CN104663663B - A kind of containing spiral shell prestige and the compound pesticide preparation of niclosamide alcohol salt with application - Google Patents
A kind of containing spiral shell prestige and the compound pesticide preparation of niclosamide alcohol salt with application Download PDFInfo
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- CN104663663B CN104663663B CN201510110138.1A CN201510110138A CN104663663B CN 104663663 B CN104663663 B CN 104663663B CN 201510110138 A CN201510110138 A CN 201510110138A CN 104663663 B CN104663663 B CN 104663663B
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Abstract
The invention discloses a kind of containing spiral shell prestige and the compound pesticide preparation of niclosamide alcohol salt with application, this pesticidal preparations includes following components in percentage by weight: spiral shell prestige mother's medicine or the preparation containing spiral shell prestige 20% 50%, niclosamide alcohol salt 10% 30% and the auxiliary agent of surplus.Its preparation method is: weighs each component according to above-mentioned quality proportioning, first each component is mixed, is crushed to 300 400 mesh after stirring.This pesticidal preparations formula is reasonable, and low cost is easy to use, kills oncomelania effective.Its preparation method is simple, and technological process is extremely simple, operates extremely simple, thus preparation cost is the cheapest.This pesticidal preparations can kill oncomelania, and it is effective to kill oncomelania, and the killing rate killing oncomelania after spraying medication 7 days reaches more than 81%, and makes oncomelania be not likely to produce Drug resistance.
Description
Technical field
The present invention relates to technical field of pesticide, be more particularly to a kind of containing spiral shell prestige with the compounding agriculture of niclosamide alcohol salt
Medicine preparation, also relates to a kind of compound pesticide preparation containing spiral shell prestige and niclosamide alcohol salt in killing oncomelania medicine
Purposes.
Background technology
Schistosomicide is also referred to as schistosomicide (schistosoma), is to colonize in the platyhelminthes in host's vein, parasitizes many
Number vertebrates, is distributed mainly on and is distributed in Asia, African and Hispanic 76 countries and regions.Japonice ovum passes
Wall of vein enters bladder, and with urine ejection, larva enters breechblock, intermediate host snail (predominantly Bulinus belong to and
Physopsis belongs to) internal growth, ripe larva enters in final host human body by skin or mouth, harmful to human.Schistosomicide is
The harm most important parasitic disease of people's health, there are 74 popular schistosomicide in countries and regions, people from Endemic Area in the whole world
Mouth reaches 600,000,000, has 200,000,000 people infected, dies from this patient every year and reach million more than.
The simply Schistosoma japonicum (abbreviation schistosomicide) that China is popular, this schistosomicide is that first Japanese sends out in Japan
Existing, therefore name as Schistosoma japonicum.It is big that Schistosoma japonicum (S.japonicum, i.e. Schistosoma japonicum) is mainly seen in China
Land, Japan, TaiWan, China, East Indies and Philippine, in addition to invasion and attack human body, also attack other vertebratess, such as domestic animal and
Rat etc..The schistosome ovum seized in Jiangling, Hubei Western Han Dynastry mummy body is true, show schistosomicide China existence at least
The history of existing more than 2100 year.Adding up at the beginning of liberation, the whole nation about more than 10,000,000 patient, 100,000,000 populations are infected threat, have spiral shell
Nearly 12,800,000,000 square metres of area, 13 provinces, municipalities and autonomous regions have schistosomicide to be distributed.Severe epidemic district, suffers from patient and dies off, people
Cigarette is rare, and nine houses out of ten are stripped bare, and rural area lies waste, and causes the miserable scene of " thousand village Caulis fici pumilae (Fructus Fici Pumilae) people empty one's bowels Thousands of homes are deserted ghost is sung ".Liberation
After, government has carried out large-scale preventing and controlling of a mass character to schistosomicide, achieves very great achievement, and the spiral surface that goes out is long-pending reaches more than 90 hundred million
Square metre, occupy spiral surface and amass more than 80%, to the latter stage seventies, number of patients is reduced to 2,500,000, and end-stage patients are the most rarely found
Arrive.But reach to utterly destroy the purpose of schistosomicide, in addition it is also necessary to make long-term and arduous effort and the effort of more people.
Oncomelania is bilharzial unique intermediate host, is the indispensable link of schistosomiasis propagation.Prevention and cure of snail fever
Practice have shown that, the higher risk area spiral shell that goes out is one of direct effective measures of prevention schistosomicide.Oncomelania control measure mainly includes
Ecology, physics and the big class of snail control with drugs 3, wherein snail control with drugs is one of most common method.Up to the present, China's medicine goes out
Spiral shell still uses chemosynthesis medicament, but chemistry snail killing agent exists other target bio-toxicities, environmental pollution and expensive etc.
Problem.
Niclosamide (have another name called niclosamide, hundred spiral shells kill, chlorine spiral shell disappears) is the organic invertebrate poison of phenols, and nineteen fifty-nine is by moral
Bayer AG of state develops.Sterling is colorless solid.Half-life 1.1-2.9 days in soil.For paddy field water-snail eradication, valid density
For 0.3-1.0 mg/litre.Owing to niclosamide is insoluble in water, affect molluscicidal effect, be made generally in Clonitrilide.
Niclosamide is the snail killing agent that World Health Organization (WHO) uniquely recommends, and Ye Shi China kills schistosomicide intermediate host nail at present
The choice drug of spiral shell.Along with the use the most on a large scale, over a long time of this medicine, the problem day whether oncomelania may develop immunity to drugs
Benefit receives publicity.In niclosamide production process, produce substantial amounts of two English, environment is adversely affected.Chlorine nitre willow
Environment and biology in use, also can be had an impact by amine.Therefore, the biological molluscicide promoting green safety is imperative.
In recent years, Jinhaichao Science-Technology Co., Ltd., Hubei the flora-originated molluscicide spiral shell prestige researched and developed, is a kind of from oil
The pentacyclic triterpene material of Theaceae plant, has excellent insecticidal activity, have stomach toxicity, tag, the effect such as haemolysis, to many evils
Worm has certain killing action, is prone to degraded in the environment, is a kind of outstanding botanical pesticide.Its mechanism of action is to pass through
After contact insect, destroy its cell wall, so that pest cell occurs serious haemolysis.2013, spiral shell prestige product passed through
The Ministry of Agriculture formally registers, and registration card number is PD20131345 and PD20131346, and its shortcoming is the highest for worm's ovum killing action,
Lasting period is the longest.
Summary of the invention
For solving the problem that above-mentioned prior art exists, the invention provides a kind of containing spiral shell prestige and niclosamide alcohol salt
Compound pesticide preparation, this pesticidal preparations formula is reasonable, and low cost is easy to use, kills oncomelania effective.Its preparation method letter
Single, technological process is extremely simple, operates extremely simple, thus preparation cost is the cheapest.
Present invention also offers a kind of compound pesticide preparation containing spiral shell prestige and niclosamide alcohol salt in killing oncomelania
Application, it is effective that this pesticidal preparations kills oncomelania, sprays medication and kills the killing rate of oncomelania after 7 days and reach more than 81%, and
Oncomelania is made to be not likely to produce Drug resistance.
Realizing the technical scheme that above-mentioned purpose of the present invention used is:
A kind of containing spiral shell prestige with the compound pesticide preparation of niclosamide alcohol salt, including following components in percentage by weight:
Spiral shell prestige mother's medicine or the preparation 20%-50% containing spiral shell prestige
Niclosamide alcohol salt 10%-30%
Adjuncts Balance.
Its preparation method is: weighs each component according to described weight proportion, first each component is mixed, powder after stirring
It is broken to 300-400 mesh.
A kind of containing spiral shell prestige with the compound pesticide preparation of niclosamide alcohol salt, including following components in percentage by weight:
Spiral shell prestige mother's medicine or the preparation 25%-45% containing spiral shell prestige
Niclosamide alcohol salt 15%-25%
Adjuncts Balance
Improving technique scheme, this compound pesticide preparation is wettable powder;The described preparation containing spiral shell prestige is
4% spiral shell prestige powder, described auxiliary agent includes wetting agent, dispersant and inserts;Described wetting agent is DBSA
Sodium, sodium laurylsulfate, dialkyl succinylsuccinate sulfonate or fatty alcohol-polyoxyethylene ether;Described dispersant is methylene dinaphthalene sulphur
Acid sodium, sodium lignin sulfonate, naphthalene sulfonic acid-formaldehyde condensation product or to methoxyl group fatty acyl anilinesulfonic acid;Described inserts is tea
Withered powder.
The application in killing oncomelania medicine of a kind of compound pesticide preparation containing spiral shell prestige and niclosamide alcohol salt.
Compared with prior art, its beneficial effect and advantage are the present invention:
1, this pesticidal preparations decreases the consumption of chemical pesticide Clonitrilide, reduces arable land, soil etc.
The pollution of environment, reduces the toxic action to environmental organism.
2, this pesticidal preparations improves the effect killing oncomelania, and ratio is used alone chemical pesticide Clonitrilide
Effect to be got well, and is not likely to produce drug resistance.
3, the usage amount of this pesticidal preparations is than individually containing spiral shell prestige or the usage amount of the pesticidal preparations of Clonitrilide
Low, cost relatively Clonitrilide class pesticidal preparations low cost, therefore the use cost of this pesticidal preparations is low, cost performance is high.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1
A kind of containing spiral shell prestige with the compound pesticide preparation of niclosamide alcohol salt, including following components in percentage by weight:
The preparation method of above-mentioned compound pesticide preparation is as follows:
Weighing spiral shell prestige 40 kilograms, niclosamide 20 kilograms, sodium laurylsulfate 5 kilograms, sodium metnylene bis-naphthalene sulfonate 12 is public
Jin, 23 kilograms of tea seed cake powder, first each component is mixed, be crushed to 300-400 mesh with jet mill after stirring, obtain containing spiral shell
Prestige and the wettable powder of niclosamide.
Embodiment 2-10
Embodiment 2-9 is from embodiment 1 in addition to component proportion is different, and its preparation method is same as in Example 1, and effect and reality
Execute example 1 suitable.The component proportion of embodiment 2-9 is as shown in table 1.
The component proportion of table 1 embodiment 2-10
Wettable powder prepared by inspection embodiment 1-9, wherein active constituent content is >=11.0%, moisture≤2.0%,
PH value 8.5-10.5, screen rate (being sieved by 50 μm) >=95%, suspensibility >=90%, persistent foamability (1min)≤10mL, profit
Moist≤1min, accelerates heat storage stability qualified.
In embodiment 1-9, sodium laurylsulfate can use dodecylbenzene sodium sulfonate, dialkyl succinylsuccinate sulfonate (such as alkyl
Succinic acid sodium sulfonate), Negel or fatty alcohol-polyoxyethylene ether substitute, sodium metnylene bis-naphthalene sulfonate can use sulfomethylated lignin
Acid sodium, naphthalene sulfonic acid-formaldehyde condensation product (such as poly-naphthalene formaldehyde sulfonate salt) or to methoxyl group fatty acyl anilinesulfonic acid replace, tea seed cake
Adding part white carbon in powder, after replacing with these materials, effect is front with replacement quite.
The synergism test of oncomelania is killed in test one, wettable powder containing spiral shell prestige and niclosamide alcohol salt
Test unit: Hubei Prov. Inst. of Prevention and Cure of Schistosomiasis
Test period: in June, 2013-July
Reagent agent: A group, embodiment 1 preparation containing spiral shell prestige and the wettable powder of niclosamide alcohol salt;
B group, 4% spiral shell prestige powder (Jinhaichao Science-Technology Co., Ltd., Hubei);
C group, 50% niclosamide alcohol salt wettable powder (development of Sichuan chemical research institute);
D group, clear water.
Test method: according to pesticide inspection (raw survey) [2005] No. 77 " agriculture chemical registration health molluscacide test of pesticide effectiveness sides of letter
Method and evaluation " regulation of (trying) method of testing tests, and the medicament of A, B, C tri-groups is configured to 1000mL concentration respectively is
The medicinal liquid of 2.5mg/L, 2.5mg/L, 2.0mg/L, pours into the medicinal liquid prepared respectively in 3 large beakers, puts in each beaker
Enter 30 preferable oncomelanias in the same size, active, be placed on medicinal liquid surface with plastic gauze in case oncomelania climbs out of, set clear water pair simultaneously
According to group D.After leaching kills 24,48,72 hours, remove medicinal liquid, rinse with clear water, identify Death of Oncomelania Snails situation, statistics with hammering method
Mortality rate.
Result of the test: result of the test is as shown in table 2.
The synergism test result of oncomelania killed by the table 2 wettable powder containing spiral shell prestige and niclosamide alcohol salt
Experimental group | Liquor strength | Mortality of snails % |
24h | 48h | 72h | ||
A | 2.5mg/L | 93.67 | 97.87 | 100.00 |
B | 2.5mg/L | 83.34 | 89.43 | 96.89 |
C | 2.0mg/L | 87.25 | 91.65 | 97.78 |
D | —— | 0.00 | 0.00 | 2.22 |
As shown in Table 2, A group is compared with B, C two groups, and A group screw is far above B group and C at the mortality rate of 24,48,72 hours
Group.As can be seen here, the effect ratio of oncomelania killed by the wettable powder containing spiral shell prestige and niclosamide alcohol salt of embodiment 1 preparation
The effect being used alone 4% spiral shell prestige powder or 50% niclosamide alcohol salt wettable powder to be got well.
Being shown by test, the compound pesticide preparation containing spiral shell prestige and niclosamide alcohol salt of the present invention has potentiation and makees
With.Embodiment 10
Oncomelania is killed below as a example by the wettable powder containing spiral shell prestige and niclosamide alcohol salt of embodiment 1 preparation
Test, the purposes containing spiral shell prestige and the compound pesticide preparation of niclosamide alcohol salt is elaborated.
Test unit: Hubei Prov. Inst. of Prevention and Cure of Schistosomiasis
Test period: in June, 2014
Reagent agent: A group, embodiment 1 obtain containing spiral shell prestige and the wettable powder of niclosamide alcohol salt.
B group, 50% niclosamide alcohol salt wettable powder (WPN).
C group: 4% spiral shell prestige powder (Jinhaichao Science-Technology Co., Ltd., Hubei's development).
D group, clear water.
Testing program:
Irrigation canals and ditches and a piece of river shoal in great Yuan town, Jianli County, Hubei Province selects a protective embankment, according to " agriculture chemical registration is with killing oncomelania
Agent test of pesticide effectiveness method and evaluation " method, being respectively adopted concentration is 2.5g/m3、5.0g/m2Embodiment 1 preparation2Wettability
Powder medicinal liquid carries out leaching and kills method and spraying snail killing test, with 2.0g/m3、5.0g/m250% niclosamide alcohol salt wettability
Powder (WPN) medicinal liquid and 2.5g/m3、5.0g/m24% spiral shell prestige powder medicinal liquid is comparison, sets clear water matched group the most respectively.Statistics
Analyze varying environment, the on-the-spot molluscicidal effect of different agents.
Result of the test: result of the test is as shown in table 4.
The result of the test of oncomelania killed by the table 4 wettable powder containing spiral shell prestige and niclosamide alcohol salt
As shown in Table 4, after 1 day, 2 days, 3 days and 7 days are killed in on-the-spot leaching, A group, B group, C group spiral shell mortality rate are all in gradually rising
Trend, the spiral shell that goes out is after 7 days, and A group, B group, C group mortality of snails are respectively 96.42%, 98.61%, 95.45%, two group differences
Not statistically significant (x2=3.22, P > 0.05).Spraying molluscicide 1 day, 3 days, 7 days time, A group mortality of snails is respectively
59.71%, 76.72%, 81.90%, B group mortality of snails is respectively 50.73%, 68.57%, 76.14%, and C group oncomelania is dead
The rate of dying is respectively 49.56%, 65.93%, 75.52%, two groups of each time point comparing differences the most statistically significant (P < 0.05).Adopt
When killing oncomelania by the leaching method of killing, embodiment 1 obtain containing spiral shell prestige and the wettable powder of niclosamide alcohol salt and 50% chlorine
Nitre willow amine alcohol salt wettable powder, 4% spiral shell prestige powder are suitable.When using spraying to kill oncomelania, what embodiment 1 obtained contains
The effect ratio killing oncomelania of the wettable powder of spiral shell prestige and niclosamide alcohol salt is used alone 50% niclosamide ethanol ammonium
Salt wettable powder, 4% spiral shell prestige powder to be got well, and consumption is suitable.
In sum, the compound pesticide preparation containing spiral shell prestige and niclosamide alcohol salt of the present invention kills oncomelania effect
Good, the killing rate killing oncomelania after spraying medication 7 days reaches more than 81%.And reach identical when killing oncomelania effect, amount ratio
50% niclosamide alcohol salt wettable powder, 4% spiral shell prestige powder to lack, but the cost of the complex preparation of the present invention and 50%
Niclosamide alcohol salt wettable powder, 4% spiral shell prestige powder production cost suitable.
Claims (8)
1. one kind contains spiral shell prestige and the compound pesticide preparation of niclosamide alcohol salt, it is characterised in that include following percentage by weight
Component:
4% spiral shell prestige powder 20%-50%
Niclosamide alcohol salt 10%-30%
Adjuncts Balance
Its preparation method is: weighs each component according to described weight proportion, first each component is mixed, be crushed to after stirring
300-400 mesh.
It is the most according to claim 1 containing spiral shell prestige with the compound pesticide preparation of niclosamide alcohol salt, it is characterised in that:
4% spiral shell prestige powder 25%-45%
Niclosamide alcohol salt 15%-25%
Adjuncts Balance.
It is the most according to claim 2 containing spiral shell prestige with the compound pesticide preparation of niclosamide alcohol salt, it is characterised in that: should
Compound pesticide preparation is wettable powder.
It is the most according to claim 3 containing spiral shell prestige with the compound pesticide preparation of niclosamide alcohol salt, it is characterised in that: institute
The auxiliary agent stated includes wetting agent, dispersant and inserts.
It is the most according to claim 4 containing spiral shell prestige with the compound pesticide preparation of niclosamide alcohol salt, it is characterised in that: institute
The wetting agent stated is dodecylbenzene sodium sulfonate, sodium laurylsulfate, dialkyl succinylsuccinate sulfonate or fatty alcohol-polyoxyethylene ether.
It is the most according to claim 4 containing spiral shell prestige with the compound pesticide preparation of niclosamide alcohol salt, it is characterised in that: institute
The dispersant stated is sodium metnylene bis-naphthalene sulfonate, sodium lignin sulfonate, naphthalene sulfonic acid-formaldehyde condensation product or to methoxyl group fatty acid amide
Base benzenesulfonic acid.
It is the most according to claim 4 containing spiral shell prestige with the compound pesticide preparation of niclosamide alcohol salt, it is characterised in that: institute
The inserts stated is the mixture of tea seed cake powder or tea seed cake powder and white carbon.
8. the compound pesticide preparation containing spiral shell prestige and niclosamide alcohol salt described in a claim 1 is killing oncomelania medicine
In application.
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Effective date of registration: 20190312 Address after: 430223 No. 88 Guanggu Eighth Road, Wuhan Donghu Development Zone, Hubei Province Patentee after: Jinhaichao Science-Technology Co., Ltd., Hubei Address before: 430075 Gaonong Building, Guanggu Biological City, Donghu Development Zone, Wuhan City, Hubei Province Patentee before: Zhang Nengmin |