CN104664160A - Composite particle preparation having physiological functions for freshwater fishes and production method of composite particle preparation - Google Patents
Composite particle preparation having physiological functions for freshwater fishes and production method of composite particle preparation Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Abstract
The invention relates to a composite particle preparation having physiological functions for freshwater fishes and a production method of the composite particle preparation. The composite particle preparation is produced from 50-100 parts of composite traditional Chinese medicine, 50-100 parts of feed complex enzyme, 60-100 parts of immunopolysaccharide, 30-80 parts of an acidifying agent, 200-500 parts of montmorillonite, 60-100 parts of activated carbon and 400-500 parts of oil bran; the production method comprises the following steps: crushing the large-particle raw materials until the particle size is 40 meshes, evenly mixing and then granulating by use of a feed granulator and cooling to obtain the composite particle preparation. The composite particle preparation has the effects of protecting the liver, increasing the activity of the digestive enzyme, enhancing digestive absorption and reducing the feed coefficient, adsorbing and immobilizing harmful microorganisms in the digestive track, boosting the immunity of the organism and improving the disease resistance, and reducing the excretion of phosphorus and organic matters in excrement and reducing water quality deterioration; besides, the composite particle preparation has no residue in the bodies of fishes and has remarkable physiological effects; furthermore, the composite particle preparation is safe and non-toxic without side effects, energy-saving and environmentally friendly, and capable of reducing the pollution of the breeding environment, and has remarkable economic and social benefits.
Description
Technical field
The present invention relates to technical field of aquaculture, be specifically related to a kind of freshwater fish composite particles preparation with physiological function and preparation method thereof.
Background technology
The continuous intensivization development of Fish-water Fish Farming, along with cultivation density constantly increases, a large amount of uses of commercial feed, cause fish culture environment constantly to worsen, body eutrophication, regulating and controlling water quality difficulty strengthens, fish immunity power declines, and disease is multiple and complicated, and result for the treatment of is not good; In addition commercial feed holds at high price, and aquaculture cost significantly rises, and feed coefficient is difficult to significantly reduce, and culture benefit is low.
Compound formulations more of the prior art often function singleness, only have part physiological function, effect is also undesirable; And due to the lubricity of raw material and bond degree inadequate, result in the granulation difficulty of raw material.Many present situations impel research and development one to have growth promoting effects, strengthen immunity of organisms, and reduce the excretion of ight soil organic matter, the feed addictive that safety non-toxic has no side effect is extremely urgent.
Summary of the invention
Object of the present invention: overcome the function singleness that freshwater fish feed addictive of the prior art exists, the inapparent problem of effect, provides composite particles preparation and the preparation method of a kind of freshwater fish with having physiological function.
To achieve these goals, the present invention adopts following technical scheme:
A freshwater fish composite particles preparation with physiological function, is made up of the weight portion of following material: containing compound Chinese medicine 50 ~ 100 parts, feed complex enzyme 50 ~ 100 parts, immune polysaccharide 60 ~ 100 parts, acidulant 30 ~ 80 parts, montmorillonite 2 00 ~ 500 part, active carbon 60 ~ 100 parts, the oily chaff 400 ~ 800 parts of rheum officinale, golden cypress, the root of large-flowered skullcap, effective ingredient of isatis root.
The weight portion of described compound Chinese medicine is: rheum officinale 20 parts, golden cypress 10 parts, the root of large-flowered skullcap 20 parts, Radix Isatidis 30 parts, mix and be crushed to 40 orders.
Described feed complex enzyme is the aquatic products special composite enzyme that Ningxia Sunson Industrial Group Co., Ltd. produces, product type: SFF-091, wherein cellulase 16000U/g, zytase 260000U/g, 1,4 beta-glucanase 400000U/g, pectase 40000U/g, mannase 2500U/g, neutral proteinase 3000U/g, amylase 50U/g, carbohydrase 2000U/g.
Described immune polysaccharide is astragalus polyose.
Described acidulant is " acid is strong fertile " feeder acidulant that Guangzhou Zhiteqi Biotechnology Co., Ltd produces, it is based on the compound acidulant of citric acid, lactic acid, fumaric acid, its active ingredient and content: lactic acid content is not less than 400g/kg, citric acid is not less than 100g/kg, and fumaric acid is not less than 90g/kg.
The freshwater fish preparation method of composite particles preparation with physiological function, comprises the following steps:
(1) pulverize: particle diameter is greater than 40 object raw materials and pulverizes;
(2) mix: be added in feed mixing machine by number weighing by all raw materials and mix, add saturated vapor modified, vapor (steam) temperature is lower than 80 DEG C.
(3) granulation cooling: the mixed material after modified is granulated through ring die pelleter, by cool drying after cooler, obtains described granular preparation.
Described mixing refining temperature is 60-70 DEG C, moisture content≤13% of granular preparation after dry.
Pharmacology analysis of the present invention
The present invention is based on traditional Chinese medicine and pharmacy theory, and the advanced technology of comprehensive modern nutritional physiology, in conjunction with the clinical practice of inventor, selects materials superior, and drug effect is complementary, and effect is good, have short long, increase and exempt from, reduce discharging the multiple actions such as water conservation.In the present invention, effect of each raw material is as follows:
Compound Chinese medicine: selected compound Chinese medicine contains rheum officinale, golden cypress, the root of large-flowered skullcap, Radix Isatidis are composite." three is yellow " and Radix Isatidis have anti-inflammation, clearing heat and detoxicating, antiviral, the function of liver protecting, thus can improve the disease-resistant of aquatic livestock body and anti-stress ability.
Aquatic products special composite enzyme: comprise cellulase, zytase, 1,4 beta-glucanase, pectase, mannonase neutral proteinase, amylase, carbohydrase etc.Wherein, cellulase can promote that animal intestinal is wriggled, and stimulates the secretion of endogenous digestive ferment; SNSP in feed can be resolved into the xylo-oligosaccharide of the less degree of polymerization by zytase, thus improve feed performance, eliminate or reduce that SNSP causes because viscosity is comparatively large in animal stomach anti-nutritional while, the structure of plant cell wall can also be destroyed, improve the activity of endogenous digestive ferment, improve the utilization of feed nutrient; 1,4 beta-glucanase can eliminate the anti-oxidant action of beta glucan, improves nutritive value and the conversion ratio thereof of wheat class diet; Pectase can supplement the deficiency of endogenous enzymes in animal body, degrading plant cell membrane, and nutrient is better discharged, be convenient to digesting and assimilating of animal, in addition, pectase can also reduce the viscosity of animal intestinal content, promote the diffusion of endogenous enzymes, increase the absorption of nutrient; Mannase can promote the secretion of quasi-insulin growthing factor I GF-I, promotes the synthesis of protein, improves lean meat percentage, promotes the growth of animal; Neutral proteinase can improve Protease Activities In Digestive Tube, promotes that protein digestibility absorbs; Amylase can improve alimentary canal amylase activity, promotes starch based nutrient absorption, promotes enteron aisle villus growth, improves bait digestibility, growth promoting effects, reduces feed coefficient; Carbohydrase can by Amylase Hydrolysis, lower-molecular substance is hydrolyzed to glucose further, absorbed by animal, improves the utilization rate of feed.Aquatic products special composite enzyme can decompose non-starch saccharide compound smoothly, reduces gastral viscosity, effectively improves the digestive function of aquatic livestock; Promote the secretion of endogenous digestive ferment, accelerate the hydrolysis of the larger molecular organicses such as protein, starch, fat in bait, improve energy content, save protein, reduce the feed coefficient of aquatic livestock, the raising speed of growth of animal and the utilization rate of feed; The raising of feed efficiency can reduce the concentration of phosphorus and other nutrient in excreta, reduce the organic human waste such as nitrogen, phosphorus to the pollution of pond waters, active influence is produced to the sustainable cycle development of aquaculture, the activate the phagocytic capacity of aquatic livestock blood middle leukocytes and the sterilizing ability of serum can also be improved simultaneously, strengthen the immunity of aquatic livestock.
Immune polysaccharide: the immune system that can activate animal self; strengthen the immunity function of aquatic livestock; strengthen body opposing virus, bacterium, fungi and parasitic ability; strengthen the anti-stress ability of body; improve the production performance of animal; removing toxic substances and the nutrition conversion capability of liver can also be promoted, effectively reduce the hepar damnification of aquatic livestock, have good protective effect to liver.In addition, immune polysaccharide have efficiently, low toxicity, noresidue feature.Wherein, astragalus polyose can significantly improve the speed of growth of animal, promotes Abwehrkraft des Koepers.
Acidulant: acidulant not only can activate propepsin, helps the softening of feed, the decomposition of nutrient, stops pathogenic microorganism to enter in body through alimentary canal from external environment, the secretion of the enzyme that simultaneously also can directly stimulate digestion.Citric acid, lactic acid, fumaric acid etc. is selected to be main compound acidulant, the protease of fish liver pancreas, anterior intestine and middle intestines, diastatic activity can be significantly improved, promote fish growth, reduce feed coefficient, improve the activity of superoxide dismutase, glutathione peroxidase and lysozyme in fish serum, improve Serum alkaline phosphatase activity, reduce the content of Serum MDA, strengthen anti-oxidant and immunocompetence.
Montmorillonite: the quality that can improve feed, improve the mycotoxin in the production performance of animal, disengaging feed, Adsorption of Heavy Metals, prevention and therapy animal bacteria enteritis, effectively improves breeding water body environment.
Active carbon: all on the books in " Chinese Pharmacopoeia " 2000 editions second " medical charcoal ", " American Pharmacopeia " and Korea S " great Han pharmacopeia " people's medicine, powdered carbon is made up of fine porous body, with the adsorptivity that it is strong, protein dregs corrupt in adsorbable intestines or lipochondrion, remains of pesticide, heavy metal etc., play clean intestines effect, purify the blood and body fluid, improve Abwehrkraft des Koepers.The powdered carbon adding 5% in feed carries out zoopery, does not affect the trace element in animal blood and urine and protein content after testing, safety non-toxic evil.
Positive beneficial effect of the present invention
(1) the present invention selects materials science, and in side, each material combination is good, the complementary synergy of physiological function, the party has growth promoting effects, strengthens immunity of organisms, reduces the excretion of ight soil phosphorus, safe without toxic side effect, ensure the healthy aquaculture of aquatic livestock, improve breeding environment, there are good ecological benefits.
(2) this compound granular formulation, the pharmacology of preventing and curing diseases for oral administration of initiative reference Human Active charcoal, adds active carbon in aquatic livestock bait; Active carbon price and montmorillonite cheap, wide material sources, energy-conserving and environment-protective, have good economic benefit.
(3) the present invention selects oily chaff to do lubricant, and solve the difficult problem that product granulation is difficult, simultaneously also for aquatic livestock provides energy supplement, oily chaff is cheap, wide material sources, and cost is low, has good practical value.
(4) show through effect experiment, the feed adding compound granular formulation of the present invention significantly can promote fish growth, strengthen intestinal enzyme activity, promote the absorption of nutriment, reduce feed coefficient, remarkable enhancing immune enzyme activity and liver detoxification function, strengthen immunity of organisms and premunition, reduce the death rate, reduce water systems'phosphorus discharge capacity, keep breeding environment good, there is good economic benefit.
Detailed description of the invention
Below by specific embodiment, the present invention is described further.
Embodiment 1 one kinds of freshwater fish composite particles preparations with physiological function, are made up of the weight portion of following material: containing compound Chinese medicine 50 parts, feed complex enzyme 50 parts, immune polysaccharide 60 parts, acidulant 30 parts, montmorillonite 2 00 part, active carbon 60 parts, the oily chaff 400 parts of rheum officinale, golden cypress, the root of large-flowered skullcap, effective ingredient of isatis root.
Its weight portion of described compound Chinese medicine is: rheum officinale 20 parts, golden cypress 10 parts, the root of large-flowered skullcap 20 parts, Radix Isatidis 30 parts, mix and be crushed to 40 orders.
Described feed complex enzyme is the aquatic products special composite enzyme that Ningxia Sunson Industrial Group Co., Ltd. produces, product type: SFF-091, wherein cellulase 16000U/g, zytase 260000U/g, 1,4 beta-glucanase 400000U/g, pectase 40000U/g, mannase 2500U/g, neutral proteinase 3000U/g, amylase 50U/g, carbohydrase 2000U/g.
Described immune polysaccharide is astragalus polyose.
Described acidulant is " acid is strong fertile " feeder acidulant that Guangzhou Zhiteqi Biotechnology Co., Ltd produces, it is based on the compound acidulant of citric acid, lactic acid, fumaric acid, its active ingredient and content: lactic acid content is not less than 400g/kg, citric acid is not less than 100g/kg, and fumaric acid is not less than 90g/kg.
Its preparation method comprises the following steps:
(1) pulverize: particle diameter is greater than 40 object raw materials and pulverizes;
(2) mix: be added in feed mixing machine by number weighing by all raw materials and mix, add saturated vapor modified, vapor (steam) temperature is lower than 80 DEG C.
(3) granulation cooling: the mixed material after modified is granulated through ring die pelleter, by cool drying after cooler, obtains described granular preparation.
Described mixing refining temperature is 60-70 DEG C, moisture content≤13% of granule after dry.
Embodiment 2 one kinds of freshwater fish composite particles preparations with physiological function, are made up of the weight portion of following material: containing compound Chinese medicine 75 parts, feed complex enzyme 75 parts, immune polysaccharide 80 parts, acidulant 55 parts, montmorillonite 350 parts, active carbon 80 parts, the oily chaff 600 parts of rheum officinale, golden cypress, the root of large-flowered skullcap, effective ingredient of isatis root.
Other ingredient requirements and preparation method are with embodiment 1.
Embodiment 3 one kinds of freshwater fish composite particles preparations with physiological function, are made up of the weight portion of following material: containing compound Chinese medicine 100 parts, feed complex enzyme 100 parts, immune polysaccharide 100 parts, acidulant 80 parts, montmorillonite 500 parts, active carbon 100 parts, the oily chaff 800 parts of rheum officinale, golden cypress, the root of large-flowered skullcap, effective ingredient of isatis root.
Other ingredient requirements and preparation method are with embodiment 1.
Embodiment 4 one kinds of freshwater fish composite particles preparations with physiological function, are made up of the weight portion of following material: containing compound Chinese medicine 50 parts, feed complex enzyme 50 parts, immune polysaccharide 60 parts, acidulant 30 parts, montmorillonite 300, active carbon 60 parts, the oily chaff 450 parts of rheum officinale, golden cypress, the root of large-flowered skullcap, effective ingredient of isatis root.
Other ingredient requirements and preparation method are with embodiment 1.
Embodiment 5 one kinds of freshwater fish composite particles preparations with physiological function, are made up of the weight portion of following material: containing compound Chinese medicine 65 parts, feed complex enzyme 60 parts, immune polysaccharide 70 parts, acidulant 40 parts, montmorillonite 400, active carbon 75 parts, the oily chaff 475 parts of rheum officinale, golden cypress, the root of large-flowered skullcap, effective ingredient of isatis root.
Other ingredient requirements and preparation method are with embodiment 1.
Embodiment 6 one kinds of freshwater fish composite particles preparations with physiological function, are made up of the weight portion of following material: containing compound Chinese medicine 80 parts, feed complex enzyme 70 parts, immune polysaccharide 80 parts, acidulant 50 parts, montmorillonite 500, active carbon 90 parts, the oily chaff 500 parts of rheum officinale, golden cypress, the root of large-flowered skullcap, effective ingredient of isatis root.
Other ingredient requirements and preparation method are with embodiment 1.
Effect experiment of the present invention is as follows:
1, select the Yellow River carp 200 tail, equal body weight 50.4g, is divided into two groups at random, throws something and feeds for one group and does not add the feed of composite particles preparation, blank; The feed of the composite particles preparation (product of embodiment 1) of the alternative interpolation 10% of one group of mixing of throwing something and feeding.Freely ingest, ensure that the dissolved oxygen of cultivation carp is sufficient.At two groups of feedstuff feedings after 60 days, weigh the rear body weight of experiment, calculate rate of body weight gain, survival rate, the rate of change of feed coefficient, enteron aisle height of naps growth rate, Activity of Digestive Enzymes in Intestine increases ratio, contrasts with the total phosphorus concentration before examination, detect the change of the discharge capacity of phosphorus in water body, immune enzyme activity change value added.Experimental group compares above-mentioned each index result of variations as following table with control group.
Short length, emission reduction effect are added up compared with before examination
Carp intestinal enzyme activity and middle villi height increase statistics
The immunoenzymatic impact statistics of Carp Liver pancreas
Serum of Common Carp immune enzyme activity change statistics
2, select Grass carp 200 tail, equal body weight 50.8g, is divided into two groups at random, throws something and feeds for one group and does not add the feed of composite particles preparation, blank; The feed of the composite particles preparation (product of embodiment 1) of the alternative interpolation 10% of one group of mixing of throwing something and feeding.Freely ingest, ensure that the dissolved oxygen of cultivation grass carp is sufficient.At two groups of feedstuff feedings after 60 days, weigh the rear body weight of experiment, calculate rate of body weight gain, survival rate, the rate of change of feed coefficient, enteron aisle height of naps growth rate, Activity of Digestive Enzymes in Intestine increases ratio, contrasts with the total phosphorus concentration before examination, detect the change of the discharge capacity of phosphorus in water body, immune enzyme activity change value added.Experimental group compares above-mentioned each index result of variations as following table with control group.
Short length, emission reduction effect are added up compared with before examination
Grass carp intestinal enzymatic activity and middle villi height increase statistics
The immunoenzymatic impact statistics of Grass Carp Liver pancreas
Grass Carp Serum immune enzyme activity change statistics
Adopt the compound granular formulation of other embodiments to carry out contrast test, can similar results be drawn.Experimental result shows, the feed adding compound granular formulation of the present invention significantly can promote fish growth, strengthen intestinal enzyme activity, promote absorption of nutrient ingredients, reduce feed coefficient, significantly can strengthen the function of detoxification of immune enzyme activity and liver, strengthen immunity of organisms and resistance against diseases, reduce the death rate, reduce water systems'phosphorus discharge capacity, keep breeding environment good.Through administering transgenic, measure each group of change and show, experimental group is Be very effective compared with control group; Related experiment is done to the freshwater fish such as blunt snout bream, crucian simultaneously, obtain similar results.
Claims (8)
1. a freshwater fish composite particles preparation with physiological function, is characterized in that: be made up of the weight portion of following material: containing compound Chinese medicine 50 ~ 100 parts, feed complex enzyme 50 ~ 100 parts, immune polysaccharide 60 ~ 100 parts, acidulant 30 ~ 80 parts, montmorillonite 2 00 ~ 500 part, active carbon 60 ~ 100 parts, the oily chaff 400 ~ 800 parts of rheum officinale, golden cypress, the root of large-flowered skullcap, effective ingredient of isatis root.
2. a kind of freshwater fish composite particles preparation with physiological function according to claim 1, is characterized in that: containing compound Chinese medicine 50 ~ 80 parts, feed complex enzyme 50 ~ 70 parts, immune polysaccharide 60 ~ 80 parts, acidulant 30 ~ 50 parts, montmorillonite 300 ~ 500, active carbon 60 ~ 90 parts, the oily chaff 450 ~ 500 parts of rheum officinale, golden cypress, the root of large-flowered skullcap, effective ingredient of isatis root.
3. a kind of freshwater fish composite particles preparation with physiological function according to claim 1 and 2, it is characterized in that: its weight portion of described compound Chinese medicine is: rheum officinale 20 parts, golden cypress 10 parts, the root of large-flowered skullcap 20 parts, Radix Isatidis 30 parts, mix and be crushed to 40 orders.
4. a kind of freshwater fish composite particles preparation with physiological function according to claim 1 and 2, it is characterized in that: described feed complex enzyme is aquatic products special composite enzyme, wherein cellulase 16000 U/g, zytase 260000 U/g, 1,4 beta-glucanase 400000 U/g, pectase 40000 U/g, mannase 2500 U/g, neutral proteinase 3000 U/g, amylase 50 U/g, carbohydrase 2000 U/g.
5. a kind of freshwater fish composite particles preparation with physiological function according to claim 1 and 2, is characterized in that: described immune polysaccharide is astragalus polyose.
6. a kind of freshwater fish composite particles preparation with physiological function according to claim 1 and 2, is characterized in that: described acidulant is citric acid, lactic acid, fumaric acid are main compound acidulant; Wherein active ingredient and content: lactic acid content is not less than 400g/ kg, citric acid is not less than 100g/ kg, and fumaric acid is not less than 90g/ kg.
7. the preparation method of composite particles preparation with physiological function of a kind of freshwater fish described in any one of claim 1-6, is characterized in that: the method comprises the following steps:
(1) pulverize: particle diameter is greater than 40 object raw materials and pulverizes;
(2) mix: be added in feed mixing machine by number weighing by all raw materials and mix, add saturated vapor modified, vapor (steam) temperature is lower than 80 DEG C;
(3) granulation cooling: the mixed material after modified is granulated through ring die pelleter, by cool drying after cooler, obtains described granular preparation.
8. a kind of freshwater fish according to claim 7 preparation method of composite particles preparation with physiological function, is characterized in that: wherein refining temperature is 60-70 DEG C, moisture content≤13% of granule after dry.
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Cited By (8)
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| CN104886354A (en) * | 2015-07-07 | 2015-09-09 | 福建植物黑金生物科技有限公司 | Vegetable carbon black composition and application thereof in animal feed additives |
| CN104996832A (en) * | 2015-08-12 | 2015-10-28 | 四川国凤中科生物科技有限公司 | Feed for silver carps |
| CN105233278A (en) * | 2015-08-31 | 2016-01-13 | 闽南师范大学 | Compound drug for treating bacillary enteritis in freshwater grass carp and its preparation method and application |
| CN107019124A (en) * | 2017-06-06 | 2017-08-08 | 明光市泰丰新材料有限公司 | It is a kind of to promote feed of fresh-water fishes growth and preparation method thereof |
| CN107981102A (en) * | 2017-12-01 | 2018-05-04 | 无锡华诺威动物保健品有限公司 | A kind of herbivorous fishes feed compound acidulant |
| CN109247455A (en) * | 2018-08-31 | 2019-01-22 | 河南华牧生物科技有限公司 | Fresh-water fishes liver protecting Immune-enhancing effect granule and preparation method thereof |
| CN109316597A (en) * | 2018-12-11 | 2019-02-12 | 河南华牧生物科技有限公司 | Chinese materia medica preparation and preparation method thereof of the fresh-water fishes with antibacterial liver protection function |
| DE202023100017U1 (en) | 2023-01-03 | 2023-02-17 | Ravi Dhondiraj Barde | Novel drug for the prevention and treatment of bacterial mixed infections in freshwater fish |
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| CN104886354A (en) * | 2015-07-07 | 2015-09-09 | 福建植物黑金生物科技有限公司 | Vegetable carbon black composition and application thereof in animal feed additives |
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| CN109247455A (en) * | 2018-08-31 | 2019-01-22 | 河南华牧生物科技有限公司 | Fresh-water fishes liver protecting Immune-enhancing effect granule and preparation method thereof |
| CN109316597A (en) * | 2018-12-11 | 2019-02-12 | 河南华牧生物科技有限公司 | Chinese materia medica preparation and preparation method thereof of the fresh-water fishes with antibacterial liver protection function |
| CN109316597B (en) * | 2018-12-11 | 2021-09-03 | 河南华牧生物科技有限公司 | Traditional Chinese medicine preparation with antibacterial and liver-protecting functions for freshwater fish and preparation method thereof |
| DE202023100017U1 (en) | 2023-01-03 | 2023-02-17 | Ravi Dhondiraj Barde | Novel drug for the prevention and treatment of bacterial mixed infections in freshwater fish |
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