude drug, pulverize and sieve, mix homogeneously, obtains powder.
The preparation method of described gestational diabetes promoting the production of body fluid to quench thirst medicament powder, step (4) was pulverized 200-320 mesh sieve and (preferably, was pulverized 220-300 mesh sieve; Be more preferably, pulverized 260 mesh sieves).
The preparation method of described capsule is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, be placed in steamer steam 10-20 minute (preferred, steam 12-18 minute; More be added with choosing, steam 15 minutes), take out, dry in the air cool;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry in the air cool;
(4) by other medical material decontaminations except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, clean, dry together with step (1) (2) (3) made crude drug, pulverized 260 mesh sieves, and obtained medicated powder, mix homogeneously, medicated powder is incapsulated, and obtained capsule.
The preparation method of described gestational diabetes promoting the production of body fluid to quench thirst drug capsule agent, heavy 0.4-0.6g(is preferred for the every capsules of step (4), the heavy 0.5g of every capsules).
The preparation method of described unguentum is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, be placed in steamer steam 10-20 minute (preferred, steam 12-18 minute; More be added with choosing, steam 15 minutes), take out, dry;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry;
(4) by other medical material decontaminations except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, clean, 200 mesh sieves were pulverized together with step (1) (2) (3) made crude drug, be placed in pot, after soaking with boiled water (boiled water did not have medicated powder 3cm), add flour slurry to stir evenly, heating is boiled into paste, obtains unguentum.
The preparation method of described gestational diabetes promoting the production of body fluid to quench thirst medicament unguentum, step (4) boiled water soaks 20-30 minute, and (preferred, boiled water soaks 22-28 minute; Be more preferably, boiled water soaks 25 minutes).
Gestational diabetes promoting the production of body fluid to quench thirst medicament provided by the invention, can be prepared into multiple dosage form, taking convenience, be easy to carry.In addition, excellent results of the present invention also shows:
1, the present invention can be prepared into multiple dosage form, and each dosage form components is stablized, and ensures curative effect;
2, this prescription has the effects such as diuresis removing toxic substances, liver and kidney tonifying, promoting the production of body fluid to quench thirst, spleen invigorating mind calming, invigorating the stomach and promoting digestion;
3, medicine source of the present invention is wide, pure Chinese medicinal preparation, products made thereby good effect, and safety is without any side effects.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1gestational diabetes promoting the production of body fluid to quench thirst medicament, is prepared from primarily of following bulk drugs, every part of 8g: Fructus Tribuli 6 parts, Testa Phaseoli radiati 10 parts, Semen Citrulli 6 parts, Fructus Ligustri Lucidi 8 parts, Radix Cirsii Japonici 9 parts, Fructus Corni 5 parts, Radix Puerariae 10 parts, the Rhizoma Anemarrhenae 9 parts, 8 parts, Poria, Semen Sojae Preparatum 6 parts, Radix Morindae Officinalis 7 parts, Rhizoma Alismatis 5 parts, 6 parts, Poria, Semen Vaccariae 8 parts, Herba Leonuri 9 parts, Cacumen Platycladi 7 parts, Endothelium Corneum Gigeriae Galli (grind into powder and take after mixing it with water) 5 parts.
The preparation method of above-mentioned gestational diabetes promoting the production of body fluid to quench thirst medicament decoction is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, is placed in steamer and steams 15 minutes, take out, dry in the air cool;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry, grind into powder;
(4) by other crude drug except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, decontamination, clean, and step (2) made crude drug, be placed in marmite together, add the water soaking of boiled crude drug quality 7 times after 20 minutes, be heated to boiling, continue 10 minutes, turn little fire and boil 30 minutes, filter, collect filtrate;
(5) while hot step (1) and (3) made crude drug are added in step (4) made filtrate together with mature vinegar (amount of mature vinegar is 0.8 times of Endothelium Corneum Gigeriae Galli quality), stir, obtain decoction.
The instructions of taking of decoction of the present invention: decoction is 7 days courses for the treatment of, (warm) taken three times a day, each 50m1-80m1.
embodiment 2gestational diabetes promoting the production of body fluid to quench thirst medicament, is prepared from primarily of following bulk drugs, every part of 8g: Fructus Tribuli 12 parts, Testa Phaseoli radiati 20 parts, Semen Citrulli 9 parts, Fructus Ligustri Lucidi 12 parts, Radix Cirsii Japonici 15 parts, Fructus Corni 10 parts, Radix Puerariae 20 parts, the Rhizoma Anemarrhenae 15 parts, 14 parts, Poria, Semen Sojae Preparatum 12 parts, Radix Morindae Officinalis 12 parts, Rhizoma Alismatis 10 parts, 12 parts, Poria, Semen Vaccariae 12 parts, Herba Leonuri 12 parts, Cacumen Platycladi 12 parts, Endothelium Corneum Gigeriae Galli (grind into powder and take after mixing it with water) 8 parts.
The preparation method of gestational diabetes promoting the production of body fluid to quench thirst medicament powder is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, is placed in steamer and steams 15 minutes, take out, dry in the air cool;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry in the air cool;
(4) by other medical material decontaminations except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, clean, dry together with step (1) (2) (3) made crude drug, pulverized 260 mesh sieves, mix homogeneously, and obtained powder.
Model case: xxx, female, 36 years old.Conceived 27 weeks, self-induction was weak, waist hypodynia, urinary micturition, dry mouth with parched lips, medical check, patient has denied diabetic history, blood glucose 6.3mmol/L on an empty stomach, does further 50g glucose tolerance inspection, after taking sugared 1h, blood glucose value 8.3mmol/L, to have a physical examination other indices, be showed no exception, be diagnosed as gestational diabetes.
Take the present embodiment gained gestational diabetes promoting the production of body fluid to quench thirst medicament powder, each one bag, every day 2 times, warm boiled water, 7 days courses for the treatment of.After taking 2 days, blood sugar recovery is extremely normal, after taking 5 days, xerostomia, lumbago is obviously alleviated, after taking one week, malaise symptoms disappears, after continuing to take two weeks, and check, blood sugar recovery in normal range, patient fully recover, after again without recur, until fertility, neonate is healthy, without exception, and puerperal, patient blood glucose was normal.
embodiment 3gestational diabetes promoting the production of body fluid to quench thirst medicament, is prepared from primarily of following bulk drugs, every part of 8g: Fructus Tribuli 7 parts, Testa Phaseoli radiati 12 parts, Semen Citrulli 7 parts, Fructus Ligustri Lucidi 9 parts, Radix Cirsii Japonici 11 parts, Fructus Corni 6 parts, Radix Puerariae 12 parts, the Rhizoma Anemarrhenae 11 parts, 9 parts, Poria, Semen Sojae Preparatum 8 parts, Radix Morindae Officinalis 9 parts, Rhizoma Alismatis 6 parts, 8 parts, Poria, Semen Vaccariae 9 parts, Herba Leonuri 10 parts, Cacumen Platycladi 8 parts, Endothelium Corneum Gigeriae Galli (grind into powder and take after mixing it with water) 6 parts.
The preparation method of gestational diabetes promoting the production of body fluid to quench thirst drug capsule agent is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, is placed in steamer and steams 15 minutes, take out, dry in the air cool;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry in the air cool;
(4) by other medical material decontaminations except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, clean, dry together with step (1) (2) (3) made crude drug, pulverized 260 mesh sieves, obtained medicated powder, mix homogeneously, incapsulated by medicated powder, the heavy 0.5g of every capsules, obtains capsule.
Model case: xxx, female, 29 years old.Conceived existing 32 weeks, weight ratio pregnancy increased by 30 jin nearly, within nearly one week, came, polyphagia, easy famine, constipation with dry stool, red tongue with yellow fur, medical check, B ultrasonic display fetus is bigger than normal, blood sugar test, on an empty stomach, blood glucose is 6.8mmol/L, and patient has denied diabetic history, do 75g glucose tolerance inspection further, 1h, blood glucose >=10.5mmol/L after clothes sugar, 2h after clothes sugar, blood glucose >=9.0mmol/L, is diagnosed as gestational diabetes.
Take the agent of the present embodiment gained gestational diabetes promoting the production of body fluid to quench thirst drug capsule, every day three times, each 4, with warm water delivery service, 7 days courses for the treatment of.Take two days later, patient's fasting glucose is down to 6.1mmol/L, and after continuing to take one week, patient's fasting glucose returns to 4.6mmol/L, dietary, the mental status is good, and consolidate curative effect takes again two courses for the treatment of, and patient checks, health indices is all normal, next girl baby of last cesarean, healthy, puerperal, patient blood glucose was normal.
embodiment 4gestational diabetes promoting the production of body fluid to quench thirst medicament, is prepared from primarily of following bulk drugs, every part of 8g: Fructus Tribuli 11 parts, Testa Phaseoli radiati 18 parts, Semen Citrulli 8 parts, Fructus Ligustri Lucidi 11 parts, Radix Cirsii Japonici 13 parts, Fructus Corni 9 parts, Radix Puerariae 18 parts, the Rhizoma Anemarrhenae 13 parts, 13 parts, Poria, Semen Sojae Preparatum 10 parts, Radix Morindae Officinalis 10 parts, Rhizoma Alismatis 9 parts, 10 parts, Poria, Semen Vaccariae 11 parts, Herba Leonuri 11 parts, Cacumen Platycladi 11 parts, Endothelium Corneum Gigeriae Galli (grind into powder and take after mixing it with water) 7 parts.
The preparation method of gestational diabetes promoting the production of body fluid to quench thirst medicament unguentum is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, is placed in steamer and steams 15 minutes, take out, dry;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry;
(4) by other medical material decontaminations except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, clean, 200 mesh sieves were pulverized together with step (1) (2) (3) made crude drug, be placed in pot, after soaking 25 minutes with boiled water (boiled water did not have medicated powder 3cm), add flour slurry to stir evenly, heating is boiled into paste, obtains unguentum.
Model case: xxx, female, 32 years old.During 36 weeks pregnancy periods, self-induction excessive thirst polydipsia, dry mouth and tougue, with frequent micturition, the symptom such as weak, medical check, patient has denied diabetic history, and B ultrasonic display normal fetal, checks blood glucose, blood glucose value 6.6mmol/L on an empty stomach, carries out 75g glucose tolerance test, 1h after clothes sugar, whole blood blood glucose 10.9mmol/L, 2h, whole blood blood glucose 9.1mmol/L after clothes sugar, other check that display is without complication, without glucose in urine, is diagnosed as gestational diabetes.
Take the present embodiment gained gestational diabetes promoting the production of body fluid to quench thirst medicament unguentum, every day three times, each 5-10ml, with warm boiled water, 7 days courses for the treatment of.Take medicine two days later, blood glucose is just down to normal range, after taking medicine one week, patient's malaise symptoms disappears completely, blood glucose maintained in normal range always, consolidated after taking two courses for the treatment of, check of seeking medical advice, health indices is all normal, fetus also grows normally, and patient blood glucose recovers normal value, and patient fully recovers, next healthy boy baby of natural labor, puerperal, patient blood glucose was normal.
embodiment 5gestational diabetes promoting the production of body fluid to quench thirst medicament, is prepared from primarily of following bulk drugs, every part of 8g: Fructus Tribuli 9 parts, Testa Phaseoli radiati 15 parts, Semen Citrulli 7.5 parts, Fructus Ligustri Lucidi 10 parts, Radix Cirsii Japonici 12 parts, Fructus Corni 7.5 parts, Radix Puerariae 15 parts, the Rhizoma Anemarrhenae 12 parts, 11 parts, Poria, Semen Sojae Preparatum 9 parts, Radix Morindae Officinalis 9.5 parts, Rhizoma Alismatis 7.5 parts, 9 parts, Poria, Semen Vaccariae 10 parts, Herba Leonuri 10.5 parts, Cacumen Platycladi 9.5 parts, Endothelium Corneum Gigeriae Galli (grind into powder and take after mixing it with water) 6.5 parts.
The preparation method of gestational diabetes promoting the production of body fluid to quench thirst medicament decoction is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, is placed in steamer and steams 15 minutes, take out, dry in the air cool;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry, grind into powder;
(4) by other crude drug except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, decontamination, clean, and step (2) made crude drug, be placed in marmite together, add the water soaking of boiled crude drug quality 7 times after 20 minutes, be heated to boiling, continue 10 minutes, turn little fire and boil 30 minutes, filter, collect filtrate;
(5) while hot step (1) and (3) made crude drug are added in step (4) made filtrate together with mature vinegar (amount of mature vinegar is 0.8 times of Endothelium Corneum Gigeriae Galli quality), stir, obtain decoction.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Tribuli: base is former: be the dry mature fruit of zygophyllaceae plant Fructus Tribuli.Nature and flavor: pungent, bitter, tepor; Slightly poisonous.Gui Jing: return Liver Channel.Function cures mainly: suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, and improving eyesight is antipruritic.Dizzy for having a headache, distending pain in the chest and hypochondrium, breast closes acute mastitis, cataract, rubella pruritus.
Testa Phaseoli radiati: base is former: be the seed coat of leguminous plant Semen phaseoli radiati.Nature and flavor: sweet in the mouth; Cold in nature.Gui Jing: lung; Liver Channel.Function cures mainly: clearing away summer-heat quenches the thirst; Diuresis is detoxified; Move back corneal nebula.Main summer-heat excessive thirst; Have loose bowels; Dysentery; Edema; Erysipelas; Corneal nebula.
Semen Citrulli: base is former: be the kernel of cucurbitaceous plant Citrullus vulgaris.Nature and flavor: sweet are flat.Gui Jing: return lung; Large intestine channel.Function cures mainly: removing heat from the lung and dissipating phlegm; With middle intestine moistening.Main just chronic cough; Spitting of blood; Constipation.
Fructus Ligustri Lucidi: base is former: be the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi.Nature and flavor: sweet, bitter, cold.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Radix Cirsii Japonici: base is former: be the aerial parts of feverfew Ji.Nature and flavor: sweet are cool.Function cures mainly: cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling.Cure mainly: epistaxis, spitting of blood, spit blood, hematuria, dysfunctional uterine hemorrhage, postpartum hemorrhage, hepatitis, nephritis, mastitis, traumatic injury; Traumatic hemorrhage is controlled in external, carbuncle furuncle and phyma poison.
Fructus Corni: base is former: be the drying and ripening sarcocarp of Cornaceae plant Fructus Corni.Nature and flavor: sour, puckery, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat is quenched one's thirst.
Radix Puerariae: base is former: be the dry root of legume pueraria lobata or Radix Puerariae rattan.Nature and flavor: sweet, pungent, cool.Gui Jing: return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
The Rhizoma Anemarrhenae: base is former: be the dry rhizome of the liliaceous plant Rhizoma Anemarrhenae.Nature and flavor: bitter, sweet, cold.Gui Jing: return lung, stomach, kidney channel.Function cures mainly: clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Poria: base is former: be the dry sclerotia of On Polyporaceae Poria.Nature and flavor: sweet, light are flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Semen Sojae Preparatum: base is former: be the fermentation processing product of the mature seed of legume soybean.Nature and flavor: bitter, pungent, cool.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: induce sweat, relieving restlessness, and a surname sends out hot and suffocating.For flu, cold and heat headache, fidgety uncomfortable in chest, restlessness of asrhenia type and insomnia.
Radix Morindae Officinalis: base is former: be the dry root of Maguireothamnus speciosus Radix Morindae Officinalis.Nature and flavor: sweet, pungent, tepor.Gui Jing: return kidney, Liver Channel.Function cures mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Rhizoma Alismatis: base is former: be the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.Nature and flavor: sweet, cold.Gui Jing: return kidney, urinary bladder channel.Function cures mainly: diuresis, clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.
Poria: base is former: be the dry sclerotia of On Polyporaceae Poria.Nature and flavor: sweet, light are flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Semen Vaccariae: base is former: be the dry mature seed of pinkwort Vaccaria segetalis.Nature and flavor: bitter are flat.Gui Jing: return liver, stomach warp.Function cures mainly: promoting blood circulation to restore menstrual flow, and stimulating milk secretion is subsided a swelling.For agalactia, amenorrhea, dysmenorrhea, acute mastitis swells and ache.
Herba Leonuri: base is former: be the fresh of labiate Herba Leonuri or dry aerial parts.Nature and flavor: bitter, pungent, are slightly cold.Gui Jing: return liver, pericardium channel.Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Cacumen Platycladi: base is former: be the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi.Nature and flavor: bitter, puckery, cold.Gui Jing: return lung, liver, spleen channel.Function cures mainly: cooling blood for hemostasis, growing and blacking hair.For hematemesis and epistaxis, spitting of blood, has blood in stool, metrostaxis, heat in blood alopecia, early whitening of beard and hair.
Endothelium Corneum Gigeriae Galli: base is former: be the dry inner wall of sandbag of Phasianidae animal man chicken.Nature and flavor: sweet are flat.Gui Jing: return spleen, stomach, small intestinal, urinary bladder channel.Function cures mainly: invigorating the stomach and promoting digestion, arresting seminal emission.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission.
test example 1the clinical practice of gained gestational diabetes promoting the production of body fluid to quench thirst medicament decoction (embodiment 5) of the present invention:
Testing data: from obstetrics and gynecology hospital and filter out the patient that 357 examples are diagnosed as gestational diabetes, age 20-43 year, 34.6 years old mean age, wherein primipara 206 example, multipara 151 example, pregnant all 24-40 weeks, average pregnant all 36.4 weeks.All experimenters are all without pregnant front diabetes medical history.Diagnostic criteria: with reference to international diabetes and pregnant seminar (2010) standard, the normal anemia of pregnant woman of trimester blood sugar test, gestation 24-28 week and 28 weeks directly carries out 75g glucose tolerance test later, on an empty stomach after kimonos sugar 1, the whole blood glucose diagnostic dividing value of 2h is respectively 5.1,10.0,8.5mml/L, any one meets or exceeds above-mentioned dividing value can be diagnosed as gestational diabetes.
Inclusive criteria: the primipara meeting diagnostic criteria all can enter group; Exclusion standard: get rid of and previously have the disease medical history persons such as diabetes, prediabetes, polycystic ovarian syndrome, metabolism syndrome; There are the pregnancy complication persons such as hypertensive disorder in pregnancy, premature labor, multiple pregnancy; Be associated with other severe primary disease patients.
Patient is divided into two groups at random, experimental group and matched group, two groups in age, pregnant week, final recognition, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, (warm) taken three times a day, each 50m1-80m1(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of, matched group takes other medicine (conventional medication such as Glipizide controlled release tablets, phenformin hydrochloride tablet, glyburide, glipizide tablet).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect situation criterion: cure: clinical malaise symptoms disappears, and blood sugar recovery is to normal range; Effective: clinical malaise symptoms obviously alleviates or cardinal symptom disappears, blood glucose close to diagnosis dividing value, but reaches normal value not yet; Invalid: after taking, clinical malaise symptoms is not improved, and blood glucose is still higher.
Table 1 liang group patient treatment outcome
Through Ureteral Calculus, show that two groups of patient treatment outcome are as shown in table 1, in table, experimental group patient cures 169 examples (79.7%), effective 38 examples (17.9%), and invalid 5 examples (2.4%), experimental group total effective rate is 97.6%.The healing example of matched group and effective example are respectively 61(42.1%) and 56(38.6%), the total effective rate of matched group is 80.7%, it can thus be appreciated that the therapeutic effect of matched group is obviously not so good as the good of experimental group.Illustrate that products made thereby of the present invention has the effect for the treatment of gestational diabetes preferably, and in therapeutic process, it is good that the malaise symptoms of experimental group patient improves that situation also comparatively contrasts,, during two groups of patient treatments, all there is not any untoward reaction in good all compared with matched group patient of the mental status of experimental group patient and diet situation.Experimental group treats effective patient, finally all gives birth to neonate, and neonate is healthy, and puerperal, patient blood glucose all recovered normal.
Reasonable material of the present invention, the Fructus Tribuli suppressing the hyperactive liver resolving depression in formula, promoting blood circulation by removing wind; Testa Phaseoli radiati clearing away summer-heat quenches the thirst, diuresis removing toxic substances; Semen Citrulli removing heat from the lung and dissipating phlegm and middle intestine moistening; Fructus Ligustri Lucidi nourishing the liver and kidney; Radix Cirsii Japonici cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling; Fructus Corni liver and kidney tonifying, essence astringing and desertion stemming; Radix Puerariae expelling pathogenic factors from muscles for reducing heat, rash of promoting the production of body fluid; Rhizoma Anemarrhenae clearing away heat-fire, promote the production of body fluid and moisturize; Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; Semen Sojae Preparatum induce sweat relieving restlessness, a surname send out hot and suffocating; Radix Morindae Officinalis kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; Rhizoma Alismatis diuresis, clearing away damp-heat; Semen Vaccariae promoting blood circulation to restore menstrual flow, stimulating milk secretion are subsided a swelling; Herba Leonuri promoting blood flow to regulate menstruation, inducing diuresis to remove edema; Cacumen Platycladi cooling blood for hemostasis, growing and blacking hair; Endothelium Corneum Gigeriae Galli invigorating the stomach and promoting digestion, arresting seminal emission, the present invention selects medicine prudent, and guarantee safety, curative effect is reliable.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. gestational diabetes promoting the production of body fluid to quench thirst medicament, is characterized in that, is prepared from primarily of following bulk drugs, is weight portion: Fructus Tribuli 6-12, Testa Phaseoli radiati 10-20, Semen Citrulli 6-9, Fructus Ligustri Lucidi 8-12, Radix Cirsii Japonici 9-15, Fructus Corni 5-10, Radix Puerariae 10-20, Rhizoma Anemarrhenae 9-15, Poria 8-14, Semen Sojae Preparatum 6-12, Radix Morindae Officinalis 7-12, Rhizoma Alismatis 5-10, Poria 6-12, Semen Vaccariae 8-12, Herba Leonuri 9-12, Cacumen Platycladi 7-12, Endothelium Corneum Gigeriae Galli (grind into powder and take after mixing it with water) 5-8.
2. gestational diabetes promoting the production of body fluid to quench thirst medicament as claimed in claim 1, it is characterized in that, Fructus Tribuli 7-11, Testa Phaseoli radiati 12-18, Semen Citrulli 7-8, Fructus Ligustri Lucidi 9-11, Radix Cirsii Japonici 11-13, Fructus Corni 6-9, Radix Puerariae 12-18, Rhizoma Anemarrhenae 11-13, Poria 9-13, Semen Sojae Preparatum 8-10, Radix Morindae Officinalis 9-10, Rhizoma Alismatis 6-9, Poria 8-10, Semen Vaccariae 9-11, Herba Leonuri 10-11, Cacumen Platycladi 8-11, Endothelium Corneum Gigeriae Galli (grind into powder and take after mixing it with water) 6-7 is (preferred, Fructus Tribuli 9, Testa Phaseoli radiati 15, Semen Citrulli 7.5, Fructus Ligustri Lucidi 10, Radix Cirsii Japonici 12, Fructus Corni 7.5, Radix Puerariae 15, the Rhizoma Anemarrhenae 12, Poria 11, Semen Sojae Preparatum 9, Radix Morindae Officinalis 9.5, Rhizoma Alismatis 7.5, Poria 9, Semen Vaccariae 10, Herba Leonuri 10.5, Cacumen Platycladi 9.5, Endothelium Corneum Gigeriae Galli (grind into powder and take after mixing it with water) 6.5).
3. the gestational diabetes promoting the production of body fluid to quench thirst medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, be placed in steamer steam 10-20 minute (preferred, steam 12-18 minute; More be added with choosing, steam 15 minutes), take out, dry in the air cool;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry, grind into powder;
(4) by other crude drug except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, decontamination, clean, with step (2) made crude drug, be placed in marmite together, add the water soaking of boiled crude drug quality 7 times after 20 minutes, be heated to boiling, continue 10 minutes, a turn little fire boils 20-40 minute, and (preferred, a turn little fire boils 25-35 minute; Be more preferably, turn little fire and boil 30 minutes), filter, collect filtrate;
(5) while hot step (1) and (3) made crude drug are added in step (4) made filtrate together with mature vinegar, stir, obtain decoction.
4. the preparation method of gestational diabetes promoting the production of body fluid to quench thirst medicament decoction as claimed in claim 3, is characterized in that, the amount of step (5) mature vinegar is the 0.5-1.0 of Endothelium Corneum Gigeriae Galli quality doubly (preferred, the amount of mature vinegar is 0.8 times of Endothelium Corneum Gigeriae Galli quality).
5. the gestational diabetes promoting the production of body fluid to quench thirst medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, be placed in steamer steam 10-20 minute (preferred, steam 12-18 minute; More be added with choosing, steam 15 minutes), take out, dry in the air cool;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry in the air cool;
(4) by other medical material decontaminations except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, clean, dry together with step (1) (2) (3) made crude drug, pulverize and sieve, mix homogeneously, obtains powder.
6. the preparation method of gestational diabetes promoting the production of body fluid to quench thirst medicament powder as claimed in claim 5, is characterized in that, step (4) was pulverized 200-320 mesh sieve and (preferably, pulverized 220-300 mesh sieve; Be more preferably, pulverized 260 mesh sieves).
7. the gestational diabetes promoting the production of body fluid to quench thirst medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, be placed in steamer steam 10-20 minute (preferred, steam 12-18 minute; More be added with choosing, steam 15 minutes), take out, dry in the air cool;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry in the air cool;
(4) by other medical material decontaminations except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, clean, dry together with step (1) (2) (3) made crude drug, pulverized 260 mesh sieves, and obtained medicated powder, mix homogeneously, medicated powder is incapsulated, and obtained capsule.
8. the preparation method of gestational diabetes promoting the production of body fluid to quench thirst drug capsule agent as claimed in claim 7, is characterized in that, heavy 0.4-0.6g(is preferred for the every capsules of step (4), the heavy 0.5g of every capsules).
9. the gestational diabetes promoting the production of body fluid to quench thirst medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) Semen Citrulli is picked clean impurity together with Oryza glutinosa, be placed in the micro-roasting of pot, after rice is ripe, take out, sieve removes rice, smashs to pieces;
(2) extracting liquorice is smashed to pieces, decocts with water, then puts into Rhizoma Alismatis and mix thoroughly, treats that water exhausts, pulls Rhizoma Alismatis out, be placed in steamer steam 10-20 minute (preferred, steam 12-18 minute; More be added with choosing, steam 15 minutes), take out, dry;
(3) Endothelium Corneum Gigeriae Galli being cleaned, be placed in frying pan, frying to heaving, take out, dry;
(4) by other medical material decontaminations except Semen Citrulli, Rhizoma Alismatis and Endothelium Corneum Gigeriae Galli, clean, 200 mesh sieves were pulverized together with step (1) (2) (3) made crude drug, be placed in pot, after soaking with boiled water (boiled water did not have medicated powder 3cm), add flour slurry to stir evenly, heating is boiled into paste, obtains unguentum.
10. the preparation method of gestational diabetes promoting the production of body fluid to quench thirst medicament unguentum as claimed in claim 9, is characterized in that, step (4) boiled water soaks 20-30 minute, and (preferred, boiled water soaks 22-28 minute; Be more preferably, boiled water soaks 25 minutes).
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| CN101091765A (en) * | 2007-06-08 | 2007-12-26 | 余仁生国际有限公司 | Medicinal comsns-and usage for preventing and treating diabets mellitus |
| CN102100813A (en) * | 2009-12-17 | 2011-06-22 | 苏州知微堂生物科技有限公司 | Preparation technology of new integrative formulation of poria five powder and production method thereof |
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| CN101091765A (en) * | 2007-06-08 | 2007-12-26 | 余仁生国际有限公司 | Medicinal comsns-and usage for preventing and treating diabets mellitus |
| CN102100813A (en) * | 2009-12-17 | 2011-06-22 | 苏州知微堂生物科技有限公司 | Preparation technology of new integrative formulation of poria five powder and production method thereof |
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