CN104644459A - Freckle-removing and beautifying cream suitable for all kinds of skin - Google Patents
Freckle-removing and beautifying cream suitable for all kinds of skin Download PDFInfo
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- CN104644459A CN104644459A CN201510065183.XA CN201510065183A CN104644459A CN 104644459 A CN104644459 A CN 104644459A CN 201510065183 A CN201510065183 A CN 201510065183A CN 104644459 A CN104644459 A CN 104644459A
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Abstract
The invention relates to the field of daily use chemicals, and in particular relates to a freckle-removing and beautifying cream suitable for all kinds of skin. The freckle-removing and beautifying cream comprises the raw materials including octyl p-methoxycinnamate, licoflavone lipid nanoemulsion, vitamin C, glycerin monostearate, benzophenone-3, octyl salicylate, titanium dioxide, hexadecanol, squalane, Vaseline, white oil, lanolin alcohol, vitamin E, microcrystalline wax, polyvinylpyrrolidone and water. The freckle-removing and beautifying cream provided by the invention is suitable for all kinds of skin and has fine texture; ultrafine molecules can directly penetrate into the basal layer of skin to deeply reach melanophore; therefore, the deep pigment group is decomposed and faded; generation of melanin is inhibited; and furthermore, the freckle-removing and beautifying cream is capable of accelerating skin metabolism, promoting detachment of horn cells containing melanin, replenishing nutritional components required by skin, promoting skin regeneration, whitening and tendering skin.
Description
Technical field
The present invention relates to household chemicals field, particularly a kind of speckle dispelling face beautifying cream being applicable to various skin quality.
Background technology
Under normal condition, melanin can absorb excessive daylight, particularly absorbs ultraviolet, protection body.If the melanin generated can not metabolism in time and assemble, be deposited on epidermis, then can make to occur freckle, chloasma, senile plaque etc. on the face.It is generally acknowledged, melanic formation mechanism, that tyrosine in melanocyte synthesizes through tyrosinase catalysis, oxidizing tyrosine becomes melanic process quite complicated, rate-limiting step is wherein tryrosinase, ultraviolet radiation can cause the enhancing of tryrosinase and melanocyte activity, thus promotes that melanin is formed.
Whitening cosmetic on the market, be main mainly with simple whitening ingredients, conventional brightening agent mainly contains retinoic acid, mequinol, hydroquinone, ascorbic acid and derivant thereof, kojic acid and derivant, arbutin, Radix Glycyrrhizae extract etc., but for the consideration of safety, the application of kojic acid, mequinol, hydroquinone is subject to restriction (Li Tong in various degree, household chemicals science, 2009 (32): 43-45).
The speckle dispelling product being applicable to various skin quality is at present actually rare, and publication number is that the application for a patent for invention of CN102048674 discloses a kind of Chinese herbal medicine beautifying whitening removing acne and freckle face mask cream, is applicable to various skin quality, has no side effect.Its concrete technical scheme is, with the Radix Angelicae Dahuricae, Margarita, Rhizoma Typhonii, the Pseudobulbus Bletillae (Rhizoma Bletillae), is equipped with appropriate allotment substrate Ovum Gallus domesticus album furnishing pasty state, use is, is mixed well by face mask cream, gets one pair, uniform application and facial skim, after about 15-20 minute, wash with warm water.
Publication number is that the application for a patent for invention of CN1762324 provides a kind of composite whitening speckle-removing rehabilitation cosmetic, this modularization cosmetic comprises matching used FUHE MEIBAI QUBAN YE and whitening restoration frost, and wherein the raw material of FUHE MEIBAI QUBAN YE comprises plant water-soluble extract, kojic acid, propylene glycol, glycerol, vitamin A, caffeic acid, vitamin C, vitamin, licoflavone etc.; The raw material of whitening restoration frost comprises stearic acid, 16/18 alcohol, monoglyceride, sorbester p18, polysorbate60, hundred Dormant oils, methyl ester, propyl ester, triethanolamine, propylene glycol, specially good effect whitening renovation agent, reparative factor, Camphora etc.Said composition can give play to the effect of effective inhibitory action Sum decomposition for freckle, chloasma, senile plaque and melanin deposition etc.But, in prior art, there is not a kind of speckle dispelling product being applicable to various skin quality taking licoflavone as raw material and be prepared into.
Summary of the invention
In order to overcome the defect of licoflavone in cosmetic field uses in prior art, the application is after being prepared into lipid nanoemulsion by licoflavone, obtain a kind of freckle whitening makeup as raw material, especially provide a kind of speckle dispelling face beautifying cream being applicable to various skin quality.
For realizing object of the present invention, the technical scheme that concrete employing is following: a kind of freckle whitening makeup, its raw material percentage composition by weight, comprises the licoflavone lipid nanoemulsion of 5 ~ 50% and the sunscreen of 1 ~ 30%; Described licoflavone lipid nanometer Ruzhong, the weight percentage of licoflavone is 0.01 ~ 10%.
Preferably, a kind of freckle whitening makeup, its raw material percentage composition by weight, comprises the licoflavone lipid nanoemulsion of 15 ~ 45% and the sunscreen of 3 ~ 20%; Described licoflavone lipid nanometer Ruzhong, the weight percentage of licoflavone is 0.5 ~ 3%.
Concrete, described licoflavone lipid nanoemulsion percentage composition by weight, comprise component A and B component, described component A comprises the licoflavone of 2%, the soybean phospholipid of 3.5%, the soybean oil of 5%, the caprylic/capric triglyceride of 20%, the Natrulon H-10 oleate of 2%, the sorbester p17 of 0.5%, the glycerol of 5%, the propylene glycol of 5%; Described B component comprises the Tween 80 of 0.5%, and the polyoxyethylene castor oil of 2%, water complements to 100%.
Further, in order to reach better effect, the preparation method of described licoflavone lipid nanoemulsion comprises the following steps:
(1) by component A, high speed shear, without the visible solid content of naked eyes to system;
(2) B component is added step (1) products therefrom, high speed shear, obtains colostrum, and colostrum, through high pressure homogenizer process, obtains licoflavone lipid nanoemulsion.
Preferably, the speed sheared in step (1) and step (2) high speed is 10000rpm.
When the process of step (2) mesohigh homogenizer, pressure 2000bar used, circulates 10 times.
At freckle whitening makeup of the present invention, described sunscreen is selected from one or more in OctMet, EHA, OXYBENZONE, ethylhexyl salicylate, titanium dioxide or zinc oxide.
The present invention, using lipid nanoemulsion as licoflavone carrier, can strengthen licoflavone water solublity, compatibility convenience and preparation stability.The ultraviolet protection (sunscreen) of abiotic activity is effectively combined with licoflavone by the present invention, have eliminate free radical, check melanin generates, improve the function of pigmentation and skin whitening.
Freckle whitening makeup provided by the invention can also add cosmetics and commonly use the dosage form that matrix composition becomes routine, the U.S. face liquid of such as speckle dispelling, speckle dispelling face beautifying cream or the U.S. face cream of speckle dispelling.
Concrete, for the U.S. face liquid of speckle dispelling, percentage composition by weight, shown in it is composed as follows:
Preferably, for the U.S. face liquid of speckle dispelling, percentage composition by weight, it is composed as follows:
The U.S. face liquid of speckle dispelling of the present invention can adopt arbitrary preparation method of the prior art, the preparation method that preferred employing is following: after B component is heated to 80 DEG C, after waxy substance is melted, component C is added when being cooled to 45 DEG C, 200rpm stirs 15min, add component A after being cooled to room temperature, homogenizing, to obtain final product.
The present invention with licoflavone lipid nanoemulsion and sunscreen for functional components, assistant is with adjuvant, learn from other's strong points to offset one's weaknesses, and grope summary in a large number through inventor and draw the detailed consumption of each component, obtain the U.S. face liquid of the good speckle dispelling of effect, the U.S. face liquid of speckle dispelling provided by the invention is easily absorbed by the skin, good stability, excitatory low, to human body skin safety, cell viability can be improved greatly, the generation of check melanin.
Concrete, for the speckle dispelling face beautifying cream being applicable to various skin quality, percentage composition by weight, shown in it is composed as follows:
Preferably, for speckle dispelling face beautifying cream, by weight percentage composition, it is composed as follows:
The speckle dispelling face beautifying cream being applicable to various skin quality of the present invention can adopt arbitrary preparation method of the prior art, the preparation method that preferred employing is following: after B component is heated to 85 DEG C, after waxy substance is melted, C is added when being cooled to 50 DEG C, 200rpm stirs 20min, add component A after being cooled to room temperature, homogenizing, to obtain final product.
Speckle dispelling face beautifying cream provided by the invention is applicable to various skin quality, exquisite quality, ultra-fine molecular energy directly penetrates skin basal layer, deeply reaches melanocyte, and deep layer pigment group is decomposed, desalinated, check melanin produces, and can skin metabolism be accelerated, promote to come off containing melanic horn cell, supplement the nutritional labeling needed for skin, promote skin revitalization, whitening and softening skin.
Concrete, for the U.S. face cream of speckle dispelling, percentage composition by weight, shown in it is composed as follows:
Preferably, for the U.S. face cream of speckle dispelling, percentage composition by weight, it is composed as follows:
The U.S. face cream of speckle dispelling of the present invention can adopt arbitrary preparation method of the prior art, preferably adopts following preparation method: component C is heated to 75 DEG C, after waxy substance is melted, add component A when being cooled to 50 DEG C, 300rpm stirs 30min, adds B component after being cooled to room temperature, homogenizing, to obtain final product.
Speckle dispelling provided by the invention U.S. face cream good stability, excitatory low, to human body skin safety, cell viability can be improved greatly, the generation of check melanin.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.
Embodiment 1: licoflavone lipid nanoemulsion
The preparation method of this lipid nanoemulsion is as follows:
1) by above-mentioned prescription, by component A, high speed shear under 10000rpm condition, without the visible solid content of naked eyes to system;
2) B component is added step 1) product, high speed shear under 10000rpm condition, obtains colostrum, and colostrum is through high pressure homogenizer process, and pressure 2000bar used, circulates 10 times, obtains transparent clear shape licoflavone lipid nanoemulsion.
Embodiment 2: the U.S. face liquid of speckle dispelling
The preparation method of the U.S. face liquid of this speckle dispelling is as follows: after B component being heated to 80 DEG C, and after waxy substance is melted, add component C when being cooled to 45 DEG C, 200rpm stirs 15min, adds component A, homogenizing, to obtain final product after being cooled to room temperature.
Embodiment 3: speckle dispelling face beautifying cream
The preparation method of this speckle dispelling face beautifying cream is as follows: after B component being heated to 85 DEG C, and after waxy substance is melted, add C when being cooled to 50 DEG C, 200rpm stirs 20min, adds component A, homogenizing, to obtain final product after being cooled to room temperature.
Embodiment 4: the U.S. face cream of speckle dispelling
The preparation method of the U.S. face cream of this speckle dispelling is as follows:
Component C is heated to 75 DEG C, after waxy substance is melted, add component A when being cooled to 50 DEG C, 300rpm stirs 30min, adds B component, homogenizing, to obtain final product after being cooled to room temperature.
Embodiment 5: speckle dispelling face beautifying cream
Embodiment 5 and the difference of embodiment 3 are only that the content of licoflavone lipid nanometer Ruzhong licoflavone is different, and in the present embodiment, licoflavone lipid nanoemulsion specifically composed as follows, the preparation method of licoflavone lipid nanoemulsion is with embodiment 1.
Embodiment 6: speckle dispelling face beautifying cream
Embodiment 6 and the difference of embodiment 3 are only that the content of licoflavone lipid nanometer Ruzhong licoflavone is different, and in the present embodiment, licoflavone lipid nanoemulsion specifically composed as follows, the preparation method of licoflavone lipid nanoemulsion is with embodiment 1.
Embodiment 7-8: the U.S. face liquid of speckle dispelling
Embodiment 7-8 and embodiment 2 are distinguished and are only that the content of component is different, specific as follows:
Embodiment 9-10: speckle dispelling face beautifying cream
From the difference of embodiment 3, embodiment 9-10 is only that the content of component is different, specific as follows:
Embodiment 11-12: the U.S. face cream of speckle dispelling
From the difference of embodiment 4, embodiment 11-12 is only that the content of component is different, specific as follows:
Experimental example 1: preparation stability is tested
Test specimen: the sample 1-5 prepared by embodiment 2-6 and reference substance 4-6.
Reference substance 4: by the prescription of embodiment 3, replaces with the licoflavone alcoholic solution of active component identical (licoflavone) by licoflavone lipid nanoemulsion, all the other compositions and preparation method constant.
Reference substance 5: by the prescription of embodiment 3, replaces with the licoflavone phosphatide complexes of the CN102949440A of active component identical (licoflavone) by licoflavone lipid nanoemulsion, all the other compositions and preparation method constant.
Reference substance 6: by the prescription of embodiment 3, replaces with the water solublity licoflavone of the CN102140144A of active component identical (licoflavone) by licoflavone lipid nanoemulsion, all the other compositions and preparation method constant.
Experimental technique: placed 6 months at 4 DEG C, 25 DEG C, 37 DEG C by sample 1-5 and reference substance 4-6, observes sample appearance.
Experimental result is in table 1.
Table 1: difference is placed and under treatment conditions, sample appearance changes
From table 1, sample 1-5 places 6 months, and outward appearance still can keep even, and reference substance 4, when temperature is raised to 25 DEG C, the existing a small amount of licoflavone precipitate in bottom, reflects licoflavone and volatilized and Precipitation by ethanol.
Experimental example 2:MTT activity test
Take the logarithm the human epidermal cell HEK-n of trophophase, according to 1 × 10
5the concentration of cells/mL inoculates 96 orifice plates, every pore volume 200 μ L, after normal cultivation 24h, in protection group cell culture fluid, adds trial target respectively, after 5min, adopts 1mM H respectively
2o
2carry out oxidative damage process 6h.After oxidative damage process terminates, take out 96 well culture plates, abandon supernatant, after carefully rushing 2-3 time with PBS, then add the fresh medium of 200 μ L containing 0.5mg/mL MTT, continue at 37 DEG C, 5%CO
24h is cultivated under condition.After cultivation terminates, discard MTT solution, every hole adds 100 μ LDMSO, vibration mixing, surveys each hole absorbance (A490) that wavelength is 490nm, calculates cell survival rate, the results are shown in Table 2.
The product of trial target prepared by embodiment of the present invention 2-6 is as sample 1-5 and reference substance, and concrete reference substance is as follows respectively:
Reference substance 1, according to embodiment 3 will wherein licoflavone lipid nanoemulsion remove, appropriate section with water polishing, all the other prescriptions and preparation method constant;
Reference substance 2, according to embodiment 3 will wherein sunscreen remove, appropriate section with water polishing, all the other prescriptions and preparation method constant;
Reference substance 3, according to embodiment 3 will wherein licoflavone lipid nanoemulsion, sunscreen remove, appropriate section with water polishing, all the other prescriptions and preparation method constant.
Reference substance 4-6 is identical with experimental example 1.
Table 2MTT activity test
As shown in Table 2, compared with reference substance, the sample containing licoflavone lipid nanoemulsion and UV screening agent, greatly can improve cell viability.
Experimental example 3: melanin inhibition test
By B16 melanocyte with 1 × 10
5the density of individual/mL is inoculated in 6 orifice plates.Every hole 3ml, after hatching 24h, abandons supernatant, adds medicine to be measured, after drug effect 3d, abandons supernatant, and PBS washs, and every hole adds 0.5mL trypsin digestion cell 3min, and every hole adds 2ml maintenance medium and stops digestion.After piping and druming mixing, often kind of concentration is taken out 0.5mL and is made cell counting.All the other cell suspension, with the centrifugal 5min of 2500r/min, abandon supernatant, add sodium hydroxide solution, melanin is dissolved in precipitation, select 490nm wavelength to survey absorbance on enzyme-linked immunosorbent assay instrument, calculate melanin generating suppression, the results are shown in Table 3.
Trial target is with experimental example 2.
Melanin generating suppression=[1-(medicine hole absorbance ÷ medicine porocyte density) ÷ (control wells absorbance ÷ control wells cell density] × 100%
Table 3 melanin generating suppression %
| Sample 1 | Sample 2 | Sample 3 | Sample 4 | Sample 5 | Contrast 1 | Contrast 2 | Contrast 3 | Contrast 4 | Contrast 5 | Contrast 6 | |
| Suppression ratio | 43.7 | 48.1 | 39.4 | 32.2 | 33.2 | 7.5 | 30.1 | 7.5 | 26.2 | 33.2 | 31.8 |
As shown in Table 3, compared with reference substance, licoflavone lipid nanoemulsion greatly can strengthen melanin generating suppression.
Experimental example 4: tryrosinase vitality test
By B16 melanocyte with 1 × 10
5the density of individual/mL is inoculated in 96 orifice plates.Every hole 100 μ L, after hatching 24h, abandons supernatant, adds medicine to be measured, after drug effect 3d, abandon supernatant, PBS washing twice, and every hole adds the PBS of 90 μ L containing 1% (volume fraction) Triton X-100.Ultrasonication in ice bath, every hole adds the L-dopa of 10 μ L 10mmoL/L, hatches 60min for 37 DEG C, and in 475nm place colorimetric, blank well returns to zero, and surveys each hole absorbance, calculates inhibitory activity against tyrosinase, the results are shown in Table 4.
Experiment product (sample and reference substance) is with experimental example 2.
Suppression ratio=(1-medicine group mean absorbance values ÷ matched group mean absorbance values) × 100%.
Table 4 inhibitory activity against tyrosinase %
As shown in Table 4, compared with reference substance, the sample containing the application's licoflavone lipid nanoemulsion, is significantly improved to tyrosinase activity inhibitory action.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. a freckle whitening makeup, is characterized in that, its raw material percentage composition by weight, comprises the licoflavone lipid nanoemulsion of 5 ~ 50% and the sunscreen of 1 ~ 30%; Described licoflavone lipid nanometer Ruzhong, the weight percentage of licoflavone is 0.01 ~ 10%.
2. freckle whitening makeup according to claim 1, is characterized in that, its raw material percentage composition by weight, comprises the licoflavone lipid nanoemulsion of 15 ~ 45% and the sunscreen of 3 ~ 20%; Described licoflavone lipid nanometer Ruzhong, the weight percentage of licoflavone is 0.5 ~ 3%.
3. freckle whitening makeup according to claim 1 and 2, is characterized in that, described licoflavone lipid nanoemulsion percentage composition by weight, comprises component A and B component,
Described component A comprises the licoflavone of 2%, the soybean phospholipid of 3.5%, the soybean oil of 5%, the caprylic/capric triglyceride of 20%, the Natrulon H-10 oleate of 2%, the sorbester p17 of 0.5%, the glycerol of 5%, the propylene glycol of 5%;
Described B component comprises the Tween 80 of 0.5%, and the polyoxyethylene castor oil of 2%, water complements to 100%.
4. freckle whitening makeup according to claim 3, is characterized in that, the preparation method of described licoflavone lipid nanoemulsion comprises the following steps:
(1) by component A, high speed shear, without the visible solid content of naked eyes to system;
(2) B component is added step (1) products therefrom, high speed shear, obtains colostrum, and colostrum, through high pressure homogenizer process, obtains licoflavone lipid nanoemulsion.
5. freckle whitening makeup according to claim 1 and 2, is characterized in that: described sunscreen is selected from one or more in OctMet, EHA, OXYBENZONE, ethylhexyl salicylate, titanium dioxide or zinc oxide.
6. the freckle whitening makeup according to any one of claim 1-5, is characterized in that: described freckle whitening makeup is the U.S. face liquid of speckle dispelling, speckle dispelling face beautifying cream or the U.S. face cream of speckle dispelling.
7. freckle whitening makeup according to claim 6, is characterized in that, the U.S. face liquid of described speckle dispelling percentage composition by weight, comprises component A, B component and component C,
Described component A is the licoflavone lipid nanoemulsion of 15 ~ 45%;
Described B component comprises the C of 3 ~ 10%
16alkyl dimethicone, the OctMet of 3 ~ 7.5%, the annular dimethyl polysiloxane of 3 ~ 10%, the octyl stearate of 5 ~ 15%, the castor oil hydrogenated of 0.1 ~ 2%, the microwax of 0.5 ~ 2%, the vitamin E of 0.1 ~ 3%, the Jojoba oil of 1 ~ 5%;
Described component C comprises the vitamin C of 0.1 ~ 3%, and the sodium chloride of 0.2 ~ 1%, water complements to 100%.
8. freckle whitening makeup according to claim 6, is characterized in that, described speckle dispelling face beautifying cream percentage composition by weight, comprises component A, B component and component C,
Described component A is the licoflavone lipid nanoemulsion of 15 ~ 45%;
Described B component comprises the glyceryl monostearate of 0.5 ~ 5%, the OXYBENZONE of 3 ~ 7%, the OctMet of 3 ~ 7.5%, the ethylhexyl salicylate of 2 ~ 5%, the titanium dioxide of 0.5 ~ 5%, the hexadecanol of 2 ~ 5%, the squalane of 3 ~ 7%, the vaseline of 3 ~ 10%, the white oil of 3 ~ 10%, the lanolin alcohol of 0.2 ~ 5%, the vitamin E of 0.1 ~ 3%, the microwax of 0.5 ~ 2%;
Described component C comprises the vitamin C of 0.1 ~ 3%, and the polyvinylpyrrolidone of 0.2 ~ 1%, water complements to 100%.
9. freckle whitening makeup according to claim 8, is characterized in that, described speckle dispelling face beautifying cream percentage composition by weight, comprises component A, B component and component C,
Described component A is the licoflavone lipid nanoemulsion of 45%;
Described B component comprises the glyceryl monostearate of 2%, the OXYBENZONE of 3%, the OctMet of 3%, the ethylhexyl salicylate of 2.5%, the titanium dioxide of 1%, the hexadecanol of 4%, the squalane of 5%, the vaseline of 6%, the white oil of 8%, the lanolin alcohol of 1.5%, the vitamin E of 1%, the microwax of 2%;
Described component C comprises the vitamin C of 0.5%, and the polyvinylpyrrolidone of 0.5%, water complements to 100%.
10. freckle whitening makeup according to claim 6, is characterized in that, the U.S. face cream of described speckle dispelling percentage composition by weight, comprises component A, B component and component C,
Described component A is the licoflavone lipid nanoemulsion of 15 ~ 45%;
Described B component is the vitamin C of 0.1 ~ 3%, and purified water is mended to 100%;
The Tween 80 of described component C 0.1 ~ 2%, the microwax of 5 ~ 15%, the propyl p-hydroxybenzoate of 0.05 ~ 0.2%, the OctMet of 3 ~ 7.5%, the Cera Flava of 0.2 ~ 5%, the vaseline of 3 ~ 10%, the lanoline of 3 ~ 10%, the Squalene of 20 ~ 40%, the vitamin E of 0.1 ~ 3%, the olein of 2 ~ 10%, the adipic acid C of 2 ~ 10%
16alkane ester.
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| CN201510065183.XA CN104644459A (en) | 2015-02-06 | 2015-02-06 | Freckle-removing and beautifying cream suitable for all kinds of skin |
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| CN111511209A (en) * | 2017-09-22 | 2020-08-07 | 德科全球收后处理股份私人有限公司 | Method for treating and controlling postharvest physiological disease of fruit through edible coating |
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| CN111511209A (en) * | 2017-09-22 | 2020-08-07 | 德科全球收后处理股份私人有限公司 | Method for treating and controlling postharvest physiological disease of fruit through edible coating |
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