CN104640973A - 切向流动灌注系统 - Google Patents

切向流动灌注系统 Download PDF

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Publication number
CN104640973A
CN104640973A CN201380050422.3A CN201380050422A CN104640973A CN 104640973 A CN104640973 A CN 104640973A CN 201380050422 A CN201380050422 A CN 201380050422A CN 104640973 A CN104640973 A CN 104640973A
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China
Prior art keywords
retentate
reactor
pressure
outlet
inlet
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Pending
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CN201380050422.3A
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English (en)
Chinese (zh)
Inventor
K.格鲍尔
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Global Life Sciences Solutions USA LLC
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GE Healthcare Bio Sciences Corp
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Priority to CN201811359986.6A priority Critical patent/CN110066730A/zh
Publication of CN104640973A publication Critical patent/CN104640973A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/02—Percolation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/12—Pulsatile flow
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B23/00—Pumping installations or systems
    • F04B23/02—Pumping installations or systems having reservoirs
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/0009—Special features
    • F04B43/0081—Special features systems, control, safety measures
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/06—Pumps having fluid drive
    • F04B43/073—Pumps having fluid drive the actuating fluid being controlled by at least one valve
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
    • F04B53/20—Filtering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means
    • B01D2313/243—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/44—Cartridge types
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/04—Backflushing

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201380050422.3A 2012-09-27 2013-09-25 切向流动灌注系统 Pending CN104640973A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811359986.6A CN110066730A (zh) 2012-09-27 2013-09-25 切向流动灌注系统

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1251091-3 2012-09-27
SE1251091 2012-09-27
PCT/SE2013/051110 WO2014051503A1 (en) 2012-09-27 2013-09-25 Tangential flow perfusion system

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811359986.6A Division CN110066730A (zh) 2012-09-27 2013-09-25 切向流动灌注系统

Publications (1)

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CN104640973A true CN104640973A (zh) 2015-05-20

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CN201380050422.3A Pending CN104640973A (zh) 2012-09-27 2013-09-25 切向流动灌注系统
CN201811359986.6A Pending CN110066730A (zh) 2012-09-27 2013-09-25 切向流动灌注系统

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US (1) US9663753B2 (enExample)
EP (1) EP2900804B1 (enExample)
JP (1) JP6321661B2 (enExample)
CN (2) CN104640973A (enExample)
IN (1) IN2015DN01067A (enExample)
WO (1) WO2014051503A1 (enExample)

Cited By (21)

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CN105950468A (zh) * 2016-05-23 2016-09-21 西安交通大学 一种用于灌流的生物反应器以及用于渗透的生物反应器
CN109415669A (zh) * 2016-07-19 2019-03-01 自动化合作关系（剑桥）有限公司 可逆液体过滤系统
CN109415673A (zh) * 2016-07-19 2019-03-01 自动化合作关系（剑桥）有限公司 液体过滤和泵系统
CN109735448A (zh) * 2019-02-02 2019-05-10 上海天引生物科技有限公司 一种细胞体外流体剪切力刺激培养装置及其方法
CN111263631A (zh) * 2017-10-26 2020-06-09 瑞普利金公司 微型交替切向流灌注过滤器、处理容器及其使用方法
CN111534411A (zh) * 2020-04-03 2020-08-14 利穗科技(苏州)有限公司 一种交替切向流罐装培养装置及其控制方法
CN111565823A (zh) * 2018-01-12 2020-08-21 富默乐有限公司 切向流过滤tff系统和包括集成泵装置的一次性tff单元
CN112020552A (zh) * 2018-02-09 2020-12-01 环球生命科技咨询美国有限责任公司 用于生物处理系统中的流体流动管理的系统和方法
CN112322496A (zh) * 2021-01-05 2021-02-05 北京百普赛斯生物科技股份有限公司 一种新冠病毒s1蛋白的灌流生产系统及方法
CN112823203A (zh) * 2018-10-17 2021-05-18 环球生命科技咨询美国有限责任公司 生物反应器系统
CN112912482A (zh) * 2018-07-27 2021-06-04 尤尼沃尔塞尔斯技术股份公司 制备生物分子的系统和方法
CN113728087A (zh) * 2019-05-02 2021-11-30 环球生命科技咨询美国有限责任公司 生物处理系统和用于生物处理系统的可消耗袋
CN113993983A (zh) * 2019-06-17 2022-01-28 思拓凡瑞典有限公司 用于分离生物分子的方法
CN114107045A (zh) * 2021-10-12 2022-03-01 江苏蒙彼利生物科技有限公司 一种无血干细胞培养灌流装置及灌流方法
CN114207106A (zh) * 2019-08-12 2022-03-18 思拓凡瑞典有限公司 用于生物反应器中的灌注控制的系统和方法
CN114867837A (zh) * 2020-01-07 2022-08-05 思拓凡瑞典有限公司 用于控制生物反应器中流体流的系统和方法
US11920119B2 (en) 2018-02-09 2024-03-05 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
US11932842B2 (en) 2018-02-09 2024-03-19 Global Life Sciences Solutions Usa Llc Bioprocessing apparatus
US12077743B2 (en) 2018-02-09 2024-09-03 Global Life Sciences Solutions Usa Llc Apparatus for fluid line management in a bioprocessing system
US12252682B2 (en) 2018-02-09 2025-03-18 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US12503681B2 (en) 2024-01-11 2025-12-23 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing

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JP6530171B2 (ja) * 2014-09-09 2019-06-12 旭化成メディカル株式会社 培養産生物の回収方法
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CN108350405A (zh) * 2015-08-08 2018-07-31 施托贝制药技术股份有限公司 支持生物活性的一次性生物处理系统
JP6862001B2 (ja) 2015-08-20 2021-04-21 サイティバ・スウェーデン・アクチボラグ タンジェンシャルフローろ過システムにおいてろ過収量を向上させるための改良された方法
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WO2017082990A1 (en) * 2015-11-10 2017-05-18 Repligen Corporation Disposable alternating tangential flow filtration units
WO2017097604A1 (en) 2015-12-07 2017-06-15 Ge Healthcare Bio-Sciences Ab Unit for treatment of a bioprocess liquid with disposable flow path elements
ITUB20160272A1 (it) * 2016-01-22 2017-07-22 Univ Degli Studi Di Palermo Bioreattore a perfusione autosufficiente monouso per crescite cellulari 3D
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JP6890389B2 (ja) * 2016-08-29 2021-06-18 株式会社日立製作所 送液装置、及びそれを用いた細胞培養装置
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TWI675696B (zh) * 2017-06-01 2019-11-01 美商Ｅｍｄ密理博公司 用於灌注應用之切向流過濾裝置
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RU2020114891A (ru) 2017-09-27 2021-10-27 Юниверселлс С.А. Система и способ получения биомолекул, таких как вирусные вакцины
US10792594B2 (en) * 2017-12-28 2020-10-06 Replegin Corporation Dual pumping arrangement for a hollow fiber filter
JP6479277B1 (ja) * 2018-02-27 2019-03-06 三菱電機株式会社 散気量制御システム及び散気量制御方法
WO2020043550A1 (en) * 2018-08-29 2020-03-05 Ge Healthcare Bio-Sciences Ab System for filtration and associated method thereof
CN113498432A (zh) * 2019-02-08 2021-10-12 隆萨沃克斯维尔股份有限公司 用于自动化生物反应器的细胞浓缩方法和装置
EP4010101A4 (en) * 2019-08-05 2022-11-16 Repligen Corporation DEVICES, SYSTEMS AND METHODS FOR CONTINUOUS TREATMENT WITH ALTERNATE TANGENTIAL FLOW
SK289034B6 (sk) * 2019-10-10 2023-01-25 EKOM spol. s r. o. Membránový separátor plynov so vstavaným ventilom a spôsob jeho otvárania a zatvárania
EP3835402B1 (de) * 2019-12-09 2025-10-15 Sartorius Stedim Biotech GmbH Modulares prozessiersystem
US20240050901A1 (en) * 2021-02-11 2024-02-15 Sani Membranes Aps Filtration Device
WO2022221626A2 (en) 2021-04-16 2022-10-20 Repligen Corporation Filtration system and method
JP7767029B2 (ja) * 2021-05-28 2025-11-11 ダイセン・メンブレン・システムズ株式会社 細胞外小胞の分離精製方法
JP7716233B2 (ja) * 2021-05-28 2025-07-31 ダイセン・メンブレン・システムズ株式会社 微小有用物質の分離精製方法と分離精製装置
CN113265330B (zh) * 2021-06-04 2022-04-01 河南大学 一种适用于疫苗及抗体高效生产的动物细胞高密度培养系统
CN119630470A (zh) * 2022-07-28 2025-03-14 株式会社大赛璐 包含微小有用物质的液体的纯化浓缩装置、以及使用了该装置的包含微小有用物质的纯化浓缩液的制造方法
KR20250058028A (ko) * 2022-09-06 2025-04-29 암젠 인크 대형 바이오리액터 시스템 및 방법
WO2025015044A1 (en) * 2023-07-11 2025-01-16 Amgen Inc. Alternating recirculating tangential flow (artf) filtration for cell culture media perfusion and bioreactor harvesting

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