CN104643069B - Composite health composition and preparation method thereof - Google Patents
Composite health composition and preparation method thereof Download PDFInfo
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- CN104643069B CN104643069B CN201510051744.0A CN201510051744A CN104643069B CN 104643069 B CN104643069 B CN 104643069B CN 201510051744 A CN201510051744 A CN 201510051744A CN 104643069 B CN104643069 B CN 104643069B
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Abstract
The invention discloses a composite health composition and a preparation method thereof. The health composition is prepared from the following raw materials in parts by weight: 100-300 parts of cordyceps taishanensis meal, 100-220 parts of bee pollen, 80-130 parts of a grape seed extract and 50-100 parts of Dondey-hide Glue Powder. The composite health composition disclosed by the invention has obvious effects of delaying senescence, improving sleep, maintaining beauty and keeping young, is small in use amount, and is especially suitable for being eaten by working women.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition with health role, said composition have anti-aging, improve the health care of sleep,
The effect of beautifying face and moistering lotion, is particularly suitable for workplace women and eats.
Background technology
In today of high speed development, social competition is especially fierce, and workplace women each and every one seems keen and wise, beautiful confidence,
Actually feel exhausted mostly, unmentionable disease is the more.Stay up late, work overtime, irregular life is almost homely food, in order to take into account society
The multiple players such as family marriage, must pay the effort that several times are had more than ordinary person.This high load capacity makes muscle power saturating with spiritual face
Branch, has a strong impact on women's health.The Chinese Academy of Social Sciences once reported and pointed out：More than 80% Chinese women enters early ageing in advance
Phase.Therefore develop a suitable workplace women, with anti-aging, improve the health care of sleep, the health products of effects of beautification and nourishing face are particularly weighed
Will.
The content of the invention
Simple it is an object of the invention to provide one kind formula, dose is low, with anti-aging, improve the health care of sleep, beauty is supported
The health composition of face effect.
The purpose of the present invention is achieved in the following ways：
A kind of compound health-care composition, the weight portion of each component is in the health composition：
Cordyceps 100-300 weight portion Bee Pollen 100-220 weight portions
Grape seed extract 80-130 weight portion gelatin powder 50-100 weight portions
It is preferred that the weight portion of each component is in said composition：
Cordyceps 100-250 weight portion Bee Pollen 120-220 weight portions
Grape seed extract 90-130 weight portion gelatin powder 60-90 weight portions
Most preferably the weight portion of each component is in said composition：
Cordyceps 130-250 weight portion Bee Pollen 150-200 weight portions
Grape seed extract 90-110 weight portion gelatin powder 60-80 weight portions
Cordyceps described in above-mentioned compound health-care composition are prepared by the following method and obtain：Strain is connected to
On fresh slant medium, culture medium prescription is：Potato 8-9%, glucose 2-4.0%, potassium dihydrogen phosphate 0.2-0.3%, sulphur
Sour magnesium 0.15-0.17%, agar 1.3-1.5%, 26-28 DEG C is cultivated 4 days；In the good strain transfer of inclined-plane culture to shaking flask,
Shake flask medium is：Glucose 2.0-4.0%, peptone 1.0-2.0%, potassium dihydrogen phosphate 0.1-0.3%, magnesium sulfate 0.05-
0.07%, 26-28 DEG C is cultivated 2 days；After Shaking culture terminates, by strain transfer to seeding tank, seed tank culture base is：Grape
Sugared 2.0-3.0%, peptone 1-2%, potassium dihydrogen phosphate 0.1-0.3%, magnesium sulfate 0.05-0.07%, defoamer 0.1-
0.2%, technological condition for fermentation is：Inoculum concentration 10%, 26 DEG C ± 1 DEG C of temperature, throughput 1: 0.5vvm, tank pressure 0.03MPa；Seed
Tank is transferred to ferment tank after fermenting 3 days, and fermentation tank culture medium is：Peptone 2-4%, glucose 1.5-1.7%, di(2-ethylhexyl)phosphate
Hydrogen potassium 0.05-0.07%, magnesium sulfate 0.07-0.08%, defoamer 0.1-0.3%.Zymotechnique is：Inoculum concentration 10%, fermentation
26 DEG C ± 1 DEG C of temperature, throughput 1: 0.5vvm, tank pressure 0.03MPa.Fermenter volume is 10 times of seeding tank.
Described cordyceps bacterial strain is Cordyceps Militaris-Paecilomyces hepiali chen CS-4.
Above-mentioned compound health-care composition can be made preparation with pharmaceutically acceptable auxiliary material.Described preparation is preferably scattered
Agent, tablet, capsule, pill, granule.Compound health-care capsule can be filled with No. 0 capsule, every 0.25g
The preparation method of described compound health-care composition is proportionally to be well mixed each component.
The compound health-care composition is preparing anti-aging, is improving the health care of sleep, applies in the medicine of beautifying face and moistering lotion or food.
The cordyceps that the present invention is used can be obtained by making by oneself, and Bee Pollen, grape seed extract and gelatin powder can pass through
Market purchase is obtained.
Cordyceps self-control is preferably carried out according to following technique：
Cordyceps bacterial strain：Cordyceps Militaris-Paecilomyces hepiali chen (Paecilomyces hepiali chen) CS-4, purchase
Buy in Chinese Academy of Sciences's Culture Collection.
Take out preservation of bacteria strain from refrigerator to be connected on fresh slant medium, culture medium prescription is：Potato 8%, glucose
3.0%, potassium dihydrogen phosphate 0.3%, magnesium sulfate 0.15%, agar 1.3%, 26 DEG C are cultivated 4 days.
In the good strain transfer of inclined-plane culture to shaking flask, Shake flask medium is：Glucose 2.0%, peptone 1.0%,
Potassium dihydrogen phosphate 0.1%, magnesium sulfate 0.05%, 26 DEG C are cultivated 2 days.
After Shaking culture terminates, by strain transfer to seeding tank, seed tank culture base is：Glucose 2.0%, peptone
1%, potassium dihydrogen phosphate 0.1%, magnesium sulfate 0.05%, defoamer 0.1%, technological condition for fermentation is：Inoculum concentration 10%, temperature 26
DEG C ± 1 DEG C, throughput 1: 0.5vvm, tank pressure 0.03MPa.
Seeding tank is transferred to bulk fermentation after fermenting 3 days, and big tank culture medium is：Peptone 2%, glucose 1.5%, phosphoric acid
Potassium dihydrogen 0.05%, magnesium sulfate 0.07%, defoamer 0.1%.Zymotechnique is：Inoculum concentration 10%, 26 DEG C ± 1 of fermentation temperature
DEG C, throughput 1: 0.5vvm, tank pressure 0.03MPa.
After fermentation ends, zymotic fluid is separated through horizontal spiral discharge sedimentation centrifuge, and mycelium vacuum below 70 DEG C is done
It is dry, 100 mesh sieves were crushed after drying and obtained final product cordyceps.
Bee Pollen is purchased from auspicious cloud Yan Song bio tech ltd；
Grape seed extract is purchased from Hubei Sheng Tianhengchuan bio tech ltd；
Gelatin powder is purchased from Dong-E donkey-hide Gelatin Co., Ltd., Shandong Prov..
The present invention is further described below by way of specific experiment example：
This capsule (loads No. 0 capsule to be packed, holds per intragranular after being well mixed by the material rate of the embodiment of the present invention 1
Thing 0.25g) Piglet s colibacillosis are done with commercially available melissa powder capsule, grape seed extract capsule and donkey-hide gelatin, choosing, there is sleep to hinder
Hinder, it is neurasthenic with the people of inferior health workplace women 250, skin is low and deep, the lacklustre people of workplace women 250, is randomly divided into 5
Group, numbering is 0 group, 1 group, 2 groups, 3 groups and 4 groups, every group of sleep-disorder, the people of neurasthenia 50, and skin is low and deep, matt 50 people,
Total 100 people, 0 group is taken capsule of the present invention, and 1 group is taken commercially available melissa powder capsule, capsule 0.25g/, Time of Administration 30 days, often
It 1 time, every time one.2 groups are taken grape seed extract capsule, capsule 0.25g/, Time of Administration 30 days, once a day, every time
Two.3 groups are taken gelatin powder, Time of Administration 30 days, once a day, each 0.5g.4 groups are taken fermented aweto capsule, capsule
0.25g/, Time of Administration 30 days, once a day, two every time.
Sleep-disorder, neurastheniac effectively show as：Evening sleep-disorder mitigates, and can fall asleep quickly, and daytime is smart
Power is abundant.
Skin is low and deep, matt patient effectively shows as：Whiteness of skin is glossy.
Its result is as follows：
It will be apparent from the above that, this prescription, with significant curative effect, can receive unexpected effect compared with one-component,
With wide market prospects.
Beneficial effects of the present invention compared with the prior art：Compound health-care composition of the present invention have significantly delay to decline
Always, improve the health care of sleep, the effect of beautifying face and moistering lotion, and dose is small, is particularly suitable for workplace female friend and eats.
Specific embodiment：
The present invention is once further illustrated by specific embodiment.But the detail of embodiment is only used for explaining this hair
It is bright, it should not be construed as limited overall technical solution.
Cordyceps are prepared according to following technique：
Cordyceps bacterial strain：Cordyceps Militaris-Paecilomyces hepiali chen (Paecilomyces hepiali chen) CS-4, purchase
Buy in Chinese Academy of Sciences's Culture Collection.
Take out preservation of bacteria strain from refrigerator to be connected on fresh slant medium, culture medium prescription is：Potato 8%, glucose
3.0%, potassium dihydrogen phosphate 0.3%, magnesium sulfate 0.15%, agar 1.3%, 26 DEG C are cultivated 4 days.
In the good strain transfer of inclined-plane culture to shaking flask, Shake flask medium is：Glucose 2.0%, peptone 1.0%,
Potassium dihydrogen phosphate 0.1%, magnesium sulfate 0.05%, 26 DEG C are cultivated 2 days.
After Shaking culture terminates, by strain transfer to seeding tank, seed tank culture base is：Glucose 2.0%, peptone
1%, potassium dihydrogen phosphate 0.1%, magnesium sulfate 0.05%, defoamer 0.1%, technological condition for fermentation is：Inoculum concentration 10%, temperature 26
DEG C ± 1 DEG C, throughput 1: 0.5vvm, tank pressure 0.03MPa.
Seeding tank is transferred to ferment tank after fermenting 3 days, and fermentation tank culture medium is：Peptone 2%, glucose 1.5%,
Potassium dihydrogen phosphate 0.05%, magnesium sulfate 0.07%, defoamer 0.1%.Zymotechnique is：Inoculum concentration 10%, 26 DEG C of fermentation temperature
± 1 DEG C, throughput 1: 0.5vvm, tank pressure 0.03MPa.
After fermentation ends, zymotic fluid is separated through horizontal spiral discharge sedimentation centrifuge, and mycelium vacuum below 70 DEG C is done
It is dry, 100 mesh sieves were crushed after drying and obtained final product cordyceps.
Bee Pollen is purchased from auspicious cloud Yan Song bio tech ltd；
Grape seed extract is purchased from Hubei Sheng Tianhengchuan bio tech ltd；
Gelatin powder is purchased from Dong-E donkey-hide Gelatin Co., Ltd., Shandong Prov..
Embodiment 1
The weight portion of 100 weight portion Bee Pollen of cordyceps 130
The weight portion of 120 weight portion gelatin powder of grape seed extract 80
Load No. 0 capsule, every dress 0.25g after being well mixed according to aforementioned proportion.
Embodiment 2
The weight portion of 150 weight portion Bee Pollen of cordyceps 190
The weight portion of 100 weight portion gelatin powder of grape seed extract 70
After being well mixed according to aforementioned proportion, granule is made using granule customary preparation methods and auxiliary material.
Embodiment 3
The weight portion of 200 weight portion Bee Pollen of cordyceps 170
The weight portion of 90 weight portion gelatin powder of grape seed extract 60
It is tabletted using tablet customary adjuvant and preparation method after being well mixed according to aforementioned proportion.
Embodiment 4
The weight portion of 260 weight portion Bee Pollen of cordyceps 200
The weight portion of 110 weight portion gelatin powder of grape seed extract 70
After being well mixed according to aforementioned proportion, load No. 0 capsule, every dress 0.25g.
Claims (8)
1. it is a kind of for anti-aging, improve the health care of sleep, the compound health-care composition of beautifying face and moistering lotion, it is characterised in that the health-care combination
The weight portion of each composition is in thing：
Cordyceps 100-300 weight portion Bee Pollen 100-220 weight portions
Grape seed extract 80-130 weight portion gelatin powder 50-100 weight portions
Described cordyceps are prepared by the following method and obtain：Strain is connected on fresh slant medium, culture medium
It is formulated and is：Potato 8-9%, glucose 2-4.0%, potassium dihydrogen phosphate 0.2-0.3%, magnesium sulfate 0.15-0.17%, agar 1.3-
1.5%, 26-28 DEG C is cultivated 4 days；In the good strain transfer of inclined-plane culture to shaking flask, Shake flask medium is：Glucose 2.0-
4.0%, peptone 1.0-2%, potassium dihydrogen phosphate 0.1-0.3%, magnesium sulfate 0.05-0.07%, 26-28 DEG C is cultivated 2 days；Shaking culture
After end, by strain transfer to seeding tank, seed tank culture base is：Glucose 2.0-3.0%, peptone 1-2%, biphosphate
Potassium 0.1-0.3%, magnesium sulfate 0.05-0.07%, defoamer 0.1-0.2%, technological condition for fermentation is：Inoculum concentration 10%, 26 DEG C of temperature
± 1 DEG C, throughput 1: 0.5vvm, tank pressure 0.03MPa；Seeding tank is transferred to ferment tank, fermentation tank culture medium after fermenting 3 days
For：Peptone 2-4%, glucose 1.5-1.7%, potassium dihydrogen phosphate 0.05-0.07%, magnesium sulfate 0.07-0.08%, defoamer 0.1-
0.3%；Zymotechnique is：Inoculum concentration 10%, 26 DEG C ± 1 DEG C of fermentation temperature, throughput 1: 0.5vvm, tank pressure 0.03MPa.
2. compound health-care composition according to claim 1, it is characterised in that the weight of each composition in the health composition
Part it is：
Cordyceps 100-250 weight portion Bee Pollen 120-220 weight portions
Grape seed extract 90-130 weight portion gelatin powder 60-90 weight portions.
3. compound health-care composition according to claim 1, it is characterised in that the weight of each composition in the health composition
Part it is：
Cordyceps 130-250 weight portion Bee Pollen 150-200 weight portions
Grape seed extract 90-110 weight portion gelatin powder 60-80 weight portions.
4. compound health-care composition according to claim 1, it is characterised in that described strain is that Cordyceps Militaris-bat moth is intended
Mould CS-4.
5. the compound health-care composition described in claim 1,2 or 3, it is characterised in that said composition is auxiliary with pharmaceutically acceptable
Material is made preparation.
6. compound health-care composition according to claim 5, it is characterised in that described preparation is powder, tablet, capsule
Agent, pill, granule.
7. the preparation method of the compound health-care composition described in a kind of claim 1,2 or 3, it is characterised in that the method be according to
Be well mixed for each component by ratio.
8. compound health-care composition described in claim 1 prepare anti-aging, improve the health care of sleep, the medicine or food of beautifying face and moistering lotion
In application.
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| CN105010900A (en) * | 2015-08-12 | 2015-11-04 | 黑龙江天一农业科技开发有限公司 | Cordyceps militaris chewable tablet and preparation method thereof |
| CN105077219A (en) * | 2015-08-25 | 2015-11-25 | 路广 | Fungus multifunctional health-care foods and making method |
| CN107616404A (en) * | 2017-10-10 | 2018-01-23 | 广西金诚双丰农牧科技有限公司 | The preparation method of health food containing bamboo rat skin |
| CN108553487A (en) * | 2018-05-25 | 2018-09-21 | 江西国药有限责任公司 | A kind of preparation method of fermentation cordyceps Cs-4 medicine materical crude slice |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011424A (en) * | 2007-02-05 | 2007-08-08 | 王德福 | Composition with anti-oxidation and metabolism-promotion functions |
| CN101214052A (en) * | 2007-12-29 | 2008-07-09 | 江西天施康中药股份有限公司 | Health food with physical energy fatigue alleviating and immunity reinforcing function |
| CN101803730A (en) * | 2009-11-12 | 2010-08-18 | 天津市百奥生物技术有限公司 | Health care food with auxiliary protection role on chemical liver injury and preparation method thereof |
| CN101879192A (en) * | 2010-05-21 | 2010-11-10 | 郭景龙 | Medicine composition with blood tonification and beautification effects |
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| JP2013063941A (en) * | 2011-09-20 | 2013-04-11 | Kao Corp | Prophylactic or improving agent of irritable bowel syndrome |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011424A (en) * | 2007-02-05 | 2007-08-08 | 王德福 | Composition with anti-oxidation and metabolism-promotion functions |
| CN101214052A (en) * | 2007-12-29 | 2008-07-09 | 江西天施康中药股份有限公司 | Health food with physical energy fatigue alleviating and immunity reinforcing function |
| CN101803730A (en) * | 2009-11-12 | 2010-08-18 | 天津市百奥生物技术有限公司 | Health care food with auxiliary protection role on chemical liver injury and preparation method thereof |
| CN101879192A (en) * | 2010-05-21 | 2010-11-10 | 郭景龙 | Medicine composition with blood tonification and beautification effects |
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