CN104662039B - 缩短的CD95-Fc变体 - Google Patents

缩短的CD95-Fc变体 Download PDF

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Publication number
CN104662039B
CN104662039B CN201380038208.6A CN201380038208A CN104662039B CN 104662039 B CN104662039 B CN 104662039B CN 201380038208 A CN201380038208 A CN 201380038208A CN 104662039 B CN104662039 B CN 104662039B
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seq
domain
fusion protein
apg101
functional fragment
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Expired - Fee Related
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CN201380038208.6A
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CN104662039A (zh
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O·黑尔
C·杰弗斯
M·斯尔曼
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Apogenix AG
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Apogenix AG
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

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CN201380038208.6A 2012-07-18 2013-07-18 缩短的CD95-Fc变体 Expired - Fee Related CN104662039B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12176980 2012-07-18
EP12176978.0 2012-07-18
EP12176980.6 2012-07-18
EP12176978 2012-07-18
PCT/EP2013/065248 WO2014013037A1 (en) 2012-07-18 2013-07-18 Shortened cd95-fc variants

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CN104662039A CN104662039A (zh) 2015-05-27
CN104662039B true CN104662039B (zh) 2019-10-08

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CN201380038208.6A Expired - Fee Related CN104662039B (zh) 2012-07-18 2013-07-18 缩短的CD95-Fc变体
CN201380043661.6A Pending CN104640876A (zh) 2012-07-18 2013-07-18 包含CD95-Fc同种型的混合物的组合物
CN201910254827.8A Pending CN109897115A (zh) 2012-07-18 2013-07-18 包含CD95-Fc同种型的混合物的组合物

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CN201380043661.6A Pending CN104640876A (zh) 2012-07-18 2013-07-18 包含CD95-Fc同种型的混合物的组合物
CN201910254827.8A Pending CN109897115A (zh) 2012-07-18 2013-07-18 包含CD95-Fc同种型的混合物的组合物

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EP (4) EP3406630B1 (cg-RX-API-DMAC7.html)
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NO2776305T3 (cg-RX-API-DMAC7.html) 2014-04-23 2018-01-27
EP3137909B1 (en) 2014-04-29 2018-06-06 Apogenix AG Diagnostic anti-cd95l antibody
US9587215B2 (en) 2014-08-07 2017-03-07 General Electric Company Devices, systems and methods for automated transfer of a sample
EP3236772A4 (en) * 2014-12-22 2018-10-17 Alexion Pharmaceuticals, Inc. Methods of purifying recombinant proteins
CN114269370A (zh) 2019-03-29 2022-04-01 迈斯特治疗公司 离体产生t细胞治疗剂的方法以及相关的组合物和方法
IL293350A (en) 2019-11-27 2022-07-01 Myst Therapeutics Llc Method of producing tumor-reactive t cell composition using modulatory agents
KR102932208B1 (ko) * 2019-12-12 2026-03-03 이엠디 밀리포어 코포레이션 정용여과 완충제를 사용한 강화된 바이러스 여과
EP4110799B1 (en) 2020-02-27 2024-11-06 Turnstone Biologics Corp. Methods for ex vivo enrichment and expansion of tumor reactive t cells and related compositions thereof
LT3972987T (lt) * 2020-04-10 2023-09-25 Akston Biosciences Corporation Antigenui specifinė imunoterapija, skirta sulietiems covid-19 baltymams ir naudojimo būdai
CN115894706A (zh) * 2021-09-30 2023-04-04 北京康辰药业股份有限公司 靶向PD-L1和FasL的融合蛋白、核苷酸序列及其应用
WO2026044087A1 (en) 2024-08-21 2026-02-26 Shape Therapeutics Inc. Increased cellular stability for aav production
WO2026073032A1 (en) 2024-09-27 2026-04-02 Shape Therapeutics Inc. Constructs for improved aav production

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WO2008080623A2 (en) * 2006-12-28 2008-07-10 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Neutralization of cd95 activity blocks invasion of glioblastoma cells in vivo
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WO1998038304A1 (en) * 1997-02-27 1998-09-03 Ono Pharmaceutical Co., Ltd. Novel polypeptide, dna encoding the same and use thereof
WO2008080623A2 (en) * 2006-12-28 2008-07-10 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Neutralization of cd95 activity blocks invasion of glioblastoma cells in vivo
CN102497886A (zh) * 2009-07-21 2012-06-13 玛丽皇后与斯特菲尔德学院 用于细胞内药物递送的Fas(Apo-1，CD95)靶向平台

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EP2875044A1 (en) 2015-05-27
EP2875044B1 (en) 2018-04-11
US20160362471A1 (en) 2016-12-15
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US20150225475A1 (en) 2015-08-13
KR102201694B1 (ko) 2021-01-12
EP3409686B1 (en) 2022-04-13
AU2013291984B2 (en) 2018-01-18
AU2013291982B2 (en) 2017-01-12
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EP2875045A1 (en) 2015-05-27
JP2015524403A (ja) 2015-08-24
AU2013291982A1 (en) 2015-02-05
MX2015000731A (es) 2015-09-04
JP6231562B2 (ja) 2017-11-15
CN109897115A (zh) 2019-06-18
KR20150048120A (ko) 2015-05-06
ES2924109T3 (es) 2022-10-04
UA116889C2 (uk) 2018-05-25
US9908928B2 (en) 2018-03-06
US20150166633A1 (en) 2015-06-18
US9315570B2 (en) 2016-04-19
BR112015000732A2 (cg-RX-API-DMAC7.html) 2017-08-15
CN104662039A (zh) 2015-05-27
ES2674662T3 (es) 2018-07-03
US10370441B2 (en) 2019-08-06
CA2878992C (en) 2020-09-22
AU2013291984A1 (en) 2015-02-05
EP3406630A1 (en) 2018-11-28
HK1207096A1 (en) 2016-01-22
BR112015000732B1 (pt) 2023-01-10
IL236659A (en) 2017-02-28
RU2015105330A (ru) 2016-09-10
WO2014013037A1 (en) 2014-01-23
US9434783B2 (en) 2016-09-06
NZ703546A (en) 2018-03-23
DK3409686T3 (da) 2022-07-18
RU2648157C2 (ru) 2018-03-22
CA2877989A1 (en) 2014-01-23
EP3406630B1 (en) 2020-09-02
DK2875045T3 (en) 2018-07-02
WO2014013039A1 (en) 2014-01-23
IL236659A0 (en) 2015-02-26
CN104640876A (zh) 2015-05-20
EP3409686A1 (en) 2018-12-05
CA2877989C (en) 2021-05-25
HK1207095A1 (en) 2016-01-22
SG11201500134QA (en) 2015-03-30
RU2015105328A (ru) 2016-09-10
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