CN103908489A - Bidirectional solid fermentation method of ginseng-radix astragali-lucid ganoderma medical mycoplasm - Google Patents
Bidirectional solid fermentation method of ginseng-radix astragali-lucid ganoderma medical mycoplasm Download PDFInfo
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Abstract
The invention provides a bidirectional solid fermentation method of ginseng-radix astragali-lucid ganoderma medical mycoplasm, and belongs to the field of traditional Chinese medicine biological fermentation. According to the bidirectional solid fermentation method of ginseng-radix astragali-lucid ganoderma medical mycoplasm, ginseng and radix astragali are smashed, and are mixed at a mass ratio of (1-9):(1-9) so as to obtain a fermentation substrate; distilled water is added, an obtained mixture is mixed uniformly for immersion, water content is adjusted to be 50 to 65%, and the mixture is delivered into culture bottles; the culture bottles are sterilized in a high-pressure sterilization pot; each of the sterilized culture bottle is inoculated with 5 blocks of lucid ganoderma strain preserved in PDA culture medium, and the sterilized culture bottles are sealed, and are subjected to culturing without light at a temperature of 24 to 30 DEG C; when the culture bottles are full filled with mycelium, fermentation is stopped, and fermentation products are collected, and are dried so as to obtain the ginseng-radix astragali-lucid ganoderma medical mycoplasm. Antioxidant activity of the ginseng-radix astragali-lucid ganoderma medical mycoplasm obtained via the bidirectional solid fermentation method of ginseng-radix astragali-lucid ganoderma medical mycoplasm is higher than that of original traditional Chinese medicine ingredients; and the ginseng-radix astragali-lucid ganoderma medical mycoplasm can be made into any solid dosage forms, including tablet and powder, via existing traditional Chinese medicine preparation technology and processes.
Description
Technical field
The invention belongs to Chinese medicine microorganism fermentation field, be specifically related to the two-way solid fermentation method of a seed ginseng stilbene sesame medicinal fungal substance.
Background technology
Radix Ginseng, the Radix Astragali are all Qi-tonifying drugs conventional in clinical treatment.Radix Ginseng sweet and slightly bitter taste and slightly warm in nature, the gas of kind tonifying five ZANG-organs, QI invigorating and hold concurrently can yin nourishing, keeps and does not walk; Radix Astragali sweet in the mouth is warm in nature, is apt to away flesh table, and QI invigorating is held concurrently can invigorating YANG, walks and does not keep.Two medicines pairings, have powerful invigorate vital energy and yang effect, invigorating primordial QI promoting generation of vital essence and blood, negative and positive are taken into account, the disease of all deficiency of vital energy deficiencies all available it.Ganoderma claims again Herba mesonae chinensis from ancient times, records by Compendium of Materia Medica: " Ganoderma property is flat, and bitter in the mouth is nontoxic, main knot in the heart, and the beneficial motive, invigorating middle warmer, increases wisdom, does not forget, and clothes of a specified duration are made light of one's life by commiting suicide not old, and angle prolongs life." modern pharmacology proves, fermented hyphostroma of Ganoderma has pharmacology effect identical with Ganoderma sporophore.
Chinese patent 201210115166.9 discloses a kind of method and the application of medicinal fungal substance in treatment pulmonary carcinoma thereof of glossy ganoderma fermentation Radix Ginseng, has confirmed that the more former Chinese medicine of gained medicinal fungal substance is suppressing to have higher activity aspect pulmonary carcinoma.But, not yet have at present any document open taking Ganoderma as fermented bacterium, the two-way solid fermentation process of the Compositional type fermentation substrate of fermented ginseng, 2 kinds of Chinese medicine composition of the Radix Astragali and and the application of medicinal fungal substance antioxidation aspect thereof.
Summary of the invention
The object of the invention is in order to provide a seed ginseng stilbene sesame medicinal fungal substance two-way solid fermentation method, the ginseng stilbene sesame medicinal fungal substance that the method obtains has higher biological activity.
The invention provides the two-way solid fermentation method of a seed ginseng stilbene sesame medicinal fungal substance, the method comprises: Chinese medicine Radix Ginseng, the Radix Astragali are pulverized, cross 10 mesh sieves, by Radix Ginseng and the Radix Astragali according to mass ratio (1～9): mix (1～9), preparation fermentation substrate, adding distil water mixes immersion, regulates water content 50%～65%, pack in 250ml culture bottle, put into 115～121 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in Ganderma lucidum strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, cultivate in 24～30 DEG C of lucifuges, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
Preferably, described Radix Ginseng and Radix Astragali mass ratio (1～3): (1～5).
Preferably, described Ganderma lucidum strain comprises cold sesame and Ganoderma lucidum (Leyss. Ex Fr.) Karst..
Beneficial effect of the present invention
The invention provides the two-way solid fermentation method of a seed ginseng stilbene sesame medicinal fungal substance, the method utilizes two-way solid-fermented technique Ganoderma to be seeded on the composite interstitial substance of Radix Ginseng, two kinds of Chinese medicine compositions of the Radix Astragali, when glossy ganoderma fermentation aerial mycelium and metabolite, the enzyme producing can catalysis Radix Ginseng, the chemical composition of the Radix Astragali transforms, improve or reduce the content of chemical composition of Chinese materia medica, thereby three tastes are there is to the organic compatibility of traditional medicine that strengthens immunity, regulates organism metabolism, slow down aging, balance pharmacological property, coordinate onset, promote the biological activity of crude drug.
The ginseng stilbene sesame medicinal fungal substance that fermentation process of the present invention obtains, antioxidant activity, higher than former Chinese crude drug, can be made any solid dosage forms by existing Chinese drug preparation technique and process, comprises tablet, powder etc.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described in detail.
Embodiment 1
Chinese medicine Radix Ginseng, the Radix Astragali are pulverized, crossed 10 mesh sieves, 1:1 mixes in mass ratio, preparation fermentation substrate, and adding distil water mixes abundant immersion, regulates water content to reach 60%, packs in 250ml culture bottle, puts into 121 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in Ganoderma lucidum (Leyss. Ex Fr.) Karst. strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, under 26 DEG C of conditions, lucifuge is cultivated, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
Fermentation is obtained to 1g ginseng stilbene sesame medicinal fungal substance Biomass, taking chitin as standard substance, be not less than 35mg by medicinal fungal substance mycelium dry weight, 1g medicinal fungal substance total saponin content is not less than 20mg taking ginsenoside Re as standard substance, 1g medicinal fungal substance general flavone content is not less than 0.35mg taking rutin as standard substance, and 1g medicinal fungal substance total polysaccharides content with glucose as a standard product meter is not less than 75mg.
Embodiment 2
Chinese medicine Radix Ginseng, the Radix Astragali are pulverized, crossed 10 mesh sieves, 1:2 mixes in mass ratio, preparation fermentation substrate, and adding distil water mixes abundant immersion, regulates water content to reach 60%, packs in 250ml culture bottle, puts into 121 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in Ganoderma lucidum (Leyss. Ex Fr.) Karst. strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, under 25 DEG C of conditions, lucifuge is cultivated, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
Fermentation is obtained to 1g ginseng stilbene sesame medicinal fungal substance Biomass, taking chitin as standard substance, be not less than 25mg by medicinal fungal substance mycelium dry weight, 1g medicinal fungal substance total saponin content is not less than 30mg taking ginsenoside Re as standard substance, 1g medicinal fungal substance general flavone content is not less than 0.25mg taking rutin as standard substance, and 1g medicinal fungal substance total polysaccharides content with glucose as a standard product meter is not less than 30mg.
Embodiment 3
Chinese medicine Radix Ginseng, the Radix Astragali are pulverized, crossed 10 mesh sieves, 1:3 mixes in mass ratio, preparation fermentation substrate, and adding distil water mixes abundant immersion, regulates water content to reach 65%, packs in 250ml culture bottle, puts into 115 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in Ganoderma lucidum (Leyss. Ex Fr.) Karst. strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, under 27 DEG C of conditions, lucifuge is cultivated, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
Fermentation is obtained to 1g ginseng stilbene sesame medicinal fungal substance Biomass, taking chitin as standard substance, be not less than 85mg by medicinal fungal substance mycelium dry weight, 1g medicinal fungal substance total saponin content is not less than 35mg taking ginsenoside Re as standard substance, 1g medicinal fungal substance general flavone content is not less than 0.30mg taking rutin as standard substance, and 1g medicinal fungal substance total polysaccharides content with glucose as a standard product meter is not less than 20mg.
Embodiment 4
Radix Ginseng, Radix Astragali crude drug are pulverized, crossed 10 mesh sieves, 2:1 mixes in mass ratio, preparation fermentation substrate, and adding distil water mixes abundant immersion, regulates water content to reach 55%, packs in 250ml culture bottle, puts into 115 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in Ganoderma lucidum (Leyss. Ex Fr.) Karst. strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, under 30 DEG C of conditions, lucifuge is cultivated, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
Fermentation is obtained to 1g ginseng stilbene sesame medicinal fungal substance Biomass, taking chitin as standard substance, be not less than 15mg by medicinal fungal substance mycelium dry weight, 1g medicinal fungal substance total saponin content is not less than 35mg taking ginsenoside Re as standard substance, 1g medicinal fungal substance general flavone content is not less than 0.25mg taking rutin as standard substance, and 1g medicinal fungal substance total polysaccharides content with glucose as a standard product meter is not less than 65mg.
Embodiment 5
Radix Ginseng, Radix Astragali crude drug are pulverized, crossed 10 mesh sieves, 3:1 mixes in mass ratio, preparation fermentation substrate, and adding distil water mixes abundant immersion, regulates water content to reach 50%, packs in 250ml culture bottle, puts into 121 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in Ganoderma lucidum (Leyss. Ex Fr.) Karst. strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, under 24 DEG C of conditions, lucifuge is cultivated, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
Fermentation is obtained to 1g ginseng stilbene sesame medicinal fungal substance Biomass, taking chitin as standard substance, be not less than 20mg by medicinal fungal substance mycelium dry weight, 1g medicinal fungal substance total saponin content is not less than 30mg taking ginsenoside Re as standard substance, 1g medicinal fungal substance general flavone content is not less than 0.65mg taking rutin as standard substance, and 1g medicinal fungal substance total polysaccharides content with glucose as a standard product meter is not less than 55mg.
Embodiment 6
Radix Ginseng, Radix Astragali crude drug are pulverized, crossed 10 mesh sieves, 5:1 mixes in mass ratio, preparation fermentation substrate, and adding distil water mixes abundant immersion, regulates water content to reach 50%, packs in 250ml culture bottle, puts into 121 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in Ganoderma lucidum (Leyss. Ex Fr.) Karst. strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, under 28 DEG C of conditions, lucifuge is cultivated, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
Fermentation is obtained to 1g ginseng stilbene sesame medicinal fungal substance Biomass, taking chitin as standard substance, be not less than 20mg by medicinal fungal substance mycelium dry weight, 1g medicinal fungal substance total saponin content is not less than 30mg taking ginsenoside Re as standard substance, 1g medicinal fungal substance general flavone content is not less than 0.45mg taking rutin as standard substance, and 1g medicinal fungal substance total polysaccharides content with glucose as a standard product meter is not less than 50mg.
Embodiment 7
Radix Ginseng, Radix Astragali crude drug are pulverized, crossed 10 mesh sieves, 1:1 mixes in mass ratio, preparation fermentation substrate, and adding distil water mixes abundant immersion, regulates water content to reach 60%, packs in 250ml culture bottle, puts into 121 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in cold sesame strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, under 28 DEG C of conditions, lucifuge is cultivated, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
Fermentation is obtained to 1g ginseng stilbene sesame medicinal fungal substance Biomass, taking chitin as standard substance, be not less than 20mg by medicinal fungal substance mycelium dry weight, 1g medicinal fungal substance total saponin content is not less than 30mg taking ginsenoside Re as standard substance, 1g medicinal fungal substance general flavone content is not less than 0.20mg taking rutin as standard substance, and 1g medicinal fungal substance total polysaccharides content with glucose as a standard product meter is not less than 40mg.
Embodiment 8
Radix Ginseng, Radix Astragali crude drug are pulverized, crossed 10 mesh sieves, 1:2 mixes in mass ratio, preparation fermentation substrate, and adding distil water mixes abundant immersion, regulates water content to reach 60%, packs in 250ml culture bottle, puts into 115 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in cold sesame strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, under 26 DEG C of conditions, lucifuge is cultivated, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
Fermentation is obtained to 1g ginseng stilbene sesame medicinal fungal substance Biomass, taking chitin as standard substance, be not less than 20mg by medicinal fungal substance mycelium dry weight, 1g medicinal fungal substance total saponin content is not less than 35mg taking ginsenoside Re as standard substance, 1g medicinal fungal substance general flavone content is not less than 0.20mg taking rutin as standard substance, and 1g medicinal fungal substance total polysaccharides content with glucose as a standard product meter is not less than 45mg.
Embodiment 9
Radix Ginseng, Radix Astragali crude drug are pulverized, crossed 10 mesh sieves, 1:3 mixes in mass ratio, preparation fermentation substrate, and adding distil water mixes abundant immersion, regulates water content to reach 65%, packs in 250ml culture bottle, puts into 121 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in cold sesame strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, under 25 DEG C of conditions, lucifuge is cultivated, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
Fermentation is obtained to 1g ginseng stilbene sesame medicinal fungal substance Biomass, taking chitin as standard substance, be not less than 65mg by medicinal fungal substance mycelium dry weight, 1g medicinal fungal substance total saponin content is not less than 35mg taking ginsenoside Re as standard substance, 1g medicinal fungal substance general flavone content is not less than 0.25mg taking rutin as standard substance, and 1g medicinal fungal substance total polysaccharides content with glucose as a standard product meter is not less than 20mg.
Embodiment 10
Radix Ginseng, Radix Astragali crude drug are pulverized, crossed 10 mesh sieves, 1:5 mixes in mass ratio, preparation fermentation substrate, and adding distil water mixes abundant immersion, regulates water content to reach 65%, packs in 250ml culture bottle, puts into 121 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in cold sesame strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, under 30 DEG C of conditions, lucifuge is cultivated, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
Fermentation is obtained to 1g ginseng stilbene sesame medicinal fungal substance Biomass, taking chitin as standard substance, be not less than 70mg by medicinal fungal substance mycelium dry weight, 1g medicinal fungal substance total saponin content is not less than 30mg taking ginsenoside Re as standard substance, 1g medicinal fungal substance general flavone content is not less than 0.35mg taking rutin as standard substance, and 1g medicinal fungal substance total polysaccharides content with glucose as a standard product meter is not less than 15mg.
The explanation of above embodiment is just for helping to understand method of the present invention and core concept thereof.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of the claims in the present invention.
To the above-mentioned explanation of the disclosed embodiments, make professional and technical personnel in the field can realize or use the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiment, General Principle as defined herein can, in the situation that not departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention will can not be restricted to these embodiment shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (3)
1. the two-way solid fermentation method of a seed ginseng stilbene sesame medicinal fungal substance, it is characterized in that, the method comprises: Chinese medicine Radix Ginseng, the Radix Astragali are pulverized, cross 10 mesh sieves, by Radix Ginseng and the Radix Astragali according to mass ratio (1～9): mix (1～9), preparation fermentation substrate, adding distil water mixes immersion, regulate water content 50%～65%, pack in 250ml culture bottle, put into 115～121 DEG C of sterilizings of high-pressure sterilizing pot 2 hours; Under aseptic condition, to grow and be stored in Ganderma lucidum strain in PDA culture medium by the truffle of 0.4cm × 0.4cm, access respectively in culture bottle 5 of every bottle graft kinds, sealing, cultivate in 24～30 DEG C of lucifuges, in the time that mycelium covers with whole bottle, stop fermentation, collect tunning, 60 DEG C of oven dry, obtain joining stilbene sesame medicinal fungal substance.
2. the two-way solid fermentation method of a seed ginseng stilbene sesame medicinal fungal substance according to claim 1, is characterized in that, described Radix Ginseng and Radix Astragali mass ratio (1～3): (1～5).
3. the two-way solid fermentation method of a seed ginseng stilbene sesame medicinal fungal substance according to claim 1, is characterized in that, described Ganderma lucidum strain comprises cold sesame and Ganoderma lucidum (Leyss. Ex Fr.) Karst..
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| CN106085879A (en) * | 2016-06-28 | 2016-11-09 | 黄秀英 | One medical material is the comprehensive mycelium of culture medium culturing Ganoderma |
| CN106820134A (en) * | 2017-02-21 | 2017-06-13 | 南京晓庄学院 | A kind of preparation method and purposes of the immunopotentiator based on sesame stilbene mycoplasma |
| CN109223668A (en) * | 2018-09-30 | 2019-01-18 | 上海清轩生物科技有限公司 | A kind of preparation method and application of the two-step fermentation product with skin repair |
| CN110218656A (en) * | 2019-05-31 | 2019-09-10 | 南京工业大学 | Ganoderma lucidum-herb residue bidirectional solid fermentation method utilizing air pressure pulsation and application |
| CN113287707A (en) * | 2021-05-28 | 2021-08-24 | 长春中医药大学 | Ginseng and hericium erinaceus bidirectional solid fermentation mycoplasm solid beverage and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106085879A (en) * | 2016-06-28 | 2016-11-09 | 黄秀英 | One medical material is the comprehensive mycelium of culture medium culturing Ganoderma |
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| CN113287707A (en) * | 2021-05-28 | 2021-08-24 | 长春中医药大学 | Ginseng and hericium erinaceus bidirectional solid fermentation mycoplasm solid beverage and preparation method thereof |
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Application publication date: 20140709 |