CN104645116A - Traditional Chinese medicine oral liquid for treating duck viral hepatitis and preparation method of traditional Chinese medicine oral liquid - Google Patents
Traditional Chinese medicine oral liquid for treating duck viral hepatitis and preparation method of traditional Chinese medicine oral liquid Download PDFInfo
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- CN104645116A CN104645116A CN201510106197.1A CN201510106197A CN104645116A CN 104645116 A CN104645116 A CN 104645116A CN 201510106197 A CN201510106197 A CN 201510106197A CN 104645116 A CN104645116 A CN 104645116A
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Abstract
The invention relates to traditional Chinese medicine oral liquid for treating duck viral hepatitis and a preparation method of the traditional Chinese medicine oral liquid. The traditional Chinese medicine oral liquid is prepared from indigowoad leaves, Indian buead, raw tuber fleeceflower root, fructus forsythiae, tree peony bark, largehead atractylodes rhizome, India madder root, radix salviae miltiorrhizae, Chinese thorowax root, virgate wormwood herb, lalang grass rhizome and liquorice root. The traditional Chinese medicine composition can be the oral liquid, and the preparation method comprises the following steps: (1) crushing traditional Chinese medicines to 60-80 meshes, weighing according to formula amount of each traditional Chinese medicine, and performing three-dimensional mixing to obtain traditional Chinese medicine powder; (2) respectively putting the traditional Chinese medicine powder after mixing and 300-600 parts of water into an extraction tank, and soaking for 5-20h; (3) heating to 40-100 DEG C and extracting for 10-15h; (4) filtering and collecting medicine liquid; (5) continuously adding 300-600 parts of water into the remaining medicine residues and extracting for 10-15h at 40-100 DEG C; (6) filtering to remove the medicine residues, merging extraction solutions obtained twice, and performing reduced pressure concentration at 30-70 DEG C to 10%-20% of original volume; and (7) filling into bottles according to 250ml per bottle to obtain finished products. The traditional Chinese medicine oral liquid provided by the invention can effectively treat the duck viral hepatitis, and the cure rate is above 90%. The traditional Chinese medicine oral liquid has the effects of clearing away heat and toxic materials, clearing the liver and benefiting the bile, removing wet heat and removing jaundice.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, especially a kind of Chinese medicine oral liquid for the treatment of duck viral hepatitis and preparation method thereof.
Background technology
Duck viral hepatitis causes the one of duckling to propagate rapidly and height lethal infectious diseases by DHV.Principal character is liver enlargement, has hemorrhage speckle and nervous symptoms.At new epidemic area, the mortality rate of primary disease is very high, can reach more than 90%.
It is scorching that duck viral hepatitis is called for short duck liver, is cause a kind of of duckling to present with liver the acute deadly infectious disease that hemorrhagic inflammation is feature by virulent duck enteritis virus.Within 1945, at U.S.'s Late Cambrian primary disease, and called after I type duck viral hepatitis, nineteen sixty-five has found duck viral hepatitis II type in Britain, within 1969, has found duck viral hepatitis type III in the U.S..At present, I type is worldwide distribution, and is once reported in the variant that India, Egypt and the U.S. find I type DHV.II type and type III duck viral hepatitis are confined to UK and USA respectively, do not find variation strain.At home, duck viral hepatitis popular for the first time, it is again popular in China that phase early 1980s plays primary disease, and after this, various places epidemic situation is risen one after another, epidemic situation can control by the immunity of duck viral hepatitis I type attenuated vaccine; Since 1997, primary disease occurs more serious popular in certain areas, its epidemic situation fully can not be controlled by standard duck viral hepatitis I type attenuated vaccine, has I type virulent duck enteritis virus variant to occur.The scorching I type of duck liver causes the Serious Mortality of duckling, and mortality rate is up to 90%, and middle one-tenth duck does not generally fall ill, and the feature of sick duckling is that consciousness is disorderly, and again and again twitch, liver is mottled hemorrhage, gollbladder dilation, and bile color is thin out.
Clinically at present specific medicament be there is no for duck viral hepatitis, mainly by putting prevention first.Therefore develop a kind of Chinese medicine oral liquid can treating duck viral hepatitis, greatly can improve the actual effect of clinical treatment.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, provides a kind of good effect, no drug residue, safe and reliable treatment duck viral hepatitis Chinese medicine oral liquid.
Another technical problem that the present invention will solve is: provide a kind of Chinese medicine formula for the treatment of duck viral hepatitis.
Another technical problem that the present invention will solve is: the preparation method providing the oral liquid formulations of above-mentioned goose Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of duck viral hepatitis, is prepared from by the raw material of following mass fraction: by Folium Isatidis 20-40 part, Poria 20-40 part, Radix Polygoni Multiflori 20-40 part, Fructus Forsythiae 20-40 part, Cortex Moutan 20-40 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Radix Rubiae 20-40 part, Radix Salviae Miltiorrhizae 20-40 part, Radix Bupleuri 20-40 part, Herba Artemisiae Scopariae 20-40 part, Rhizoma Imperatae 20-40 part, Radix Glycyrrhizae 20-40 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows:
Folium Isatidis 40 parts, 30 parts, Poria, Radix Polygoni Multiflori 30 parts, Fructus Forsythiae 40 parts, Cortex Moutan 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 30 parts, Radix Rubiae, Radix Salviae Miltiorrhizae 30 parts, Radix Bupleuri 40 parts, Herba Artemisiae Scopariae 40 parts, Rhizoma Imperatae 30 parts, 40 parts, Radix Glycyrrhizae.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
Further, the preparation method of the oral liquid formulations of said composition is: Chinese medicine powder is broken to 60-80 order by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 300-600 part water are put in extraction pot respectively, soak 5-20 hour; (3) be heated to 40-100 DEG C and extract 10-15 hour; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 300-600 part water, and 40-100 DEG C is extracted 10-15 hour; (6) excessively filter medicinal residues, merge extracted twice liquid, 30-70 DEG C is evaporated to original volume 10%-20%; (7) fill becomes bottle, and every bottle of 250ml, gets product.
The advantage that the present invention has and good effect are:
(1) the present invention is according to tcm theory, and scientific compatibility, remains the combined effect of Chinese medicinal formulae determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, through clinical verification determined curative effect, is a kind of green veterinary drug of nuisanceless, no drug residue.
(2) Chinese medicine ingredients that the present invention contains effectively can treat duck viral hepatitis, and cure rate can reach more than 90%.This prescription has heat-clearing and toxic substances removing, liver heat removing function of gallbladder promoting, damp eliminating heat, the effect of jaundice eliminating subcutaneous ulcer.
(3) pharmacology of each raw material of Chinese medicine of the present invention is:
Folium Isatidis: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing;
Poria: warming and activating heart-YANG, diuretic dampness;
Radix Polygoni Multiflori: removing toxicity for eliminating carbuncles;
Fructus Forsythiae: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation;
Cortex Moutan: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis;
The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness diuretic;
Radix Rubiae: cooling blood for hemostasis, blood stasis dispelling;
Radix Salviae Miltiorrhizae: stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle;
Radix Bupleuri: deliver bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, yang invigorating;
Herba Artemisiae Scopariae: clearing away heat-damp and promoting diuresis, jaundice eliminating;
Rhizoma Imperatae: cooling blood for hemostasis, heat-clearing and toxic substances removing;
Radix Glycyrrhizae: heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription;
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
A Chinese medicine oral liquid for treatment duck viral hepatitis, the parts by weight of each raw material are as follows: Folium Isatidis 40 parts, 30 parts, Poria, Radix Polygoni Multiflori 30 parts, Fructus Forsythiae 40 parts, Cortex Moutan 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 30 parts, Radix Rubiae, Radix Salviae Miltiorrhizae 30 parts, Radix Bupleuri 40 parts, Herba Artemisiae Scopariae 40 parts, Rhizoma Imperatae 30 parts, 40 parts, Radix Glycyrrhizae.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product.
Embodiment 2
A Chinese medicine oral liquid for treatment duck viral hepatitis, the parts by weight of each raw material are as follows: Folium Isatidis 40 parts, 30 parts, Poria, Radix Polygoni Multiflori 20 parts, Fructus Forsythiae 30 parts, Cortex Moutan 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 30 parts, Radix Rubiae, Radix Salviae Miltiorrhizae 30 parts, Radix Bupleuri 40 parts, Herba Artemisiae Scopariae 20 parts, Rhizoma Imperatae 30 parts, 40 parts, Radix Glycyrrhizae.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product
Embodiment 3
A Chinese medicine oral liquid for treatment duck viral hepatitis, the parts by weight of each raw material are as follows: Folium Isatidis 40 parts, 40 parts, Poria, Radix Polygoni Multiflori 30 parts, Fructus Forsythiae 30 parts, Cortex Moutan 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 30 parts, Radix Rubiae, Radix Salviae Miltiorrhizae 30 parts, Radix Bupleuri 30 parts, Herba Artemisiae Scopariae 40 parts, Rhizoma Imperatae 20 parts, 40 parts, Radix Glycyrrhizae.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product
Clinical trial
Experimental example:
Duck field, Jiangxi, duckling 3000, falls ill 600.Clinical identification is duck viral hepatitis.To wherein 300 use product obtained by embodiments 1.Every bottle of spice 100 kilograms, once a day, treats three days.Medication the second symptom is obviously alleviated, and spirit takes a turn for the better, and feed intake increases.Recovery from illness in 3rd day.After drug withdrawal, do not occur repeatedly.Cure rate reaches 95%, does not occur death.Another 200 use astragalus polysaccharides to coordinate cefotaxime sodium, treatment three days continuously, cure rate 69%.
Experiment proves that product obtained by embodiment 1 subtracts effect fast, determined curative effect, not easily repeatedly.
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiments according to limited range, therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (7)
1. Chinese medicine oral liquid for the treatment of duck viral hepatitis and preparation method thereof, is characterized in that: be prepared from by the raw material of following mass fraction: by Folium Isatidis 20-40 part, Poria 20-40 part, Radix Polygoni Multiflori 20-40 part, Fructus Forsythiae 20-40 part, Cortex Moutan 20-40 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Radix Rubiae 20-40 part, Radix Salviae Miltiorrhizae 20-40 part, Radix Bupleuri 20-40 part, Herba Artemisiae Scopariae 20-40 part, Rhizoma Imperatae 20-40 part, Radix Glycyrrhizae 20-40 part.
2. the Chinese medicine oral liquid for the treatment of duck viral hepatitis according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
Folium Isatidis 40 parts, 30 parts, Poria, Radix Polygoni Multiflori 30 parts, Fructus Forsythiae 40 parts, Cortex Moutan 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 30 parts, Radix Rubiae, Radix Salviae Miltiorrhizae 30 parts, Radix Bupleuri 40 parts, Herba Artemisiae Scopariae 40 parts, Rhizoma Imperatae 30 parts, 40 parts, Radix Glycyrrhizae.
3. the Chinese medicine oral liquid for the treatment of duck viral hepatitis according to claim 1 and 2, is characterized in that: this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
4. the Chinese medicine oral liquid for the treatment of duck viral hepatitis according to claim 3, is characterized in that: described preparation can be oral liquid.
5. prepare a method for the Chinese medicine oral liquid for the treatment of duck viral hepatitis as claimed in claim 4, it is characterized in that: preparation method is that Chinese medicine powder is broken to certain order number by (1), and take by formula ratio, three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, aqueous solution are put in extraction pot respectively, soak the regular hour; (3) be heated to uniform temperature, extract certain hour; (4) collecting by filtration extracting solution; (5) secondary adds a certain amount of water in medicinal residues, continues to extract certain hour at a certain temperature; (6) merge extracted twice liquid, be evaporated to certain volume at a certain temperature; (7) fill becomes bottle, gets product.
6. the preparation method of the Chinese medicine oral liquid for the treatment of duck viral hepatitis according to claim 5, is characterized in that: described pulverizing order number is 60-80 order.
7. the preparation method of the Chinese medicine oral liquid for the treatment of duck viral hepatitis according to claim 5, is characterized in that: the extracted twice time is 10-15 hour.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107469013A (en) * | 2017-09-21 | 2017-12-15 | 胡边文 | A kind of medicament and preparation method for being used to prevent and treat aquatic livestock disease in the liver and gallbladder |
| CN107519460A (en) * | 2017-10-23 | 2017-12-29 | 何正国 | A kind of medicament and preparation method for being used to prevent and treat aquatic livestock disease in the liver and gallbladder |
| CN107737264A (en) * | 2017-11-30 | 2018-02-27 | 融安县浪溪河谷金桔开发有限责任公司 | A kind of oral liquid for preventing and treating poultry hepatitis and preparation method thereof |
| CN109528850A (en) * | 2017-09-21 | 2019-03-29 | 扬中牧乐药业有限公司 | A kind of oral solution for treating duck virus hepatitis |
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| CN102579593A (en) * | 2012-02-23 | 2012-07-18 | 青岛绿曼生物工程有限公司 | Pure Chinese medicinal composition for treating infectious bursal disease, newcastle disease, duck virus hepatitis and other viral diseases, as well as preparation method thereof |
| CN103142735A (en) * | 2013-03-09 | 2013-06-12 | 河北工程大学 | Traditional Chinese medicine oral liquid for treating duck virus hepatitis |
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2015
- 2015-03-11 CN CN201510106197.1A patent/CN104645116A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102579593A (en) * | 2012-02-23 | 2012-07-18 | 青岛绿曼生物工程有限公司 | Pure Chinese medicinal composition for treating infectious bursal disease, newcastle disease, duck virus hepatitis and other viral diseases, as well as preparation method thereof |
| CN103142735A (en) * | 2013-03-09 | 2013-06-12 | 河北工程大学 | Traditional Chinese medicine oral liquid for treating duck virus hepatitis |
Non-Patent Citations (1)
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107469013A (en) * | 2017-09-21 | 2017-12-15 | 胡边文 | A kind of medicament and preparation method for being used to prevent and treat aquatic livestock disease in the liver and gallbladder |
| CN109528850A (en) * | 2017-09-21 | 2019-03-29 | 扬中牧乐药业有限公司 | A kind of oral solution for treating duck virus hepatitis |
| CN107519460A (en) * | 2017-10-23 | 2017-12-29 | 何正国 | A kind of medicament and preparation method for being used to prevent and treat aquatic livestock disease in the liver and gallbladder |
| CN107737264A (en) * | 2017-11-30 | 2018-02-27 | 融安县浪溪河谷金桔开发有限责任公司 | A kind of oral liquid for preventing and treating poultry hepatitis and preparation method thereof |
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Application publication date: 20150527 |