CN104324297A - Traditional Chinese medicine granules for treating secondary pulmonary tuberculosis and preparation method of traditional Chinese medicine granules - Google Patents

Traditional Chinese medicine granules for treating secondary pulmonary tuberculosis and preparation method of traditional Chinese medicine granules Download PDF

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CN104324297A
CN104324297A CN201410553091.1A CN201410553091A CN104324297A CN 104324297 A CN104324297 A CN 104324297A CN 201410553091 A CN201410553091 A CN 201410553091A CN 104324297 A CN104324297 A CN 104324297A
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parts
radix
traditional chinese
pulmonary tuberculosis
chinese medicine
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郭云芳
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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Abstract

The invention discloses traditional Chinese medicine granules for treating secondary pulmonary tuberculosis and a preparation method of the traditional Chinese medicine granules, and relates to the technical field of pulmonary tuberculosis treatment. The granules are prepared from the following raw materials in parts by mass: 40-50 parts of astragalus membranaceus, 35-40 parts of codonopsis pilosula, 18-25 parts of licorice root, 15-20 parts of tatarian aster root, 13-18 parts of mulberry bark, 10-15 parts of coltsfoot, 8-12 parts of rhizoma atractylodis macrocephalae, 5-10 parts of saposhnicovia divaricata, 10-14 parts of Chinese yam, 15-18 parts of fritillaria cirrhosa, 6-9 parts of fructus mume, 3-5 parts of platycodon grandiflorum, 8-12 parts of lily, 4-8 parts of lotus seed, 10-13 parts of radix stemonae, 5-8 parts of apricot kernel, 7-10 parts of sanguisorba officinalis, 15-20 parts of folium eriobotryae, 3-7 parts of fructus schizandrae and 13-18 parts of Chinese date. The traditional Chinese medicine granules are prepared from natural traditional Chinese medicinal materials, and the effective ingredients are extracted according to types of medicinal material properties; and the prepared traditional Chinese medicine granules have the characteristics of convenient carrying and using, has remarkable drug effect, and does not have side effect.

Description

A kind of Chinese medicinal granule for the treatment of secondary pulmonary tuberculosis and preparation method thereof
Technical field:
The present invention relates to tuberculosis treatment technical field, be specifically related to a kind of Chinese medicinal granule for the treatment of secondary pulmonary tuberculosis and preparation method thereof.
Background technology:
Secondary pulmonary tuberculosis is III type pulmonary tuberculosis, comprises infiltrative pulmonary tuberculosis and chronic fibro cavernous pulmonary tuberculosis two kinds of pulmonary tuberculosis that pulmonary tuberculosis five type in 1978 divides apoplexy due to endogenous wind.After mycobacterium tuberculosis primary infection, in (how in the Childhood) body, the mycobacterium tuberculosis of hiding in focus is bred again, and the focus resume combustion caused is principal pathogenetic reason (claiming endogenous recurrence).Also can again be fallen ill (claiming exogenous redying) by the extraneous mycobacterium tuberculosis of infection.This type is any age after can occurring in primary infection, common to be grown up, and is the most common type of adult pulmonary tuberculosis.
The medicine of clinical treatment secondary pulmonary tuberculosis is divided into chemical drugs and Chinese medicine two class, although and chemical drugs taking convenience, there is the shortcoming that toxic and side effects is large, and Chinese medicine exists and takes the shortcoming that inconvenience, target are indefinite and the course for the treatment of is long, bring very large misery to patient.
Summary of the invention:
Technical problem to be solved by this invention is to provide a kind of good effect, Chinese medicinal granule for the treatment of secondary pulmonary tuberculosis of having no side effect and preparation method thereof.
Technical problem to be solved by this invention adopts following technical scheme to realize:
Treat a Chinese medicinal granule for secondary pulmonary tuberculosis, be made up of the raw material of following mass fraction:
Radix Astragali 40-50 part, Radix Codonopsis 35-40 part, Radix Glycyrrhizae 18-25 part, Radix Asteris 15-20 part, Cortex Mori 13-18 part, coltsfoot 10-15 part, Rhizoma Atractylodis Macrocephalae 8-12 part, Radix Saposhnikoviae 5-10 part, Rhizoma Dioscoreae 10-14 part, Bulbus Fritillariae Cirrhosae 15-18 part, Fructus Mume 6-9 part, Radix Platycodonis 3-5 part, Bulbus Lilii 8-12 part, Semen Nelumbinis 4-8 part, Radix Stemonae 10-13 part, Semen Armeniacae Amarum 5-8 part, Radix Sanguisorbae 7-10 part, Folium Eriobotryae 15-20 part, Fructus Schisandrae Chinensis 3-7 part, Fructus Jujubae 13-18 part.
The Chinese medicinal granule of described treatment secondary pulmonary tuberculosis is made up of the raw material of following mass fraction:
The Radix Astragali 45 parts, Radix Codonopsis 37 parts, 20 parts, Radix Glycyrrhizae, Radix Asteris 18 parts, Cortex Mori 15 parts, coltsfoot 12 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Saposhnikoviae 8 parts, Rhizoma Dioscoreae 12 parts, Bulbus Fritillariae Cirrhosae 17 parts, Fructus Mume 8 parts, Radix Platycodonis 4 parts, Bulbus Lilii 10 parts, 6 parts, Semen Nelumbinis, the Radix Stemonae 11 parts, 6 parts, Semen Armeniacae Amarum, Radix Sanguisorbae 9 parts, Folium Eriobotryae 17 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Jujubae 15 parts.
The preparation method of the Chinese medicinal granule of described treatment secondary pulmonary tuberculosis comprises the steps:
(1) all medical materials clean after dry, refined honey is added certain amount of boiling water dilution be placed in pot, after sweet liquid boils, add the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae, Radix Asteris, Cortex Mori and coltsfoot, fry to the dry medical material of liquid be buff and loosen tack-free, dry after pouring out;
(2) in proportion the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, Radix Platycodonis, Bulbus Lilii, the Radix Stemonae, Radix Sanguisorbae, Folium Eriobotryae and Fructus Schisandrae Chinensis are added in pot, add the warm water higher than medical material surface 5-10cm again, heating is started after soaking 30-45min, intense fire transfers slow fire to after decocting 30-35min, after 45-60min, medicine juice is poured out, add water and carry out secondary decoction, after merging medicine juice, obtain medicinal liquid I;
(3) add in pot after Bulbus Fritillariae Cirrhosae, Semen Nelumbinis and Semen Armeniacae Amarum powder being broken to 20-40 order, add the water higher than powder 5-10cm again, intense fire adds Rhizoma Dioscoreae, Fructus Mume and Fructus Jujubae after decocting 20-25min, transfers slow fire to after continuing to decoct 10-15min, after 30-45min, medicine juice is poured out, obtain medicinal liquid II;
(4) heat concentrated medicament by after medicinal liquid I and the abundant mix homogeneously of medicinal liquid II with slow fire, and add proper honey, the lower medicinal liquid of continuous stirring gradually retrogradation becomes extractum shape, then adds appropriate amount of starch, dry after mix homogeneously, i.e. obtained Chinese medicinal granule.
The consumption of described refined honey is that every 100 parts of medical materials use refined honey 20-30 part.
The invention has the beneficial effects as follows: the present invention take natural Chinese medicine as raw material, the extraction of effective ingredient is carried out according to medicinal property classification, obtained Chinese medicinal granule not only has and carries and feature easy to use, and drug effect is remarkable, without any side effects, effectively can cure secondary pulmonary tuberculosis, and not easily recur after curing.
Detailed description of the invention:
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
Treat a Chinese medicinal granule for secondary pulmonary tuberculosis, be made up (every part of 5g) of the raw material of following mass fraction: the Radix Astragali 40 parts, Radix Codonopsis 35 parts, 18 parts, Radix Glycyrrhizae, Radix Asteris 15 parts, Cortex Mori 13 parts, coltsfoot 10 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Radix Saposhnikoviae 5 parts, Rhizoma Dioscoreae 10 parts, Bulbus Fritillariae Cirrhosae 15 parts, Fructus Mume 6 parts, Radix Platycodonis 3 parts, Bulbus Lilii 8 parts, 4 parts, Semen Nelumbinis, the Radix Stemonae 10 parts, 5 parts, Semen Armeniacae Amarum, Radix Sanguisorbae 7 parts, Folium Eriobotryae 15 parts, Fructus Schisandrae Chinensis 3 parts, Fructus Jujubae 13 parts.
Carry out the preparation of Chinese medicinal granule according to above-mentioned formula, concrete steps are as follows:
(1) all medical materials clean after dry, refined honey is added certain amount of boiling water dilution be placed in pot, after sweet liquid boils, add the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae, Radix Asteris, Cortex Mori and coltsfoot, fry to the dry medical material of liquid be buff and loosen tack-free, dry after pouring out;
(2) in proportion the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, Radix Platycodonis, Bulbus Lilii, the Radix Stemonae, Radix Sanguisorbae, Folium Eriobotryae and Fructus Schisandrae Chinensis are added in pot, add the warm water higher than medical material surface 5-10cm again, heating is started after soaking 30-45min, intense fire transfers slow fire to after decocting 30-35min, after 45-60min, medicine juice is poured out, add water and carry out secondary decoction, after merging medicine juice, obtain medicinal liquid I;
(3) add in pot after Bulbus Fritillariae Cirrhosae, Semen Nelumbinis and Semen Armeniacae Amarum powder being broken to 20-40 order, add the water higher than powder 5-10cm again, intense fire adds Rhizoma Dioscoreae, Fructus Mume and Fructus Jujubae after decocting 20-25min, transfers slow fire to after continuing to decoct 10-15min, after 30-45min, medicine juice is poured out, obtain medicinal liquid II;
(4) heat concentrated medicament by after medicinal liquid I and the abundant mix homogeneously of medicinal liquid II with slow fire, and add proper honey, the lower medicinal liquid of continuous stirring gradually retrogradation becomes extractum shape, then adds appropriate amount of starch, dry after mix homogeneously, i.e. obtained Chinese medicinal granule.
Wherein, the consumption of refined honey is that every 100 parts of medical materials use refined honey 20 parts.
Embodiment 2
Treat a Chinese medicinal granule for secondary pulmonary tuberculosis, be made up (every part of 5g) of the raw material of following mass fraction: the Radix Astragali 45 parts, Radix Codonopsis 37 parts, 20 parts, Radix Glycyrrhizae, Radix Asteris 18 parts, Cortex Mori 15 parts, coltsfoot 12 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Saposhnikoviae 8 parts, Rhizoma Dioscoreae 12 parts, Bulbus Fritillariae Cirrhosae 17 parts, Fructus Mume 8 parts, Radix Platycodonis 4 parts, Bulbus Lilii 10 parts, 6 parts, Semen Nelumbinis, the Radix Stemonae 11 parts, 6 parts, Semen Armeniacae Amarum, Radix Sanguisorbae 9 parts, Folium Eriobotryae 17 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Jujubae 15 parts.
The preparation method of the present embodiment Chinese medicinal granule is with embodiment 1, and wherein the consumption of refined honey is that every 100 parts of medical materials use refined honey 22 parts.
Embodiment 3
Treat a Chinese medicinal granule for secondary pulmonary tuberculosis, be made up (every part of 5g) of the raw material of following mass fraction: the Radix Astragali 50 parts, Radix Codonopsis 40 parts, 25 parts, Radix Glycyrrhizae, Radix Asteris 20 parts, Cortex Mori 18 parts, coltsfoot 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Saposhnikoviae 10 parts, Rhizoma Dioscoreae 14 parts, Bulbus Fritillariae Cirrhosae 18 parts, Fructus Mume 9 parts, Radix Platycodonis 5 parts, Bulbus Lilii 12 parts, 8 parts, Semen Nelumbinis, the Radix Stemonae 13 parts, 8 parts, Semen Armeniacae Amarum, Radix Sanguisorbae 10 parts, Folium Eriobotryae 20 parts, Fructus Schisandrae Chinensis 7 parts, Fructus Jujubae 18 parts.
The preparation method of the present embodiment Chinese medicinal granule is with embodiment 1, and wherein the consumption of refined honey is that every 100 parts of medical materials use refined honey 25 parts.
The using method of Chinese medicinal granule of the present invention is: every day three times, ante cibum takes after mixing it with water, each 10-15g, within 1 month, is 1 course for the treatment of.
In order to the curative effect of Chinese medicinal granule of the present invention is described, now extract 240 patients and carry out drug test, be divided into three groups at random, often organize 80 people, be respectively experimental group and matched group, experimental group takes the Chinese medicinal granule that the present invention obtains, and matched group takes Chinese medicine and the Western medicine medicine of other treatment secondary pulmonary tuberculosis, curative effect judgment criteria compares with the result taking 2 courses for the treatment of, and result of the test is as follows.
Group Drug type Case load Healing number Efficiently individual quantity Invalid number Total effective rate
Matched group Oral western medicine 80 26 29 25 69％
Oral Chinese medicine 80 34 30 16 80％
Experimental group Chinese medicine of the present invention 80 50 23 7 91％
Chinese medicinal granule of the present invention cure rate compared with the medicine of other treatment secondary pulmonary tuberculosis is high, and cure rate is 63%, and total effective rate reaches 91%, higher than the total effective rate of matched group oral western medicine by 22%, higher than the total effective rate of matched group oral Chinese medicine by 11%; And carry with easy to use, without any side effects, not easily recurring after healing, is the ideal safe drugs for the treatment of secondary pulmonary tuberculosis.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.

Claims (4)

1. treat the Chinese medicinal granule of secondary pulmonary tuberculosis for one kind, it is characterized in that, be made up of the raw material of following mass fraction: Radix Astragali 40-50 part, Radix Codonopsis 35-40 part, Radix Glycyrrhizae 18-25 part, Radix Asteris 15-20 part, Cortex Mori 13-18 part, coltsfoot 10-15 part, Rhizoma Atractylodis Macrocephalae 8-12 part, Radix Saposhnikoviae 5-10 part, Rhizoma Dioscoreae 10-14 part, Bulbus Fritillariae Cirrhosae 15-18 part, Fructus Mume 6-9 part, Radix Platycodonis 3-5 part, Bulbus Lilii 8-12 part, Semen Nelumbinis 4-8 part, Radix Stemonae 10-13 part, Semen Armeniacae Amarum 5-8 part, Radix Sanguisorbae 7-10 part, Folium Eriobotryae 15-20 part, Fructus Schisandrae Chinensis 3-7 part, Fructus Jujubae 13-18 part.
2. the Chinese medicinal granule for the treatment of secondary pulmonary tuberculosis according to claim 1, it is characterized in that, be made up of the raw material of following mass fraction: the Radix Astragali 45 parts, Radix Codonopsis 37 parts, 20 parts, Radix Glycyrrhizae, Radix Asteris 18 parts, Cortex Mori 15 parts, coltsfoot 12 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Saposhnikoviae 8 parts, Rhizoma Dioscoreae 12 parts, Bulbus Fritillariae Cirrhosae 17 parts, Fructus Mume 8 parts, Radix Platycodonis 4 parts, Bulbus Lilii 10 parts, 6 parts, Semen Nelumbinis, the Radix Stemonae 11 parts, 6 parts, Semen Armeniacae Amarum, Radix Sanguisorbae 9 parts, Folium Eriobotryae 17 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Jujubae 15 parts.
3. the preparation method of the Chinese medicinal granule for the treatment of secondary pulmonary tuberculosis according to claim 1, is characterized in that, comprise the steps:
(1) all medical materials clean after dry, refined honey is added certain amount of boiling water dilution be placed in pot, after sweet liquid boils, add the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae, Radix Asteris, Cortex Mori and coltsfoot, fry to the dry medical material of liquid be buff and loosen tack-free, dry after pouring out;
(2) in proportion the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, Radix Platycodonis, Bulbus Lilii, the Radix Stemonae, Radix Sanguisorbae, Folium Eriobotryae and Fructus Schisandrae Chinensis are added in pot, add the warm water higher than medical material surface 5-10cm again, heating is started after soaking 30-45min, intense fire transfers slow fire to after decocting 30-35min, after 45-60min, medicine juice is poured out, add water and carry out secondary decoction, after merging medicine juice, obtain medicinal liquid I;
(3) add in pot after Bulbus Fritillariae Cirrhosae, Semen Nelumbinis and Semen Armeniacae Amarum powder being broken to 20-40 order, add the water higher than powder 5-10cm again, intense fire adds Rhizoma Dioscoreae, Fructus Mume and Fructus Jujubae after decocting 20-25min, transfers slow fire to after continuing to decoct 10-15min, after 30-45min, medicine juice is poured out, obtain medicinal liquid II;
(4) heat concentrated medicament by after medicinal liquid I and the abundant mix homogeneously of medicinal liquid II with slow fire, and add proper honey, the lower medicinal liquid of continuous stirring gradually retrogradation becomes extractum shape, then adds appropriate amount of starch, dry after mix homogeneously, i.e. obtained Chinese medicinal granule.
4. the preparation method of the Chinese medicinal granule for the treatment of secondary pulmonary tuberculosis according to claim 3, is characterized in that: the consumption of described refined honey is that every 100 parts of medical materials use refined honey 20-30 part.
CN201410553091.1A 2014-10-17 2014-10-17 Traditional Chinese medicine granules for treating secondary pulmonary tuberculosis and preparation method of traditional Chinese medicine granules Pending CN104324297A (en)

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