CN104623679A - Freeze-drying method of gecko - Google Patents
Freeze-drying method of gecko Download PDFInfo
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- CN104623679A CN104623679A CN201510096294.7A CN201510096294A CN104623679A CN 104623679 A CN104623679 A CN 104623679A CN 201510096294 A CN201510096294 A CN 201510096294A CN 104623679 A CN104623679 A CN 104623679A
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- gekko swinhonis
- lyophilizing
- milk
- freeze
- dry
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Abstract
The invention relates to a freeze-drying method of a gecko without smell. The freeze-drying method is characterized by comprising the following steps: adding milk and freeze-drying together, wherein the amount of the milk is 1-5 times of that of the gecko according to the weight. The prepared gecko is high in treating effect and less smell in oral administration and can cause high compliance for patients.
Description
Invention field
The present invention relates to medicine, particularly a kind of freeze drying process of Gekko Swinhonis, belong to medical art.
Background technology
Gekko Swinhonis is also known as Gekko Swinhonis, Gekko Swinhonis etc.For Gekkonidae animal is all without the drying of web Gekko Swinhonis (Gekko swinho-nis Gunther) or many nevuss Gekko Swinhonis (Gekko japonicus Cdumerit et Bi) and other several Gekko Swinhonis, make the dosage forms such as ball, loose, cream to be used as medicine more, be widely used in clinical various diseases, particularly have definite curative effect to difficult miscellaneous diseases such as Several Kinds of Malignancy, tuberculosis, osteomyelitis.
Gekko Swinhonis generally season in autumn in summer two catch oven dry be used as medicine.Gekko Swinhonis is because making a living with episite, and thus abdomen is built-in with insect bodies such as a large amount of indigested mosquitos and flies, easily causes be with microbial reproduction, corrodes its internal organs, thus causes Gekko Swinhonis often with abnormal foul smell, makes us nauseating after news, takes orally and easily causes vomiting.
The process of preparing Chinese medicine of Gekko Swinhonis just has at Holy Benevolent Prescriptions: " smash Luo Weimo." " Shengji Zonglu " have: " removing foot ".Have in " Compendium of medicine ": the record of " oven dry ".But substantially make a living now with and make with two kinds, concocting method is " after gilling, strut with bamboo chip and make entirety flat straight, cold drying or slow fire are dried ".Jiangxi " concocted specification " is with stir-baked in pulvis TALCI to foaming crisp and having foul smell to overflow, and taking-up cools; Hunan " concocted specification " is then taken out by spray proper amount of white spirit after stir-baked in pulvis TALCI bubble and is dried.Prior art concoct after Gekko Swinhonis, abnormal flavour is still very heavy, provides a kind of Gekko Swinhonis concocting method improving mouthfeel very necessary.
Vacuum lyophilization, also known as lyophilizing, can preserve the activity of effective medicinal components to greatest extent.But lyophilizing Gekko Swinhonis abnormal flavour is still extra heavy, and mouthfeel is still very poor, direct oral patient is still difficult to accept.Study a kind of drying means improving Gekko Swinhonis curative effect, improve mouthfeel, very necessary.
Summary of the invention
The object of this invention is to provide a kind of freeze drying process of free from extraneous odour Gekko Swinhonis, make the Gekko Swinhonis curative effect of lyophilizing high, oral abnormal flavour is little, and clinical effectiveness is good.
Object of the present invention is achieved through the following technical solutions:
A freeze drying process for free from extraneous odour Gekko Swinhonis, is characterized in that: add milk lyophilizing.
The freeze drying process of a kind of free from extraneous odour Gekko Swinhonis of the present invention, is characterized in that: milk consumption is 1-10 times of Gekko Swinhonis by weight.
The freeze drying process of a kind of free from extraneous odour Gekko Swinhonis of the present invention, is characterized in that: lyophilizing is refrigerated to less than-10 DEG C, is evacuated to below drying chamber pressure 30Pa, subliming by heating; The temperature of distillation controls below 45 DEG C, and resolution temperature controls below 50 DEG C, to dry.
Gekko Swinhonis curative effect prepared by the present invention is high, and oral abnormal flavour is little, and the compliance of patient is high.
Test example is intended to further illustrate usefulness of the present invention below, but not limitation of the present invention.
By same mass products Gekko Swinhonis, put in airtight container and suffocate, clean, dry by the following method respectively.
1) dry, pulverize;
2) lyophilizing: put in freeze dryer, be refrigerated to-20 DEG C, is evacuated to drying chamber pressure 45Pa, subliming by heating, and the temperature of distillation controls at 40 DEG C, and resolution temperature controls at 45 DEG C, to dry, pulverizes;
3) lyophilizing with milk: add in the milk of 1 times by weight, puts in freeze dryer, is refrigerated to-20 DEG C, is evacuated to drying chamber pressure 45Pa, subliming by heating, and the temperature of distillation controls at 40 DEG C, and resolution temperature controls at 45 DEG C, to dry, pulverizes
The Gekko Swinhonis mouthfeel of test example one, distinct methods drying compares
Be made up of 10 people and appraise group through discussion, everyone respectively warm water for oral use mix well dry, the Gekko Swinhonis powder of lyophilizing and lyophilizing with milk, the mouthfeel mouthfeel concept such as " very well ", " better ", " rare abnormal flavour ", " poor ", " very poor " is evaluated.Evaluation result is in table 1.
The Gekko Swinhonis mouthfeel of table 1 distinct methods drying compares
| Very well | Better | Rare abnormal flavour | Poor | Very poor | |
| Lyophilizing with milk | 0 people | 1 people | 8 people | 1 people | 0 people |
| Lyophilizing | 0 people | 0 people | 0 people | 2 people | 8 people |
| Dry | 0 people | 0 people | 0 people | 0 people | 10 people |
Result shows, and the Gekko Swinhonis of lyophilizing with milk, oral abnormal flavour is little, and mouthfeel is good.
The house liyard powder of test example two, distinct methods processing is tested the tumor-inhibiting action of S180 tumor-bearing mice
S180 tumor-bearing mice belly cavity tumor cell is inoculated in mouse peritoneal continuous passage, aseptic aspiration 7d mouse peritoneal in age tumor cell, adds tumor cell to 4 × 10 in normal saline adjustment cell suspension
6/ ml, then in every mice right oxter injection 0.2ml tumor cell suspension.After 24h, at random mice is divided into 4 groups: model group, lyophilizing group with milk, lyophilizing group and dry group, often organizes 10.Body weight zero difference between each group.Model group is with normal saline 0.3 ml/d gavage.Administration group gavage gives the house liyard powder mixed well with normal saline, and every mouse stomach amount is that 0.3 ml/d(contains house liyard powder 0.2g, and the house liyard powder of lyophilizing with milk presses Gekko Swinhonis content meter).After successive administration 10d, within the 11st day, crane one and put to death mice, shell tumor, weigh, calculate tumour inhibiting rate.
The average tumor of suppression ratio (%)=(model group average tumor weight-experimental group average tumor weight)/model group heavy × 100% of implanted solid tumor growth.The results are shown in Table 2.
The house liyard powder of table 2 distinct methods processing is to the comparison of mice tumour inhibiting rate
| Model group | Lyophilizing group with milk | Lyophilizing group | Dry group | |
| Average tumor heavy (g) | 2.39±1.16 | 1.04±0.54 | 1.04±0.57 | 1.22±1.41 |
| Tumour inhibiting rate (%) | 0 | 56.49 | 56.49 | 48.95 |
Result shows, the house liyard powder of lyophilizing with milk is suitable with the house liyard powder tumor-inhibiting action of lyophilizing.Both tumor-inhibiting actions are all better than and dry Gekko Swinhonis.
Detailed description of the invention
embodiment 1
5kg removes the fresh Gekko Swinhonis that internal organs are cleaned, and add 5kg milk, put in freeze dryer, be refrigerated to-10 DEG C, be evacuated to drying chamber pressure 30Pa, subliming by heating, the temperature of distillation controls at 45 DEG C, and resolution temperature controls at 50 DEG C, to dry.Obtain the Gekko Swinhonis of free from extraneous odour.
embodiment 2
5kg removes the fresh Gekko Swinhonis that internal organs are cleaned, and add 50kg milk, put in freeze dryer, be refrigerated to-28 DEG C, be evacuated to drying chamber pressure 40Pa, subliming by heating, the temperature of distillation controls at 40 DEG C, and resolution temperature controls at 45 DEG C, to dry.Obtain the Gekko Swinhonis of free from extraneous odour.
embodiment 3
5kg Gekko Swinhonis alive, add 5kg milk and suffocate, put in freeze dryer, be refrigerated to-10 DEG C, be evacuated to drying chamber pressure 30Pa, subliming by heating, the temperature of distillation controls at 45 DEG C, and resolution temperature controls at 50 DEG C, to dry.Obtain the Gekko Swinhonis of free from extraneous odour.
embodiment 4
5kg Gekko Swinhonis alive, add 15kg milk and suffocate, put in freeze dryer, put in freeze dryer, be refrigerated to-32 DEG C, be evacuated to drying chamber pressure 30Pa, subliming by heating, the temperature of distillation controls at 30 DEG C, and resolution temperature controls at 30 DEG C, to dry.Obtain the Gekko Swinhonis of free from extraneous odour.
embodiment 5
5kg Gekko Swinhonis alive, add 7kg milk, put in freeze dryer, be refrigerated to-20 DEG C, be evacuated to drying chamber pressure 50Pa, subliming by heating, the temperature of distillation controls at 25 DEG C, and resolution temperature controls at 45 DEG C, to dry.Obtain the Gekko Swinhonis of free from extraneous odour.
Claims (3)
1. a freeze drying process for free from extraneous odour Gekko Swinhonis, is characterized in that: add milk lyophilizing.
2. the freeze drying process of a kind of free from extraneous odour Gekko Swinhonis according to claim 1, is characterized in that: milk consumption is 1-10 times of Gekko Swinhonis by weight.
3. the freeze drying process of a kind of free from extraneous odour Gekko Swinhonis according to claim 1, is characterized in that: lyophilizing is refrigerated to less than-10 DEG C, is evacuated to below drying chamber pressure 30Pa, subliming by heating; The temperature of distillation controls below 45 DEG C, and resolution temperature controls below 50 DEG C, to dry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510096294.7A CN104623679A (en) | 2015-03-05 | 2015-03-05 | Freeze-drying method of gecko |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510096294.7A CN104623679A (en) | 2015-03-05 | 2015-03-05 | Freeze-drying method of gecko |
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| Publication Number | Publication Date |
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| CN104623679A true CN104623679A (en) | 2015-05-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510096294.7A Pending CN104623679A (en) | 2015-03-05 | 2015-03-05 | Freeze-drying method of gecko |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103234A (en) * | 1993-02-05 | 1995-05-31 | 花王株式会社 | Taste modifying method and bitter taste reducing method |
| CN101884406A (en) * | 2009-05-12 | 2010-11-17 | 刘凤鸣 | Taste-masking technology by taking milk powder as taste-masking agent and application thereof |
| CN104000770A (en) * | 2014-06-05 | 2014-08-27 | 彭兆启 | Mouthwash capable of removing garlic odor |
-
2015
- 2015-03-05 CN CN201510096294.7A patent/CN104623679A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103234A (en) * | 1993-02-05 | 1995-05-31 | 花王株式会社 | Taste modifying method and bitter taste reducing method |
| CN101884406A (en) * | 2009-05-12 | 2010-11-17 | 刘凤鸣 | Taste-masking technology by taking milk powder as taste-masking agent and application thereof |
| CN104000770A (en) * | 2014-06-05 | 2014-08-27 | 彭兆启 | Mouthwash capable of removing garlic odor |
Non-Patent Citations (1)
| Title |
|---|
| 宋萍等: "鲜壁虎冻干粉抑制H22肿瘤血管生成机理的实验研究", 《中国中西医结合杂志》 * |
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Application publication date: 20150520 |
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