CN104644671A - Application of milk in drug preparation - Google Patents
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- CN104644671A CN104644671A CN201510096880.1A CN201510096880A CN104644671A CN 104644671 A CN104644671 A CN 104644671A CN 201510096880 A CN201510096880 A CN 201510096880A CN 104644671 A CN104644671 A CN 104644671A
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Abstract
The invention discloses an application of milk in preparing of a small-smell drug preparation with animal medicinal materials. The invention is characterized by containing milk in the drug preparation with animal medicinal materials; and milk and the animal medicinal materials are mixed in a weight part ratio of (0.5-5):1. The drug preparation prepared according to the invention has small smell and high patient compliance under the premise of keeping original curative effects of the pharmaceutical compositions.
Description
Invention field
The present invention relates to medicine, particularly the application in medicine prepared by milk, is specifically related to milk in the application of preparation containing the medicine of animal drugs, belongs to medical art.
Background technology
Animal drugs is the important component part of pools of traditional Chinese medicine, the advantage of himself is had compared with plant amedica, mineral drug, as strong in active ingredient effect, using dosage is little, evident in efficacy and single-minded, its toxic and side effects is low in addition, medicament sources and use are extensively, the masses to gathering medicinal herbs, medication has rich experience, makes it deeply by the attention of medical circle and the people.But many drug flavors containing animal drugs are extra heavy, and mouthfeel is very poor.Over the past thousands of years, people always encourage patient medication with " good medicine tastes bitter ".But the reality of society is, people hang back in face of the good medicine of " hardship " mouth, even talk " hardship " complexion changed.Have a strong impact on the application of the medicine containing animal drugs.
Through repetition test, we find, milk obviously can alleviate the abnormal flavour of the medicine containing animal drugs.
Summary of the invention
The object of this invention is to provide a kind of milk and preparing the application in medicine, specifically provide milk preparing the little application contained in the pharmaceutical preparation of animal drugs of abnormal flavour.
The object of the present invention is achieved like this:
The application in medicine prepared by milk, it is characterized in that: the little application contained in the pharmaceutical preparation of animal drug of abnormal flavour prepared by milk.
The application in medicine prepared by milk of the present invention, it is characterized in that: contain milk containing in the pharmaceutical preparation of animal drug.
The application in medicine prepared by milk of the present invention, it is characterized in that: milk consumption is animal drug 1 part by weight, more than milk 0.5-5 part.
The application in medicine prepared by milk of the present invention, and wherein milk can replace with milk powder, and the weight ratio of replacement is milk powder 1 part=milk 10 powder.
Pharmaceutical preparation containing animal drug of the present invention comprises compound recipe containing animal drug and single preparations of ephedrine.
So far the present invention is completed.Containing in the pharmaceutical preparation of animal drug containing milk of preparation of the present invention, obtained pharmaceutical preparation, under the former medicable prerequisite of maintenance pharmaceutical composition, evaluates with " stench highly seasoned ", " bad smell is light ", " without bad smell " etc. mouthfeel, abnormal flavour is little, and the compliance of patient is high.
Beneficial effect of the present invention is further illustrated below by specific embodiment, but not restriction of the present invention.
Detailed description of the invention
embodiment 1
Prescription: Radix Salviae Miltiorrhizae 125g, Radix Polygoni Multiflori 50g, Radix Codonopsis 30g, Radix Astragali 25g, Fructus Lycii 50g, Cortex Eucommiae 12.5g, Radix Angelicae Sinensis 62.5g, Rhizoma Chuanxiong 31.2g, Gecko 5.0g, Agkistrodon 66.2g, Solenognathus 15.0g.
Function cures mainly: benefiting QI and nourishing blood, nourishing the liver and kidney.Can improve QI and blood deficiency, the spiritlessness and weakness caused by deficiency of the liver and kindey, has a dizzy spell, the diseases such as soreness of the waist and knees.
Prepare oral liquid:
1) oral liquid: above each taste decocts with water 2 times, adds the water of 10 times amount for the 1st time, decocts 2h, second time adds the water of 8 times amount, decocts 1.5h, merges 2 decoction liquor, filter, getting filtrate reduced in volume to relative density is 1.15(60 DEG C), add ethanol, just add just stirring and evenly mixing, make alcohol content reach 70%, leave standstill 24h, filter, filtrate recycling ethanol, adds cyclamate 0.4g, sorbic acid 2g, Polysorbate 8g, stir, add water to 10000ml, obtain oral liquid 1.
2) oral liquid with milk: from " above each taste decocts with water 2 times .... filtrate recycling ethanol, " same to oral liquid, add milk 430g, cyclamate 0.4g, sorbic acid 2g, Polysorbate 8g, stir, add water to 10000ml, obtain oral liquid 2.
1, oral liquid and the mouthfeel containing milk oral liquid compare
Be made up of 10 people and appraise group through discussion, everyone distinguishes oral oral liquid and containing milk oral liquid, evaluation result is in table 1.
Table 1 different material combination mouthfeel compares
| Stench highly seasoned | Bad smell is light | Without bad smell | |
| Oral liquid | 6 people | 4 people | 0 people |
| Oral liquid with milk | 0 people | 3 people | 7 people |
Result shows, and contains milk containing in the pharmaceutical preparation of animal drug, and stench abnormal flavour is little.
2, oral liquid and containing milk oral liquid to the test of rat swimming time
Rat 30, is divided into 3 groups at random, often organize 10, be respectively matched group, oral liquid group, containing milk oral liquid 2 groups.Test group gavage every day gives oral liquid 5ml/kg, and matched group gavage gives equal-volume normal saline.After 14th day administration 30min, carry out exhausted movemeat test: use long 100cm, wide 50cm, the glass of high 60cm swims groove as swimming device, depth of water 50cm, 35 DEG C, water simultaneously.Measure rat to start swimming and exhaust the time used to power, power exhausts standard and sinks to not exposing for rear ten seconds water and degree of being with animal.The results are shown in Table 2.
Table 2 rats'swimming exhausted movemeat ability compares (min)
| Matched group | Oral liquid group | Containing milk oral liquid group | |
| Power exhausts the time (min) | 127.62±29.35 | 168.34±27.42 | 168.34±26.73 |
Result shows, oral liquid and all can significantly improve the rat exhausted movemeat time containing milk oral liquid, and the two effect quite.
Pharmaceutical preparation abnormal flavour containing animal drug prepared by application milk is little, and maintains original curative effect.
embodiment 2
Prescription: Penis et testis cervi 0.25g, Testis Et penis Bovis seu Bubali 90g, Radix Et Caulis Acanthopanacis Senticosi 300g, Fructus Cnidii 300g, Cornu Cervi Pantotrichum 10g.
Function cures mainly: kidney invigorating and YANG supporting, spermatogenesis benefit marrow.
Prepare granule:
1) granule: the above five tastes, Penis et testis cervi, Testis Et penis Bovis seu Bubali, Cornu Cervi Pantotrichum three taste, give as one thinks fit cataclasm, adds soak with ethanol 24 hours, heating and refluxing extraction three times, 3 hours first times, second time 2 hours, 1 hour third time, merge extractive liquid, filter, filtrate recycling ethanol, obtains ethanol extraction.Two tastes such as all the other Fructus Cnidiis decoct with water three times respectively, 3 hours first times, second time 2 hours, 1 hour third time, collecting decoction, filter, it is 1.12(60 DEG C that filtrate is concentrated into relative density), add triplication ethanol, place, get supernatant reclaim ethanol, water extract, merge 2 kinds of extracts, drying under reduced pressure, pulverize, add sodium citrate 5g, essence 0.5g, mixing, granulate, drying, is distributed into 100 bags, obtains final product.
2) milk powder granule
[method for making] from " the above five tastes, Penis et testis cervi, Testis Et penis Bovis seu Bubali, Cornu Cervi Pantotrichum three taste ..., merges 2 kinds of extracts, drying under reduced pressure, pulverize " same to granule, add milk powder 5g, sodium citrate 5g, essence 0.5g, mixing, granulate, drying, be distributed into 100 bags, obtain final product.
1, granule and milk powder granule mouthfeel compare
Be made up of 10 people and appraise group through discussion, everyone distinguishes oral granular formulation and milk powder granule, and evaluation result is in table 3.
Table 3 different material combination mouthfeel compares
| Fishy smell weight | Fishy smell is light | Without fishy smell | |
| Granule | 5 people | 5 people | 0 people |
| Milk powder granule | 0 people | 2 people | 8 people |
Result shows, and the oral fishy smell of milk powder granule is little, and mouthfeel is good.
2, granule and milk powder granule Yang-strengthening effect compare.
SD ♂ rat 30, be divided into 3 groups at random, namely matched group gavage gives distilled water 10ml/kg, and test group respectively gavage gives granule and milk powder granule, be 2g/10ml/kg, successive administration 30 days, after last administration 30min, puts into mouse cage separately, after adapting to 10min, put into SD ♀ Mus 1, observed and recorded ♂ Mus flutter catch ♀ Mus incubation period (first time flutter the time of catching) and 30min in flutter and catch number of times, result through statistical disposition in table 4.
Table 4 different material combination mouthfeel compares
| Flutter and catch incubation period (dividing) | Flutter and catch number of times (secondary/30min) | |
| Matched group | 15.4±5.3 | 0.9±1.0 |
| Granule group | 9.3±6.4 | 6.9±4.8 |
| Milk powder granule group | 9.3±4.8 | 6.9±5.2 |
Result shows, granule and milk powder granule all have remarkable yang invigorating functions, and the two effect quite.
Pharmaceutical preparation abnormal flavour containing animal drug prepared by application milk is little, and maintains original curative effect.
embodiment 3
Prescription: Pheretima 2kg, Hirudo 2kg, Radix Scutellariae 10kg, Spica Prunellae 6kg, Flos Sophorae Immaturus 6kg, Magnetitum (forging) 6kg, Radix Achyranthis Bidentatae 6kg, Radix Angelicae Sinensis 10kg, Radix Rehmanniae 4kg, Radix Salviae Miltiorrhizae 4kg, Ramulus Uncariae Cum Uncis 6kg, Semen Cassiae 10kg, Concha Margaritifera 4kg, sucrose 10kg.
Function cures mainly: suppressing the hyperactive liver and subsiding YANG, brain-benefiting blood pressure-reducing.For excessive rising of liver-YANG, slight Hypertension, dizzy dizzy, insomnia forgetfulness.
Method for making:
1) powder: above each taste is pulverized, and crosses 80 mesh sieves, is distributed into 6g/ bag.
2) milk pulvis: the prescription of powder with milk powder 200g, the same powder of method for making.
1, powder and milk pulvis mouthfeel compare
Be made up of 10 people and appraise group through discussion, everyone distinguishes oral powder and milk pulvis, and evaluation result is in table 5.
Table 5 different material combination mouthfeel compares
| Stench highly seasoned | Bad smell is light | Without bad smell | |
| Brain-benefiting blood pressure-reducing oral liquid | 10 people | 0 people | 0 people |
| Milk brain-benefiting blood pressure-reducing oral liquid | 0 people | 4 people | 6 people |
Result shows, and compositions of the present invention, oral stench abnormal flavour is little, and mouthfeel is good.
2, powder and milk pulvis Hypertension disease belong to the clinical observation of liver-Yang sthenia type
1) the routine patient of case basic condition 60 meets Evaluation of Diagnostic Criteria of Hypertension, and all has dizziness, headache, insomnia, stringy pulse, yellow fur, meets differential diagnosis in tcm liver-Yang sthenia type.Patient is divided into two groups at random, oral blood pressure lowering oral liquid 1 group 30 example, wherein man 14 example, female 16 example, age 50-75 year; Compositions 2 oral liquid group 30 example, man 15 example, female 15 example, age 50-78 year.Two groups of patient ages, the data such as sex and the course of disease, through statistical test, has comparability without significant difference.
2) Therapeutic Method
Two groups of patients oral powder and milk pulvis respectively, 2 times/d, 1 bag/time.Take 10d as the observation period.
3) curative effect standards of grading
Recovery from illness: SBP < 140mmHg, DBP < 90mmHg, headache, dizziness waits disease disappearance; Effective: SBP < 140mmHg, DBP < 90mmHg, the diseases such as headache, dizziness alleviate; Invalid: blood pressure decline to some extent but the diseases such as dizziness, headache without improvement.
5) observation index
Observe clinical symptoms and blood pressure before and after medication
6) the results are shown in Table 6.
Table 6 liang group Clinical efficacy comparison
| Number of cases | Effective example | Effective example | Invalid example | Total effective rate (%) | |
| Powder | 30 | 17 | 5 | 8 | 73.33 |
| Milk pulvis | 30 | 18 | 4 | 8 | 73.33 |
Result shows, powder and milk pulvis all have remarkable therapeutical effect to hypertension, and the two effect quite.
Pharmaceutical preparation abnormal flavour containing animal drug prepared by application milk is little, and maintains original curative effect.
embodiment 4
[prescription] Cornu Cervi Pantotrichum 2g, Gecko (wine is processed) 19.5g, Penis et testis canitis (wine is processed) 9.6g, Semen Platycladi 65g, Fructus Lycii 100g, Semen pini koraiensis 50g, Rhizoma Polygonati 200g.
[method for making] above seven flavor medicine, decocts with water secondary, and first time adds 10 times of water gagings, decoct 2 hours, second time adds 8 times of water gagings, decocts 1 hour, secondary decocting liquid merges, and filter, being evaporated to relative density is 1.10, adding ethanol makes alcohol content reach 70%, leaves standstill 12 hours, filters, decompression filtrate recycling ethanol, to without alcohol taste, after adding suitable quantity of water dilution, adds milk 100ml, add water to 1000ml, obtain the oral liquid without stench abnormal flavour.For kidney yang deficiency, sexual impotence, spermatorrhea, premature ejaculation, soreness of the waist and knees, cold extremities is weak, forgetful, dynamic then diseases such as asthma.
embodiment 5
With a collection of periplaneta americana, powder will be prepared into by following material combination respectively.
1) powder: periplaneta americana 5kg, glucose 1kg; Mixing, pulverizes, is distributed into 1000 bags;
2) milk pulvis: periplaneta americana 5kg, glucose 1kg, milk powder 2.5kg; Mixing, pulverizes, is distributed into 1000 bags.
3, powder and milk pulvis liver protective effect compare
Adopt CCl
4the impact test of caused Liver Damage in Rats.The healthy SD rat of body weight 180-220g, is divided into powder group, milk pulvis group, matched group at random, often organizes 10; Contrast with test group in experiment the 1st, 5 days subcutaneous injection 50%CCl
4vegetable oil suspension 5mL/kg, difference gastric infusion every day 1 time from experiment starts day, 1 time 3g/kg(is equivalent to periplaneta americana), matched group gives equal-volume distilled water, continuous 9 days, and drug withdrawal 24 hours eye sockets get blood, survey serum glutamic pyruvic transminase with reitman-frankel method.The results are shown in Table 7.
The preparation of table 7 distinct methods is to CCl
4the impact of caused hepatic injury rat blood serum glutamate pyruvate transaminase
| Group | Dosage (g/kg) | Glutamate pyruvate transaminase in serum |
| Matched group | 365.2±116.4 | |
| Milk pulvis group | 3 | 174.5±109.7 |
| Powder group | 3 | 174.5±113.6 |
Result shows, powder and milk pulvis are to rat CCl
4the protective effect of caused hepatic injury is suitable.Pharmaceutical preparation abnormal flavour containing animal drug prepared by application milk powder is little, and maintains original curative effect.
embodiment 6
Water intaking trematodiasis, Eupolyphaga Seu Steleophaga, Pheretima, Gekko Swinhonis, Penis et testis cervi, Testis Et penis Caprae seu Ovis, Testis et penis callorhini, Air Bladder pseudosciaenae seu Acipenser, Solenognathus, Hippocampus are pulverized, add 0.5-5 milk doubly respectively by weight, make powder, granule, oral liquid, decoction, to the mouthfeel mouthfeel such as " stench highly seasoned ", " bad smell is light ", " without bad smell ", comparative evaluation is carried out with preparation not with milk, preparation prepared by each animal drugs of result, mouthfeel all improves significantly.
Claims (5)
1. the application in medicine prepared by milk, it is characterized in that: the little application contained in the pharmaceutical preparation of animal drug of abnormal flavour prepared by milk.
2. the application in medicine prepared by milk according to claim 1, it is characterized in that: contain milk containing in the pharmaceutical preparation of animal drug.
3. preparing the application in medicine according to the milk of claim 1 or claim 2, it is characterized in that: milk consumption is animal drug 1 part by weight, be more than milk 0.5-5 part.
4. the application in medicine prepared by milk according to claim 4, and wherein milk can replace with milk powder, and the weight ratio of replacement is milk powder 1 part=milk 10 powder.
5. preparing the application in medicine according to the milk of claim 1 or claim 2, it is characterized in that: the pharmaceutical preparation containing animal drug is comprising compound recipe containing animal drug and single preparations of ephedrine.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103891895A (en) * | 2012-12-31 | 2014-07-02 | 内蒙古伊利实业集团股份有限公司 | Liquid dairy product containing earthworm protein and preparation method of liquid dairy product |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103891895A (en) * | 2012-12-31 | 2014-07-02 | 内蒙古伊利实业集团股份有限公司 | Liquid dairy product containing earthworm protein and preparation method of liquid dairy product |
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Application publication date: 20150527 |
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