CN104645068A - Enema for treatment of radiation proctitis - Google Patents
Enema for treatment of radiation proctitis Download PDFInfo
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- CN104645068A CN104645068A CN201510058876.6A CN201510058876A CN104645068A CN 104645068 A CN104645068 A CN 104645068A CN 201510058876 A CN201510058876 A CN 201510058876A CN 104645068 A CN104645068 A CN 104645068A
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Abstract
The invention discloses an enema for the treatment of radiation proctitis, and the enema is composed of panax notoginseng, pear peels, the roots of kudzu vine, sanguisorba officinalis, chickweed, radix paeoniae alba, fructus mume, herba violae, melaleuca leucadendron, agrimonia pilosa ledeb, radix codonopsis, clitocybe gigantean, atractylodes macrocephala koidz, fructus gardeniae, rhizoma atractylodis, caulis spatholobi, dendrobium, malabar spinach, coriolus versicolor, rhizoma corydalis, and radix glycyrrhizae. The enema can be used for significantly easing the clinical symptoms such as mucosanguineous feces, diarrhea, abdominal pain, tenesmus, anal causalgia and bearing-down pains and the like, improving positive stool occult bloods, intestinal mucosal lesions and radiation damages, and improving the living quality of patients; and the enema is low in recurrence rate, reliable in curative effect, stable in function, and has no toxic and side effect, so that the enema is a relatively satisfactory medicament for the treatment of radiation proctitis.
Description
Technical field
The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of enema of radiotherapy proctitis.
Background technology
Radiation rectitis is gynecologic malignant tumor or the radiocurable major complications of male prostate malignant tumor.In bibliographical information cervical cancer extracorporeal irradiation binding cavity during High dose rate irradiation treatment, in, the incidence rate of severe radiation rectitis is about 5.3 ~ 15.6%.Radiation rectitis is also the common complication of pelvic cavity radiation therapy.It is a kind of self-healing property disease.As treated and nursing timely, proper, its course of disease can be shortened, alleviate misery and the financial burden of patient, improve its life quality.
Rectum is bled, and is scarlet or kermesinus, how flows out when defecation, be generally hemorrhage on a small quantity, bleed profusely once in a while.Have slough to come off discharge after ulceration, frowziness, anorectum is ached or causalgia, occurs tenesmus because of sphincter irriate later.Woman uterus cancer, pudendum and cancer of vagina and Anal canal cancer, application of radiation radium, cobalt, caesium etc. carry out irradiation treatment, and these radioactivity essences have inhibitory action to cancer, and normal tissue also has infringement, during infringement mucous membrane of rectum, can cause radiation rectitis.So the radiation rectitis caused because of radiotherapy, be more common clinically.
Radiation enteritis early stage or damage comparatively the lighter, touch can without special discovery.Also anal sphincter contraction and tenderness can be only had.Some rectum front walls can have edema, thicken, hardening, fingerstall stains.Sometimes can touch ulcer, narrow or fistula road, have 3% serious rectum impairer to form recto-vaginal fistula.Visible intestinal mucosa hyperemia within the several weeks started, edema, granular change and fragility increase, and touch easily hemorrhage, rectum front wall is very.Thicken later, hardening and distinctive telangiectasis, ulcer and stenosis of bowel.Ulcer can be patch shape or boring sample, and its formation is differed in size, and is often positioned at the rectum front wall of cervix uteri horizontal plane.Narrow multidigit 8 ~ 12cm place above anus edge of rectum.Some colonic pathological change exactly likes ulcerative colitis.Thicken the hard boring sample ulcer of the intestinal segment of hardening mucosa and ring constriction or edge, not showing as gone thin vasodilation around, all can be mistaken for cancerous protuberance.
Proctitis the lighter only mucosa irritation, severe one inflammation involves tela submucosa, muscle layer, even rectum surrounding tissue; Sometimes just a part of mucous membrane of rectum is got involved, and the whole inflammation of mucous membrane of rectum sometimes, also can involve colon portion mucosa has inflammation.Proctitis head heavily checks, only has the state of an illness making a definite diagnosis enteritis in detail, could symptomatic treatment.Proctitis such as treatment not in time can transfer rectal cancer to.
Radiotherapy is the primary treatments of cervical cancer, and chronic radioactive proctitis is a kind of common complication occurred after irradiation for cervical cancer, and it brings very large misery to patient, has a strong impact on the life quality of patient.But there is no standard treatments both at home and abroad, at present, whole body therapeutic is treated based on infection, hemostasis, reinforcement nutrition etc., topical therapeutic is mainly with compound recipe procaine liquid coloclysis, there is certain curative effect, but studies have found that, the enema that life-time service contains steroid hormone can cause Fu Niye gangrene, and can make exacerbation of symptoms of having blood in stool.Therefore, Therapeutic Method is safely and effectively found particularly important.The present inventor is proved by clinical trial for many years, the radiation rectitis utilizing herbal drug enema in treatment to cause because of radiotherapy cervical cancer, and have good curative effect, particularly side effect is little.
Summary of the invention
The object of the present invention is to provide a kind of enema of radiotherapy proctitis.The traditional Chinese medical science thinks that cervical cancer radiation rectitis belongs to the category such as " having loose bowels ", " having blood in stool ", " spouting bleeding from anus ", and lonizing radiation are the heresy of pyretic toxicity, and pathogenic heat is stopped up in stagnant intestinal, the large intestine that caves in is fought mutually with QI and blood, disorder of QI movement, and intestinal network is injured, conduct not normal, thus occur having blood in stool, the symptom such as difficult defecation.
Above-mentioned purpose of the present invention is realized by following technical proposals:
An enema for radiotherapy proctitis, the crude drug of described enema is made up of Radix Notoginseng, Pericarpium Pyri, Radix Puerariae, Radix Sanguisorbae, Herba stellariae mediae, the Radix Paeoniae Alba, Fructus Mume, Herba Violae, Cortex Melaleucae leucadendrae, Herba Agrimoniae, Radix Codonopsis, Leucopaxillus giganteus (Sow ex Franch.) singer., the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae, Rhizoma Atractylodis, Caulis Spatholobi, Herba Dendrobii, Herba basellae rubrae, Coriolous Dersicolor (Fr.) Quel, Rhizoma Corydalis, Radix Glycyrrhizae.
Further, raw material composition and the parts by weight of making described enema are: Radix Notoginseng 2-4 part, Pericarpium Pyri 6-8 part, Radix Puerariae 20-30 part, Radix Sanguisorbae 16-25 part, Herba stellariae mediae 4-7 part, Radix Paeoniae Alba 12-18 part, Fructus Mume 5-12 part, Herba Violae 3-5 part, Cortex Melaleucae leucadendrae 13-20 part, Herba Agrimoniae 16-30 part, Radix Codonopsis 30-50 part, Leucopaxillus giganteus (Sow ex Franch.) singer. 15-20 part, Rhizoma Atractylodis Macrocephalae 9-14 part, Fructus Gardeniae 10-15 part, Rhizoma Atractylodis 6-10 part, Caulis Spatholobi 22-30 part, Herba Dendrobii 7-10 part, Herba basellae rubrae 4-8 part, Coriolous Dersicolor (Fr.) Quel 3-6 part, Rhizoma Corydalis 5-12 part, Radix Glycyrrhizae 5-8 part.
Further, raw material composition and the parts by weight of making described enema are: Radix Notoginseng 2 parts, Pericarpium Pyri 8 parts, Radix Puerariae 25 parts, Radix Sanguisorbae 20 parts, Herba stellariae mediae 4 parts, the Radix Paeoniae Alba 16 parts, Fructus Mume 10 parts, Herba Violae 4 parts, Cortex Melaleucae leucadendrae 20 parts, Herba Agrimoniae 28 parts, Radix Codonopsis 50 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 15 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Fructus Gardeniae 12 parts, Rhizoma Atractylodis 10 parts, Caulis Spatholobi 25 parts, Herba Dendrobii 7 parts, Herba basellae rubrae 8 parts, Coriolous Dersicolor (Fr.) Quel 4 parts, Rhizoma Corydalis 10 parts, 8 parts, Radix Glycyrrhizae.
Further, raw material composition and the parts by weight of making described enema are: Radix Notoginseng 4 parts, Pericarpium Pyri 8 parts, Radix Puerariae 20 parts, Radix Sanguisorbae 18 parts, Herba stellariae mediae 5 parts, the Radix Paeoniae Alba 12 parts, Fructus Mume 5 parts, Herba Violae 3.5 parts, Cortex Melaleucae leucadendrae 16 parts, Herba Agrimoniae 30 parts, Radix Codonopsis 30 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 18 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Fructus Gardeniae 10 parts, Rhizoma Atractylodis 6 parts, Caulis Spatholobi 22 parts, Herba Dendrobii 10 parts, Herba basellae rubrae 4 parts, Coriolous Dersicolor (Fr.) Quel 6 parts, Rhizoma Corydalis 12 parts, 5 parts, Radix Glycyrrhizae.
Further, raw material composition and the parts by weight of making described enema are: Radix Notoginseng 3 parts, Pericarpium Pyri 6 parts, Radix Puerariae 20 parts, Radix Sanguisorbae 16 parts, Herba stellariae mediae 7 parts, the Radix Paeoniae Alba 18 parts, Fructus Mume 6 parts, Herba Violae 3 parts, Cortex Melaleucae leucadendrae 18 parts, Herba Agrimoniae 18 parts, Radix Codonopsis 40 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 20 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Gardeniae 15 parts, Rhizoma Atractylodis 12 parts, Caulis Spatholobi 28 parts, Herba Dendrobii 8 parts, Herba basellae rubrae 5 parts, Coriolous Dersicolor (Fr.) Quel 3 parts, Rhizoma Corydalis 5 parts, 3 parts, Radix Glycyrrhizae.
Further, raw material composition and the parts by weight of making described enema are: Radix Notoginseng 2 parts, Pericarpium Pyri 8 parts, Radix Puerariae 30 parts, Radix Sanguisorbae 25 parts, Herba stellariae mediae 6 parts, the Radix Paeoniae Alba 13 parts, Fructus Mume 12 parts, Herba Violae 5 parts, Cortex Melaleucae leucadendrae 13 parts, Herba Agrimoniae 23 parts, Radix Codonopsis 35 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 16 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Fructus Gardeniae 13 parts, Rhizoma Atractylodis 8 parts, Caulis Spatholobi 30 parts, Herba Dendrobii 9 parts, Herba basellae rubrae 6 parts, Coriolous Dersicolor (Fr.) Quel 6 parts, Rhizoma Corydalis 8 parts, 7 parts, Radix Glycyrrhizae.
Further, raw material composition and the parts by weight of making described enema are: Radix Notoginseng 4 parts, Pericarpium Pyri 7 parts, Radix Puerariae 28 parts, Radix Sanguisorbae 22 parts, Herba stellariae mediae 4 parts, the Radix Paeoniae Alba 15 parts, Fructus Mume 5 parts, Herba Violae 3 parts, Cortex Melaleucae leucadendrae 14 parts, Herba Agrimoniae 16 parts, Radix Codonopsis 45 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 19 parts, the Rhizoma Atractylodis Macrocephalae 11 parts, Fructus Gardeniae 14 parts, Rhizoma Atractylodis 9 parts, Caulis Spatholobi 23 parts, Herba Dendrobii 7 parts, Herba basellae rubrae 7 parts, Coriolous Dersicolor (Fr.) Quel 6 parts, Rhizoma Corydalis 6 parts, glycosides grass 8 parts.
Further, the preparation method of described enema is: above-mentioned each crude drug is added clear water and decocts into 150-250mL, filtered through gauze with warm fire in right amount, add Mel 5-12 part, retention enema.
The enema of radiotherapy proctitis provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:
Radix Notoginseng: sweet in the mouth, micro-hardship, warm in nature, there is removing stasis to stop bleeding, effects such as analgesic therapy of invigorating blood circulation.For controlling the good merchantable brand of all cards of blood stasis, it is traumatology key medicine.Radix Notoginseng mainly containing Ginsenosides, arasaponin class, Radix Notoginseng propylhomoserin class and Radix Notoginseng polysaccharide class etc., is the active substance that it is main.Radix Notoginseng propylhomoserin has obvious anastalsis, and obviously can increase platelet counts and shorten clotting time; Ginsenoside, arasaponin energy anticoagulant and inhibition thrombosis; Radix Notoginseng total glycosides can immunity moderation, and have significant antiinflammatory action, and have significant maincenter analgesic effect, saponin Rb group has stronger analgesic effect.
Pericarpium Pyri: sweet in the mouth, puckery, cool in nature, nontoxic; Return lung, the heart, kidney, large intestine channel.Clearing away heart-fire and moistening the lung, pathogenic fire reducing promotes the production of body fluid, and separates sore.Cure mainly summer-heat excessive thirst, xeropulmonary cough, spit blood, dysentery, scabies, carbuncle on the back, furuncle." book on Chinese herbal medicine is new again " carries: " quench the thirst in main Tianjin, relieving restlessness is dried for clearing heart fire, nourishing kidney tonifying YIN.”
Radix Puerariae: nature and flavor: Gan Xin is flat.Gui Jing: enter spleen, stomach warp.Function cures mainly: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, and relieving restlessness is temperature only.Cure the wound cold, warm headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.
Radix Sanguisorbae: the property of medicine: picric acid; Cold; Nontoxic.Gui Jing: liver; Lung; Kidney; Large intestine channel.Effect: cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Effect is classified: hemorrhage: blood-cooling hemostatic.Function cures mainly: spit blood, and spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting.
Herba stellariae mediae: sweet in the mouth, acid, cool in nature.Heat-clearing and toxic substances removing, blood-activating analgetic, lactogenic.For enteritis, dysentery, hepatitis, appendicitis, postnatal blood stasis is suffered from abdominal pain, uterine contraction pain, toothache, early whitening of hair, agalactia, mastitis, traumatic injury, sore swollen toxin." Bencao Tujing " carries: " wipe tooth a surname dew, dry work is not useful.”
The Radix Paeoniae Alba: nature and flavor: picric acid is cool.Gui Jing: enter liver, spleen channel.Function cures mainly: nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
Fructus Mume: nature and flavor: sour, puckery is flat.Gui Jing: return liver, spleen, lung, large intestine channel.Function cures mainly: astringe the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung; Deficiency-heat excessive thirst; Chronic malaria; Chronic diarrhea; Dysentery; Have blood in stool; Hematuria; Metrorrhagia; The ascariasis of biliary tract is suffered from abdominal pain; Vomiting; Ancylostomiasis.
Herba Violae meridian distribution of property and flavor: bitter, acrid, cold is nontoxic; GUIXIN, Liver Channel.Function with cure mainly: heat-clearing and toxic substances removing, removing heat from blood subside a swelling.Cure mainly jaundice, dysentery.
Cortex Melaleucae leucadendrae: acrid in the mouth is slightly warm in nature, flat.Fragrance induces sweat, wind-expelling pain-stopping.For cold, fever, rheumatic arthritis, neuralgia, enteritis, diarrhea, allergic dermatitis is controlled in external, eczema, calms the nerves, neurasthenia, insomnia.
Herba Agrimoniae: nature and flavor: bitter, puckery is flat.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: astringing to arrest bleeding, dysentery relieving, parasite killing.Be widely used in various hemorrhage card, such as: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage.
Radix Codonopsis: nature and flavor: property is put down, sweet in the mouth, micro-acid.Return spleen, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Leucopaxillus giganteus (Sow ex Franch.) singer.: sweet in the mouth, property are flat; Return lung meridian.Induce sweat heat clearing away, rash helps digestion, anti-consumptive disease.Cure mainly cold cough, measles is sent out not smooth thoroughly, and food stagnation is stagnated, distension and fullness in the abdomen, pulmonary tuberculosis.
Rhizoma Atractylodis Macrocephalae bitter but sweet flavor temperature; Return taste warp.Function with cure mainly: invigorating the spleen and benefiting QI, dampness diuretic.Rhizoma Atractylodis polysaccharide has restitution to lymphocytic expanding capacity, can enhancing human body immunity function, has antioxidation, anticoagulation, antitumor action.
Its cold in nature, bitter in the mouth of Fructus Gardeniae, function with cure mainly: pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, Shennong's Herbal: " cure mainly pathogen in five, tuberculoid leprosy, red leprosy, skin infection ....”
Rhizoma Atractylodis acrid in the mouth, hardship, warm in nature.Return spleen, stomach, Liver Channel.Function cures mainly: drying damp and strengthening spleen, expelling wind and cold.For distension and fullness in the abdomen, edema of having loose bowels.
Caulis Spatholobi: bitter, sweet, temperature.Return liver, kidney channel.Be called as the plant that can bleed, function cures mainly: enrich blood, and invigorates blood circulation, dredging collateral.Join Chinese angelica blood supplementing, promoting flow of qi by warming channel." decoction pieces is newly joined ": Caulis Spatholobi blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates.Control summer filthy infection, wind arthralgia due to stagnation of blood disease.Modern medicine is studied, and has antitumaous effect.
Herba Dendrobii sweet in the mouth, cold nature, return stomach, kidney channel.Function cures mainly: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.Herba Dendrobii, replenishing YIN and removing heat Radix Ophiopogonis, reinforcing stomach reg fluid.
Herba basellae rubrae: sweet in the mouth, acid, cold in nature; Enter the heart, liver, spleen, intestine and small intestine warp.Heat clearing away laxation, removing pathogenic heat from blood and toxic substance from the body.Control constipation, oliguria is puckery, and dysentery makes blood, macule, spit of fland skin ulcer." Quanzhou book on Chinese herbal medicine " carries: " control constipation, oliguria is puckery, and chest is gloomy.”
Coriolous Dersicolor (Fr.) Quel: property slightly sweet flavor is slightly cold.Return liver spleen lung meridian.Have heat clearing away, removing toxic substances, antiinflammatory, anticancer, the effect such as to protect the liver.
Rhizoma Corydalis, bitter in the mouth, pungent, warm in nature; Return liver, the heart, stomach warp; Benefaction is wandered away, and can rise and can fall, have promoting blood circulation to remove blood stasis, effect of promoting the circulation of QI to relieve pain.Cure mainly obstruction of qi in the chest and cardialgia, the side of body rib, all pains of gastral cavity abdomen, headache, lumbago, colicky, bones and muscles pain, dysmenorrhea, amenorrhea, puerperal, the stasis of blood was suffered from abdominal pain, traumatic injury.
Radix Glycyrrhizae, property is flat, sweet in the mouth, returns 12 warps.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
This ointment is made up of Radix Notoginseng, Pericarpium Pyri, Radix Puerariae, Radix Sanguisorbae, Herba stellariae mediae, the Radix Paeoniae Alba, Fructus Mume, Herba Violae, Cortex Melaleucae leucadendrae, Herba Agrimoniae, Radix Codonopsis, Leucopaxillus giganteus (Sow ex Franch.) singer., the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae, Rhizoma Atractylodis, Radix Rehmanniae, Caulis Spatholobi, Herba Dendrobii, Herba basellae rubrae, Coriolous Dersicolor (Fr.) Quel, Rhizoma Corydalis, Radix Glycyrrhizae.Radix Notoginseng removing stasis to stop bleeding, analgesic therapy of invigorating blood circulation in side, Radix Sanguisorbae cooling blood for hemostasis, detumescence sore, antiperspirant is received in Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, yin fluid astringing, and Caulis Spatholobi is enriched blood, invigorate blood circulation, dredging collateral, and Radix Notoginseng, Radix Sanguisorbae, the Radix Paeoniae Alba, Caulis Spatholobi are monarch drug altogether; Radix Puerariae yang invigorating expelling pathogenic factors from muscles, relieving restlessness only temperature, Fructus Mume is astringed the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, Herba Agrimoniae astringing to arrest bleeding, Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat, Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, induce sweat heat clearing away, rash of Leucopaxillus giganteus (Sow ex Franch.) singer. helps digestion, and Radix Puerariae, Fructus Mume, Herba Agrimoniae, Herba Dendrobii, Rhizoma Atractylodis, Leucopaxillus giganteus (Sow ex Franch.) singer. are ministerial drug altogether; Herba stellariae mediae heat-clearing and toxic substances removing, blood-activating analgetic, Cortex Melaleucae leucadendrae fragrance induces sweat, wind-expelling pain-stopping, Pericarpium Pyri pathogenic fire reducing promotes the production of body fluid, separates sore, Herba Violae heat-clearing and toxic substances removing, removing heat from blood are subsided a swelling, Coriolous Dersicolor (Fr.) Quel heat clearing away, removing toxic substances, antiinflammatory, anticancer, Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, Fructus Gardeniae, Herba basellae rubrae clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body are adjuvant drug; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, Rhizoma Corydalis promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain, Radix Glycyrrhizae heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Radix Glycyrrhizae are for making medicine.All medicines share and define removing toxic substances heat clearing away, removing the necrotic tissue and promoting granulation, and effect of cooling blood for hemostasis is used for the treatment of the diseases such as the stomachache caused by radiation rectitis, diarrhoea, hemafecia, can regulates again human physiological functions, reach the object for the treatment of both the principal and secondary aspects of a disease.Medicine has no side effect little, good effect.
Enema of the present invention significantly can alleviate the clinical symptoms such as mucosanguineous feces, diarrhoea, stomachache, tenesmus, anus causalgia pendant pain; Improve the fecal occult blood positive, intestinal mirror mucosa infection and radiation injury; Patients ' life quality can be improved; Relapse rate is low, and curative effect is reliable, and effect is stable, and having no side effect, is the medicine that radiotherapy proctitis is comparatively satisfied with.
Detailed description of the invention
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.
Embodiment 1:
The enema of a kind of radiotherapy proctitis of the present invention, gets following traditional Chinese medicine raw medicine: Radix Notoginseng 2 parts, Pericarpium Pyri 8 parts, Radix Puerariae 25 parts, Radix Sanguisorbae 20 parts, Herba stellariae mediae 4 parts, the Radix Paeoniae Alba 16 parts, Fructus Mume 10 parts, Herba Violae 4 parts, Cortex Melaleucae leucadendrae 20 parts, Herba Agrimoniae 28 parts, Radix Codonopsis 50 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 15 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Fructus Gardeniae 12 parts, Rhizoma Atractylodis 10 parts, Caulis Spatholobi 25 parts, Herba Dendrobii 7 parts, Herba basellae rubrae 8 parts, Coriolous Dersicolor (Fr.) Quel 4 parts, Rhizoma Corydalis 10 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: above-mentioned each crude drug is added clear water and decocts into 150mL, filtered through gauze with warm fire in right amount, add Mel 8 parts, retention enema.
Embodiment 2:
The enema of a kind of radiotherapy proctitis of the present invention, gets following traditional Chinese medicine raw medicine: Radix Notoginseng 4 parts, Pericarpium Pyri 8 parts, Radix Puerariae 20 parts, Radix Sanguisorbae 18 parts, Herba stellariae mediae 5 parts, the Radix Paeoniae Alba 12 parts, Fructus Mume 5 parts, Herba Violae 3.5 parts, Cortex Melaleucae leucadendrae 16 parts, Herba Agrimoniae 30 parts, Radix Codonopsis 30 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 18 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Fructus Gardeniae 10 parts, Rhizoma Atractylodis 6 parts, Caulis Spatholobi 22 parts, Herba Dendrobii 10 parts, Herba basellae rubrae 4 parts, Coriolous Dersicolor (Fr.) Quel 6 parts, Rhizoma Corydalis 12 parts, 5 parts, Radix Glycyrrhizae.
Preparation method: above-mentioned each crude drug is added clear water and decocts into 200mL, filtered through gauze with warm fire in right amount, add Mel 5 parts, retention enema.
Embodiment 3:
The enema of a kind of radiotherapy proctitis of the present invention, gets following traditional Chinese medicine raw medicine: Radix Notoginseng 3 parts, Pericarpium Pyri 6 parts, Radix Puerariae 20 parts, Radix Sanguisorbae 16 parts, Herba stellariae mediae 7 parts, the Radix Paeoniae Alba 18 parts, Fructus Mume 6 parts, Herba Violae 3 parts, Cortex Melaleucae leucadendrae 18 parts, Herba Agrimoniae 18 parts, Radix Codonopsis 40 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 20 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Gardeniae 15 parts, Rhizoma Atractylodis 12 parts, Caulis Spatholobi 28 parts, Herba Dendrobii 8 parts, Herba basellae rubrae 5 parts, Coriolous Dersicolor (Fr.) Quel 3 parts, Rhizoma Corydalis 5 parts, 3 parts, Radix Glycyrrhizae.
Preparation method: above-mentioned each crude drug is added clear water and decocts into 250mL, filtered through gauze with warm fire in right amount, add Mel 12 parts, retention enema.
Embodiment 4:
The enema of a kind of radiotherapy proctitis of the present invention, gets following traditional Chinese medicine raw medicine: Radix Notoginseng 2 parts, Pericarpium Pyri 8 parts, Radix Puerariae 30 parts, Radix Sanguisorbae 25 parts, Herba stellariae mediae 6 parts, the Radix Paeoniae Alba 13 parts, Fructus Mume 12 parts, Herba Violae 5 parts, Cortex Melaleucae leucadendrae 13 parts, Herba Agrimoniae 23 parts, Radix Codonopsis 35 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 16 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Fructus Gardeniae 13 parts, Rhizoma Atractylodis 8 parts, Caulis Spatholobi 30 parts, Herba Dendrobii 9 parts, Herba basellae rubrae 6 parts, Coriolous Dersicolor (Fr.) Quel 6 parts, Rhizoma Corydalis 8 parts, 7 parts, Radix Glycyrrhizae.
Preparation method: above-mentioned each crude drug is added clear water and decocts into 220mL, filtered through gauze with warm fire in right amount, add Mel 10 parts, retention enema.
Embodiment 5:
The enema of a kind of radiotherapy proctitis of the present invention, gets following traditional Chinese medicine raw medicine: Radix Notoginseng 4 parts, Pericarpium Pyri 7 parts, Radix Puerariae 28 parts, Radix Sanguisorbae 22 parts, Herba stellariae mediae 4 parts, the Radix Paeoniae Alba 15 parts, Fructus Mume 5 parts, Herba Violae 3 parts, Cortex Melaleucae leucadendrae 14 parts, Herba Agrimoniae 16 parts, Radix Codonopsis 45 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 19 parts, the Rhizoma Atractylodis Macrocephalae 11 parts, Fructus Gardeniae 14 parts, Rhizoma Atractylodis 9 parts, Caulis Spatholobi 23 parts, Herba Dendrobii 7 parts, Herba basellae rubrae 7 parts, Coriolous Dersicolor (Fr.) Quel 6 parts, Rhizoma Corydalis 6 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: above-mentioned each crude drug is added clear water and decocts into 180mL, filtered through gauze with warm fire in right amount, add Mel 6 parts, retention enema.
Enema Pharmacodynamic test of active extract of the present invention is summarized as follows:
Method:
Select mice to be experimental animal, get mice 80, be divided into 4 groups at random by body weight, be divided into model group, treatment group, western medicine group and Chinese medicine matched group.Utilize the local irradiation of linear accelerator single-bolus high-dose pelvic cavity, set up radiation rectitis animal model.
Model group: feed clear water, does not adopt any medicine.
Treatment group: give the enema described in the embodiment of the present invention 3, point high, medium and low three dosage groups;
Western medicine group: use dexamethasone to add gentamycin;
Chinese medicine matched group: use medicine XILEI SAN.
Observe treatment and put to death whole mice after one week.Observe animal general status, body weight, defecation situation, light microscopic and electron microscopic observation mucous membrane of rectum degree of injury, and detect mucous membrane of rectum IL-l β mrna expression by RT-PCR method, detect mucous membrane of rectum NF-κ B with ImmunohistochemistryMethods Methods to express, measure blood TAX2,6-keto-PGF1 α and LN level by RIA method, carry out statistical procedures.
Result:
There is diarrhoea, mucopurulent bloody stool in model group mice, the performance such as to become thin.The structural deterioration of light Microscopic observation rectum crypts, a large amount of cell infiltration, submucosal blood vessel is congested, the chief of a pit, many stoves ulcer, and electric Microscopic observation gland structure is disorderly, and surperficial fine hair destroys, epithelial cell shedding, ulcer.
Treatment group mice general status improves, and the remission such as to suffer from diarrhoea, have blood in stool, compares with model group and have significant difference (P < 0.05).Treatment group mucous membrane of rectum degree of injury significantly improves, and IL-1 β mrna expression and NF-KB express and significantly reduce, with model group and in, western medicine group more all has significant difference (P < 0.05).Treatment high dose group is better than low dose group.
Conclusion: utilize linear accelerator pelvic cavity local single fraction irradiation 20Gy, can successfully inducing mouse radiation rectitis.The present invention can improve effectively irradiates rear animal general status; control diarrhoea and have blood in stool; improve the long mucosa injury of radiation rectitis mice; protection intestinal mucosa; promote ulcer healing, lower the damage of radiation rectitis mice mucous membrane of rectum, IL-1 β mRNA and NF-κ B expression; reduce inflammation reaction, improves mucosa injury.Raise radiation rectitis mice 6-Kote-PGF1 alpha levels, lower its TXB
2level and TXB
2/ 6-Kote-PGF1 α ratio, improves local microcirculation, promotes ulcer healing.Anti-local fibrosis.Observe treatment 1 week, the horizontal no difference of science of statistics of LN between each race.
Clinical trial:
In order to verify the effect of pharmaceutical composition of the present invention, in June ,-2013 in November, 2011, under the guidance of Shandong hospital anorectum department expert, the routine radiation rectitis patient of outpatient service place Stochastic choice 120,33 ~ 71 years old age, be divided into treatment group and matched group at random, often organize 60 examples, wherein 53.2 years old treatment group mean age; From radiotherapy to occurring chronic radioactive proctitis (8.5 ± 1.3) moon average time; I degree 34 example; II degree 18 example; III degree 8 example; Symptom overall score (6.25 ± 1.75) point.51.3 years old matched group mean age; From radiotherapy to occurring chronic radioactive proctitis (9.1 ± 1.25) moon average time; I degree 39 example; II degree 11 example; III degree 10 example: symptom overall score (7.10 ± I.55) point; The equal not statistically significants of difference (P < 0.05) such as two groups of ages, chronic radioactive proctitis time of origin, chronic radioactive proctitis calibration, symptom overall scores, have comparability.
Diagnostic criteria is with reference to chronic radioactive proctitis diagnostic criteria in " Occupational sanitary standard ", pelvic organ tumor once caused more than mucosa injury later six months by radiotherapy or rectum local external exposure (once having acute proctitis history), several years, even there is difficult defecation in more than 10 years, stool attenuates or defecation is frequent, loose stool, have blood in stool, the rectum in late period such as pendant pain reacts when defecating, proctostenosis, ulcer, fistulization.
Therapeutic Method: the Chinese medicinal enema that treatment group adopts the embodiment of the present invention 1 preparation method to obtain, gets 150mL coloclysis, every day 2 times, each 15 minutes at every turn; Matched group: adopt normal saline 100ml to add 2% lignocaine 5ml, gentamycin 240,000 U mixed liquor retention enema 50min, every day 1 time, two groups equal 2 weeks is 1 course for the treatment of.
Symptom score standard (1) calibration standard, with reference to chronic radioactive proctitis calibration standard in " Occupational sanitary standard ", is specially;
I degree: accidentally to have blood in stool, myxedema, defecation is irregular, loose stool or constipation;
II degree: commonly to have blood in stool, pachymucosa, proctostenosis, difficult defecation, still available drugs is alleviated;
III degree: whole blood just, ulcer or fistulization, proctostenosis, defecation exceptional hardship, even blocks.
" common sympton scalar quantization table of having loose bowels " that symptom score canonical reference " new Chinese medicine guideline of clinical investigations " designs about " guideline of clinical investigations that treatment by Chinese herbs is had loose bowels " is formulated.
Symptom overall score=stool and frequency are scored+have blood in stool score+difficult defecation degree score.1. stool and frequency: stool is shaped substantially, defecation every day less than 3 times meters 0 point; Stool can not be shaped, and every day counts 1 point 3 ~ 4 times; Loose stool, every day counts 2 points 5 ~ 10 times; Stool is as water sample, and every day more than 10 times counts 3 points.2. hemafecia: without hemafecia meter 0 point; To have blood in stool once in a while meter 1 point; Often to have blood in stool meter 2 points; Whole blood just counts 3 points.3. difficult defecation degree: without difficult defecation meter 1 point; Defecation is slightly difficult, and each defecation time is less than 30 minutes and counts 1 point; Difficult defecation, each defecation time counted 2 points between 30 minutes ~ 1 hour; Defecation exceptional hardship, each defecation time is greater than 1 hour and counts 3 points.
Criterion of therapeutical effect is formulated about the curative effect determinate standard of " new Chinese medicine treats the guideline of clinical investigations of having loose bowels " with reference to " new Chinese medicine guideline of clinical investigations ";
Recovery from illness: transference cure or substantially disappear, symptom overall score reduces >=95%;
Effective: symptom is obviously improved, 70%≤symptom overall score reduces < 95%;
Effective: symptom obviously takes a turn for the better to some extent, 30%≤symptom overall score reduces < 70%;
Invalid: symptom is not improved, even increase the weight of, symptom overall score reduces < 30%.
Therapeutic outcome: treat comparitive study after two courses for the treatment of for two groups, treatment group 60 example, 43 examples of wherein fully recovering account for 71.7%, and effective 12 examples account for 20%, and effective 4 examples account for 6.7%, and invalid 1 example accounts for 1.7%, total effective rate 98.3%; Matched group 60 example, 19 examples of wherein fully recovering account for 31.7%, and effective 13 examples account for 21.7%, and effective 11 examples account for 18.3%, and invalid 17 examples account for 28.3%, total effective rate 71.7%; Two groups are compared, and treatment group cure rate, total effective rate are obviously better than matched group, have comparability P < 0.05.
Untoward reaction: treatment group does not occur untoward reaction over the course for the treatment of, matched group has 6 examples to occur untoward reaction; Follow up a case by regular visits to half a year, in healing, treatment group is without recurrence, matched group recurrence 9 example.
Here is the sufferer that the daily clinic of inventor contacts and the model case contacted with outpatient service in Shandong hospital anorectum department expert cooperative process:
Case 1:
Zhao, man, 55 years old, in February, 2012 carcinoma of prostate postoperation radiotherapy 2 months, because hemafecia 3 days is gone to a doctor, main suit started stomachache before 5 days, it is rare to defecate, take levofloxacin and YUANHU ZHITONG PIAN has no improvement, over nearly 3 days, stool has blood, color scarlet: have a medical check-up: lower abdomen has tenderness.The fecal occult blood testing positive (+++), namely adopts the enema of the embodiment of the present invention 4, occurs after using 7 days continuously without hemafecia, and after continuation coloclysis cleans 10 days, clinical symptoms disappears completely, does not recur so far.
Case 2:
Money, female, 67 years old, people from Lixia District, Jinan City, in JIUYUE, 2012 was gone to a doctor.Tumor of pelvic cavity postoperation radiotherapy 20 days.Intermittent appearance diarrhoea loose stool 3 days, companion's lower abdomen stomachache dull pain 1 day, without naked eyes hemafecia, looks into fecal occult blood testing feminine gender.Colour ultrasound diagnosis: prompting rectum inflammation.Adopt the enema of the embodiment of the present invention 2, remission after using 10 days continuously.Drug withdrawal 2 days, continue use after 10 days, clinical symptoms disappears completely, does not recur so far.
Case 3:
Grandson, female, 42 years old, people from Linzhou City, Zibo, cervical cancer postoperation radiotherapy 19 days, because defecation is frequent, loose stool, to have blood in stool, pendant pain during stool, and hospitalization 1 week is bad during fashion, medical in January, 2010, haves a medical check-up: shallow complexion, malaise, abdominal tenderness.Fecal occult blood experiment positive (++).Adopt the enema of the embodiment of the present invention 2, remission after using 7 days continuously.Drug withdrawal 2 days, continue use after 10 days, clinical symptoms disappears completely, does not recur so far.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.
Claims (8)
1. an enema for radiotherapy proctitis, is characterized in that: the crude drug of described enema is made up of Radix Notoginseng, Pericarpium Pyri, Radix Puerariae, Radix Sanguisorbae, Herba stellariae mediae, the Radix Paeoniae Alba, Fructus Mume, Herba Violae, Cortex Melaleucae leucadendrae, Herba Agrimoniae, Radix Codonopsis, Leucopaxillus giganteus (Sow ex Franch.) singer., the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae, Rhizoma Atractylodis, Caulis Spatholobi, Herba Dendrobii, Herba basellae rubrae, Coriolous Dersicolor (Fr.) Quel, Rhizoma Corydalis, Radix Glycyrrhizae.
2. the enema of radiotherapy proctitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described enema are: Radix Notoginseng 2-4 part, Pericarpium Pyri 6-8 part, Radix Puerariae 20-30 part, Radix Sanguisorbae 16-25 part, Herba stellariae mediae 4-7 part, Radix Paeoniae Alba 12-1g part, Fructus Mume 5-12 part, Herba Violae 3-5 part, Cortex Melaleucae leucadendrae 13-20 part, Herba Agrimoniae 16-30 part, Radix Codonopsis 30-50 part, Leucopaxillus giganteus (Sow ex Franch.) singer. 15-20 part, Rhizoma Atractylodis Macrocephalae 9-14 part, Fructus Gardeniae 10-15 part, Rhizoma Atractylodis 6-10 part, Caulis Spatholobi 22-30 part, Herba Dendrobii 7-10 part, Herba basellae rubrae 4-8 part, Coriolous Dersicolor (Fr.) Quel 3-6 part, Rhizoma Corydalis 5-12 part, Radix Glycyrrhizae 5-8 part.
3. the enema of radiotherapy proctitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described enema are: Radix Notoginseng 2 parts, Pericarpium Pyri 8 parts, Radix Puerariae 25 parts, Radix Sanguisorbae 20 parts, Herba stellariae mediae 4 parts, the Radix Paeoniae Alba 16 parts, Fructus Mume 10 parts, Herba Violae 4 parts, Cortex Melaleucae leucadendrae 20 parts, Herba Agrimoniae 28 parts, Radix Codonopsis 50 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 15 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Fructus Gardeniae 12 parts, Rhizoma Atractylodis 10 parts, Caulis Spatholobi 25 parts, Herba Dendrobii 7 parts, Herba basellae rubrae 8 parts, Coriolous Dersicolor (Fr.) Quel 4 parts, Rhizoma Corydalis 10 parts, 8 parts, Radix Glycyrrhizae.
4. the enema of radiotherapy proctitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described enema are: Radix Notoginseng 4 parts, Pericarpium Pyri 8 parts, Radix Puerariae 20 parts, Radix Sanguisorbae 18 parts, Herba stellariae mediae 5 parts, the Radix Paeoniae Alba 12 parts, Fructus Mume 5 parts, Herba Violae 3.5 parts, Cortex Melaleucae leucadendrae 16 parts, Herba Agrimoniae 30 parts, Radix Codonopsis 30 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 18 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Fructus Gardeniae 10 parts, Rhizoma Atractylodis 6 parts, Caulis Spatholobi 22 parts, Herba Dendrobii 10 parts, Herba basellae rubrae 4 parts, Coriolous Dersicolor (Fr.) Quel 6 parts, Rhizoma Corydalis 12 parts, 5 parts, Radix Glycyrrhizae.
5. the enema of radiotherapy proctitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described enema are: Radix Notoginseng 3 parts, Pericarpium Pyri 6 parts, Radix Puerariae 20 parts, Radix Sanguisorbae 16 parts, Herba stellariae mediae 7 parts, the Radix Paeoniae Alba 18 parts, Fructus Mume 6 parts, Herba Violae 3 parts, Cortex Melaleucae leucadendrae 18 parts, Herba Agrimoniae 18 parts, Radix Codonopsis 40 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 20 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Gardeniae 15 parts, Rhizoma Atractylodis 12 parts, Caulis Spatholobi 28 parts, Herba Dendrobii 8 parts, Herba basellae rubrae 5 parts, Coriolous Dersicolor (Fr.) Quel 3 parts, Rhizoma Corydalis 5 parts, 3 parts, Radix Glycyrrhizae.
6. the enema of radiotherapy proctitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described enema are: Radix Notoginseng 2 parts, Pericarpium Pyri 8 parts, Radix Puerariae 30 parts, Radix Sanguisorbae 25 parts, Herba stellariae mediae 6 parts, the Radix Paeoniae Alba 13 parts, Fructus Mume 12 parts, Herba Violae 5 parts, Cortex Melaleucae leucadendrae 13 parts, Herba Agrimoniae 23 parts, Radix Codonopsis 35 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 16 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Fructus Gardeniae 13 parts, Rhizoma Atractylodis 8 parts, Caulis Spatholobi 30 parts, Herba Dendrobii 9 parts, Herba basellae rubrae 6 parts, Coriolous Dersicolor (Fr.) Quel 6 parts, Rhizoma Corydalis 8 parts, 7 parts, Radix Glycyrrhizae.
7. the enema of radiotherapy proctitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described enema are: Radix Notoginseng 4 parts, Pericarpium Pyri 7 parts, Radix Puerariae 28 parts, Radix Sanguisorbae 22 parts, Herba stellariae mediae 4 parts, the Radix Paeoniae Alba 15 parts, Fructus Mume 5 parts, Herba Violae 3 parts, Cortex Melaleucae leucadendrae 14 parts, Herba Agrimoniae 16 parts, Radix Codonopsis 45 parts, Leucopaxillus giganteus (Sow ex Franch.) singer. 19 parts, the Rhizoma Atractylodis Macrocephalae 11 parts, Fructus Gardeniae 14 parts, Rhizoma Atractylodis 9 parts, Caulis Spatholobi 23 parts, Herba Dendrobii 7 parts, Herba basellae rubrae 7 parts, Coriolous Dersicolor (Fr.) Quel 6 parts, Rhizoma Corydalis 6 parts, 8 parts, Radix Glycyrrhizae.
8. according to the enema of the arbitrary described radiotherapy proctitis of claim 2-7, it is characterized in that, the preparation method of described enema is: above-mentioned each crude drug is added clear water and decocts into 150-250mL, filtered through gauze with warm fire in right amount, add Mel 5-12 part, retention enema.
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