CN104650068B - 二氢嘧啶类化合物及其在药物中的应用 - Google Patents
二氢嘧啶类化合物及其在药物中的应用 Download PDFInfo
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- CN104650068B CN104650068B CN201410657898.XA CN201410657898A CN104650068B CN 104650068 B CN104650068 B CN 104650068B CN 201410657898 A CN201410657898 A CN 201410657898A CN 104650068 B CN104650068 B CN 104650068B
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- 0 *C1Nc2ccccc2C=C1 Chemical compound *C1Nc2ccccc2C=C1 0.000 description 19
- CCPVCZYOGHGBBD-NMXLAWLUSA-N CC(C[C@@H](C1)N(CC(NC(c2ncc[s]2)=N[C@H]2c(c(Cl)c3)ccc3F)=C2C(OC)=O)CC1(F)F)C(O)=O Chemical compound CC(C[C@@H](C1)N(CC(NC(c2ncc[s]2)=N[C@H]2c(c(Cl)c3)ccc3F)=C2C(OC)=O)CC1(F)F)C(O)=O CCPVCZYOGHGBBD-NMXLAWLUSA-N 0.000 description 1
- OGUVUOIKRVWUDL-ZDUSSCGKSA-N CC(NC(c1ncc[s]1)=N[C@H]1c(c(Cl)c2)ccc2Cl)=C1C(OC)=O Chemical compound CC(NC(c1ncc[s]1)=N[C@H]1c(c(Cl)c2)ccc2Cl)=C1C(OC)=O OGUVUOIKRVWUDL-ZDUSSCGKSA-N 0.000 description 1
- CWKTUACHRCCTNM-WQVVZYPJSA-N CC1(C2=N[C@@H](c(c(Cl)c3)ccc3F)C(C(OC)=O)=C(CN(C3)[C@@H](CCCCC(O)=O)CC3(F)F)N2)SC=CN1 Chemical compound CC1(C2=N[C@@H](c(c(Cl)c3)ccc3F)C(C(OC)=O)=C(CN(C3)[C@@H](CCCCC(O)=O)CC3(F)F)N2)SC=CN1 CWKTUACHRCCTNM-WQVVZYPJSA-N 0.000 description 1
- FMXVSJPWIBXXKQ-XLDIYJRPSA-N CCOC(C1=C(CN(C2)C(CC(NC(C(C3CC3)=O)=O)=O)CC2(F)F)NC(c2ncc[s]2)=N[C@H]1c(c(Br)c1)ccc1F)=O Chemical compound CCOC(C1=C(CN(C2)C(CC(NC(C(C3CC3)=O)=O)=O)CC2(F)F)NC(c2ncc[s]2)=N[C@H]1c(c(Br)c1)ccc1F)=O FMXVSJPWIBXXKQ-XLDIYJRPSA-N 0.000 description 1
- LICCPCYNFDNCBM-JQHMPQBSSA-N CCOC(C1=C(CN(C2)[C@@H](CC(C)C(N=O)=O)CC2(F)F)NC(c2ncc[s]2)=N[C@H]1c(c(Br)c1)ccc1F)=O Chemical compound CCOC(C1=C(CN(C2)[C@@H](CC(C)C(N=O)=O)CC2(F)F)NC(c2ncc[s]2)=N[C@H]1c(c(Br)c1)ccc1F)=O LICCPCYNFDNCBM-JQHMPQBSSA-N 0.000 description 1
- FAVFYVJJBLNTBK-HKUYNNGSSA-N CCOC(C1=C(CN(CCSC2)[C@@H]2C(NOC)=O)NC(c2ncc[s]2)=N[C@H]1c(c(Cl)c1)ccc1F)=O Chemical compound CCOC(C1=C(CN(CCSC2)[C@@H]2C(NOC)=O)NC(c2ncc[s]2)=N[C@H]1c(c(Cl)c1)ccc1F)=O FAVFYVJJBLNTBK-HKUYNNGSSA-N 0.000 description 1
- PYWSMGHXJUXUSK-VIFPVBQESA-N CCOC([C@H](CCC(C1)(F)F)N1C(OC(C)(C)C)=O)=O Chemical compound CCOC([C@H](CCC(C1)(F)F)N1C(OC(C)(C)C)=O)=O PYWSMGHXJUXUSK-VIFPVBQESA-N 0.000 description 1
- ONELXRQCJBCEOV-ZDUSSCGKSA-N COC(C1=C(CBr)NC(c2ncc[s]2)=N[C@H]1c(c(Cl)c1)ccc1F)=O Chemical compound COC(C1=C(CBr)NC(c2ncc[s]2)=N[C@H]1c(c(Cl)c1)ccc1F)=O ONELXRQCJBCEOV-ZDUSSCGKSA-N 0.000 description 1
- BHRBGLXLHBPROD-VLIAUNLRSA-N C[n]1c(C2=N[C@@H](c(c(Cl)c3)ccc3F)C(C(OC)=O)=C(CN(C3)[C@H](CCC(O)=O)CC3(F)F)N2)ncc1 Chemical compound C[n]1c(C2=N[C@@H](c(c(Cl)c3)ccc3F)C(C(OC)=O)=C(CN(C3)[C@H](CCC(O)=O)CC3(F)F)N2)ncc1 BHRBGLXLHBPROD-VLIAUNLRSA-N 0.000 description 1
- XMIAFAKRAAMSGX-UHFFFAOYSA-N Nc1cccc2ncccc12 Chemical compound Nc1cccc2ncccc12 XMIAFAKRAAMSGX-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410657898.XA CN104650068B (zh) | 2013-11-19 | 2014-11-18 | 二氢嘧啶类化合物及其在药物中的应用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013105906836 | 2013-11-19 | ||
| CN201310590683 | 2013-11-19 | ||
| CN201410108925 | 2014-03-23 | ||
| CN2014101089258 | 2014-03-23 | ||
| CN201410657898.XA CN104650068B (zh) | 2013-11-19 | 2014-11-18 | 二氢嘧啶类化合物及其在药物中的应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104650068A CN104650068A (zh) | 2015-05-27 |
| CN104650068B true CN104650068B (zh) | 2018-08-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410657898.XA Active CN104650068B (zh) | 2013-11-19 | 2014-11-18 | 二氢嘧啶类化合物及其在药物中的应用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9498479B2 (https=) |
| EP (1) | EP3071564B1 (https=) |
| JP (1) | JP6524081B2 (https=) |
| KR (1) | KR20160077050A (https=) |
| CN (1) | CN104650068B (https=) |
| AU (1) | AU2014352404B2 (https=) |
| CA (1) | CA2920415A1 (https=) |
| MX (1) | MX2016006564A (https=) |
| RU (1) | RU2678990C1 (https=) |
| WO (1) | WO2015074546A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201601813UA (en) | 2013-11-27 | 2016-04-28 | Sunshine Lake Pharma Co Ltd | Processes for preparing dihydropyrimidine derivatives and intermediates thereof |
| SG11201605896WA (en) | 2014-03-28 | 2016-08-30 | Sunshine Lake Pharma Co Ltd | Dihydropyrimidine compounds and their application in pharmaceuticals |
| US10098889B2 (en) | 2015-02-07 | 2018-10-16 | Sunshine Lake Pharma Co., Ltd. | Complexes and salts of dihydropyrimidine derivatives and their application in pharmaceuticals |
| US20160286398A1 (en) | 2015-03-23 | 2016-09-29 | Qualcomm Incorporated | Schedule selection and connection setup between devices participating in a nan data link |
| US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10179131B2 (en) * | 2015-07-13 | 2019-01-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| JP6668468B2 (ja) | 2015-11-03 | 2020-03-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｈｂｖキャプシドアセンブリ阻害剤とインターフェロンの併用療法 |
| WO2017136403A1 (en) | 2016-02-02 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2017136254A1 (en) * | 2016-02-04 | 2017-08-10 | Merck Sharp & Dohme Corp. | Methods of preparing hydroxylamine derivatives useful in the preparation of anti-infective agents |
| JP6904970B2 (ja) | 2016-03-07 | 2021-07-21 | エナンタ ファーマシューティカルズ インコーポレイテッド | Ｂ型肝炎抗ウイルス剤 |
| CN109843296A (zh) | 2016-06-10 | 2019-06-04 | 英安塔制药有限公司 | 乙型肝炎抗病毒药剂 |
| CN109689059A (zh) | 2016-08-24 | 2019-04-26 | 豪夫迈·罗氏有限公司 | Hbv衣壳组装抑制剂和核苷或核苷酸类似物的组合疗法 |
| SG10202010180YA (en) * | 2016-11-18 | 2020-11-27 | Sichuan Kelun Biotech Biopharmaceutical Co Ltd | Dihydropyrimidine compound and preparation method and use thereof |
| US11166954B2 (en) | 2016-11-18 | 2021-11-09 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Dihydropyrimidine compound and preparation method and use thereof |
| CN109111451B (zh) * | 2017-06-26 | 2020-08-11 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
| KR20200020887A (ko) | 2017-06-27 | 2020-02-26 | 얀센 파마슈티카 엔.브이. | 헤테로아릴디히드로피리미딘 유도체 및 b형 간염 감염의 치료 방법 |
| US10952978B2 (en) | 2017-08-28 | 2021-03-23 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11261190B2 (en) * | 2017-10-18 | 2022-03-01 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and uses thereof in medicine |
| TW201927789A (zh) | 2017-12-06 | 2019-07-16 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
| TW201936192A (zh) | 2017-12-06 | 2019-09-16 | 美商因那塔製藥公司 | B 型肝炎抗病毒試劑 |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2019191166A1 (en) | 2018-03-29 | 2019-10-03 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| CN108329308B (zh) | 2018-05-16 | 2022-11-01 | 四川科伦博泰生物医药股份有限公司 | 一种二氢嘧啶类化合物的固体形式及其制备方法 |
| US11053235B2 (en) | 2018-08-09 | 2021-07-06 | Janssen Sciences Ireland Unlimited Company | Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases |
| UY38383A (es) | 2018-09-21 | 2020-04-30 | Enanta Pharm Inc | Heterociclos funcionalizados como agentes antivirales |
| US20210395751A1 (en) | 2018-10-31 | 2021-12-23 | The University Of Sydney | Compositions and methods for treating viral infections |
| US11198693B2 (en) | 2018-11-21 | 2021-12-14 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| WO2020247561A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| WO2020247575A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US11236108B2 (en) | 2019-09-17 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| CN113831359B (zh) * | 2020-06-24 | 2026-03-06 | 广东东阳光药业股份有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
| CN118955353A (zh) * | 2024-10-14 | 2024-11-15 | 南京恒远科技开发有限公司 | 一种(s)-4,4-二氟-1-甘氨酰吡咯烷-2-氰基的合成方法 |
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| WO2001068641A1 (de) * | 2000-03-17 | 2001-09-20 | Bayer Aktiengesellschaft | 6-aminoalkyl-dihydroppyrimidine und ihre verwendung als arzneimittel gegen virale erkrankungen |
| EP1265889B1 (de) * | 2000-03-16 | 2004-06-16 | Bayer HealthCare AG | Arzneimittel gegen virale erkrankungen |
| CN101328168A (zh) * | 2007-06-18 | 2008-12-24 | 张中能 | 一种乙氧碳酰基-取代噻唑二氢嘧啶 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61271278A (ja) | 1985-05-20 | 1986-12-01 | イ− ア−ル スクイブ アンド サンズ インコ−ポレ−テツド | ２−置換チオまたはオキソ−４−アリ−ルまたはヘテロシクロ−５−カルボキシ−１，４−ジヒドロピリミジン |
| GB8906168D0 (en) | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
| SE9702564D0 (sv) | 1997-07-02 | 1997-07-02 | Astra Ab | New compounds |
| SE9702563D0 (sv) | 1997-07-02 | 1997-07-02 | Astra Ab | Compounds |
| DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
| DE19817262A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue 2-heterocyclisch substituierte Dihydropyrimidine |
| DE19817265A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Verwendung von Dihydropyrimidinen als Arzneimittel und neue Stoffe |
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- 2014-11-18 CN CN201410657898.XA patent/CN104650068B/zh active Active
- 2014-11-18 EP EP14863769.7A patent/EP3071564B1/en active Active
- 2014-11-18 CA CA2920415A patent/CA2920415A1/en not_active Abandoned
- 2014-11-18 AU AU2014352404A patent/AU2014352404B2/en active Active
- 2014-11-18 WO PCT/CN2014/091444 patent/WO2015074546A1/en not_active Ceased
- 2014-11-18 US US15/022,562 patent/US9498479B2/en active Active
- 2014-11-18 JP JP2016530248A patent/JP6524081B2/ja active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| CN104650068A (zh) | 2015-05-27 |
| EP3071564B1 (en) | 2020-08-05 |
| AU2014352404B2 (en) | 2018-07-19 |
| MX2016006564A (es) | 2017-09-12 |
| KR20160077050A (ko) | 2016-07-01 |
| EP3071564A4 (en) | 2017-04-26 |
| CA2920415A1 (en) | 2015-05-28 |
| AU2014352404A1 (en) | 2016-02-18 |
| JP6524081B2 (ja) | 2019-06-05 |
| EP3071564A1 (en) | 2016-09-28 |
| US9498479B2 (en) | 2016-11-22 |
| RU2678990C1 (ru) | 2019-02-05 |
| WO2015074546A1 (en) | 2015-05-28 |
| JP2016537358A (ja) | 2016-12-01 |
| US20160206616A1 (en) | 2016-07-21 |
| HK1224286A1 (en) | 2017-08-18 |
| RU2016122908A (ru) | 2017-12-25 |
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